Article
Multidisciplinary Sciences
Bernadette A. M. Heemskerk-Gerritsen, Antoinette Hollestelle, Christi J. van Asperen, Irma van den Beek, Willemien J. van Driel, Klaartje van Engelen, Encarna B. Gomez Garcia, Joanne A. de Hullu, Marco J. Koudijs, Marian J. E. Mourits, Maartje J. Hooning, Ingrid A. Boere
Summary: Germline BRCA1 and BRCA2 pathogenic variant carriers of epithelial ovarian cancer showed survival benefits after chemotherapy, indicating a higher sensitivity to treatment. However, these benefits were limited to a relatively short period after the diagnosis of epithelial ovarian cancer.
Article
Oncology
Jiayi Li, Dongyan Cao
Summary: We developed two prognostic nomograms for predicting recurrence and long-term survival in patients with ovarian clear cell carcinoma (OCCC) after primary treatment, and validated them in patients from the same center. This tool, which uses variables specifically related to OCCC, was more accurate than the FIGO system, making it relatively easy to use in clinic for patient counseling, postoperative management, and follow-up for individual patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Patriciu Andrei Achimas-Cadariu, Diana Loreta Paun, Andrei Pasca
Summary: This systematic review and meta-analysis investigated the safety and effect of Hormone Replacement Therapy (HRT) on overall survival and progression-free survival in ovarian cancer treatments. The results showed a slight benefit in terms of survival and recurrence rates in favor of the HRT groups. However, subgroup analyses revealed no statistically significant results in terms of recurrence, but HRT remains advantageous in improving the quality of life for these patients.
Article
Obstetrics & Gynecology
Xingyu Liu, Yingjun Zhao, Xiaofei Jiao, Yang Yu, Ruyuan Li, Shaoqing Zeng, Jianhua Chi, Guanchen Ma, Yabing Huo, Ming Li, Zikun Peng, Jiahao Liu, Qi Zhou, Dongling Zou, Li Wang, Qingshui Li, Jing Wang, Shuzhong Yao, Youguo Chen, Ding Ma, Ting Hu, Qinglei Gao
Summary: This study explored the impact of the primary treatment sequence on the post-relapse survival and recurrence characteristics of recurrent epithelial ovarian cancer. The results showed that neoadjuvant chemotherapy and interval debulking surgery were associated with post-relapse survival and may lead to worse recurrence pattern and shorter platinum-free interval.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jamie Garside, Qin Shen, Bernd Westermayer, Michiel van de Ven, Sonja Kroep, Viktor Chirikov, Ingolf Juhasz-Boess
Summary: This study found a strong correlation between progression-free survival (PFS)/time to progression (TTP) and overall survival (OS) in the first-line treatment of advanced/recurrent endometrial cancer. Improvements in PFS/TTP are likely to translate into subsequent improvements in OS.
CLINICAL THERAPEUTICS
(2023)
Article
Oncology
Irene Tizianel, Mario Caccese, Francesca Torresan, Giuseppe Lombardi, Laura Evangelista, Filippo Crimi, Matteo Sepulcri, Maurizio Iacobone, Marta Padovan, Francesca Galuppini, Vittorina Zagonel, Carla Scaroni, Filippo Ceccato
Summary: The study found a significant improvement in survival rates for ACC patients after multidisciplinary team evaluation in 2013. Therefore, it is suggested that ACC patients should be referred to a tertiary center from the time of diagnosis in order to promptly apply all available treatments.
Review
Oncology
Maria Teresa Climent, Anna Serra, Maria Llueca, Antoni Llueca
Summary: Ovarian cancer has a high mortality rate due to advanced diagnosis and high recurrence rate. Systemic chemotherapy is the standard treatment for recurrent ovarian cancer, but secondary cytoreductive surgery may also be effective. This study analyzed multiple randomized controlled trials and found significant improvements in overall survival and disease-free survival for patients who underwent complete secondary cytoreductive surgery.
Article
Oncology
I-Chun Chen, Fu-Chang Hu, Ching-Hung Lin, Shu-Min Huang, Dwan-Ying Chang, Ann-Lii Cheng, Yen-Shen Lu
Summary: The meta-analysis results revealed that in patients with HER2-positive metastatic breast cancer, treatment with anti-HER2 antibodies led to a prolongation of OS more than PFS, with the absolute increment in median OS time being double that of median PFS time, and this increase was linearly correlated, indicating the need for further investigation into the efficacy of anti-HER2 antibodies.
Article
Oncology
Fang Ren, Shengtan Wang, Feifei Li, Jian Gao, Haoya Xu, Xianli Li, Liancheng Zhu
Summary: This study aimed to construct nomograms using data from the SEER database to predict overall survival and cancer-specific survival of ovarian carcinosarcoma (OCS) patients. The nomograms based on independent prognostic factors showed good predictive power and clinical practicality, outperforming traditional staging and grading systems. They enable personalized evaluation of OS and CSS, guiding treatment decisions.
Article
Nutrition & Dietetics
Hailun Xie, Lishuang Wei, Shunhui Gao, Mingxiang Liu, Yanren Liang, Guanghui Yuan, Qiwen Wang, Yansong Xu, Shuangyi Tang, Jialiang Gan
Summary: This study investigated the prognostic significance of sarcopenia diagnosed based on anthropometric equations for PFS and OS in CRC patients. Sarcopenia was found to be significantly associated with advanced age, large tumor size, and high mortality. Compared to non-sarcopenic patients, sarcopenic patients had worse PFS and OS. Predictive models based on sarcopenia were effective in predicting adverse outcomes in CRC patients.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Coralie Courtinard, Sophie Gourgou, William Jacot, Matthieu Carton, Olivier Guerin, Laure Vacher, Aurelie Bertaut, Marie-Cecile Le Deley, David Perol, Patricia Marino, Christelle Levy, Lionel Uwer, Genevieve Perrocheau, Renaud Schiappa, Florence Bachelot, Damien Parent, Mathias Breton, Thierry Petit, Thomas Filleron, Agnes Loeb, Simone Mathoulin Pelissier, Mathieu Robain, Suzette Delaloge, Carine Bellera
Summary: This study aimed to describe the individual-level association between real-world progression-free survival (rwPFS) and overall survival (OS) in female patients with metastatic breast cancer (mBC) according to first-line treatment. The results showed that the degree of association between PFS and OS varied across different subtypes and first-line treatments.
Article
Reproductive Biology
Zhongyu Wang, Yake Huang, Ling Long, Li Zhou, Yan Huang, Lei Gan, Aimin Pu, Sufen Li, Rongkai Xie
Summary: Biochemical recurrence in ovarian cancer, characterized by rising CA-125 levels without radiographic evidence of disease, poses a challenge in treatment strategies. Apatinib, either alone or in combination with chemotherapy, has shown efficacy in delaying clinical progression in recurrent ovarian cancer patients, particularly those with biochemical-only relapse. This study highlights the promising prospect of using apatinib to treat ovarian cancer patients with asymptomatic biochemical recurrence.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Shintaro Yanazume, Takashi Ushiwaka, Mika Fukuda, Shinichi Togami, Masaki Kamio, Hiroaki Kobayashi
Summary: This study evaluated factors influencing post-progression survival in patients with advanced recurrent ovarian cancer, finding that platinum-sensitive patients had longer survival than platinum-resistant patients. The use of bevacizumab, secondary debulking surgery, and olaparib maintenance in recurrence were associated with increased post-progression survival.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Reproductive Biology
Pavan Kumar, Samruddhi Ranmale, Sanket Mehta, Hemant Tongaonkar, Vainav Patel, Amit Kumar Singh, Jayanti Mania-Pramanik
Summary: This study investigated the NK cell receptor expression, their ligands, serum cytokines, and soluble ligands in primary and recurrent HGSOC patients. The results revealed differential immune profiles of primary and recurrent ovarian cancer patients, as well as alterations in tumor infiltrated immune cells. These findings may provide insights for developing alternative therapeutic approaches for HGSOC patients.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Marco Rossi, Lorenzo Gay, Federico Ambrogi, Marco Conti Nibali, Tommaso Sciortino, Guglielmo Puglisi, Antonella Leonetti, Cristina Mocellini, Manuela Caroli, Susanna Cordera, Matteo Simonelli, Federico Pessina, Piera Navarria, Andrea Pace, Riccardo Soffietti, Roberta Ruda, Marco Riva, Lorenzo Bello
Summary: The study found that supratotal resection is strongly associated with good oncological outcomes in molecularly defined lower-grade gliomas, regardless of molecular subtypes and grading.
Article
Health Care Sciences & Services
Laura Kudrna, Paul Bird, Karla Hemming, Laura Quinn, Kelly Schmidtke, Richard Lilford
Summary: This study evaluated the impact of a short-term training program on improving the use of SPCs in hospital board papers. The results showed that the training program was effective in increasing the use of SPCs within the organization.
BMJ QUALITY & SAFETY
(2023)
Article
Health Care Sciences & Services
Kelly Ann Schmidtke, Felicity Evison, Amy Grove, Laura Kudrna, Olga Tucker, Andy Metcalfe, Andrew W. Bradbury, Aneel Bhangu, Richard Lilford
Summary: This study examines the effects and reasons for the uptake of six trials with actionable findings on clinical practice. The quantitative analysis reveals that practice changed in accordance with the findings for three trials, while the qualitative analysis found that evidence from other sources and various reasons influenced the non-adoption or delayed uptake of trial evidence.
BMJ QUALITY & SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Suleman Aktaa, Gorav Batra, Stefan K. James, Daniel J. Blackman, Peter F. Ludman, Mamas A. Mamas, Mohamed Abdel-Wahab, Gianni D. Angelini, Martin Czerny, Victoria Delgado, Giuseppe De Luca, Agricola Eustachio, Dan Foldager, Christian W. Hamm, Bernard Iung, Norman Mangner, Julinda Mehilli, Gavin J. Murphy, Darren Mylotte, Radoslaw Parma, Anna Sonia Petronio, Bodgan A. Popescu, Lars Sondergaard, Rui C. Teles, Manel Sabate, Christian J. Terkelsen, Luca Testa, Jianhua Wu, Aldo P. Maggioni, Lars Wallentin, Barbara Casadei, Chris P. Gale
Summary: The EuroHeart project aims to create pan-European data standards for cardiovascular diseases and interventions, including TAVI, to quantify quality of care and patient outcomes.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Adam C. Jowett, Simon J. Littlewood, Trevor M. Hodge, Harmeet K. Dhaliwal, Jianhua Wu
Summary: This study compared different types of bonded retainers in terms of stability, retainer failures, and patient satisfaction. The results showed that the upper Memotain (R) retainers had a higher failure rate compared to the upper Ortho-FlexTech (TM) retainers.
JOURNAL OF ORTHODONTICS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Harriet Larvin, Jing Kang, Vishal R. Aggarwal, Susan Pavitt, Jianhua Wu
Summary: This review examines and quantifies the long-term risk of immune-mediated systemic conditions in people with periodontitis compared to those without. The results show that people with periodontitis have an increased risk of developing diabetes, rheumatoid arthritis, and osteoporosis.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Oncology
Anastasios Kanatas, Emma G. Walshaw, Jianhua Wu, Gillon Fabbroni, Preetha Chengot
Summary: This prospective longitudinal study found that oral cancer surgery is complicated due to the diverse clinical and histopathological presentations. Surgical margin status plays a significant role in patient survival, while the importance of other histopathological factors varies in the literature.
Review
Geriatrics & Gerontology
Harriet Larvin, Chenyi Gao, Jing Kang, Vishal R. Aggarwal, Susan Pavitt, Jianhua Wu
Summary: The study found that there is an association between periodontal disease and cognitive disorders. The risk of cognitive decline is higher in individuals with severe periodontal disease and a higher proportion of females. Additionally, self-reported periodontal disease is associated with a lower risk of cognitive disorders compared to clinically diagnosed cases.
Article
Oncology
Robert D. Morgan, Andrew R. Clamp, Bethany M. Barnes, Kirsten Timms, Helene Schlecht, Laura Yarram-Smith, Yvonne Wallis, Mikel Valganon-Petrizan, Suzanne MacMahon, Rhian White, Sian Morgan, Sarah McKenna, Emma Hudson, Laura Tookman, Angela George, Ranjit Manchanda, Sudha S. Sundar, Shibani Nicum, James D. Brenton, Rebecca S. Kristeleit, Susana Banerjee, Iain A. McNeish, Jonathan A. Ledermann, Stephen S. Taylor, D. Gareth R. Evans, Gordon C. Jayson
Summary: This study reports data from the first year of routine homologous recombination deficiency testing in the NHS in England, Wales, and Northern Ireland, demonstrating the significant survival benefits of olaparib plus bevacizumab maintenance therapy in women with newly diagnosed, advanced, high-grade ovarian cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Editorial Material
Obstetrics & Gynecology
Christina Fotopoulou, Tabassum Khan, Juraj Bracinik, James Glasbey, Nadeem Abu-Rustum, Luis Chiva, Anna Fagotti, Keiichi Fujiwara, Rahel Ghebre, Murat Gutelkin, Thomas O. Konney, Joseph Ng, Rene Pareja, Rajkumar Kottayasamy Seenivasagam, Jalid Sehouli, Shylasree T. S. Surappa, Aneel Bhangu, Elaine Leung, Sudha Sundar
Summary: The COVID-19 pandemic has disproportionately affected women with gynecologic cancers and surgical care delivery. A cohort study was conducted to analyze the impact of pandemic-related modifications on clinical management and surgical outcomes of gynecologic cancer patients.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2023)
Article
Oncology
Marc Daniel Algera, Rhett Morton, Sudha S. Sundar, Rhonda Farrell, Willemien J. van Driel, Donal Brennan, Marcus J. Rijken, Selina Sfeir, Lucy Allen, Mary Eiken, Robert L. Coleman
Summary: This study aimed to evaluate global ovarian cancer care and barriers to care. The survey results from 115 countries showed variation in care organization and barriers across different income levels. The findings emphasize the importance of improving care quality and reducing survival disparities globally.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chenyi Gao, Harriet Larvin, David Timothy Bishop, David Bunce, Susan Pavitt, Jianhua Wu, Jing Kang
Summary: This study comprehensively investigates the bidirectional association between oral diseases and cognitive function. The results show associations between various oral diseases and global cognitive score, and a significant correlation between these oral diseases and cognitive function is also found using structural equation modeling.
Article
Medicine, General & Internal
Christopher J. Hayward, Jonathan A. Batty, David R. Westhead, Owen Johnson, Chris P. Gale, Jianhua Wu, Marlous Hall
Summary: By analyzing large-scale health records data, we found that there are various disease trajectories following myocardial infarction (MI), with multiple circulatory diagnoses and neuro-psychiatric diagnoses being more common and associated with increased mortality. Early intervention, particularly focusing on psychological and behavioral pathways, for MI survivors can help mitigate adverse disease trajectories, multimorbidity, and premature mortality.
Article
Public, Environmental & Occupational Health
Aya M. Riad, N. I. H. R. Global Health Unit on Global GlobalSurg Collaborative, writing group Aya M. NIHR Global Hlth Unit Global Surg, Stephen R. Knight, Dhruv Ghosh, Pamela A. Kingsley, Marie Carmela Lapitan, Marie Dione Parreno-Sacdalan, Sudha Sundar, Ahmad Uzair Qureshi, Apple P. Valparaiso, Riinu Pius, Catherine A. Shaw, Thomas M. Drake, Lisa Norman, Adesoji O. Ademuyiwa, Adewale O. Adisa, Maria Lorena Aguilera, Sara W. Al-Saqqa, Ibrahim Al-Slaibi, Aneel Bhangu, Bruce M. Biccard, Peter Brocklehurst, Sorrel Burden, Kathryn Chu, Ainhoa Costas-Chavarri, Anna J. Dare, Muhammed Elhadi, Cameron J. Fairfield, J. Edward Fitzgerald, James Glasbey, Mark I. van Berge Henegouwen, J. C. Allen Ingabire, T. Peter Kingham, Ismail Lawani, Bettina Lieske, Richard Lilford, Laura Magill, Mayaba Maimbo, Janet Martin, Sonia Mathai, Kenneth A. Mclean, Rachel Moore, Dion Morton, Dmitri Nepogodiev, John Norrie, Faustin Ntirenganya, Francesco Pata, Thomas Pinkney, Rajkumar Kottayasamy Seenivasagam, Antonio Ramos-De la Medina, Tracey E. Roberts, Hosni Khairy Salem, Joana Simoes, Richard J. E. Skipworth, Richard Spence, Neil Smart, Stephen K. Tabiri, Evropi Theodoratou, Hannah Thomas, Malcolm West, John Whitaker, Thomas G. Weiser, Edwin Yenli, Ewen M. Harrison
Summary: This international study examined the impact of global nutritional state on early postoperative outcomes in patients undergoing surgery for colorectal or gastric cancer. Severe malnutrition was found to be a risk factor for 30-day mortality and major complications following elective surgery, with a greater burden in low-income and lower-middle-income countries. Therefore, there is an urgent need for global nutritional interventions to improve early outcomes in patients with gastrointestinal cancer.
LANCET GLOBAL HEALTH
(2023)
Review
Oncology
Ben-Lawrence Kemah, Nanak Bhagat, Aayushi Pandya, Richard Sullivan, Sudha S. Sundar
Summary: Recent advances in gynecologic cancer care have improved patient outcomes, but have also reduced surgical training opportunities. Supplementing training strategies with evidence-based adjuncts, such as virtual reality and augmented reality, can help address this issue.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Surgery
Dale Vimalachandran, Robert P. Jones, Ed Dickson, Jaspreet Seehra, Austin Acheson, Ewen A. Griffiths, Sivesh Kamarajah, Elaine Leung, Andrew Torrance, Christian Ottensmeier, Andrew D. Beggs, Ellen Whiteside, Helen Sanna, Danielle Bury, Esther Youd, Gareth Leopold, Matthew Pugh, Sudha Sundar, Graham S. Taylor
BRITISH JOURNAL OF SURGERY
(2023)
