Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Review
Pharmacology & Pharmacy
Poonam Sagar, Stanzin Angmo, Rajat Sandhir, Vikas Rishi, Hariom Yadav, Nitin Kumar Singhal
Summary: Iron is essential for mammals but its homeostasis must be accurately regulated for proper physiological functioning. Hepcidin plays a crucial role in maintaining iron balance in the body, while inflammatory disorders can disrupt this balance. Therapeutic approaches targeting the hepcidin-FPN axis have been developed to address iron-related disorders.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Food Science & Technology
Mauricio Restrepo-Gallego, Luis E. Diaz, Patricia H. C. Rondo
Summary: Iron deficiency is the leading cause of anemia, and assessing iron nutritional status requires consideration of various laboratory tests and indicators. Using multiple indicators in combination may be the best practice due to the influence of different factors on these indicators. Constant validation, improvement of assessment methods, and identification of new indicators are key to refining the assessment of iron nutritional status and selecting appropriate treatment for improvement.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Cell Biology
Daniel N. Srole, Tomas Ganz
Summary: ERFE is the main erythroid regulator that suppresses hepcidin synthesis and mobilizes cellular iron stores for heme synthesis. In conditions of ineffective erythropoiesis, the overproduction of ERFE can cause iron overload.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Naseem Mohammad Alshwaiyat, Aryati Ahmad, Hamid Ali Nagi Al-Jamal
Summary: This study aimed to evaluate the effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia. The results showed that weight loss intervention led to significant improvements in iron status and its markers. These findings suggest that diet-induced weight loss can improve iron status and related clinical markers in this population.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Peng Sun, Yueqin Zhou, Suhua Xu, Xiaotong Wang, Xiuxiu Li, Hailin Li, Zongyu Lin, Fenglian Huang, Lewei Zhu, Yanna Zhu
Summary: This study aimed to investigate the association between first-trimester maternal serum hepcidin and third-trimester iron deficiency anemia (IDA). The study found that higher levels of first-trimester hepcidin were negatively associated with the risk of third-trimester IDA, suggesting that elevated hepcidin may predict a reduced risk for developing IDA.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Chie Ogawa, Ken Tsuchiya, Naohisa Tomosugi, Kunimi Maeda
Summary: Our study found that Hb synthesis was maintained with lower TSAT and s-ft levels during Rox therapy compared to DA therapy. Ideal s-ft and TSAT levels before switching from DA to Rox to avoid iron deficiency during the 4 weeks after the switch were determined as 81.6 ng/mL and 23.9%, respectively.
Review
Medicine, Research & Experimental
Elizabeta Nemeth, Tomas Ganz
Summary: Hepcidin, secreted by hepatocytes, controls the activity of ferroportin to regulate plasma iron concentrations and total body iron content. Iron loading and inflammation increase hepcidin levels, while erythropoietic stimulation and pregnancy suppress its levels. Hepcidin deficiency leads to iron overload, while hepcidin excess causes iron-restrictive anemias. Developing hepcidin diagnostics and therapeutics will improve the treatment of iron disorders.
ANNUAL REVIEW OF MEDICINE
(2023)
Article
Urology & Nephrology
Cristina Capusa, Ana-Maria Mehedinti, Liliana Barsan, Ana Stanciu, Andreea Calenic, Gabriel Mircescu
Summary: This study found that iron deficiency anemia (IDA) and anemia of chronic disorders (ACD) can coexist in patients with chronic kidney disease (CKD), and ferritin and transferrin saturation (TSAT) are useful markers for differentiating IDA-ACD from ACD, while hepcidin, a marker of iron in bone marrow macrophages, has limited utility.
Review
Biochemistry & Molecular Biology
Jolanta Artym, Michal Zimecki, Marian L. Kruzel
Summary: Pregnancy requires higher levels of nutrients, including iron, for the growth and maintenance of the fetus. Iron deficiency during pregnancy can lead to serious health issues, making iron supplementation essential for pregnant women. Studies suggest that lactoferrin can be an effective prophylaxis and treatment for iron deficiency anemia during pregnancy, offering various beneficial effects on iron homeostasis and overall health.
Article
Urology & Nephrology
Anil K. Agarwal
Summary: Anemia is common in CKD patients due to dysregulation of iron metabolism and erythropoiesis. Hepcidin plays a key role in iron availability, with levels affected by factors like hypoxia and inflammation. Current laboratory tests for iron supply have limitations, and CKD anemia treatment can disrupt iron homeostasis.
KIDNEY INTERNATIONAL SUPPLEMENTS
(2021)
Article
Nutrition & Dietetics
Antonella Giliberti, Annalisa Curcio, Nicola Marchitto, Luca Di Lullo, Fulvia Paolozzi, Fabiana Nano, Michele Pironti, Gianfranco Raimondi
Summary: The study investigated the efficacy of a new oral iron formulation in patients with moderate CKD and functional IDA, demonstrating that the formulation based on ferric sodium EDTA showed superior efficacy in improving iron blood parameters and reducing inflammatory status compared to other oral iron sources.
Article
Biochemistry & Molecular Biology
Hilde van der Staaij, Albertine E. Donker, Dirk L. Bakkeren, Jan M. J. I. Salemans, Lisette A. A. Mignot-Evers, Marlies Y. Bongers, Jeanne P. Dieleman, Tessel E. Galesloot, Coby M. Laarakkers, Siem M. Klaver, Dorine W. Swinkels
Summary: In this study, the TSAT/hepcidin ratio was found to be a useful tool for distinguishing IRIDA from IDA, with excellent performance in early diagnosis. This method helps identify IRIDA related to gene mutations, while recent iron therapy and moderate-to-severe inflammation should be excluded.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Naseem Mohammad Alshwaiyat, Aryati Ahmad, Wan Mohd Razin Wan Hassan, Hamid Ali Nagi Al-Jamal
Summary: Obesity is associated with iron deficiency anemia, possibly due to disruptions in iron homeostasis and increased hepcidin levels mediated by chronic inflammation. Significant weight loss in overweight and obese individuals may improve iron status by reducing inflammation and increasing iron absorption, but additional randomized controlled trials are needed to confirm this effect.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Physiology
Yihang Li, Ian Miller, Princy Prasad, Nisha Ajit George, Nermi L. Parrow, Robert E. Fleming
Summary: This study investigates the role of transferrin in the erythropoietic response to iron deficiency and iron deficiency anemia. The results demonstrate that transferrin not only plays a role in iron delivery but also affects iron homeostasis and erythropoiesis. Administration of exogenous iron-loaded transferrin restores iron levels and influences the expression of regulatory proteins involved in erythropoiesis. In iron deficiency anemia, transferrin treatment increases erythropoietin sensitivity, highlighting its importance in the recovery from iron deficiency anemia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Markus Anliker, Daniela Drees, Lorin Loacker, Susanne Hafner, Andrea Griesmacher, Gregor Hoermann, Vilmos Fux, Harald Schennach, Paul Hoertnagl, Arthur Dopler, Stefan Schmidt, Rosa Bellmann-Weiler, Gunter Weiss, Astrid Marx-Hofmann, Sixten Koerper, Britta Hoechsmann, Hubert Schrezenmeier, Christoph Q. Schmidt
Summary: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic disease caused by impaired complement regulation. This study found increased expression levels of the checkpoint ligand PD-L1 in PNH patients, which correlated with complement activation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
S. Momsen Reincke, Meng Yuan, Hans-Christian Kornau, Victor M. Corman, Scott van Hoof, Elisa Sanchez-Sendin, Melanie Ramberger, Wenli Yu, Yuanzi Hua, Henry Tien, Marie Luisa Schmidt, Tatjana Schwarz, Lara Maria Jeworowski, Sarah E. Brandl, Helle Foverskov Rasmussen, Marie A. Homeyer, Laura Stoffler, Martin Barner, Desiree Kunkel, Shufan Huo, Johannes Horler, Niels von Wardenburg, Inge Kroidl, Tabea M. Eser, Andreas Wieser, Christof Geldmacher, Michael Hoelscher, Hannes Ganzer, Gunter Weiss, Dietmar Schmitz, Christian Drosten, Harald Pruss, Ian A. Wilson, Jakob Kreye
Summary: The Beta variant of concern (VOC) of SARS-CoV-2 shows resistance to neutralization by antibodies from COVID-19 patients and vaccinated individuals. Researchers have identified specific antibodies in serum from Beta-infected patients that are able to cross-react with the wild type virus. This finding provides insights into the antibody response to antigenic drift and has implications for the development of future vaccines and therapeutics.
Article
Biochemistry & Molecular Biology
Thomas Sonnweber, Philipp Grubwieser, Sabina Sahanic, Anna Katharina Boehm, Alex Pizzini, Anna Luger, Christoph Schwabl, Sabine Koppelstaetter, Katharina Kurz, Bernhard Puchner, Barbara Sperner-Unterweger, Katharina Huefner, Ewald Woell, Manfred Nairz, Gerlig Widmann, Ivan Tancevski, Judith Loeffler-Ragg, Guenter Weiss
Summary: This study describes iron dyshomeostasis in COVID-19 patients during follow-up and investigates its association with long-term pulmonary and symptomatic recovery. The study found that iron dyshomeostasis and anemia are common findings after COVID-19 and may contribute to long-term symptomatic outcomes.
Review
Hematology
Orian Marques, Guente Weiss, Martina U. Muckenthaler
Summary: Anemia of inflammation is a common comorbidity in patients with chronic inflammatory disorders, negatively impacting disease outcome and quality of life. The pathophysiology of anemia of inflammation involves inflammatory hypoferremia and iron-restricted erythropoiesis. This review discusses recent advances in understanding the molecular mechanisms of iron dysregulation in anemia of inflammation, the impact of hypoferremia and anemia on disease progression, and therapeutic strategies for its treatment.
Editorial Material
Infectious Diseases
Guenter Weiss
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Letter
Gastroenterology & Hepatology
Felix J. Krendl, Rupert Oberhuber, Robert Breitkopf, Guenter Weiss, Stefan Schneeberger
JOURNAL OF HEPATOLOGY
(2023)
Article
Cell Biology
Qian Wu, Euclides Sacomboio, Lara Valente de Souza, Rui Martins, Jamil Kitoko, Silvia Cardoso, Temitope W. Ademolue, Tiago Paixao, Jaakko Lehtimaki, Ana Figueiredo, Caren Norden, Pierre-Louis Tharaux, Guenter Weiss, Fudi Wang, Susana Ramos, Miguel P. Soares
Summary: Iron recycling is important in preventing anemia, and its role in preventing anemia during infection is unclear. In severe Plasmodium falciparum malaria, acute kidney injury (AKI) is associated with life-threatening anemia. A study using a rodent model shows that renal proximal tubule epithelial cells (RPTECs) have the ability to store and recycle iron during P. chabaudi chabaudi (Pcc) infection, preventing the onset of life-threatening malarial anemia.
Review
Biochemistry & Molecular Biology
Clemens M. Gehrer, Anna-Maria Mitterstiller, Philipp Grubwieser, Esther G. Meyron-Holtz, Guenter Weiss, Manfred Nairz
Summary: Iron plays a crucial role in metabolism, but its redox properties can be both beneficial and harmful. Labile iron can generate reactive oxygen species, which is why it is stored in a safe form inside ferritin. Although the physiological functions of ferritin are not completely understood, research on its functions, including secretion, distribution mechanisms, and intracellular compartmentalization via NCOA4, is progressing rapidly. This review discusses established knowledge and recent findings, and their implications for host-pathogen interactions during bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Manfred Nairz, Theodora Todorovic, Clemens M. Gehrer, Philipp Grubwieser, Francesco Burkert, Martina Zimmermann, Kristina Trattnig, Werner Klotz, Igor Theurl, Rosa Bellmann-Weiler, Guenter Weiss
Summary: This study retrospectively analyzed the implementation and routine use of multiplex RT-PCR testing for patients in a tertiary care center in Western Austria. The study found that the switch to a more liberal RT-PCR test strategy resulted in a substantial increase in the number of tests. The extensive use of the combined RT-PCR test enabled the monitoring of re-emergence of influenza and RSV detections.
Article
Virology
Ellen Gelpi, Sigrid Klotz, Miriam Beyerle, Sven Wischnewski, Verena Harter, Harald Kirschner, Katharina Stolz, Christoph Reisinger, Elisabeth Lindeck-Pozza, Alexander Zoufaly, Marlene Leoni, Gregor Gorkiewicz, Martin Zacharias, Christine Haberler, Johannes Hainfellner, Adelheid Woehrer, Simon Hametner, Thomas Roetzer, Till Voigtlaender, Gerda Ricken, Verena Endmayr, Carmen Haider, Judith Ludwig, Andrea Polt, Gloria Wilk, Susanne Schmid, Irene Erben, Anita Nguyen, Susanna Lang, Ingrid Simonitsch-Klupp, Christoph Kornauth, Maja Nackenhorst, Johannes Klaeger, Renate Kain, Andreas Chott, Richard Wasicky, Robert Krause, Guenter Weiss, Judith Loeffler-Rag, Thomas Berger, Patrizia Moser, Afshin Soleiman, Martin Asslaber, Roland Sedivy, Nikolaus Klupp, Martin Klimpfinger, Daniele Risser, Herbert Budka, Lucas Schirmer, Anne-Katrin Probstel, Romana Hoeftberger
Summary: We conducted a neuropathological analysis on 32 patients who died from COVID-19 in Austria between 2020 and 2021. The results showed diffuse white matter damage and microglial activation in all cases, indicating indirect brain damage rather than direct virus-specific damage. Inflammatory changes and vascular pathologies were also observed, along with silent neurodegenerative pathologies in elderly patients. These findings align with experimental data on SARS-CoV-2-related brain damage and provide a better understanding of the mechanisms underlying neurological symptoms after COVID-19.
Article
Cell Biology
Natascha Brigo, Emely Neumaier, Christa Pfeifhofer-Obermair, Philipp Grubwieser, Sabine Engl, Sylvia Berger, Markus Seifert, Vera Reinstadler, Herbert Oberacher, Gunter Weiss
Summary: Macrophages can be polarized into pro-inflammatory or anti-inflammatory subtypes, depending on whether they are primed with interferon-gamma (IFN gamma) or interleukin-4 (IL-4). This polarization affects the enzymes produced by the macrophages, which in turn determine the host's response to infection. L-arginine, a substrate for these enzymes, plays a crucial role in this process. While IL-4 impairs host resistance to Salmonella enterica serovar Typhimurium (S.tm), little is known about its effects on unpolarized macrophages during infection.
Article
Biochemistry & Molecular Biology
Katharina Obermoser, Natascha Brigo, Andrea Schroll, Pablo Monfort-Lanzas, Johanna M. Gostner, Sabine Engl, Simon Geisler, Miriam Knoll, Harald Schennach, Guenter Weiss, Dietmar Fuchs, Rosa Bellmann-Weiler, Katharina Kurz
Summary: This pilot study investigated the effects of a multi-strain probiotic preparation on fatigue, depression, and quality of life in patients with post-infectious fatigue. The results showed that both the probiotic and placebo groups experienced improvements, but the probiotic group had greater improvements. After 6 months, the probiotic group had significantly lower fatigue and depression scores, as well as improved quality of life.
Article
Microbiology
Astrid I. Knell, Anna K. Boehm, Michael Jaeger, Julia Kerschbaum, Sabine Engl, Michael Rudnicki, Lukas Buchwinkler, Rosa Bellmann-Weiler, Wilfried Posch, Guenter Weiss
Summary: Patients with chronic kidney disease (CKD) or immunosuppression are at increased risk of severe SARS-CoV-2 infection. The vaccination of CKD patients has resulted in lower antibody concentrations and possibly reduced protection. However, little information is available on how T-cell-mediated immune response is affected in those patients and how vaccine-induced immune responses can neutralise different SARS-CoV-2 variants.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michaela Plaikner, Lukas Lanser, Christian Kremser, Guenter Weiss, Benjamin Henninger
Summary: The study compares the measurement of splenic and pancreatic iron content using a commercial 3D-Dixon sequence (qDixon) and an established fat-saturated R2* relaxometry method (ME-GRE). The results show good concordance between the two methods, with the qDixon sequence proving to be a reliable tool for non-invasive evaluation of iron content in the spleen and pancreas.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Mario Gietl, Francesco Burkert, Stefanie Seiwald, Anna Boehm, Stefanie Hofer, Johanna M. Gostner, Talia Piater, Simon Geisler, Guenter Weiss, Judith Loeffler-Ragg, Thomas Sonnweber, Ivan Tancevski, Alex Pizzini, Sabina Sahanic, Dietmar Fuchs, Rosa Bellmann-Weiler, Katharina Kurz
Summary: This pilot study investigated the interferon gamma inducible biochemical pathways during acute COVID-19 and reconvalescence, and found that inflammation-induced alterations of amino acid metabolism might be related to acute and persisting symptoms of COVID-19.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2023)