Review
Medicine, General & Internal
Chloe Friedrich, Olivier Kosmider
Summary: This article discusses the role of the mesenchymal niche in the pathophysiology of Myelodysplastic syndromes (MDS) and provides an overview of currently available in vitro and in vivo models that can be used to study the effects of the mesenchymal niche on hematopoietic stem cells (HSCs).
Article
Multidisciplinary Sciences
Johann-Christoph Jann, Maximilian Mossner, Vladimir Riabov, Eva Altrock, Nanni Schmitt, Johanna Flach, Qingyu Xu, Verena Nowak, Julia Oblaender, Iris Palme, Nadine Weimer, Alexander Streuer, Ahmed Jawhar, Ali Darwich, Mohammad Jawhar, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak
Summary: Exome sequencing revealed mutations in bone marrow-derived MSCs from patients with myelodysplastic syndrome (MDS), but validation experiments indicate these mutations are secondary to in vitro expansion rather than primary mutations in the BM.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Petter S. Woll, Tetsuichi Yoshizato, Eva Hellstrom-Lindberg, Thoas Fioretos, Benjamin L. Ebert, Sten Eirik W. Jacobsen
Summary: The genetic architecture of cancer has been extensively studied, leading to the identification of new therapeutic targets and the development of promising treatment strategies. However, disease progression, relapse, and treatment-related mortality remain challenging in certain types of cancer such as myelodysplastic syndromes and acute myeloid leukemia. The persistence of rare leukemic stem cells following therapy underscores the resistance mechanisms of these cells and their role in relapse. To improve treatment strategies, there is a need to better understand and characterize the stem cells associated with these diseases at the cellular, molecular, and genetic levels.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Benjamin Roux, Frederic Picou, Christelle Debeissat, Myriam Koubi, Nathalie Gallay, Pierre Hirsch, Noemie Ravalet, Marie C. Bene, Michel Maigre, Mathilde Hunault, Jean Mosser, Amandine Etcheverry, Emmanuel Gyan, Francois Delhommeau, Jorge Domenech, Olivier Herault
Summary: DNA methylation plays a significant role in regulating hematologic malignancies, and the DNA methylation status of MSCs may contribute to the pathophysiology of these diseases. This study analyzed the modifications of DNA methylation profiles of MSCs induced by MDS or AML, and found global hypomethylation and aberrant methylation profiles in MDS and a subgroup of AML-MSCs, particularly in homeobox genes. These results suggest the importance of DNA methylation in MSCs in the development of hematologic malignancies.
CANCER GENE THERAPY
(2022)
Article
Cell & Tissue Engineering
Ying-Cheng Chen, Ying-Wei Lan, Shiaw-Min Huang, Chih-Ching Yen, Wei Chen, Wan-Ju Wu, Theresa Staniczek, Kowit-Yu Chong, Chuan-Mu Chen
Summary: The study demonstrates that hAFMSCs can inhibit the proliferation, tumor growth, and invasion of PDAC cells by altering cell cycle and signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Changzhen Wang, Hongmei Ning, Jiao Gao, Teng Xue, Ming Zhao, Xiaoxia Jiang, Xiaoming Zhu, Ximin Guo, Hong Li, Xiaoyan Wang
Summary: This study investigated the impact of hematopoietic cells on MSCs and found that partial deletion of the Pten gene in hematopoietic cells can lead to abnormal differentiation of MSCs. There is a reciprocal relationship between hematopoietic cells and MSCs, with an important role in bone development.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Oncology
Olga Kouroukli, Argiris Symeonidis, Periklis Foukas, Myrto-Kalliopi Maragkou, Eleni P. Kourea
Summary: This review examines the role of the bone marrow microenvironment in normal hematopoiesis, chronic inflammatory states, and myelodysplastic syndromes (MDS). It discusses the impact of cellular and biochemical immune parameters on the pathogenesis and evolution of MDS. The immune microenvironment of the bone marrow plays a critical role in both preventing and supporting the development of MDS, affecting normal hematopoiesis and the progression of the disease.
Article
Medicine, General & Internal
Huan Li, Fang Hu, Robert Peter Gale, Mikkael A. Sekeres, Yang Liang
Summary: Myelodysplastic syndromes (MDS) are a group of blood cancers characterized by dysregulated hematopoiesis and risk of transformation to acute myeloid leukemia. Prognostic systems can predict survival in MDS patients. Treatment goals differ for low-risk and high-risk MDS, with the aim to improve quality of life and prolong survival, respectively. Hematopoietic cell transplantation can cure MDS, but it is not widely used.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Review
Cell Biology
Mathieu Meunier, David Laurin, Sophie Park
Summary: The bone marrow niche plays an important role in the development of myelodysplastic syndromes. Mesenchymal stromal cells secrete extracellular vesicles and their miRNA, affecting the fate of hematopoietic stem cells and contributing to leukemogenesis. Extracellular vesicles containing miRNA and proteins can be used as diagnostic and prognostic markers for MDS. Targeting these vesicles or modulating their secretion may offer potential therapeutic directions for MDS.
Article
Cell & Tissue Engineering
Jennifer Steens, Lea Klar, Christine Hansel, Alexis Slama, Thomas Hager, Verena Jendrossek, Clemens Aigner, Diana Klein
Summary: Human lungs contain endogenous mesenchymal stem cells, with lung-resident MSCs predominantly located in the vascular stem cell niche of lung arteries. These LR-MSCs bear similarities to MSCs derived from adult human blood vessel walls, expressing a specific HOX code. The identification of LR-MSCs as VW-MSCs has implications for understanding lung physiology, pulmonary diseases, and therapeutic approaches.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
P. S. Woll, S. E. W. Jacobsen
Summary: According to the cancer stem cell hypothesis, cancer stem cells are the only cells capable of producing and maintaining all cells in a cancer. Studies on specific cancers such as MDS suggest that the rare hematopoietic stem cell compartment may be the primary target cell, with hematopoietic stem cells playing a crucial role in disease propagation.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cell Biology
Zhaoyun Liu, Yixuan Guo, Lei Huang, Yue Jia, Hui Liu, Fengping Peng, Lixiang Duan, Hongkai Zhang, Rong Fu
Summary: This study found that MDS patients have reduced number and function of NK cells. Further research showed that TIGIT is the most highly expressed marker on NK cells, and the expression of CD155 on BMSCs is significantly higher than CD112 and CD113.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Medicine, General & Internal
Kathrin Nachtkamp, Guido Kobbe, Norbert Gattermann, Ulrich Germing
Summary: Myelodysplastic syndromes (MDS) are malignant diseases arising from hematopoietic stem cells, with an incidence of 4 cases per 100,000 persons per year. They are usually diagnosed when evaluating cytopenia, and the median survival time is three years. This review summarizes the latest research on the diagnosis and treatment of MDS.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Review
Cell & Tissue Engineering
Len Frisbie, Ronald J. Buckanovich, Lan Coffman
Summary: The interaction between tumor cells and non-malignant host cells within the tumor microenvironment (TME) is crucial for cancer progression. Mesenchymal stem/stromal cells (MSCs), one of the non-malignant host cells, play a critical role in the formation and function of the TME. These MSCs, when reprogrammed by cancer cells, become carcinoma-associated MSCs (CA-MSCs) and contribute to tumor growth, metastasis, and TME formation. CA-MSCs can differentiate into various stromal sub-lineages, secrete extracellular matrix, promote angiogenesis, and recruit immunosuppressive myeloid cells, thereby impacting almost every aspect of the TME. However, the heterogeneity of CA-MSCs and the lack of definitive markers for their identification pose challenges in accurately understanding their origin and characteristics.
Article
Cell & Tissue Engineering
Zhou Ji, Songsheng Chen, Jin Cui, Weiguang Huang, Rui Zhang, Jianrui Wei, Shaoheng Zhang
Summary: The study found that upregulation of FoxC1 in cardiac endothelial cells after ischemic injury promotes intrinsic angiogenesis. Inducing a vascular microenvironment by overexpressing FoxC1 enhances survival and neovascularization of MSCs under hypoxic conditions, potentially improving cardiac repair.
STEM CELL RESEARCH & THERAPY
(2021)
Letter
Oncology
Hidetsugu Kawai, Hiromichi Matsushita, Hibiki Akashi, Daisuke Furuya, Shohei Kawakami, Rikio Suzuki, Makiko Moriuchi, Yoshiaki Ogawa, Hiroshi Kawada, Naoya Nakamura, Kiyoshi Ando
LEUKEMIA & LYMPHOMA
(2020)
Article
Oncology
Munehiro Ito, Yutaka Fujiwara, Takashi Kubo, Hiromichi Matsushita, Tadashi Kumamoto, Tatsuya Suzuki, Kuniko Sunami, Noboru Yamamoto, Takashi Kohno
FRONTIERS IN ONCOLOGY
(2020)
Letter
Hematology
Yo Saito, Shinichi Makita, Shotaro Chinen, Momoko Kito, Takahiro Fujino, Hanae Ida, Rika Hosoba, Takashi Tanaka, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Akiko Miyagi-Maeshima, Hiromichi Matsushita, Koji Izutsu
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Kenta Noda, Kouki Matsuda, Shigehiro Yagishita, Kenji Maeda, Yutaro Akiyama, Junko Terada-Hirashima, Hiromichi Matsushita, Satoshi Iwata, Kazuto Yamashita, Yusuke Atarashi, Shunsuke Watanabe, Nobuyuki Ide, Tomokazu Yoshida, Norio Ohmagari, Hiroaki Mitsuya, Akinobu Hamada
Summary: A new diagnostic test has been developed to detect antibodies against SARS-CoV-2 with high accuracy and reproducibility. The test system showed high performance in detecting antibody levels in infected patients and may help in analyzing the immunological response to the virus and vaccine effectiveness.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Medicine, General & Internal
M. Kojima, K. Namikawa, Y. Kase, H. Matsushita
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Article
Hematology
Midori Hasegawa, Hiromichi Matsushita, Kensei Yahata, Akira Sugawara, Yoshitaka Ishibashi, Ryoko Kawahara, Yoshifumi Hamasaki, Hitoshi Kanno, Sachie Yamada, Norio Nii, Masao Kato, Atsushi Ohashi, Shigehisa Koide, Hiroki Hayashi, Yukio Yuzawa, Naotake Tsuboi
Summary: The study evaluated the performance of a new machine, Plasauto mu, in processing malignant ascites, showing improved recovery rates for protein and IgG. Recovery rates were positively correlated with the amount of original ascites and negatively correlated with total protein concentration.
THERAPEUTIC APHERESIS AND DIALYSIS
(2021)
Article
Hematology
Moemi Kasane, Saiko Kurosawa, Minoru Kojima, Nao Iwashita, Yuki Kase, Misato Tsubokura, Saori Nakabayashi, Chiaki Ikeda, Kimihiko Kawamura, Hiromichi Matsushita, Ryuichi Narita, Hidetomo Fukumoto, Takahiro Fujino, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Ayumu Ito, Takashi Tanaka, Yoshihiro Inamoto, Sung-Won Kim, Kinuko Tajima, Ryuji Tanosaki, Koji Izutsu, Takahiro Fukuda
Summary: This study examined the usefulness of monitoring hematopoietic progenitor cells (HPCs) in predicting the timing of autologous peripheral blood stem cell harvest (APBSCH). The results indicate that both the HPC count on the day before collection and the day of collection strongly influence the quantity of CD34-positive cells collected, suggesting that they are good indicators for appropriate APBSCH timing.
TRANSFUSION AND APHERESIS SCIENCE
(2021)
Article
Hematology
Ryujiro Hara, Makoto Onizuka, Eri Kikkawa, Sawako Shiraiwa, Kaito Harada, Yasuyuki Aoyama, Daisuke Ogiya, Masako Toyosaki, Rikio Suzuki, Sinichiro Machida, Ken Ohmachi, Yoshiaki Ogawa, Hiroshi Kawada, Hiromichi Matsushita, Kiyoshi Ando
Summary: This study retrospectively analyzed data of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) and found that measurable residual disease (MRD) kinetics was a significant predictor for disease-free survival (DFS) and relapse rates.
ANNALS OF HEMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Yu Aruga, Chiaki Ikeda, Arisa Hanai, Sakiko Yoshimura, Momoko Kito, Satoe Miyaki, Misato Tsubokura, Yuka Yasuno, Chiaki Hayashi, Motoi Miyakoshi, Takahiro Nishino, Kimihiko Kawamura, Hiromichi Matsushita
Summary: The study investigated the effectiveness of an optical method using Hgb-O in measuring Hgb concentrations in samples with chylous turbidity. Results showed that Hgb-O was not affected by chylous turbidity, unlike SLS-Hgb concentration which falsely increased with the dose of fat emulsion in healthy volunteer samples.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Shu Yazaki, Tatsuya Yoshida, Yuki Kojima, Shigehiro Yagishita, Hiroko Nakahama, Keiji Okinaka, Hiromichi Matsushita, Mika Shiotsuka, Osamu Kobayashi, Satoshi Iwata, Yoshitaka Narita, Akihiro Ohba, Masamichi Takahashi, Satoru Iwasa, Kenya Kobayashi, Yuichiro Ohe, Tomokazu Yoshida, Akinobu Hamada, Toshihiko Doi, Noboru Yamamoto
Summary: This study evaluated the serum SARS-CoV-2 antibody status in cancer patients and healthcare workers in Japan during the COVID-19 pandemic. The seroprevalence did not differ significantly between the two groups, but it was found that cancer comorbidity and treatment with chemotherapy and immune checkpoint inhibitors may impact the immune response to SARS-CoV-2.
Article
Oncology
Misato Tsubokura, Yuko Adegawa, Minoru Kojima, Ryuji Tanosaki, Ryuzaburo Ohtake, Yuki Kase, Nao Iwashita, Moemi Kasane, Saori Nakabayashi, Sayaka Takeuchi, Ken Kato, Narikazu Boku, Yukihide Kanemitsu, Takuji Okusaka, Hiroyuki Fujimoto, Kan Yonemori, Hiroto Ishiki, Kimihiko Kawamura, Eriko Satomi, Hiromichi Matsushita
Summary: This study aimed to assess the safety of cell-free and concentrated ascites reinfusion therapy (CART) in a single cancer institute. The results showed that CART was safe in cancer patients, with adverse events being mainly mild reactions after reinfusion.
Article
Oncology
Suguru Fukuhara, Yuji Oshikawa-Kumade, Yasunori Kogure, Sumito Shingaki, Hirokazu Kariyazono, Yoshiya Kikukawa, Junji Koya, Yuki Saito, Mariko Tabata, Kota Yoshifuji, Kota Mizuno, Akiko Miyagi-Maeshima, Hiromichi Matsushita, Masanaka Sugiyama, Chitose Ogawa, Yoshihiro Inamoto, Takahiro Fukuda, Masato Sugano, Nobuhiko Yamauchi, Yosuke Minami, Makoto Hirata, Teruhiko Yoshida, Takashi Kohno, Shinji Kohsaka, Hiroyuki Mano, Yuichi Shiraishi, Seishi Ogawa, Koji Izutsu, Keisuke Kataoka
Summary: NGS-based genomic profiling can effectively detect various mutations and genetic variants in hematological malignancies, providing valuable information for diagnosis, treatment selection, and prognosis prediction. The clinical utility of this profiling is highest in acute myeloid leukemia and may be less informative in T/natural killer-cell lymphoma.
Article
Pathology
Naoki Kojima, Yasuhito Arai, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Taisuke Mori, Hiromichi Matsushita, Toshikazu Ushijima, Yasushi Yatabe, Tatsuhiro Shibata, Kan Yonemori, Koichi Ichimura, Hitoshi Ichikawa, Akira Kawai, Akihiko Yoshida
Summary: CIC-rearranged sarcoma is a type of cancer characterized by undifferentiated round cell histology, frequent expression of ETV4 and WT1, and aggressive behavior. In some cases, ERG and CD31 may be co-expressed, leading to potential misdiagnosis as angiosarcoma. It is important to differentiate between these two diseases as they require different treatment approaches.
Article
Oncology
Yosuke Tanaka, Fumiko Chiwaki, Shinya Kojima, Masahito Kawazu, Masayuki Komatsu, Toshihide Ueno, Satoshi Inoue, Shigeki Sekine, Keisuke Matsusaki, Hiromichi Matsushita, Narikazu Boku, Yae Kanai, Yasushi Yatabe, Hiroki Sasaki, Hiroyuki Mano
Summary: A comprehensive multi-omic analysis was conducted on malignant ascitic fluid samples and corresponding tumor cell lines from 98 patients with peritoneal metastasis of gastric cancer, revealing two distinct molecular subtypes with potential targeted therapy options. The study identified higher frequency of receptor tyrosine kinase and mitogen-activated protein kinase pathway alterations in peritoneal metastasis compared to primary gastric cancer. Inhibition of the TEAD pathway was shown to circumvent therapy resistance in a specific subtype, suggesting a potential targeted therapeutic strategy.
Article
Hematology
Rika Hosoba, Shinichi Makita, Mika Shiotsuka, Osamu Kobayashi, Kiyoko Nakano, Mimiko Muroya, Naoko Okada, Makiko Suzuki, Hanae Ida, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Akiko Miyagi Maeshima, Hiromichi Matsushita, Noboru Yamamoto, Yuichiro Ohe, Satoshi Iwata, Koji Izutsu
JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY
(2020)