期刊
HAEMATOLOGICA
卷 98, 期 3, 页码 399-403出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2012.064337
关键词
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类别
资金
- Associazione Italiana contro le Leucemie
- Linfomi e Mieloma (AIL)-Bari
- MIUR (Minister dell'Istruzione, dell'Universita' e della Ricerca)
There have been few reports of a response to dasatinib or nilotinib after failure of two prior sequential tyrosine kinase inhibitors. We report the outcome of 82 chronic phase patients who received nilotinib or dasatinib as third-line alternative tyrosine kinase inhibitor therapy. Thirty-four patients failed to respond to nilotinib and were started on dasatinib as third-line tyrosine kinase inhibitor therapy while 48 patients were switched to nilotinib after dasatinib failure. Overall, we obtained a cytogenetic response in 32 of 82 patients and major molecular response in 13 patients; disease progression occurred in 12 patients. At last follow up, 70 patients (85.4%) were alive with a median overall survival of 46 months. Our results show that third-line tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients after failure of two prior sequential tyrosine kinase inhibitors may induce a response that, in some instances, could prolong overall survival and affect event-free survival.
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