Novel synergistic combination of active ingredients for melasma topical therapy

作者

Alfredo Martínez-Gutiérrez¹ , Eloy Pena-Rodríguez¹ , Susana Gómez-Escalante¹ , Mari Carmen González¹ , Luis Shotze Luis¹

1. Mesoestetic Pharma Group

会议/活动

International Pigment Cell Conference 2023, May 2023 (Bilbao, Spain)

海报摘要

Melasma has a complex pathophysiology with different cell types and signaling pathways involved, including paracrine factors secreted by keratinocytes, fibroblasts and endothelial cells act stimulating melanogenesis on melanocytes. The aim of this research was to find a novel synergy between compounds to effectively treat skin hyperpigmentation conditions such as melasma. Artificial Neural Networks (ANNs) algorithm was used to select the best combinations among 12 selected depigmenting compounds. The proposed combination of compounds by artificial intelligence had a synergistic effect in vitro. The combination reduced the levels of COX-2 and ET-1 in fibroblasts. The combination also inhibited αMSH-induced dendricity in melanocytes. Finally, the combination significantly reduced pigmentation in a reconstructed human epidermis model after 8 days of treatment. This combination of compounds shows promising results for the treatment of skin hyperpigmentation conditions such as melasma by regulating the key pathways involved in its pathogenesis (inflammatory, vascular and hormonal pathways).

关键词

Melasma, Synergy, Vascular, Inflammation, Hormonal

研究领域

Biological Sciences, Pharmacy and Pharmacology

参考文献

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基金

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补充材料

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附加信息

利益冲突

All authors work for the company mesoestetic Pharma Group. s.l.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Martínez-Gutiérrez et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.