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Small molecule lipid (SURYA-101) as a potential drug to prevent and manage diabetic retinopathy (DR)
PUBLISHED March 29, 2023 (DOI: https://doi.org/10.54985/peeref.2303p3549992)
NOT PEER REVIEWED
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Authors
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Undurti Das1
- UND Life Sciences
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Conference / event
- 10th International Conference on Advanced Technologies and Treatments for Diabetes (ATTD), February 2017 (Paris, France)
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Poster summary
- Diabetic retinopathy (DR) is a common cause of significant vision loss and blindness in those with diabetes mellitus. Yet, there is no effective therapeutic intervention available for its prevention and management. SURYA-101, a lipid based small molecule-lipoxin A4 (LXA4) that has potent anti-inflammatory and immunomodulatory actions is being developed as a potential drug for DR. It also has the potential to treat AMD (age-related macular degeneration) and retinopathy of prematurity.
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Keywords
- Lipoxin A4, Diabetic retinopathy, Inflammation
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Research areas
- Medicine, Immunology, Biochemistry, Molecular and Cellular Biosciences, Biological Sciences
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References
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- Kaviarasan K, Mohanlal J, Mohammad Mulla MA, Shanmugam S, Sharma T, Das UN, Angayarkanni N. Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance as potential risk factors for diabetic retinopathy. Metabolism 2015; 64: 958-966.
- Shen J, Bi Y-L, Das UN. Potential role of polyunsaturated fatty acids in diabetic retinopathy. Arch Med Sci 2014; 10: 1167-1174.
- Dalan D, Nandini P, Angayarkanni N, Kaviarasan K, Thanikachalam S, Das UN, Ratra D. Interchangeability of retinal perfusion indices in different-sized angiocubes: An optical coherence tomography angiography study in diabetic retinopathy. Indian J Ophthalmol. 2020 Mar;68(3):484-489.
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Funding
- No data provided
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Supplemental files
- No data provided
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Additional information
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- Competing interests
- WE are planning to develop SURYA-101 as a potential drug for Diabetic retinopathy
- Data availability statement
- The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
- Creative Commons license
- Copyright © 2023 Das. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Das, U. Small molecule lipid (SURYA-101) as a potential drug to prevent and manage diabetic retinopathy (DR) [not peer reviewed]. Peeref 2023 (poster).
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