Article
Oncology
Wenjing Gong, Tracey A. Martin, Andrew J. Sanders, Rachel Hargest, Aihua Jiang, Ping Sun, Wen G. Jiang
Summary: The study demonstrated that anaesthetics can influence the expression of key molecules SDF-1 and HGF in fibroblasts, potentially impacting tumor progression within the tumor microenvironment.
Article
Hematology
Zemin Ren, Marcel Spaargaren, Steven T. Pals
Summary: Plasma cells in multiple myeloma rely heavily on communication with the bone marrow microenvironment for survival, with specific growth and survival factors being regulated by syndecan-1/HSPGs and their synthesis machinery.
Article
Oncology
Ye-Rang Yun, Jun-Hyeog Jang
Summary: SDF-1 enhances cell proliferation, migration, and neurite outgrowth in a dose-dependent manner, with low cytotoxicity, making it a potential candidate for neural regeneration and tissue engineering.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Orthopedics
J. Li, H. Chen, D. Zhang, J. Xie, X. Zhou
Summary: Stromal cell-derived factor 1 (SDF-1), also known as CXCL12, plays a crucial role in cartilage development and diseases by affecting chondrocytes through binding to CXCR4. It is not only a subject of research in cartilage development mechanisms, but also a potential therapeutic target for osteoarthritis and rheumatoid arthritis.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Polymer Science
Yi Wang, Vanessa Penna, Richard J. Williams, Clare L. Parish, David R. Nisbet
Summary: Peptide self-assembly into nanostructured bioactive hydrogels has the potential to repair traumatic brain injuries by maintaining a stable environment and delivering therapeutic proteins. In this study, a recombinant SDF-1 protein was incorporated into a self-assembled peptide hydrogel to create a supportive environment for transplanted cells. The hydrogel successfully delivered viable neural progenitor cells and active SDF-1, resulting in increased neuronal differentiation and improved graft integration.
Article
Multidisciplinary Sciences
Sukhneeraj P. Kaur, Arti Verma, Hee K. Lee, Lillie M. Barnett, Payaningal R. Somanath, Brian S. Cummings
Summary: The study investigates the role of CAFs in the tumor microenvironment and the regulation of HS-5 activation by glypican-1 (GPC-1). Inhibition of GPC-1 alters cellular morphology, increases migration and contractility, and upregulates pro-inflammatory signaling and CAF marker expression in HS-5 cells. These findings suggest that GPC-1 may be a potential pharmacological target for anti-CAF therapy in cancer treatment.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Hui Wang, Xiaofei Li, Tetsuhiro Kajikawa, Jieun Shin, Jong-Hyung Lim, Ioannis Kourtzelis, Kosuke Nagai, Jonathan M. Korostoff, Sylvia Grossklaus, Ronald Naumann, Triantafyllos Chavakis, George Hajishengallis
Summary: The secreted protein DEL-1 plays a critical role in regulating inflammatory cell recruitment and protecting against inflammatory arthritis. DEL-1 functions both locally in the joints and systemically in lymph nodes to inhibit Tfh responses, making it a promising therapeutic target for inflammatory arthritis treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Madelon M. E. de Jong, Zoltan Kellermayer, Natalie Papazian, Sabrin Tahri, Davine Hofste Op Bruinink, Remco Hoogenboezem, Mathijs A. Sanders, Pieter C. van de Woestijne, P. Koen Bos, Cyrus Khandanpour, Jessica Vermeulen, Philippe Moreau, Mark van Duin, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo
Summary: The progression and therapy response of multiple myeloma is influenced by the bone marrow niche. A study identified inflammatory mesenchymal stromal cells that interact with tumor cells, indicating a potential role in disease persistence. Tracking bone marrow inflammation over time revealed a link to disease persistence despite successful antitumor therapy.
Article
Chemistry, Physical
Hui-Chen Chen, Mei-Lang Kung, Wei-Xiang Huang, Ru-Huei Fu, Alex Yang-Hao Yu, Ya-Tsu Yang, Huey-Shan Hung
Summary: The study utilized a novel AuNP-Col nanocarrier to deliver SDF-1 alpha, enhancing the biological performance, cellular uptake and proliferation capacity of DCs vaccine. It also promoted DCs migration and induction of T cell cytokine production.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Joy M. Davis, Binglu Cheng, Madeline M. Drake, Qiang Yu, Baibing Yang, Jing Li, Chunhui Liu, Mamoun Younes, Xiurong Zhao, Jennifer M. Bailey, Qiang Shen, Tien C. Ko, Yanna Cao
Summary: Chronic pancreatitis is a major risk factor for pancreatic ductal adenocarcinoma, but the mechanism by which CP promotes pancreatic oncogenesis remains unclear. Our study found that GREM1 expression by fibroblasts correlates with the development of PDAC and is associated with macrophages in the pancreatic tumor microenvironment. Gremlin 1 may play a role in promoting PDAC development and influencing macrophage phenotype.
Article
Multidisciplinary Sciences
Chong Fu, Yan Chen, Wei Xu, Yanping Zhang
Summary: Using genetic data, a Mendelian randomization analysis was conducted to explore the causal relationships between inflammatory cytokines and migraine. The results showed a positive association between hepatocyte growth factor (HGF) and migraine risk, while interleukin-2 (IL-2) was considered a downstream consequence of migraine.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Rimma Sergeevna Kamentseva, Marianna Viktorovna Kharchenko, Gulnara Vladikovna Gabdrahmanova, Michael Alexandrovich Kotov, Vera Vladislavovna Kosheverova, Elena Sergeevna Kornilova
Summary: This study compared the effects of EGF, TGF-α, and AREG on physiological responses in endometrial MSCs and HeLa cells, and investigated the internalization and degradation of EGFR stimulated by these ligands. The study found that while EGF and TGF-α stimulated cell proliferation and prevented differentiation in enMSCs in an EGFR-dependent manner, AREG had no effect. Additionally, differences were observed in the degradation and recovery of EGFR in different cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lucas Eduardo Botelho de Souza, Fernanda Ursoli Ferreira, Carolina Hassibe Thome, Heloisa Brand, Maristela Delgado Orellana, Vitor Marcel Faca, Aparecida Maria Fontes, Dimas Tadeu Covas
Summary: Melanoma cells have the capability to activate an EMT-like program and acquire metastatic traits through distinct pathways induced by MSCs' secretome, both in mouse and human cells.
Article
Gastroenterology & Hepatology
Melanie Kirchmeyer, Anthoula Gaigneaux, Florence A. Servais, Anita Arslanow, Markus Casper, Marcin Krawczyk, Frank Lammert, Iris Behrmann
Summary: This study assessed cytokine profiles in patients with chronic liver diseases genotyped for the risk variant p.I148M of PNPLA3, and found that cytokines have potential as biomarkers for early detection of fatty liver and associated complications.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Fan Qiu, Bo Jiang, Yangui Lin, Huaming Li, Dan Li, Min Luo, Hongliang Hui, Haoran Miao, Yiqian Zhang
Summary: The combined use of PEDF and HGF can effectively treat PH by inhibiting angiogenesis and reducing vascular permeability. PEDF targets VEGFR2 and suppresses its phosphorylation at specific sites, leading to enhanced therapeutic efficacy of HGF. This study provides new insights into treatment strategies for clinical PH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Health Care Sciences & Services
Elin Hoien Bergene, Torstein Baade Ro, Aslak Steinsbekk
SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
(2017)
Article
Pediatrics
E. H. Bergene, H. Nordeng, T. B. Ro, A. Steinsbekk
Article
Hematology
Toril Holien, Oddrun E. Olsen, Kristine Misund, Hanne Hella, Anders Waage, Torstein B. Ro, Anders Sundan
EUROPEAN JOURNAL OF HAEMATOLOGY
(2013)
Article
Hematology
Ida B. Kristensen, Lise Pedersen, Torstein B. Ro, Jacob H. Christensen, Maria B. Lyng, Lars M. Rasmussen, Henrik J. Ditzel, Magne Borset, Niels Abildgaard
EUROPEAN JOURNAL OF HAEMATOLOGY
(2013)
Article
Hematology
Tobias Schmidt Slordahl, Tinneke Denayer, Siv Helen Moen, Therese Standal, Magne Borset, Cedric Ververken, Torstein Baade Ro
EUROPEAN JOURNAL OF HAEMATOLOGY
(2013)
Article
Hematology
Torstein Baade Ro, Toril Holien, Unn-Merete Fagerli, Hakon Hov, Kristine Misund, Anders Waage, Anders Sundan, Randi Utne Holt, Magne Borset
EXPERIMENTAL HEMATOLOGY
(2013)
Article
Cell Biology
Karin F. Wader, Unn-Merete Fagerli, Magne Borset, Stian Lydersen, Hakon Hov, Anders Sundan, Anna Bofin, Anders Waage
Article
Oncology
T. Holien, T. K. Vatsveen, H. Hella, C. Rampa, G. Brede, L. A. G. Groseth, M. Rekvig, M. Borset, T. Standal, A. Waage, A. Sundan
Article
Multidisciplinary Sciences
Rebekka Mueller, Kristine Misund, Toril Holien, Siri Bachke, Karin M. Gilljam, Thea K. Vatsveen, Torstein B. Ro, Emanuele Bellacchio, Anders Sundan, Marit Otterlei
Article
Oncology
O. E. Olsen, K. F. Wader, K. Misund, T. K. Vatsveen, T. B. Ro, A. K. Mylin, I. Turesson, B. F. Stordal, S. H. Moen, T. Standal, A. Waage, A. Sundan, T. Holien
BLOOD CANCER JOURNAL
(2014)
Article
Oncology
Anders Tondell, Yashwanth Subbannayya, Sissel Gyrid Freim Wahl, Arnar Flatberg, Sveinung Sorhaug, Magne Borset, Markus Haug
Summary: The study identified two novel immunosuppressive pathways that may dampen the anti-tumor T cell immune response in lung cancer, emphasizing the importance of tumor-associated macrophages as a promising target for immunotherapy. Non-small cell lung carcinoma (NSCLC) commonly shows beneficial responses to immunotherapy with immune checkpoint inhibitors, but only in a proportion of patients. Identification of novel immunosuppressive pathways in NSCLC-associated immune cells is crucial for improving immunotherapy in NSCLC.
Article
Biochemistry & Molecular Biology
Nur Mahammad, Felicity J. Ashcroft, Astrid J. Feuerherm, Samah Elsaadi, Esten N. Vandsemb, Magne Borset, Berit Johansen
Summary: The study demonstrates that cytosolic phospholipase A2 alpha (cPLA2 alpha) is overexpressed in certain hematological malignancies, including multiple myeloma, and inhibition of this enzyme significantly reduces cell viability and induces apoptosis. This implicates cPLA2 alpha as a potential target for treating hematological cancers such as multiple myeloma.
Article
Hematology
Magne Borset, Samah Elsaadi, Esten N. Vandsemb, Eli Svorkdal Hess, Ida J. Steiro, Miguel Cocera Fernandez, Anne-Marit Sponaas, Pegah Abdollahi
Summary: The study investigates how cancer cells can convert proto-oncoproteins into oncoproteins without mutations by increasing gene expression. Through analyzing highly expressed genes in cancer cells from multiple myeloma patients, potential key players in the disease pathogenesis were identified, providing a guide for future studies aiming at promising treatment targets.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
