Unknown gonadotoxicity chemotherapy and preservation of fertility: Example of Temozolomide

Objectives. - To evaluate the effect of Temozolomide on female fertility and the relevance of our coverage in preservation of fertility. Patients and methods. - From 2005 to 2009, 24 patients treated with Temozolomide for a low-grade glioma were included in the study (12 women who underwent a fertility preservation consultation and 12 women who did not). A retrospective study of their medical records and sending a questionnaire were undertaken to assess their fertility after treatment. Results. - Of the 24 patients, 15 patients had no fertility preservation and the remaining nine had a cryopreservation of embryos with or without an oocyte cryopreservation. Four patients are or have been pregnant (delivery, spontaneous miscarriage, pregnancy being in the group of preserving fertility and a current pregnancy in the group where no fertility preservation has been achieved). Discussion. - First study on the effect of Temozolomide on female fertility. Conclusion. - Temozolomide is not totally gonadotoxic. (C) 2010 Elsevier Masson SAS. All rights reserved.