Article
Physiology
Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen, Jingjing Zhang
Summary: This study found that loss of membranous Claudin-5 led to hypoxia-induced autophagy in cerebrovascular endothelial cells, partially attenuating endothelial cell apoptosis. Mechanism studies showed that membranous Claudin-5 affected the stimulation of HIF-1a and iNOS under hypoxic conditions, leading to suppressed endothelial autophagy. Loss of Claudin-5 also influenced the generation of ROS and expression of Bnip3, contributing to the inhibition of endothelial autophagy under hypoxia.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Margaret C. Neville, Patricia G. Webb, Heidi K. Baumgartner, Benjamin G. Bitler
Summary: In this study, the localization of Claudin-4 protein in ovarian tumor cells was investigated. It was found that Claudin-4 is mainly localized in the perinuclear region, plasma membranes, and cytoplasmic puncta, but does not form tight junctions. Additionally, Claudin-4 is mainly localized to the Golgi compartment and is associated with Golgi markers GM130 and plasma membrane receptor Notch2 in dividing cells.
Review
Cell Biology
Tamsin Wesley, Stuart Berzins, George Kannourakis, Nuzhat Ahmed
Summary: The plakin family of cytoskeletal proteins, particularly plectin, periplakin, and envoplakin, play crucial roles in disease-states and cancers, with a focus on ovarian cancer. They are involved in regulating cancer cell growth, survival, migration, invasion, and drug resistance, potentially impacting progression, chemoresistance, and recurrence. Abnormal expression of plakins may lead to the transition of benign ovarian tumors to carcinomas and contribute to the sustenance and progression of the disease.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Diana Luisa Almeida-Nunes, Ana Mendes-Frias, Ricardo Silvestre, Ricardo Jorge Dinis-Oliveira, Sara Ricardo
Summary: Ovarian cancer spreads via transcoelomic metastasis, with malignant ascites playing a crucial role in tumor cell dissemination. The microenvironment of malignant ascites affects tumor behavior, including proliferation, progression, chemoresistance, and immune evasion. Tumor cells induce immune suppression, leading to disease progression and treatment failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Wei-Ting Kuo, Matthew A. Odenwald, Jerrold R. Turner, Li Zuo
Summary: Epithelial cells are the first line of defense in mucosal defense. The tight junction, formed by interactions between claudins, zonula occludens, and tight junction-associated MARVEL protein (TAMP) families, plays a key role in sealing the paracellular space and preventing leakage. In addition to their canonical functions in barrier formation, ZO-1 and occludin also have essential noncanonical functions, including regulating apoptosis and proliferation, facilitating viral entry, and organizing specialized epithelial structures.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Clinical Neurology
Ayse Usta, Faruk Kilic, Arif Demirdas, Umit Isik, Duygu Kumbul Doguc, Mustafa Bozkurt
Summary: The research aimed to assess serum zonulin and claudin-5 levels in schizophrenia patients, finding that zonulin was increased and claudin-5 was decreased compared to healthy controls. This suggests a potential link between the dysregulation of intestinal permeability and blood-brain barrier and the etiology of schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Muhammad Adeel, Salvatore Parisi, Matteo Mauceri, Kanwal Asif, Michele Bartoletti, Fabio Puglisi, Isabella Caligiuri, Md Mahbubur Rahman, Vincenzo Canzonieri, Flavio Rizzolio
Summary: High-grade serous ovarian cancer (HGSOC) is a major life-threatening cancer in women, with chemotherapy being the main therapeutic tool. However, the synthesized inorganic cobalt hydroxide nanosheets (Co(OH)(2) NS) show promising potency in killing ovarian cancer cells, potentially serving as an effective self-therapeutic drug.
Article
Cell Biology
Gerrit Hugendieck, Marcus Lettau, Svenja Andreas, Sabrina Neumann, Natalie Reinhardt, Philipp Arnold, Franziska Theilig, Lorenz Bastian, Christoph Rogmans, Jorg P. Weimer, Inken Floerkemeier, Daniela Wesch, Norbert Arnold, Nicolai Maass, Ottmar Janssen, Dirk Bauerschlag, Nina Hedemann
Summary: Ovarian cancer (OvCa) is a gynecological disorder with poor prognosis due to fast development of chemoresistance. This study reveals that cancer cell-derived extracellular vesicles (EV) play a role in sustaining chemoresistance through the release of active ADAM17 which promotes tumor cell proliferation and survival via the EGFR pathway.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Medicine, Research & Experimental
Ning Luo, Zubaidan Sulaiman, Chunyan Wang, Jinye Ding, Yingying Chen, Biting Liu, Zhongping Cheng, Shupeng Liu
Summary: The study identified circRNAs (hsa_circ_0000497 and hsa_circ_0000918) that promote metastasis of EOC via regulating epithelial-mesenchymal transition (EMT), suggesting their potential as therapeutic targets or prognostic biomarkers for EOC peritoneal metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Benjamin Steinhart, Kimberly R. Jordan, Jaidev Bapat, Miriam D. Post, Lindsay W. Brubaker, Benjamin G. Bitler, Julia Wrobel
Summary: The study analyzed the immune cell composition within ovarian cancer tumors and found a correlation between increased presence of B cells and CD4 T cells with overall survival, as well as a significant correlation between the proximity of tumor-associated macrophages and B cells or CD4 T cells with overall survival.
MOLECULAR CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pawel Uruski, Justyna Mikula-Pietrasik, Martyna Pakula, Sylwia Budkiewicz, Marcin Drzewiecki, Andrey N. Gaiday, Malgorzata Wierzowiecka, Eryk Naumowicz, Rafal Moszynski, Andrzej Tykarski, Krzysztof Ksiazek
Summary: This study found that malignant ascites (MAs) promoted the adhesion of cancer cells to peritoneal cells more efficiently than benign ascites (BAs), possibly through the modulation of various growth factors affecting the interaction between cancer cells and normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marzia Robotti, Francesca Scebba, Debora Angeloni
Summary: miRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level, and can be detected in cell and tissue extracts, as well as body fluids. The stability of circulating miRNAs in body fluids and their accessibility to sampling make them potential disease biomarkers with diagnostic and prognostic relevance. Saliva, as a representative body fluid, accurately reflects systemic pathophysiological conditions and holds promise as a diagnostic resource for low-cost screening procedures for systemic diseases, including cancer.
Article
Oncology
Mehri Monavarian, Amal Taher Elhaw, Priscilla W. Tang, Zaineb Javed, Zainab Shonibare, Carly Bess Scalise, Rebecca Arend, Mohit Kumar Jolly, Mary Kathryn Sewell-Loftin, Nadine Hempel, Karthikeyan Mythreye
Summary: The study focuses on the impact of non-cellular components in ovarian cancer ascites on metabolic pathways, particularly highlighting the roles of growth factors, chemokines, and cytokines in influencing metabolism through gene regulation. It emphasizes the need for further research to understand how these factors in malignant ascites contribute to disease heterogeneity and suggests potential unexplored roles and mechanisms in ovarian cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Esther Schoutrop, Lidia Moyano-Galceran, Stephanie Lheureux, Jonas Mattsson, Kaisa Lehti, Hanna Dahlstrand, Isabelle Magalhaes
Summary: This article summarizes the current knowledge on the development and metastatic progression of ovarian cancer, with a specific focus on the characteristics and functions of the immunosuppressive tumor microenvironment. Additionally, current and future treatment modalities are discussed, and an overview of different experimental models used for developing novel therapies is provided.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Marcin Wroblewski, Karolina Szewczyk-Golec, Iga Holynska-Iwan, Joanna Wroblewska, Alina Wozniak
Summary: Ovarian cancer is a prevalent malignancy among women worldwide, with metastasis and accumulation of ascites in the peritoneal cavity influencing carcinogenesis. Adipokines, such as adiponectin, play a role in both tumor growth and metastasis.
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)
