Article
Oncology
Meifang Wang, Chunxia Dong, Yan Gao, Jianlan Li, Mengru Han, Lijun Wang
Summary: The study developed a convolutional neural network model that can automatically recognize aplastic anemia, myelodysplastic syndromes, and acute myeloid leukemia. The model exhibited high accuracy in distinguishing these diseases, providing a convenient tool for clinicians.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Meidan Hou, Yanan Huang, Jinsong Yan, Guoguang Fan
Summary: This study evaluated the use of quantitative Dixon and intravoxel incoherent motion diffusion imaging for the differential diagnosis of AA and AML. The results showed that Q-Dixon parameters have the potential to be used as new biomarkers to differentiate AA from AML.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Ik-Chan Song, Deog-Yeon Jo, Hyeoung-Joon Kim, Yoo-Hong Min, Dae Sik Hong, Won-Sik Lee, Ho-Jin Shin, Je-Hwan Lee, Jinny Park, Hee-Je Kim
Summary: Patients with hypocellular AML are typically older, have lower white blood cell counts, and exhibit fewer FLT3-ITD and NPM1 mutations. However, the clinical outcomes of hypocellular AML do not differ significantly from those of non-hypocellular AML patients.
Article
Medicine, Research & Experimental
Lingling Liu, Danfeng Zhang, Qiuhao Fu, Jingdi Wang, Jifeng Yu, Dandan Chen, Fang Wang, Rong Guo, Xinsheng Xie, Zhongxing Jiang, Yingmei Li
Summary: Aplastic anemia (AA) is a potentially fatal bone marrow failure syndrome characterized by a paucity of hematopoietic stem cells and progenitor cells. Recent research has shown somatic mutations in AA patients, but the impact of these mutations remains uncertain. A retrospective study was conducted on AA and myelodysplastic syndromes (MDS) patients, revealing different gene mutation patterns between the two groups, with a lower mutation frequency in AA patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Jonathan Feld, Amir Steinberg, Siraj M. El Jamal, Ilan Shapira
Summary: The use of TKIs in CML has significantly improved patient outcomes, but it can also lead to rare complications such as aplastic anemia. Despite attempts at dose reduction and trying multiple TKIs or growth factor support, some patients may only find resolution of cytopenias through more aggressive treatments like immunosuppression or stem cell transplant. Aplasia/aplastic anemia can rarely occur with dasatinib treatment, highlighting the importance of considering this diagnosis in CML patients with unexplained cytopenias.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2022)
Article
Medical Laboratory Technology
Yingying Sun, Chengcheng Wu, Chunyan Liu, Huaquan Wang, Yang Zhang, Yu Zhang, Ningyuan Ran, Zonghong Shao
Summary: The phagocytosis of myeloid dendritic cells (mDC) in untreated severe aplastic anemia (SAA) patients is significantly stronger than that in remission and healthy controls, and is negatively correlated with levels of white blood cells, platelets, and reticulocytes. Phagocytosis of mDC is positively correlated with IL-2 and IL-4 concentrations, and negatively correlated with CD4(+)/CD8(+) ratio.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Medicine, General & Internal
Laura F. Newell, Rachel J. Cook
Summary: AML, a rare and potentially catastrophic diagnosis, has seen recent advancements in personalized therapy and novel treatment options due to discoveries of molecular drivers of the disease.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Oncology
Murali Kesavan, J. Harvey Turner
Summary: Emerging genomic analytic techniques in cancer patients can potentially define the risks of myelo dysplastic syndrome and acute leukemia following targeted radionuclide therapy. Identifying patients at heightened risk of hematologic toxic complication using novel genomic technology before radionuclide therapy can ameliorate myelotoxicity. Personalized precision nuclear oncology aims to minimize toxicity while preserving optimal individualized efficacy.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Medical Laboratory Technology
Weiwei Qi, Yu Zhang, Yachen Wang, Huaquan Wang, Rong Fu, Zonghong Shao
Summary: This study aimed to investigate the balance between histone acetyltransferases (HATs) and histone deacetylases (HDACs) mRNA levels in CD8+ T cells of patients with severe aplastic anemia (SAA). The findings suggest that EP300 and CREBBP are increased in CD8+ T cells of SAA patients and are correlated with disease severity.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Editorial Material
Medicine, General & Internal
Jennifer Cai, Ping Ji, Sarah Tomassetti, Xin Qing
Summary: Abnormal eosinophils with immature eosinophilic granules are commonly observed in acute myeloid leukemia, especially in patients with inv(16)(p13.1q22) or t(16;16)(p13.1;q22), but can also be seen in chronic myeloid leukemia.
CLINICAL CASE REPORTS
(2021)
Article
Hematology
Zhi Wen, Grant Yun, Alexander Hebert, Guangyao Kong, Erik A. Ranheim, Remington Finn, Adhithi Rajagoplan, Shuyi Li, Yun Zhou, Mei Yu, Alisa Damnernsawad, Jeroen P. Roose, Joshua J. Coon, Renren Wen, Demin Wang, Jing Zhang
Summary: ETP-ALL is characterized by hyperactivation of cytokine receptor/Ras signaling, with downregulation of WT KRAS and Rasgrp1 serving as negative regulators of Ras/ERK pathway, contributing to cell proliferation in oncogenic Nras-driven ETP-like leukemia.
Article
Cell Biology
Vivian Fonseca Gonzaga, Cristiane Valverde Wenceslau, Daniel Perez Vieira, Bruna de Oliveira Policiquio, Charbel Khalil, Rodrigo Pinheiro Araldi, Irina Kerkis
Summary: Aplastic anemia is a disorder of hematopoietic stem cells, and current treatment options are limited. The use of human immature dental pulp stem cells has been identified as a potential alternative therapy to facilitate hematopoiesis recovery and protect hematopoietic function.
Article
Hematology
Fanny Delehaye, Jeremie Rouger, David Brossier, Meinolf Suttorp, Adalet Meral Gunes, Petr Sedlacek, Birgitta Versluys, Chi Kong Li, Krzysztof Kalwak, Birgitte Lausen, Culic Srdjana, Michael Dworzak, Andrea Hraskova, Barbara De Moerloose, Farah Roula, Anais Briant, Jean-Jacques Parienti, Frederic Millot
Summary: The clinical presentation of chronic myeloid leukemia (CML) differs in children compared to adults. Anemia at diagnosis is frequent in pediatric CML and may be considered as a prognostic factor. Moderate and severe anemia at diagnosis in children with CML is significantly associated with younger age, asthenia, splenomegaly, increased leukocyte and basophil counts, delayed major and deep molecular responses, and more frequent failure of imatinib treatment. However, the hemoglobin level is not significantly associated with survival.
ANNALS OF HEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Xian-Fu Sheng, Li-Li Hong, Fei-Yan Huang, Hai-Feng Zhuang
Summary: This case report describes a rare diagnostic dilemma of mixed phenotype acute leukemia and acute myeloid leukemia with myelodysplasia-related changes (AML-MRC). The patient was initially diagnosed with myelodysplastic syndrome but progressed to acute leukemia with blast cells expressing both T-lymphoid and myeloid antigens. Cytogenetic analysis and next-generation sequencing confirmed the diagnosis of AML-MRC with the mixed T/myeloid phenotype. After several cycles of treatment, remission was achieved using an ALL-like regimen.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Letter
Oncology
Hu Lei, Li Yang, Yingying Wang, Zhihui Zou, Meng Liu, Hanzhang Xu, Yingli Wu
Summary: JOSD2 blocks the nuclear localization of PKM2 by reducing its K433 acetylation, thereby reducing AML progression.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Letter
Hematology
Nicole Kucine, Mustafa Al-Kawaaz, Daher Hajje, James Bussel, Attilio Orazi
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Cell Biology
Konnie M. Hebeda, Alexandar Tzankov, Ludmila Boudova, Leonie Saft, Rob P. Hasserjian, Mirthe de Boer, Falko Fend, Attilio Orazi, Roos Leguit
Article
Pathology
Yen-Chun Liu, Elizabeth Margolskee, John N. Allan, Susan Mathew, Erica Bhavsar, Joseph Casano, Attilio Orazi, Richard R. Furman, Julia T. Geyer
Review
Hematology
V. F. Sangiorgio, A. Orazi, D. A. Arber
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
(2020)
Review
Hematology
Valentina Fabiola Ilenia Sangiorgio, Daniel A. Arber, Attilio Orazi
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2020)
Review
Cell Biology
Roos Leguit, Konnie Hebeda, Marcus Kremer, Jon van der Walt, Umberto Gianelli, Alexandar Tzankov, Attilio Orazi
Article
Hematology
Marco Pizzi, Gianni Binotto, Giulia Rigoni Savioli, Angelo Paolo Dei Tos, Attilio Orazi
Summary: Bone marrow studies are essential for the diagnosis of haematological disorders and can be traced back to the work of Giovanni Ghedini. His research was based on his clinical experience and the scientific developments of his time.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Pathology
R. J. Leguit, A. Orazi, N. Kucine, H. M. Kvasnicka, U. Gianelli, D. A. Arber, A. Porwit, M. Ponzoni
Summary: The first section of the bone marrow workshop at the European Association of Haematopathology 2020 Virtual Meeting focused on pediatric myeloid neoplasms. The section provided an overview of the different types of myeloid neoplasms and presented rare cases, including primary myelofibrosis, pediatric MDS with fibrosis, and MDS/MPN with JMML-like features and t(4;17)(q12;q21); FIP1L1::RARA fusion.
Review
Hematology
Jurgen Thiele, Hans Michael Kvasnicka, Attilio Orazi, Umberto Gianelli, Naseema Gangat, Alessandro M. Vannucchi, Tiziano Barbui, Daniel A. Arber, Ayalew Tefferi
Summary: A group of international experts met to update the World Health Organization classification system for hematopoietic tumors and introduced the new International Consensus Classification (ICC) for Myeloid Neoplasms and Acute Leukemias. The focus of this review is on the ICC-2022 category of JAK2 mutation-prevalent myeloproliferative neoplasms (MPNs) and the importance of bone marrow morphology and genetic markers in disease classification and diagnostics.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Review
Pathology
Roos J. Leguit, Sa A. Wang, Tracy George, Alexandar Tzankov, Attilio Orazi
Summary: Mastocytosis is a neoplasm characterized by clonal proliferation of mast cells, which can accumulate in the skin and multiple organs, leading to various clinical presentations. According to the 2022 international consensus classification, mastocytosis can be divided into a benign form confined to the skin and a malignant form with systemic involvement.
Correction
Hematology
Juergen Thiele, Hans Michael Kvasnicka, Attilio Orazi, Umberto Gianelli, Naseema Gangat, Alessandrom M. Vannucchi, Tiziano Barbui, Daniel A. Arber, Ayalew Tefferi
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Editorial Material
Hematology
Daniel A. A. Arber, Robert P. P. Hasserjian, Attilio Orazi
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Review
Pathology
Sonam Prakash, Daniel A. Arber, Carlos Bueso-Ramos, Robert P. Hasserjian, Attilio Orazi
Summary: The MDS/MPN category includes diseases with both myelodysplastic and myeloproliferative features. The revised International Consensus Classification now requires the presence of increased peripheral blood cell counts and concomitant cytopenia for diagnosis. The use of modern gene sequencing has improved understanding of the biological characteristics and specific mutations of these diseases, which are now included in the diagnostic criteria for some MDS/MPN entities. This review highlights the changes in diagnostic criteria and provides practical guidance for diagnosis.
Review
Hematology
Sa A. Wang, Attilio Orazi, Jason Gotlib, Andreas Reiter, Alexandar Tzankov, Robert P. Hasserjian, Daniel A. Arber, Ayalew Tefferi
Summary: Based on new data and increased understanding of disease molecular genetics, the international consensus classification has made changes in the diagnosis and classification of eosinophilic disorders and systemic mastocytosis. The changes include renaming myeloid/lymphoid neoplasms with eosinophilia and gene rearrangements, expanding the category to include more gene fusions, and introducing bone marrow morphologic criteria. The review focuses on the updates related to these diseases, including changes in morphology, molecular genetics, clinical features, prognosis, and treatment.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Ayalew Tefferi, Maymona Abdelmagid, Aref Al-Kali, Mrinal Patnaik, William J. Hogan, Kebede Begna, Naseema Gangat, Attilio Orazi, Dong Chen, Kaaren K. Reichard, Animesh Pardanani
Summary: This study demonstrates the independent prognostic contribution of the ICC system for SM-Adv and the Mayo alliance risk factors for survival in SM.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
