Small molecule lipid (SURYA-101) as a potential drug to prevent and manage diabetic retinopathy (DR)

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作者

Undurti Das¹

1. UND Life Sciences

会议/活动

10th International Conference on Advanced Technologies and Treatments for Diabetes (ATTD), February 2017 (Paris, France)

海报摘要

Diabetic retinopathy (DR) is a common cause of significant vision loss and blindness in those with diabetes mellitus. Yet, there is no effective therapeutic intervention available for its prevention and management. SURYA-101, a lipid based small molecule-lipoxin A4 (LXA4) that has potent anti-inflammatory and immunomodulatory actions is being developed as a potential drug for DR. It also has the potential to treat AMD (age-related macular degeneration) and retinopathy of prematurity.

关键词

Lipoxin A4, Diabetic retinopathy, Inflammation

研究领域

Medicine, Immunology, Biochemistry, Molecular and Cellular Biosciences, Biological Sciences

参考文献

1. Kaviarasan K, Mohanlal J, Mohammad Mulla MA, Shanmugam S, Sharma T, Das UN, Angayarkanni N. Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance as potential risk factors for diabetic retinopathy. Metabolism 2015; 64: 958-966.
2. Shen J, Bi Y-L, Das UN. Potential role of polyunsaturated fatty acids in diabetic retinopathy. Arch Med Sci 2014; 10: 1167-1174.
3. Dalan D, Nandini P, Angayarkanni N, Kaviarasan K, Thanikachalam S, Das UN, Ratra D. Interchangeability of retinal perfusion indices in different-sized angiocubes: An optical coherence tomography angiography study in diabetic retinopathy. Indian J Ophthalmol. 2020 Mar;68(3):484-489.

基金

暂无数据

补充材料

暂无数据

附加信息

利益冲突

WE are planning to develop SURYA-101 as a potential drug for Diabetic retinopathy

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Das. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.