Article
Biochemistry & Molecular Biology
Maria Maddalena Tumedei, Filippo Piccinini, Irene Azzali, Francesca Pirini, Sara Bravaccini, Serena De Matteis, Claudio Agostinelli, Gastone Castellani, Michele Zanoni, Michela Cortesi, Barbara Vergani, Biagio Eugenio Leone, Simona Righi, Anna Gazzola, Beatrice Casadei, Davide Gentilini, Luciano Calzari, Francesco Limarzi, Elena Sabattini, Andrea Pession, Marcella Tazzari, Clara Bertuzzi
Summary: The majority of patients with Follicular Lymphoma (FL) experience subsequent phases of remission and relapse, making the disease virtually incurable. Clinical-based prognostic scores have been proposed to predict the outcome of FL patients at diagnosis, but they continue to fail for a subset of patients. Gene expression profiling has highlighted the pivotal role of the tumor microenvironment (TME) in the FL prognosis, but there is still a need to standardize the assessment of immune-infiltrating cells for prognostic classification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Adam Jona, Anna Kenyeres, Sandor Barna, Arpad Illes, Zsofia Simon
Summary: The study found that maximum standardized uptake value (SUVmax) and lymphocyte/monocyte (Ly/Mo) ratio at staging PET/CT can predict FL patients' progression-free survival (PFS) significantly, improving prognostic assessment. The combination of staging and interim SUVmax values can also help predict poor prognosis and translate into overall survival (OS) advantage. Additional biological prognostic factors should be investigated while emphasizing the role of PET/CT in FL.
Article
Medicine, General & Internal
Roberto Tamma, Giuseppe Ingravallo, Tiziana Annese, Francesco Gaudio, Tommasina Perrone, Pellegrino Musto, Giorgina Specchia, Domenico Ribatti
Summary: This study analyzed the cellular components of the tumor microenvironment in patients with follicular lymphoma (FL) and found a significant increase in the expression of macrophages and mast cells in lymph nodes with different histological grades. Additionally, a reduction in the number of certain cell types and a positive correlation between CD34(+) microvessels and macrophages were observed in FL samples, indicating the important angiogenic potential of macrophages.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Celia Dobano-Lopez, Ferran Araujo-Ayala, Neus Serrat, Juan G. Valero, Patricia Perez-Galan
Summary: This review discusses the interaction between tumor cells and the microenvironment in the development of follicular lymphoma, as well as the impact of genetic mutations on the tumor microenvironment and potential therapeutic approaches. Research has uncovered specific cellular phenotypes in the FL microenvironment, with recurring mutations such as KMT2D, CREBBP, EZH2, and TNFRSF14 playing a significant role in modulating this interaction. Novel therapies targeting the FL microenvironment aim to disrupt the contact network, weaken tumor cell support, and enhance the host's immune response against the tumor.
Review
Biochemistry & Molecular Biology
Tianyuan Xu, Zhong Zheng, Weili Zhao
Summary: Follicular lymphoma (FL) is a heterogeneous lymphoma originating from germinal center B cells. Multi-omics analysis has revealed abnormalities in FL cells and tumor microenvironment, providing insights into the mechanisms of FL progression and potential therapeutic options.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Yanan Li, Yan Zhang, Wei Wang, Chong Wei, Danqing Zhao, Wei Zhang
Summary: This study aims to evaluate prognostic predictors of follicular lymphoma among Chinese patients. The study found that LMR is a new independent predictor that has better predictive ability compared to FLIPI.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Qianqian Xue, Yue Wang, Qiang Zheng, Lijun Chen, Yicong Lin, Yan Jin, Xuxia Shen, Yuan Li
Summary: This study found that tumor microenvironment factors are associated with recurrence/metastasis and survival in stage I lung adenocarcinoma patients. Higher levels of CD8+ T lymphocytes, B lymphocytes, and myeloid DC infiltration are associated with better survival outcomes, while higher levels of neutrophils are associated with no recurrence/metastasis. Additionally, different immune cell expression patterns were observed in tumor and stromal regions.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Hematology
Emil Kumar, Lucy Pickard, Jessica Okosun
Summary: Follicular lymphoma (FL) is a heterogeneous disease with increasing recognition of recurrent genetic alterations in epigenetic regulators as a pivotal hallmark. Studies are beginning to uncover the convergence between genetics, epigenetics, and the tumor microenvironment, emphasizing the need to integrate biology with therapeutics for optimal patient care.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Carla Faria, Fabien Gava, Pauline Gravelle, Juan Garcia Valero, Celia Dobano-Lopez, Nathalie Van Acker, Cathy Quelen, Gael Jalowicki, Renaud Morin, Cedric Rossi, Jean-Michel Lagarde, Jean-Jacques Fournie, Loic Ysebaert, Camille Laurent, Patricia Perez-Galan, Christine Bezombes
Summary: This study developed a patient-derived lymphoma spheroid (FL-PDLS) model to capture disease heterogeneity and microenvironment cues. The model cultured FL cells from lymph nodes with an optimized cytokine cocktail that mimics LN stimuli and maintains tumor cell viability.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Michael Mentz, William Keay, Carolin Dorothea Strobl, Martina Antoniolli, Louisa Adolph, Michael Heide, Axel Lechner, Sarah Haebe, Elisa Osterode, Robert Kridel, Christoph Ziegenhain, Lucas Esteban Wange, Johannes Adrian Hildebrand, Tanaya Shree, Elisabeth Silkenstedt, Annette M. Staiger, German Ott, Heike Horn, Monika Szczepanowski, Julia Richter, Ronald Levy, Andreas Rosenwald, Wolfgang Enard, Ursula Zimber-Strobl, Michael Von Bergwelt-Baildon, Wolfgang Hiddemann, Wolfram Klapper, Marc Schmidt-Supprian, Martina Rudelius, Deepak Bararia, Verena Passerini, Oliver Weigert
Summary: The clinical course of follicular lymphoma (FL) is influenced by the molecular heterogeneity of tumor cells and interactions within the tumor microenvironment (TME). In this study, we found STAT6 mutations in 13% of FL cases, which enhanced the response of FL cells to IL-4 and were associated with increased expression of target genes and nuclear accumulation of pSTAT6. We identified PARP14 as a potential therapeutic target in STAT6-mutated FL cells, as its expression was upregulated and it played a role in the regulatory circuit.
Article
Oncology
Anna-Maria Tsakiroglou, Susan Astley, Manas Dave, Martin Fergie, Elaine Harkness, Adeline Rosenberg, Matthew Sperrin, Catharine West, Richard Byers, Kim Linton
Summary: This study tested an automated approach to quantify the immune infiltrate diversity in FL patients and found that increased diversity of cell types and cell spatial interactions was associated with favorable overall survival. The use of multiplex immunofluorescence and Shannon's entropy provides objective measures of immune infiltrate diversity and prognostic information in FL.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Hematology
Karthik Nath, Soi-Cheng Law, Muhammed B. Sabdia, Jay Gunawardana, Lilia M. de Long, David Sester, Mohamed Shanavas, Hennes Tsang, Joshua W. D. Tobin, Sarah-Jane Halliday, Annette Hernandez, Donna Cross, Robert J. Bird, Sanjiv Jain, Colm Keane, Dipti Talaulikar, Judith Trotman, Phillip Law, Maher K. Gandhi
Summary: In patients with follicular lymphoma, low intratumoral T cells are associated with higher TMTV, and nodes with high TMTV exhibit increased malignant B-cell infiltration and fewer clonally expanded T-follicular helper cells. Additionally, CD4(+) and CD8(+) T cells demonstrate higher fluorescently labeled glucose uptake compared to intratumoral B cells.
Article
Immunology
Tingting Zhang, Hengqi Liu, Fenghua Gao, Wenchen Gong, Yaoli Cui, Jin He, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Bin Meng, Xiubao Ren, Huilai Zhang, Xianhuo Wang
Summary: This study investigates the role of N6-methyladenosine (m6A) modification in the tumor microenvironment of follicular lymphoma (FL). The researchers found that the m6A score is associated with prognosis and biological behavior in FL patients, and can predict the response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Mariola Blanco, Ana Collazo-Lorduy, Natalia Yanguas-Casas, Virginia Calvo, Mariano Provencio
Summary: Follicular lymphoma, a common type of indolent non-Hodgkin lymphoma, is characterized by its heterogeneity and variable course. The immune microenvironment plays a fundamental role in the pathogenesis of the disease. Responses to treatment vary among patients, and outcomes are often unpredictable. The crosstalk between follicular lymphoma B-cells and the tumor microenvironment as well as the impact on prognosis and transformation risk are important research areas. Novel therapies targeting specific mutations and modulating the tumor microenvironment have been developed.
Article
Immunology
Shidai Mu, Deyao Shi, Lisha Ai, Fengjuan Fan, Fei Peng, Chunyan Sun, Yu Hu
Summary: The study revealed that the IPI-IPM has independent prognostic significance for DLBCL patients, showing that high-risk patients had worse overall survival and were correlated with immune-related signaling pathways, high mutation rates, and upregulation of inhibitory immune checkpoints, suggesting a greater potential response to ICB therapy.
FRONTIERS IN IMMUNOLOGY
(2021)