Article
Oncology
Myeong-Seon Kim, Seung Hun Baek, Joseph J. Noh, Jung In Shim, Jun Hyeok Kang, Soo Young Jeong, Chel Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Yoo-Young Lee
Summary: This study investigated the incidence of reactive thrombocytosis and its impact on survival in patients with advanced epithelial ovarian cancer (EOC) after maximal cytoreductive surgery. The results showed that thrombocytosis was observed in 34.8% of patients one week after surgery, and it had the most significant effects on overall survival when observed during adjuvant chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Minh Tung Phung, Penelope M. Webb, Anna DeFazio, Sian Fereday, Alice W. Lee, David D. L. Bowtell, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Beth Y. Karlan, Jenny Lester, Keitaro Matsuo, Francesmary Modugno, James D. Brenton, Toon Van Gorp, Paul D. P. Pharoah, Joellen M. Schildkraut, Karen McLean, Rafael Meza, Bhramar Mukherjee, Jean Richardson, Bronwyn Grout, Anne Chase, Cindy McKinnon Deurloo, Kathryn L. Terry, Gillian E. Hanley, Malcolm C. Pike, Andrew Berchuck, Susan J. Ramus, Celeste Leigh Pearce, Ovarian Canc Assoc Consortium
Summary: This study analyzed the association between 12 lifestyle and personal exposures and having residual disease after surgery in patients with high-grade serous ovarian cancer (HGSC). The use of menopausal estrogen-only therapy (ET) was associated with a lower likelihood of having macroscopic residual disease, while parous women who did not breastfeed also had a lower likelihood of residual disease. These factors could potentially be included in risk stratification models for HGSC patients.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
David Pierce Mysona, Sharad Ghamande, Jin-Xiong She, Lynn Tran, Paul Tran, Bunja J. Rungruang, John K. Chan, Victoria Bae-Jump, Paola A. Gehrig
Summary: This study found that IDS was associated with lower overall survival, and a CGR at PDS had prolonged median OS compared to a CGR at IDS. Continued efforts should be made to improve cytoreductive outcomes in women with advanced ovarian and peritoneal malignancies.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Gatske M. M. Nieuwenhuyzen-de Boer, Hanane Aamran, Caroline B. B. van den Berg, Sten Willemsen, Jurgen M. J. Piek, Nathalie Reesink-Peters, Marianne Maliepaard, Helena C. van Doorn, Suzanne Polinder, Heleen J. van Beekhuizen
Summary: This study aimed to determine whether the use of the PlasmaJet Surgical device during surgery has an effect on the quality-of-life of patients with advanced ovarian cancer. The results showed that using the PlasmaJet device during surgery leads to a higher quality-of-life compared to surgery with electrocoagulation alone. The differences in quality-of-life mainly relate to physical and role functioning, fatigue, and pain.
Correction
Medicine, General & Internal
Philipp Harter, Jalid Sehouli, Ignace Vergote, Gwenael Ferron, Alexander Reuss, Werner Meier, Stefano Greggi, Berit J. Mosgard, Frederic Selle, Frederic Guyon, Christophe Pomel, Fabrice Lecuru, Rongyu Zang, Elisabeth Avall-Lundqvist, Jae-Weon Kim, Jordi Ponce, Francesco Raspagliesi, Gunnar Kristensen, Jean-Marc Classe, Peter Hillemanns, Pernille Jensen, Annette Hasenburg, Sadaf Ghaem-Maghami, Mansoor R. Mirza, Bente Lund, Alexander Reinthaller, Ana Santaballa, Adeola Olaitan, Felix Hilpert, Andreas du Bois
Summary: In patients with recurrent ovarian cancer, cytoreductive surgery followed by chemotherapy resulted in longer overall survival than chemotherapy alone. Patients with a complete resection had the most favorable outcome.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Sabrina Piedimonte, Lauren Erdman, Delvin So, Marcus Q. Bernardini, Sarah E. Ferguson, Stephane Laframboise, Genevieve Bouchard Fortier, Paulina Cybulska, Taymaa May, Liat Hogen
Summary: This study developed a machine learning algorithm to predict the outcome of primary cytoreductive surgery in patients with advanced ovarian cancer. The algorithm demonstrated high accuracy in predicting optimal cytoreduction and may assist in decision-making.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Alexander Melamed, Eric L. Eisenhauer
Summary: With the increasing use of neoadjuvant chemotherapy, it is apparent that some patients may benefit from less extensive interval cytoreductive surgery performed using minimally invasive techniques. Surgeons in various countries, including the United States, have started adopting these techniques based on their expertise in minimally invasive surgery for other indications in gynecologic oncology. Further research will determine the most suitable patients for this approach.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Joo-Hyuk Son, Jimin Lee, Sun-Hyung Yum, Jeeyeon Kim, Tae-Wook Kong, Suk-Joon Chang, Hee-Sug Ryu
Summary: This study evaluated the clinical characteristics of 262 patients with recurrent ovarian cancer to identify factors associated with the selection of patients who would benefit from secondary cytoreductive surgery (SCS). The study found that patients who received SCS had significantly longer median survival compared to those who received chemotherapy alone. Limited regional recurrence emerged as a simplified factor for predicting no residual disease after SCS.
Review
Oncology
Eelco de Bree, Dimosthenis Michelakis, Elisavet Anagnostopoulou
Summary: Ovarian cancer is the second most common and fatal gynecological malignancy worldwide, with most patients presenting in advanced stages. Cytoreductive surgery in combination with platinum-based chemotherapy is the standard treatment. Despite advancements, recurrence and death from the disease are still common. The role of secondary cytoreductive surgery in recurrent ovarian cancer is controversial and should be continuously reviewed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
N. M. S. Baldewpersad Tewarie, W. J. van Driel, M. van Ham, M. W. Wouters, R. Kruitwagen
Summary: The study found that patients undergoing primary debulking surgery had a higher rate of complete cytoreduction but also a higher rate of complications requiring re-intervention, resulting in a longer time to start adjuvant chemotherapy. It is important to balance the aggressiveness of surgery with the outcomes of severe complications to improve the quality of surgical outcomes.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Anne-Sophie Navarro, Carlos Martinez Gomez, Martina Aida Angeles, Regis Fuzier, Jean Ruiz, Muriel Picard, Alejandra Martinez, Gwenael Ferron
Summary: This study aimed to evaluate the indications and management of grade III-IV postoperative complications in patients requiring vacuum-assisted open abdomen after debulking surgery for ovarian carcinomatosis. The results showed that 2% of patients required further management after laparotomy, and the indications included gastrointestinal perforation, necrotic enterocolitis, intestinal ischemia, anastomotic leakages, and intra-abdominal hemorrhages. The use of vacuum-assisted wound closure proved to be effective in reducing the risk of postoperative mortality.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Min-Hyun Baek, Eun Young Park, Hyeong In Ha, Sang-Yoon Park, Myong Cheol Lim, Christina Fotopoulou, Robert E. Bristow
Summary: This study focused on evaluating the survival impact of secondary cytoreductive surgery in patients with platinum-sensitive recurrent ovarian cancer. The findings indicated that complete cytoreductions were associated with better survival outcomes and that maximal tumor resection significantly increased overall survival in this patient population.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Sudha Sundar, Carole Cummins, Satyam Kumar, Joanna Long, Vivek Arora, Janos Balega, Tim Broadhead, Tim Duncan, Richard Edmondson, Christina Fotopoulou, Ros Glasspool, Desiree Kolomainen, Simon Leeson, Ranjit Manchanda, Orla McNally, Jo Morrison, Asima Mukhopadhyay, Jim Paul, John Tidy, Nick Wood
Summary: This study aimed to investigate the quality of life (QoL) after surgical resection for advanced ovarian cancer and explore the association with surgical complexity and disease burden. The results showed that increasing surgical complexity did not lead to a decline in QoL. For patients with advanced ovarian cancer, higher surgical complexity was associated with greater improvement in postoperative QoL.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
P. Harter, J. Sehouli, I Vergote, G. Ferron, A. Reuss, W. Meier, S. Greggi, B. J. Mosgard, F. Selle, F. Guyon, C. Pomel, F. Lecuru, R. Zang, E. Avail-Lundqvist, J-W Kim, J. Ponce, F. Raspagliesi, G. Kristensen, J-M Classe, P. Hillemanns, P. Jensen, A. Hasenburg, S. Ghaem-Maghami, M. R. Mirza, B. Lund, A. Reinthaller, A. Santaballa, A. Olaitan, F. Hilpert, A. du Bois
Summary: The study demonstrates that in patients with recurrent ovarian cancer, secondary cytoreductive surgery followed by chemotherapy results in longer overall survival compared to chemotherapy alone. Quality of life measures did not differ significantly between the two treatment groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Daniel Huddart, Savithri Rajkumar, Desiree Kolomainen, Gautam Mehra, Rahul Nath, Ahmad Sayasneh
Summary: Cytoreductive surgery for advanced ovarian cancer commonly involves bowel resection. However, the degree to which UK gynaecological oncologists independently perform bowel surgery varies nationally. A survey of British Gynaecological Cancer Society members found that colorectal/general surgical teams are more commonly involved in large bowel procedures and left colon procedures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
C. Biele, L. Kaufner, A. Schwickert, A. Nonnenmacher, K. von Weizsacker, M. Z. Muallem, W. Henrich, T. Braun
Summary: Routine monitoring of coagulation parameters and signs of infection is recommended during conservative management of abnormally invasive placenta. Postpartum tranexamic acid oral dosage should be considered when fibrinogen levels are decreasing and D-dimers are increasing.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Oncology
Mustafa Zelal Muallem, Andrea Miranda, Jumana Muallem
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Letter
Obstetrics & Gynecology
C. Biele, L. Kaufner, A. Nonnenmacher, K. von Weizsaecker, M. Z. Muallem, W. Henrich, Thorsten Braun
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Cell Biology
Devivasha Bordoloi, Ganesan Padmavathi, Kishore Banik, Khwairakpam Amrita Devi, Choudhary Harsha, Sosmitha Girisa, Constanze Buhrmann, Mehdi Shakibaei, Ajaikumar B. Kunnumakkara
Summary: Lung cancer is a prevalent neoplasm globally, with factors such as tobacco smoking and exposure to carcinogens playing a significant role in its development. The protein TIPE1 shows promise as an important biomarker in lung cancer pathogenesis, with potential therapeutic implications.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Obstetrics & Gynecology
Kemal Gungorduk, Jumana Muallem, Osman Asicioglu, Varol Gulseren, Umran Kucukgoz Gulec, Mehmet Mutlu Meydanli, Jalid Sehouli, Aykut Ozdemir, Hanifi Sahin, Ghanim Khatib, Andrea Miranda, Nurettin Boran, Taylan Senol, Nuri Yildirim, Taner Turan, Tufan Oge, Salih Taskin, Mehmet Ali Vardar, Ali Ayhan, Mustafa Zelal Muallem
Summary: In patients with G3-EEC, inadequate lymphadenectomy and lymphovascular space invasion are independent prognostic factors. Adequate lymphadenectomy and optimal surgery are independent prognostic factors for better outcomes. Further research is needed for patients with advanced stage cancer.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Biochemistry & Molecular Biology
Constanze Buhrmann, Aranka Brockmueller, Anna-Lena Mueller, Parviz Shayan, Mehdi Shakibaei
Summary: Curcumin has shown potential in modulating the pathophysiology of osteoarthritis by inhibiting inflammation through NF-kB-Sox9 coupling, thereby contributing to the maintenance of homeostasis in OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Mustafa Zelal Muallem
Summary: The current classifications of radical hysterectomy are limited by focusing only on lateral resection extension, while the new proposed three-dimensional classification takes into account tumor size, stage, localization, and infiltration in the vaginal vault for more precise surgical planning and customization.
Article
Oncology
Mustafa Zelal Muallem, Sara Nasser, Andrea Miranda
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Elena Ioana Braicu, Andreas du Bois, Jalid Sehouli, Julia Beck, Sonia Prader, Hagen Kulbe, Bernd Eiben, Philipp Harter, Alexander Traut, Klaus Pietzner, Ralf Glaubitz, Beyhan Ataseven, Radoslav Chekerov, Christoph Keck, Thomas Winkler, Sebastian Heikaus, Peggy Gellendin, Ekkehard Schuetz, Florian Heitz
Summary: This study demonstrates the use of low-coverage cell-free tumor DNA sequencing to detect chromosomal instability (CI) in ovarian cancer patients. The CI can serve as a reliable marker for ovarian cancer detection and is associated with prognostic and predictive clinical measures. The findings suggest that ctDNA analysis based on the CNI-Score can be an important tool for diagnostics and therapy monitoring in high-grade epithelial ovarian cancer.
Article
Oncology
Judith Altmann, Radoslav Chekerov, Christina Fotopoulou, Mustafa-Zelal Muallem, Andreas du Bois, William Cliby, Sean Dowdy, Karl Podratz, Werner Lichtenegger, Omar Camara, Ralf Tunn, David Cibula, Sherko Kuemmel, Giovanni Scambia, Ignace Vergote, Vito Chiantera, Klaus Pietzner, Melisa Guelhan Inci, Sascha Chopra, Matthias Biebl, Joerg Neymeyer, Jens-Uwe Blohmer, Jalid Sehouli
Summary: This study analyzed the peri-operative risks in patients who underwent live surgeries during the Charite-MAYO Conferences. The results showed that live surgeries performed within a multidisciplinary setting are safe, with no increase in surgical morbidity and mortality, and without compromising patients' outcomes.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Mustafa Zelal Muallem, Jalid Sehouli, Andrea Miranda, Helmut Plett, Ahmad Sayasneh, Yasser Diab, Jumana Muallem, Imad Hatoum
Summary: In the management of advanced vulval cancer, there is a dilemma between primary closure and reconstructive surgery. This study compared the preoperative parameters and postoperative results between these two approaches. The findings suggest that reconstructive surgery may lead to better treatment outcomes by improving complete resection rates, anatomical restoration, and wound healing, consequently reducing recurrence rates.
Article
Oncology
Eva Roser, Philipp Harter, Dario Zocholl, Dominik Denschlag, Radoslav Chekerov, Pauline Wimberger, Christian Kurzeder, Annette Hasenburg, Mustafa-Zelal Muallem, Alexander Mustea, Guenter Emons, A. G. Zeimet, Felix Beck, Tjadina Arndt, Sara Y. Brucker, Stefan Kommoss, Florian Heitz, Julia Welz, Eva-Katharina Egger, Matthias Kalder, Paul Buderath, Maximilian Klar, Christian Marth, Uwe Andreas Ulrich, Michael Weigel, Lea Traub, Christoph Anthuber, Hans Strauss, Lars Hanker, Theresa Link, Karol Kubiak, Badrig Melekian, Daniela Hornung, Martin Poelcher, Bjoern Lampe, Thomas Krauss, Ulrich Keilholz, Anne Floercken, Klaus Pietzner, Jalid Sehouli
Summary: This study aimed to describe the treatment strategies used in patients with gynecological sarcomas. The results showed heterogeneous treatment methods, and further research is needed to implement new treatment strategies.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Florian Heitz, Beyhan Ataseven, Claudia Staniczok, Carsten Denkert, Kerstin Rhiem, Eric Hahnen, Sebastian Heikaus, Malak Moubarak, Julia Welz, Timoleon Dagres, Vasilios Vrentas, Mareike Bommert, Stephanie Schneider, Nicole Concin, Philipp Harter
Summary: Testing for HRD is crucial for recommending appropriate therapy in primary high-grade ovarian cancer patients. While patients with a BRCA mutation are defined as HRD deficient, approximately 20% of patients without BRCA mutation can still have HRD deficiency based on tumor genomic analysis. This study highlights the importance of obtaining sufficient tumor tissue and conducting additional BRCA germline testing to improve the accuracy of HRD testing and inform treatment decisions.
Article
Oncology
Majdi Imterat, Philipp Harter, Kerstin Rhiem, Florian Heitz, Stephanie Schneider, Nicole Concin, Malak Moubarak, Julia Welz, Vasileios Vrentas, Alexander Traut, Eric Hahnen, Rita Schmutzler, Andreas du Bois, Beyhan Ataseven
Summary: Limited data is available on deleterious variants in genes other than BRCA1/2. A retrospective cohort study investigated the impact of germline mutations on ovarian cancer prognosis. The study found that germline mutations, including BRCA1/2 and other genes, were detected in a quarter of ovarian cancer patients and were associated with significantly better outcomes in terms of overall survival and progression-free survival.
Article
Oncology
Jacek P. Grabowski, Joanna Glajzer, Rolf Richter, Helmut Plett, Mustafa-Zelal Muallem, Elena Ioana Braicu, Eliane Taube, Jalid Sehouli
Summary: This study found an association between lymphovascular space invasion, Ki67 expression, and risk of lymph node metastasis in primary low grade ovarian cancer. Further prospective trials are needed to evaluate lymphovascular space invasion and Ki-67 as predictors of lymph node metastasis.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)
