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Bioavailability and pharmacokinetic parameters of a formulation containing secoisolariciresinol diglucoside–rich extractdetermination of absolute bioavailability

发表日期 June 30, 2023 (DOI: https://doi.org/10.54985/peeref.2306p3619596)

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作者

Chhaya Gadgoli1 , Archana Naik1 , Siddhi Bhandekar1 , Harshala Bhere1
  1. Saraswathi Vidya Bhavan's College of Pharmacy

会议/活动

Conference of Society for Ethnopharmacology, April 2022 (Mysore, India)

海报摘要

The study is related to the development of a standardized preparation of Secoisolariciresinol Diglucoside (SDG) rich extract from Linum ussititasinum seeds. Further the formulation was evaluated for bioavailability and pharmacokinetic parameters. The bioavailability studies were carried out later the development of bioanalytical method using HPTLC technique. The method was validated as per ICH guidelines.The method was found to be accurate, sensitive, simple and rapid. Bioavailability studies in rats, involved determination of absolute bioavailablity of pure Secoisolariciresinol (SECO) which appears in blood after admininstration of SDG,followed by relative bioavailability of the standardized capsule formulation. The study has significance in reducing batch to batch variations of herbal crude drug and the bioaavailability is related to the efficacy with fate of the active compound in body. The absolute bioavailability ofSECOis found to be 17 % while the relative bioavailability of the formulation is observed to 98%.

关键词

Bioanalytical, Lignan, Linseed, Standardization, Pharmacokinetic, Validation

研究领域

Pharmacy and Pharmacology

参考文献

  1. De Silva SF, Alcorn J (2019) Flaxseed lignans as important dietary polyphenols for cancer prevention and treatment: chemistry, pharmacokinetics, and molecular targets. Pharmaceuticals 12:68. https:// doi.org/10.3390/ph12020068
  2. Yang X, Guo Y, Tse TJ, Purdy SK, Mustafa R, Shen J, Alcorn J, Reaney MJ (2021) Oral pharmacokinetics of enriched secoisolariciresinol diglucoside and its polymer in rats. J Nat Prod 84:1816–1822. https://doi.org/10.1021/acs.jnatprod.1c00335
  3. Li X, Yuan JP, Xu SP, Wang JH, Liu X (2008) Separation and determination of secoisolariciresinol diglucoside oligomers and their hydrolysates in the faxseed extract by high-performance liquid chromatography. J Chromatogr A 1185:223–232. https://doi.org/10.1016/j. chroma.2008.01.066

基金

暂无数据

补充材料

  1. Supplementary File   Download

附加信息

利益冲突
No competing interests were disclosed.
数据可用性声明
The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
知识共享许可协议
Copyright © 2023 Gadgoli et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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引用
Gadgoli, C., Naik, A., Bhandekar, S., Bhere, H. Bioavailability and pharmacokinetic parameters of a formulation containing secoisolariciresinol diglucoside–rich extractdetermination of absolute bioavailability [not peer reviewed]. Peeref 2023 (poster).
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