Article
Parasitology
Hiroka Tsutsumi, Moeko Abe, Naohiro Uchida, Mitsuyoshi Takiguchi, Masahiro Yamasaki
Summary: This study investigated the role of heat shock protein 90 (HSP90) in the proliferation and survival of Babesia gibsoni in vitro. It was found that an anti-BgHSP90 antibody did not directly inhibit the entry of the parasite into erythrocytes. Two HSP90 inhibitors, geldanamycin (GA) and tanespimycin (17AAG), were shown to decrease DNA synthesis and the number of infected erythrocytes, indicating the important roles of BgHSP90 in the proliferation of the parasite. GA was found to suppress the superoxide generation in canine neutrophils.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Oncology
Lan Yin, Yuhan Yang, Wanglong Zhu, Yu Xian, Zhengyu Han, Houyi Huang, Liaotian Peng, Kun Zhang, Ye Zhao
Summary: The study revealed that overexpression of Hsp90 in multi-drug resistant ovarian cancer cells can be reduced to increase sensitivity to paclitaxel and cisplatin, decrease drug-induced apoptosis, and regulate the expressions of multidrug resistance proteins. Further, Hsp90 affects beta-catenin accumulation and transcriptional activity, contributing to multi-drug resistance through AKT/GSK3 beta signaling.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Article
Oncology
Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk
Summary: Summary Hyperthermia can improve the effects of radio- and chemotherapy, but its efficacy is limited by the heat stress response (HSR). In this study, we evaluated the HSP90 inhibitor ganetespib in promoting the effects of radiotherapy or cisplatin combined with hyperthermia. Our results showed that ganetespib could enhance the efficacy of hyperthermia when combined with radiation.
Article
Biochemistry & Molecular Biology
Joel Selkrig, Megan Stanifer, Andre Mateus, Karin Mitosch, Inigo Barrio-Hernandez, Mandy Rettel, Heeyoung Kim, Carlos G. P. Voogdt, Philipp Walch, Carmon Kee, Nils Kurzawa, Frank Stein, Clement Potel, Anna Jarzab, Bernhard Kuster, Ralf Bartenschlager, Steeve Boulant, Pedro Beltrao, Athanasios Typas, Mikhail M. Savitski
Summary: Understanding how SARS-CoV-2 manipulates host cellular machinery on a system-wide scale is crucial for developing host-directed therapies. In this study, temporal alterations in host protein thermostability during infection were observed, converging on cellular processes such as cell cycle regulation. Pharmacological inhibition of host proteins with altered thermal stability or abundance could suppress SARS-CoV-2 replication.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li-rong Yan, Shi-xuan Shen, Ang Wang, Han-xi Ding, Ying-nan Liu, Yuan Yuan, Qian Xu
Summary: The study showed differential expression of heat shock proteins (HSPs) in various cancers, with HSP expression levels generally associated with prognosis in multiple cancer types. While HSP gene mutations were generally linked to poor prognosis in cancers, copy number variations of HSPs had varying impacts on survival status in different cancers. HSPs were found to be involved in the activation and inhibition of multiple cancer-related pathways and closely correlated with immune cell infiltrations in different cancer types.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xin Xie, Nan Zhang, Xiang Li, He Huang, Cheng Peng, Wei Huang, Leonard J. Foster, Gu He, Bo Han
Summary: Hsp90 is a crucial molecular chaperone that plays a critical role in biological pathways and cellular operations. It is closely linked to cancer and has been studied as a potential drug target. Combining Hsp90 inhibitors with other tumor inhibitors has shown synergistic antitumor effects, making the development of Hsp90 dual-target inhibitors a promising strategy in cancer treatment.
BIOORGANIC CHEMISTRY
(2023)
Review
Cell Biology
Xiude Ren, Tao Li, Wei Zhang, Xuejun Yang
Summary: Heat-shock protein 90 (HSP90) is an important molecule chaperone associated with tumorigenesis and malignancy. It plays a role in the malignant behaviors of cancer cells, but currently there are no effective single-agent treatments. Combining HSP90 inhibitors with other anticancer therapies may be a better strategy.
Article
Biochemistry & Molecular Biology
Wene Wei, Jiahui Zhou, Lipeng Chen, Haizhou Liu, Fuyong Zhang, Jilin Li, Shufang Ning, Shirong Li, Chen Wang, Yi Huang, Chang Zou, Litu Zhang
Summary: The study showed that plasma Hsp90 alpha levels were significantly higher in colorectal cancer patients and were associated with disease progression, certain tumor biomarkers, and immune cells. However, plasma Hsp90 alpha failed to demonstrate a prognostic value in progression-free survival for colorectal cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Shuangshuang Mei, Xing Chen, Kai Wang, Yuxin Chen
Summary: Ovarian cancer is a common gynecological malignancy with high morbidity and mortality. Peritoneal metastasis is common in ovarian cancer, involving large amounts of ascites. The mechanism behind this is still unclear.
CANCER CELL INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Tao Qin, Ke Chen, Jie Li, Weikun Qian, Ying Xiao, Erxi Wu, Jiguang Ma, Zheling Chen, Zheng Wang, Qingyong Ma, Zheng Wu
Summary: This study reveals that HSF1 promotes chemoresistance to gemcitabine in pancreatic cancer by modulating CSC-like properties. Inhibition of HSF1 could be a promising strategy to improve treatment outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Sarah Brunty, Lauren Clower, Brenda Mitchell, Taylor Fleshman, Nadim Bou Zgheib, Nalini Santanam
Summary: Ovarian cancer ranks as the 4th leading cause of cancer death in women, with a significant proportion of cases linked to endometriosis. Studies suggest that peritoneal fluid from women with endometriosis can induce transformative changes in ovarian cells, promoting the progression from endometriosis to ovarian cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Richard T. Penson, Allison J. Ambrosio, Christin A. Whalen, Carolyn N. Krasner, Panagiotis A. Konstantinopoulos, Charles Bradley, Ursula A. Matulonis, Michael J. Birrer
Summary: This article evaluates the potential efficacy of iniparib in combination with gemcitabine and carboplatin in platinum-sensitive ovarian cancer. The results show that the overall response rate was 66% in platinum-sensitive disease and 26% in platinum-resistant disease. Notably, 93% of the patients experienced clinical benefit, with 41.2% achieving CA125 response without tumor shrinkage.
Review
Immunology
Xuanrong Fu, Qimeng Wang, Hang Du, Huifang Hao
Summary: CXCL8 is a chemokine that is predominantly produced by tumor cells, endothelial cells, and lymphocytes in an autocrine or paracrine manner. Upon binding with CXCR1/2, it activates various signaling pathways, including PI3K-Akt, PLC, JAK-STAT, and others, playing important roles in normal tissues and tumors. Peritoneal metastasis is highly prevalent in ovarian and gastric cancer, resulting in poor prognosis, low 5-year survival rate, and mortality. Studies have shown excessive secretion of CXCL8 in various cancers. Therefore, this paper aims to further elucidate the mechanism of CXCL8 and peritoneal metastasis in ovarian and gastric cancer, providing a theoretical basis for the development of new approaches for the prevention, diagnosis, and treatment of cancer peritoneal metastasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Keith W. Pratz, Michelle A. Rudek, Ivana Gojo, Mark R. Litzow, Michael A. McDevitt, Jiuping Ji, Larry M. Karnitz, James G. Herman, Robert J. Kinders, B. Douglas Smith, Steven D. Gore, Hetty E. Carraway, Margaret M. Showel, Douglas E. Gladstone, Mark J. Levis, Hua-Ling Tsai, Gary Rosner, Alice Chen, Scott H. Kaufmann, Judith E. Karp
CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
Ivana Gojo, Jan H. Beumer, Keith W. Pratz, Michael A. McDevitt, Maria R. Baer, Amanda L. Blackford, B. Douglas Smith, Steven D. Gore, Hetty E. Carraway, Margaret M. Showel, Mark J. Levis, Amy E. Dezern, Douglas E. Gladstone, Jiuping Jay Ji, Lihua Wang, Robert J. Kinders, Marie Pouquet, Ismail Ali-Walbi, Michelle A. Rudek, Weijie Poh, James G. Herman, Larry M. Karnitz, Scott H. Kaufmann, Alice Chen, Judith E. Karp
CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
H. Ding, K. L. Peterson, C. Correia, B. Koh, P. A. Schneider, G. S. Nowakowski, S. H. Kaufmann
Article
Oncology
Gerardo Colon-Otero, S. John Weroha, Nathan R. Foster, Paul Haluska, Xiaonan Hou, Andrea E. Wahner-Hendrickson, Aminah Jatoi, Matthew S. Block, Tri A. Dinh, Matthew W. Robertson, John A. Copland
GYNECOLOGIC ONCOLOGY
(2017)
Article
Oncology
Elizabeth M. Swisher, Kevin K. Lin, Amit M. Oza, Clare L. Scott, Heidi Giordano, James Sun, Gottfried E. Konecny, Robert L. Coleman, Anna V. Tinker, David M. O'Malley, Rebecca S. Kristeleit, Ling Ma, Katherine M. Bell-McGuinn, James D. Brenton, Janiel M. Cragun, Ana Oaknin, Isabelle Ray-Coquard, Maria I. Harrell, Elaina Mann, Scott H. Kaufmann, Anne Floquet, Alexandra Leary, Thomas C. Harding, Sandra Goble, Lara Maloney, Jeff Isaacson, Andrew R. Allen, Lindsey Rolfe, Roman Yelensky, Mitch Raponi, Iain A. McNeish
Article
Oncology
Madalene A. Earp, Rama Raghavan, Qian Li, Junqiang Dai, Stacey J. Winham, Julie M. Cunningham, Yanina Natanzon, Kimberly R. Kalli, Xiaonan Hou, S. John Weroha, Paul Haluska, Kate Lawrenson, Simon A. Gayther, Chen Wang, Ellen L. Goode, Brooke L. Fridley
Article
Oncology
Cheyne Kurokawa, Ianko D. Iankov, S. Keith Anderson, Ileana Aderca, Alexey A. Leontovich, Matthew J. Maurer, Ann L. Oberg, Mark A. Schroeder, Caterina Giannini, Suzanne M. Greiner, Marc A. Becker, E. Aubrey Thompson, Paul Haluska, Mark E. Jentoft, Ian F. Parney, S. John Weroha, Jin Jen, Jann N. Sarkaria, Evanthia Galanis
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2018)
Article
Oncology
Cheyne Kurokawa, Ianko D. Iankov, S. Keith Anderson, Ileana Aderca, Alexey A. Leontovich, Matthew J. Maurer, Ann L. Oberg, Mark A. Schroeder, Caterina Giannini, Suzanne M. Greiner, Marc A. Becker, E. Aubrey Thompson, Paul Haluska, Mark E. Jentoft, Ian F. Parney, S. John Weroha, Jin Jen, Jann N. Sarkaria, Evanthia Galanis
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2018)
Article
Multidisciplinary Sciences
Yuanhang Liu, Pritha Chanana, Jaime I. Davila, Xiaonan Hou, Valentina Zanfagnin, Cordelia D. McGehee, Ellen L. Goode, Eric C. Polley, Paul Haluska, S. John Weroha, Chen Wang
SCIENTIFIC REPORTS
(2019)
Article
Gastroenterology & Hepatology
Angela L. McCleary-Wheeler, Ryan M. Carr, Shanique R. Palmer, Thomas C. Smyrk, Jacob B. Allred, Luciana L. Almada, Ezequiel J. Tolosa, Maria J. Lamberti, David L. Marks, Mitesh J. Borad, Julian R. Molina, Yingwei Qi, Wilma L. Lingle, Axel Grothey, Henry C. Pitot, Aminah Jatoi, Donald W. Northfelt, Alan H. Bryce, Robert R. McWilliams, Scott H. Okuno, Paul Haluska, George P. Kim, Gerardo Colon-Otero, Val J. Lowe, Matthew R. Callstrom, Wen We Ma, Tanios Bekaii-Saab, Mien-Chie Hung, Charles Erlichman, Martin E. Fernandez-Zapico
Review
Genetics & Heredity
Taylor M. Weiskittel, Cristina Correia, Grace T. Yu, Choong Yong Ung, Scott H. Kaufmann, Daniel D. Billadeau, Hu Li
Summary: Machine learning plays a crucial role in bridging the analytical gaps in single-cell studies and works synergistically with single-cell data. System biology algorithms have integrated machine learning with biological components to provide system-level analyses of single-cell omics data, shedding light on complex biological mechanisms.
Review
Oncology
Clifford M. Csizmar, Antoine N. Saliba, Elizabeth M. Swisher, Scott H. Kaufmann
Summary: PARP inhibitors have potential roles in the treatment of myeloid diseases, especially in acute myeloid leukemia (AML) with specific genetic characteristics. They may enhance the efficacy of other agents in AML but long-term use is associated with an increased risk of myelodysplastic syndrome (MDS) and AML.
Article
Oncology
Andrea E. Wahner Hendrickson, Michael E. Menefee, Lynn C. Hartmann, Harry J. Long, Donald W. Northfelt, Joel M. Reid, Felix Boakye-Agyeman, Olumide Kayode, Karen S. Flatten, Maria I. Harrell, Elizabeth M. Swisher, Guy G. Poirer, Daniel Satele, Jake Allred, Janet L. Lensing, Alice Chen, Jiuping Ji, Yiping Zang, Charles Erlichman, Paul Haluska, Scott H. Kaufmann
CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Courtney L. Andersen, Matthew J. Sikora, Michelle M. Boisen, Tianzhou Ma, Alec Christie, George Tseng, Yongseok Park, Soumya Luthra, Uma Chandran, Paul Haluska, Gina M. Mantia-Smaldone, Kunle Odunsi, Karen McLean, Adrian V. Lee, Esther Elishaev, Robert P. Edwards, Steffi Oesterreich
CLINICAL CANCER RESEARCH
(2017)
Article
Medicine, Research & Experimental
Brittney S. Harrington, Yaowu He, Tashbib Khan, Simon Puttick, Paul J. Conroy, Thomas Kryza, Tahleesa Cuda, Kamil A. Sokolowski, Brian W. C. Tse, Katherine K. Robbins, Buddhika J. Arachchige, Samantha J. Stehbens, Pamela M. Pollock, Sarah Reed, S. John Weroha, Paul Haluska, Carlos Salomon, Rohan Lourie, Lewis C. Perrin, Ruby H. P. Law, James C. Whisstock, John D. Hooper