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Multidrug resistant Pseudomonas aeruginosa bloodstream infection in adult patients with hematologic malignancies

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)

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HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

卷 96, 期 1, 页码 E1-E3

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FERRATA STORTI FOUNDATION

DOI: 10.3324/haematol.2010.036640

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Pseudomonas aeruginosa; multidrug resistance; bloodstream infections; hematologic malignancies

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Hematology

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Unmet Clinical Needs and Management Recommendations for Blastic Plasmacytoid Dendritic Cell Neoplasm: A Consensus-based Position Paper From an Ad Hoc International Expert Panel

Livio Pagano, Pier Luigi Zinzani, Stefano Pileri, Pietro Quaglino, Branko Cuglievan, Emilio Berti, Naveen Pemmaraju, Francesco Onida, Rein Willemze, Alberto Orfao, Giovanni Barosi

Summary: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with recurrent skin nodules, aggressive clinical course, and poor prognosis. Due to its rarity, there is limited research, lack of controlled clinical trials, and absence of evidence-based guidelines for its management. This review presents recommendations and proposals by a panel of experts to address the unmet clinical needs in the management of BPDCN. The hope is that this comprehensive overview will improve the practice of BPDCN and guide future studies in the field.

HEMASPHERE (2023)

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Article Oncology

Eltrombopag for Low-Risk Myelodysplastic Syndromes With Thrombocytopenia: Interim Results of a Phase II, Randomized, Placebo-Controlled Clinical Trial (EQOL-MDS)

Esther Natalie Oliva, Marta Riva, Pasquale Niscola, Valeria Santini, Massimo Breccia, Valentina Giai, Antonella Poloni, Andrea Patriarca, Elena Crisa, Isabella Capodanno, Prassede Salutari, Gianluigi Reda, Nicola Cascavilla, Dario Ferrero, Attilio Guarini, Giovanni Tripepi, Giuseppe Ianni, Emilio Russo, Andrea Castelli, Bruno Fattizzo, Germana Beltrami, Monica Bocchia, Alfredo Molteni, Pierre Fenaux, Ulrich Germing, Alessandra Ricco, Giuseppe A. Palumbo, Stefana Impera, Nicola Di Renzo, Flavia Rivellini, Francesco Buccisano, Aspasia Stamatoullas-Bastard, Anna Marina Liberati, Anna Candoni, Ilaria Maria Delfino, Maria Teresa Arcadi, Patrizia Cufari, Lorenzo Rizzo, Irene Bova, Maria Grazia D'Errigo, Gina Zini, Roberto Latagliata

Summary: This study demonstrates the efficacy and safety of eltrombopag in treating low-risk MDS patients with severe thrombocytopenia. Eltrombopag significantly increases the duration of platelet response and reduces the incidence of clinically significant bleeding.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Oncology

Multicenter Observational Retrospective Study on Febrile Events in Patients with Acute Myeloid Leukemia Treated with Cpx-351 in Real-Life: The SEIFEM Experience

Luana Fianchi, Fabio Guolo, Francesco Marchesi, Chiara Cattaneo, Michele Gottardi, Francesco Restuccia, Anna Candoni, Elettra Ortu La Barbera, Rita Fazzi, Crescenza Pasciolla, Olimpia Finizio, Nicola Fracchiolla, Mario Delia, Federica Lessi, Michelina Dargenio, Valentina Bonuomo, Maria Ilaria Del Principe, Patrizia Zappasodi, Marco Picardi, Claudia Basilico, Monica Piedimonte, Paola Minetto, Antonio Giordano, Patrizia Chiusolo, Lucia Prezioso, Caterina Buquicchio, Lorella Maria Antonia Melillo, Daniele Zama, Francesca Farina, Valentina Mancini, Irene Terrenato, Michela Rondoni, Irene Urbino, Mario Tumbarello, Alessandro Busca, Livio Pagano

Summary: This study evaluated the absolute infectious risk in 200 AML patients treated with CPX-351 and found it to have a good safety profile, with an incidence of infectious complications comparable to that of pivotal studies. The only factor significantly associated with mortality was a lack of response to CPX-351 treatment.

CANCERS (2023)

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Meeting Abstract Hematology

COVID-19 AND ITS IMPACT ON HEMATOLOGICAL TREATMENT STRATEGIES

L. Pagano

ANNALS OF HEMATOLOGY (2023)

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