期刊
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
卷 94, 期 6, 页码 857-860出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2008.000034
关键词
angiotensin; CD34; hematopoietic stem cell
类别
资金
- National Institute of Health (NIH) [5R01HL082722-02]
- Federal Ministry of Education and Research (BMBF) [01GN0528]
Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under ill vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34(+) cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.
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