Article
Cell Biology
Maxence Wisztorski, Soulaimane Aboulouard, Lucas Roussel, Marie Duhamel, Philippe Saudemont, Tristan Cardon, Fabrice Narducci, Yves-Marie Robin, Anne-Sophie Lemaire, Delphine Bertin, Nawale Hajjaji, Firas Kobeissy, Eric Leblanc, Isabelle Fournier, Michel Salzet
Summary: This study conducted an in-depth proteomic analysis of pre-neoplastic epithelial lesions in ovarian cancer using mass spectrometry imaging and immunohistochemistry techniques. Specific lesion markers were identified, and a lipidomic analysis confirmed the presence of specific lipid signatures in these lesions. The study provides new insights into the molecular mechanisms underlying the progression of ovarian cancer and confirms the fimbria origin of high-grade serous carcinoma.
CELL DEATH & DISEASE
(2023)
Review
Medicine, General & Internal
Dan L. Longo, Rachel C. Sisodia, Marcela G. del Carmen
Summary: Lesions of the ovary and fallopian tube can be acute or chronic, and it is important to distinguish between benign and malignant causes. Referral to a gynecologic oncologist is often necessary for diagnostic assessment.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Yoshiaki Maru, Naotake Tanaka, Yasutoshi Tatsumi, Yuki Nakamura, Ryoji Yao, Tetsuo Noda, Makiko Itami, Yoshitaka Hippo
Summary: Genetically engineered organoids have been shown to develop tumors in immunocompromised mice, providing new insights into the interactions among genotype, cell type, and tumor phenotype in tumorigenesis.
JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Guyu Qin, Eun-Sil Park, Xueqing Chen, Sen Han, Dongxi Xiang, Fang Ren, Gang Liu, Huidong Chen, Guo-Cheng Yuan, Zhe Li
Summary: Epithelial ovarian cancer (EOC) can originate from either fallopian tube epithelial (FTE) or ovarian surface epithelial (OSE) cells, but they exhibit different latencies and disease outcomes. Single cell RNA-sequencing revealed that FTE secretory stem/progenitor cells resemble mammary luminal progenitors, while OSE cells resemble basal cells. Additionally, an FT stromal subpopulation may serve as a niche for FTE cells, while Lgr5(+) OSE cells may self-sustain as their own niche. The differences in intrinsic expression programs and niche organizations of FTE and OSE cells may contribute to the development of EOCs.
Article
Oncology
Anne Kathrin Hoehn, Sabine Klagges, Albrecht Glaeser, Sabine Taubenheim, Nadja Dornhoefer, Jens Einenkel, Grit Gesine Ruth Hiller, Christine E. Brambs, Lars-Christian Horn
Summary: For non-uterine pelvic cancers, there is an increase in tumors originating from the fallopian tubes and a decrease in tumors originating from the ovaries. This trend is likely due to the reclassification of tumors previously classified as ovarian and a greater emphasis on examining resection specimens of non-uterine pelvic cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Sweta Dash, Sean Yoder, Tania Mesa, Andrew Smith, Ling Cen, Steven Eschrich, Guillermo N. Armaiz-Pena, Alvaro N. A. Monteiro
Summary: The study found that sustained adrenergic stimulation by norepinephrine has significant effects on ovarian cancer initiation and progression, particularly affecting ovarian surface epithelial cells and fallopian tube cells differently. Mutations in the p53 gene also influence the cellular response to NE stimulation.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Anthony I. Jang, Joshua D. Bernstock, David J. Segar, Marcello Distasio, Ursula Matulonis, Wenya Linda Bi
Summary: This case report presents a rare occurrence of fallopian tube cancer brain metastasis and reviews the literature on the subject. The patient underwent surgical resection of the brain lesions, which were confirmed to be of fallopian tube origin through immunohistochemical staining. The study highlights the need for further research on the treatment and management of brain metastasis from fallopian tube carcinoma.
FRONTIERS IN SURGERY
(2021)
Article
Biology
Kai Doberstein, Rebecca Spivak, Hunter D. Reavis, Jagmohan Hooda, Yi Feng, Paul T. Kroeger, Sarah Stuckelberger, Gordon B. Mills, Kyle M. Devins, Lauren E. Schwartz, Marcin P. Iwanicki, Mina Fogel, Peter Altevogt, Ronny Drapkin
Summary: This research provides evidence that L1 cell adhesion molecule (L1CAM) plays a role in the dissemination of transformed fallopian tube secretory cells (FTSECs) to the ovary in the early stages of high-grade serous carcinoma (HGSC) development. L1CAM upregulates integrins and fibronectin in malignant cells and activates the AKT and ERK pathways, increasing cell survival under non-adherent conditions and facilitating ovarian colonization.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Phyllis van der Ploeg, Aniek Uittenboogaard, Steven L. Bosch, Paul J. van Diest, Yvonne J. W. Wesseling-Rozendaal, Anja van de Stolpe, Sandrina Lambrechts, Ruud L. M. Bekkers, Jurgen M. J. Piek
Summary: This study investigated the activity of key signal transduction pathways in serous tubal intraepithelial carcinoma (STIC) and high-grade serous carcinoma (HGSC) and compared them to normal Fallopian tube epithelium (FTE). The results showed that the ER pathway activity was lower, while the PI3K and HH pathway activity was higher in STIC and HGSC compared to FTE. This suggests that these pathways may play a crucial role in the neoplastic transformation of FTE into STIC.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Cell Biology
Yu-Hsun Chang, Kun-Chi Wu, Kai-Hung Wang, Dah-Ching Ding
Summary: This study successfully generated induced pluripotent stem cells (iPSCs) from fallopian tube epithelial cells (FTECs) and compared their differentiation potential with iPSCs derived from different cell sources. The findings showed that iPSCs derived from orthologous cell sources exhibited comparable differentiation capabilities, making them promising tools for modeling and investigating diseases associated with specific cell types.
Review
Biochemistry & Molecular Biology
Isao Otsuka
Summary: High-grade serous carcinomas of the ovaries are a heterogeneous group of diseases with multifactorial etiology, potentially linked to inflammation from ovulation and genetic mutations like TP53. Other key genetic alterations include homologous recombination deficiency and CCNE1 amplification, which may be mutually exclusive. Intratumor heterogeneity from genomic instability can be observed early in tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Zhihua Ma, Li Gao, Han Li, Jie Li, Guanjun Zhang, Yan Xue
Summary: PFTC patients younger than 60 years old and those presenting with abnormal vaginal bleeding are more likely to be misdiagnosed. The presence of adnexal masses on color Doppler ultrasonography may help in the diagnosis of PFTC. Tumor stage and residual tumor size significantly affect the overall survival rate.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Review
Medicine, General & Internal
Shan Xiao, Yijia Chen, Qianjue Tang, Lianwei Xu, Li Zhao, Zhenzhen Wang, Erkai Yu
Summary: LAM is a rare tumor disease that is difficult to diagnose. This case report emphasizes the importance of diagnosis and treatment for LAM.
FRONTIERS IN MEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Guangxin Duan, Zhuxin Wei, Jingyu Zhang, Xuexiao Li, Shuwang Wu, Jianfeng Zeng, Ximing Wang, Hong Zhang, Ling Wen, Mingyuan Gao
Summary: Fallopian tube blockage-related diseases are the main cause of female infertility. Traditional hysterosalpingogram (HSG) has disadvantages, so there is an urgent need for a safe and accurate method to replace it. This study synthesized a rare-earth Erbium-based nanoprobe for NIR-II fluorescence imaging and explored its potential for tubal diagnosis.
MATERIALS & DESIGN
(2023)
Review
Oncology
Dongxue Kang, Danyang Zhao, Xiaodi Jiang, Deming Li
Summary: This is the first reported case of isolated splenic metastasis from primary fallopian tube carcinoma. The diagnosis was made through blood tests and abdominal CT scan. The patient underwent laparoscopic splenectomy and had a good recovery. This case highlights the importance of serum tumor marker assessment, medical imaging examination, and history of malignancy during follow-up.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Marion Curtis, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, Raquel Batlle, Xiaojing Liu, Nuria Gutierrez, Xia Gao, S. Diane Yamada, Ricardo Lastra, Anthony Montag, Nagib Ahsan, Jason W. Locasale, Arthur R. Salomon, Angel R. Nebreda, Ernst Lengyel
Article
Engineering, Biomedical
Daniela Loessner, Anja Rockstroh, Ali Shokoohmand, Boris M. Holzapfel, Ferdinand Wagner, Jeremy Baldwin, Melanie Boxberg, Barbara Schmalfeldt, Ernst Lengyel, Judith A. Clements, Dietmar W. Hutmacher
Article
Oncology
Melissa Javellana, Claire Hoppenot, Ernst Lengyel
GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Sean McGuire, Betul Kara, Peter C. Hart, Anthony Montag, Kristen Wroblewski, Sarah Fazal, Xin-Yun Huang, Ernst Lengyel, Hilary A. Kenny
GYNECOLOGIC ONCOLOGY
(2019)
Letter
Medicine, General & Internal
Maryl G. Sackeim, Ernst Lengyel
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Oncology
Monal Patel, Yinu Wang, Elizabeth T. Bartom, Rohin Dhir, Kenneth P. Nephew, Daniela Matei, Andrea E. Murmann, Ernst Lengyel, Marcus E. Peter
Summary: Research has shown that the balance of miRNAs carrying toxic and nontoxic 6mer seeds is closely related to platinum resistance in ovarian cancer. Analysis of RISC-bound miRNAs in tumors can predict treatment outcomes.
Review
Oncology
Mark A. Eckert, Carlos Orozco, Jason Xiao, Melissa Javellana, Ernst Lengyel
Summary: While most approved therapies target cancer cells, there is growing evidence that these agents also play important roles in regulating the biology of host cells in the tumor microenvironment. Understanding how non-transformed cells respond and adapt to established therapeutics is crucial for developing novel treatments that disrupt undesired tumor-stroma interactions.
Article
Oncology
Melissa Javellana, Fay J. Hlubocky, Sahana Somasegar, Mia Sorkin, Katherine C. Kurnit, Ina Jani, Elizabeth Stock, Kathryn Mills, Ernst Lengyel, Nita K. Lee
Summary: This study aimed to evaluate the psychological impact and changes in medical care caused by the COVID-19 pandemic on ovarian cancer survivors. The results showed that despite the pandemic, the quality of life of ovarian cancer survivors remained good, with high levels of resilience and mental health.
JCO ONCOLOGY PRACTICE
(2022)
Review
Oncology
Abir Mukherjee, Agnes J. Bilecz, Ernst Lengyel
Summary: Tumor cells interact with adipocytes to convert them into cancer-associated adipocytes, supporting tumor growth. Tumors can stimulate lipolysis in adipocytes and uptake of fatty acids for various cellular processes.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Acoustics
Roni Yoeli-Bik, Ernst Lengyel, Kathryn A. Mills, Jacques S. Abramowicz
Summary: Adnexal lesions are common in women and most of them are benign, requiring a conservative approach. Transvaginal ultrasound plays a key role in evaluating the risk of malignancy, but recognizing the acoustic shadow is a difficult skill to master and its usefulness may be underestimated.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Cell Biology
Ernst Lengyel, Yan Li, Melanie Weigert, Lisha Zhu, Heather Eckart, Melissa Javellana, Sarah Ackroyd, Jason Xiao, Susan Olalekan, Dianne Glass, Shilpa Iyer, Rahul Krishnan, Agnes Julia Bilecz, Ricardo Lastra, Mengjie Chen, Anindita Basu
Summary: As part of the Human Cell Atlas Initiative, this study aims to analyze the cellular composition and regulatory features of the normal postmenopausal ovary and fallopian tube using single-cell transcriptomics and chromatin accessibility data. The findings reveal differences in gene expression and active communication between fimbrial epithelial cells and ovarian stromal cells, providing insights into gynecologic diseases in menopause.
Article
Oncology
Lucy Kelliher, Ernst Lengyel
Summary: High-grade serous ovarian cancer (HGSOC) is a highly lethal subtype of ovarian cancer. However, approximately 15% of advanced-stage HGSOC patients survive longer than 10 years, and the underlying reasons for this prolonged survival remain unclear. In this study, researchers investigated the tumor microenvironment (TME) in both long- and short-term survivors and found that different populations of cancer-associated fibroblasts (CAF) in the TME play different roles in supporting the malignant phenotype of ovarian cancer cells. Short-term survivors had a higher density of CAFs, which promoted tumorigenicity, stemness, and chemoresistance in the nearby tumor.
Article
Medicine, Research & Experimental
Preety Bajwa, Kasjusz Kordylewicz, Agnes Bilecz, Ricardo R. Lastra, Kristen Wroblewski, Yuval Rinkevich, Ernst Lengyel, Hilary A. Kenny
Summary: Ovarian cancer preferentially metastasizes in association with mesothelial cell-lined surfaces. The presence of mesothelial cells is required for ovarian cancer metastasis, and the interaction between mesothelial cells and ovarian cancer cells leads to alterations in gene expression and cytokine secretion. The secretion of ANGPTL4 by mesothelial cells promotes ovarian cancer metastasis through various mechanisms.
Article
Medicine, Research & Experimental
Hironari Akasaka, WonJae Lee, Song Yi Ko, Ernst Lengyel, Honami Naora
Summary: The administration of normal saline into the peritoneal cavity of mice promotes absorption by the omentum, exfoliates its mesothelium, and induces expression of CX3CL1. This leads to an accumulation of CX3CR1+ monocytes/macrophages in the omentum, expanding milky spots and promoting neoangiogenesis within these niches. Additionally, normal saline administration promotes the implantation of ovarian and colorectal cancer cells onto the omentum. These effects are not observed with the use of lactated Ringer's solution.
Article
Multidisciplinary Sciences
Agnieszka Chryplewicz, Samantha M. Tienda, Dominik A. Nahotko, Pamela N. Peters, Ernst Lengyel, Mark A. Eckert
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)