Article
Oncology
Priti Kumari, Indu Sharma, Subhas Chandra Saha, Radhika Srinivasan, Priyanka Minhas
Summary: The study found that miR-99b and miR-125a have high diagnostic potential for endometriosis, miR-143 plays an important role in predicting endometrioid ovarian cancer, and miR-16, miR-99b, and miR-145 are the best predictors for endometrial cancer. These miRNAs could act as good predictors and discriminators of these three diseases, potentially serving as biomarkers for them.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Public, Environmental & Occupational Health
Aya Ishizaka, Ayumi Taguchi, Tetsushi Tsuruga, Marie Maruyama, Akira Kawata, Yuichiro Miyamoto, Michihiro Tanikawa, Masako Ikemura, Kenbun Sone, Mayuyo Mori, Kaori Koga, Tetsuo Ushiku, Katsutoshi Oda, Yutaka Osuga
Summary: This study found that endometrial cancer patients with endometriosis have a higher risk of concomitant endometrial and ovarian cancer. Furthermore, endometrioid carcinoma is the most common histological subtype of simultaneous endometrial and ovarian cancer regardless of the presence of endometriosis.
Article
Pathology
Lawrence Hsu Lin, Douglas H. R. Allison, Gulisa Turashvili, Varshini Vasudevaraja, Ivy Tran, Jonathan Serrano, Britta Weigelt, Marc Ladanyi, Nadeem R. Abu-Rustum, Matija Snuderl, Sarah Chiang
Summary: This study found that co-occurring sporadic endometrioid endometrial carcinoma (EEC) and endometrioid ovarian carcinoma (EOC) are clonally related, but there is a shift in DNA methylation signatures between the ovarian and endometrial tumors. The results also indicate epigenetic overlap between ovarian and peritoneal tumors, suggesting a role for the tumor microenvironment in the epigenetic modulation of metastatic EEC.
Article
Oncology
Adriana Gaia-Oltean, Laura A. Pop, Roxana M. Cojocneanu, Mihail Buse, Andreea A. Zimta, Paul Kubelac, Alexandru Irimie, Ovidiu F. Coza, Horace Roman, Ioana Berindan-Neagoe
Summary: The study found common mutated genes in patients with endometriosis and ovarian endometrioid carcinoma, as well as specific mutated genes for each group. In addition, certain genes were highly methylated in endometriosis samples, while others were methylated in ovarian endometrioid carcinoma samples. Moreover, BRCA1, CADM1, PAX6, and PAH genes were mainly methylated in patients with ovarian endometrioid carcinoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Nikola Zmarzly, Szymon Januszyk, Pawel Mieszczanski, Emilia Morawiec, Paulina Buda, Konrad Dziobek, Marcin Oplawski, Dariusz Boron
Summary: This study found that the expression of endothelins changes in endometrial cancer, and this may be mainly due to the silencing of EDN3 activity caused by DNA methylation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Marjolein Hermens, Anne M. van Altena, Iris Velthuis, Danielle C. M. van de Laar, Johan Bulten, Huib A. A. M. van Vliet, Albert G. Siebers, Ruud L. M. Bekkers
Summary: This study confirms an increased risk of endometrial cancer in women with histologically proven endometriosis and adenomyosis, with most cases of endometrial cancer being detected at the time of histological diagnosis of endometriosis/adenomyosis. Women with these conditions should be vigilant about the potential increased risk of endometrial cancer.
Review
Oncology
Nozomi Yachida, Kosuke Yoshihara, Manako Yamaguchi, Kazuaki Suda, Ryo Tamura, Takayuki Enomoto
Summary: Driver gene mutations have been identified in both endometriosis and normal endometrium, potentially leading to endometriosis-associated ovarian cancer. Despite the continuum of genomic alterations, the molecular mechanism of ovarian carcinogenesis from the normal endometrium through endometriosis remains unclear.
Article
Oncology
Logan Blankenship, Uday P. Pratap, Xue Yang, Zexuan Liu, Kristin A. Altwegg, Bindu Santhamma, Kumaraguruparan Ramasamy, Swapna Konda, Yidong Chen, Zhao Lai, Siyuan Zheng, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Hareesh B. Nair, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli
Summary: The study demonstrates that obese conditions upregulate LIF/LIFR signaling, promoting progression of endometrioid endometrial cancer (EEC). The LIFR inhibitor EC359 shows potential in suppressing tumor progression in obese patients.
Review
Oncology
Nicoletta D'Alessandris, Antonio Travaglino, Angela Santoro, Damiano Arciuolo, Giulia Scaglione, Antonio Raffone, Frediano Inzani, Gian Franco Zannoni
Summary: This study evaluated the distribution and clinicopathological features of the TCGA groups in ovarian endometrioid carcinoma (OEC) and found differences in distribution between OEC and endometrial endometrioid carcinoma (EEC), but similar prognostic value.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Hoon Kim, Hyun Jung Kim, Hyeong Sik Ahn
Summary: This study investigated the association between endometriosis and the risks of endometrial hyperplasia and endometrial cancer. The results showed that women with endometriosis had significantly higher risks of developing endometrial hyperplasia and endometrial cancer.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Marcin Oplawski, Robert Nowakowski, Agata Srednicka, Dominika Ochnik, Beniamin Oskar Grabarek, Dariusz Boron
Summary: Modern diagnostics focus on molecular analysis and the search for new molecular markers. This study evaluated the differences in mRNA and miRNA expression related to endometrial cancer grades, aiming to select promising molecular markers. The analysis identified potential diagnostic markers associated with epithelial-mesenchymal transition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Takahiro Minamikawa, Nozomi Yachida, Kotaro Takahashi, Kyota Saito, Tomoyuki Sekizuka, Hidehiko Akashi, Miho Suzuki, Yutaro Mori, Kaoru Yamawaki, Kazuaki Suda, Ryo Tamura, Sosuke Adachi, Kosuke Yoshihara
Summary: This study retrospectively analyzed the medical records of women with endometrial cancer to evaluate the clinicopathological relationship with endometriosis. The results showed that endometrial cancer patients with endometriosis were younger, had fewer pregnancies and deliveries, and were more often classified as early stage. There was also a higher rate of dual primary cancer with ovarian cancer among patients with endometriosis.
Article
Oncology
Beryl L. Manning-Geist, Eric Rios-Doria, Emeline M. Aviki, Qin Zhou, Alexia Iasonos, Nadeem R. Abu-Rustum, Carol L. Brown, Jennifer J. Mueller
Summary: This study aimed to analyze trends and demographic shifts associated with guideline implementation in patients with endometrioid endometrial cancer. The results showed that after guideline implementation, there was a significant increase in ovarian conservation and a decrease in uptake disparities across different demographic groups.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Endocrinology & Metabolism
Jun Guan, Xiao-Jun Chen
Summary: Progestin therapy is the main treatment for preserving fertility in women with endometrial cancer and atypical endometrial hyperplasia. Studies suggest that metformin may have potential benefits in improving the therapeutic outcome of progestin treatment. However, there is still a lack of strong evidence supporting the use of metformin in this context due to heterogeneity and design limitations in existing studies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Dariusz Boron, Robert Nowakowski, Beniamin Oskar Grabarek, Nikola Zmarzly, Marcin Oplawski
Summary: The study investigated the expression profile of leptin-related genes in endometrial cancer patients, showing an overexpression of leptin and its receptors, particularly correlating with patient body mass index, which may contribute to the progression of cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Alessandra Alteri, Greta Chiara Cermisoni, Mirko Pozzoni, Gerarda Gaeta, Paolo Ivo Cavoretto, Paola Vigano
Summary: This review examines the impact of embryo biopsy on obstetric and neonatal outcomes. Limited evidence suggests that embryo biopsy may increase the risk of preterm delivery, low birthweight, and hypertensive disorders of pregnancy. However, more research is needed to fully understand the potential consequences of this procedure and develop alternative non-invasive approaches for preimplantation genetic testing (PGT).
HUMAN REPRODUCTION UPDATE
(2023)
Article
Genetics & Heredity
Paola Vigano, Marco Reschini, Marta Ciaffaglione, Veronica Cuce, Maira Casalechi, Laura Benaglia, Paolo Vercellini, Edgardo Somigliana
Summary: This study aimed to compare the factors underlying infertility in women with endometriosis. The results showed that there were no significant differences in fertilization rate, embryo quality, and clinical pregnancy rate between women with and without endometriosis. Therefore, conventional IVF can still be used in endometriosis patients unless there is a male factor involved.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Environmental Sciences
Lidia Caporossi, Paola Vigano, Enrico Paci, Silvia Capanna, Alessandra Alteri, Daniela Pigini, Giovanna Tranfo, Bruno Papaleo
Summary: Male infertility is a significant public health concern, and the potential link between exposure to plasticizers like phthalates and bisphenol A and this condition is a topic of debate. A study was conducted with 155 infertility cases and 211 controls to investigate this issue. The results showed higher urinary concentrations of phthalates in cases compared to controls, but no significant difference in BPA levels. However, no clear quantitative correlation between specific plasticizers and sperm parameters was identified, calling for further research on the risks associated with exposure to these chemicals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
Paolo Vercellini, Paola Vigano, Veronica Bandini, Laura Buggio, Nicola Berlanda, Edgardo Somigliana
Summary: This review synthesized systematic reviews and meta-analyses published in the last 5 years to explore the association between endometriosis and adenomyosis with reproductive and obstetric outcomes. The findings suggest that women with endometriosis and adenomyosis have reduced pregnancy and live birth rates, increased miscarriage rates, and higher risks of various adverse obstetric outcomes. Women with deep infiltrating endometriosis and severe adenomyosis should be considered at high obstetric risk and referred to tertiary care centers for safe management during pregnancy and delivery. It is uncertain whether the same applies to pregnant women with minimal endometriosis and adenomyosis forms. Emerging evidence suggests that some adverse outcomes observed in women with endometriosis are associated with coexisting adenomyosis.
FERTILITY AND STERILITY
(2023)
Review
Obstetrics & Gynecology
Edgardo Somigliana, Fabio Parazzini, Alice Goisis, Giovanna Esposito, Letizia Li Piani, Francesca Filippi, Paola Vigano
Summary: The article calls for more research on infertile couples to understand their intended number of children and the rate of return after the first IVF treatment. This could potentially impact clinical practice by improving chances of conceiving a second child and identifying barriers to non-return or a gap between intended and realized number of children. However, the current evidence is insufficient to recommend any interventions.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Noemi Salmeri, Letizia Li Piani, Paolo Ivo Cavoretto, Edgardo Somigliana, Paola Vigano, Massimo Candiani
Summary: The risk of gestational diabetes mellitus (GDM) is significantly higher in women with endometriosis, especially in more severe stages of the disease. This association is present in naturally conceived pregnancies but not in pregnancies conceived through assisted reproductive technologies (ART).
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Laura Buggio, Marco Reschini, Paola Vigano, Dhouha Dridi, Giulia Galati, Alessandra Chine, Francesca Giola, Edgardo Somigliana, Laura Benaglia
Summary: This study compared the 2D:4D ratio between women with endometriosis and healthy controls and found that women with endometriosis had a significantly higher 2D:4D ratio. This result supports the hypothesis that intrauterine hormonal and endocrine disruptor exposures may play a role in the onset of the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Paola Vigano, Maira Casalechi, Paolo Vercellini, Edgardo Somigliana
Article
Obstetrics & Gynecology
Giovanna Esposito, Fabio Parazzini, Paola Vigano, Matteo Franchi, Sonia Cipriani, Francesco Fedele, Giovanni Corrao, Edgardo Somigliana
Summary: Limited evidence exists on the role of medically assisted reproduction (MAR) in achieving desired family size. This study aimed to assess the probability and mode of conception of a second live birth based on the mode of conception of the first child. The findings showed that women who used MAR for their first child were more likely to use MAR again for a second child.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Endocrinology & Metabolism
Noemi Salmeri, Paola Vigano, Paolo Cavoretto, Roberto Marci, Massimo Candiani
Summary: Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with opposite alterations in reproductive processes and phenotypic traits. Recent discovery of kisspeptin as a pivotal mediator in human reproduction and its involvement in metabolism, inflammation, and pain sensitivity provides new insights into understanding these conditions. This review discusses the clinical relevance and potential translational applications of these discoveries in developing novel therapies for endometriosis and PCOS.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Medicine, General & Internal
Chiara Dallagiovanna, Laura Benaglia, Marco Reschini, Luca Di Gesaro, Letizia Li Piani, Nicola Persico, Paola Vigano', Edgardo Somigliana
Summary: The modality of endometrial preparation for the transfer of frozen-thawed embryos may impact maternal and fetal adaptation to pregnancy and the results of the first trimester combined screening test.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Barbara Herranz-Blanco, Elza Daoud, Paola Vigano, Juan Antonio Garcia-Velasco, Enrico Colli
Summary: Endometriosis affects more than 10% of women of reproductive age and significantly impacts their quality of life. Diagnosis often takes several years due to the invasive nature of the gold standard diagnostic method, laparoscopy. Two studies were conducted to develop a diagnostic test combining serum biomarkers and clinical variables, resulting in a specific and accurate test for early disease identification.
Article
Obstetrics & Gynecology
Alessandra Chine, Marco Reschini, Gianfranco Fornelli, Ludovica Basili, Andrea Busnelli, Paola Vigano, Ludovico Muzii, Edgardo Somigliana
Summary: Low ovarian reserve, indicated by anti-Mullerian hormone (AMH) or antral follicle count (AFC), does not increase the risk of miscarriage in young women conceiving with ART.
HUMAN REPRODUCTION OPEN
(2023)
Article
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Paola Vigano, Giorgia Di Stefano, Camilla Erminia Maria Merli, Edgardo Somigliana
Summary: Repetitive ovulation and menstruation provided an advantage in the Palaeolithic era, but societal changes have created a mismatch between genetic adaptation and environment, leading to an increased risk of estrogen-related diseases.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Paola Vigano, Deborah Ambruoso, Giulia Emily Cetera, Edgardo Somigliana
Summary: According to epidemiological data, the incidence of endometriosis increases rapidly around the age of 25. The delay in diagnosis is usually between 5 and 8 years in adult women and over 10 years in adolescents. Ovulation and menstruation, which are inflammatory events, may contribute to the early development of endometriosis and adenomyosis. Therefore, secondary prevention targeting severely symptomatic adolescents is crucial for reducing suffering, limiting lesion progression, and preserving future reproductive potential.
HUMAN REPRODUCTION
(2023)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)