Article
Biotechnology & Applied Microbiology
Jing Zhang, Xinyan Xu, Yongfeng Chen, Xiaoju Guan, Hong Zhu, Yuhong Qi
Summary: In this study, the regulatory effect of the CRM1-Survivin axis on the progression of ovarian cancer was explored. The results showed that CRM1 silencing inhibited the proliferation and colony formation of ovarian cancer cells and promoted cell apoptosis by promoting Caspase-3 activation. Survivin was positively regulated by CRM1 and promoted the development of ovarian cancer. This suggests that the CRM1-Survivin axis may serve as a potential therapeutic target for ovarian cancer.
Article
Biochemistry & Molecular Biology
Zied Boudhraa, Kossay Zaoui, Hubert Fleury, Maxime Cahuzac, Sophie Gilbert, Guergana Tchakarska, Jennifer Kendall-Dupont, Euridice Carmona, Diane Provencher, Anne-Marie Mes-Masson
Summary: The study demonstrates a new approach to target epithelial ovarian cancer survival by inhibiting Ran. There is an inverse correlation between Ran and NR1D1, playing a crucial role in aneuploid cells. Ran affects DNA repair pathways by destabilizing NR1D1 mRNA through miR4472 interference.
Article
Cell Biology
Xiaoling Hong, Ning Ma, Danjie Li, Mengwen Zhang, Wenqiuzi Dong, Jie Huang, Xinxin Ci, Songling Zhang
Summary: Dissemination of ovarian cancer cells can lead to poor prognosis. This study identified UBE2E2 as an upregulated protein in ovarian cancer and showed that it is associated with poor prognosis. UBE2E2 was found to promote ovarian cancer cell migration, epithelial-mesenchymal transition (EMT), and metastasis through the activation of the Nrf2-p62-Snail signaling pathway. The deletion of UBE2E2 reduced tumorigenicity and metastasis in mice models. These findings provide novel therapeutic targets for preventing ovarian cancer metastasis.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Emilia J. Orzechowska-Licari, Joseph F. LaComb, Aisharja Mojumdar, Agnieszka B. Bialkowska
Summary: Tumor development and progression rely on the reprogramming of signaling pathways that regulate cell metabolism, with transcription factors SP and KLF playing crucial roles in modulating these alterations and thus impacting tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Arun Pandian Chandrasekaran, Apoorvi Tyagi, Naresh Poondla, Neha Sarodaya, Janardhan Keshav Karapurkar, Kamini Kaushal, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim, Suresh Ramakrishna
Summary: This study demonstrates that USP19 plays a dual role in mitosis and tumorigenesis by regulating Survivin expression and protein stability. Depletion of USP19 leads to mitotic defects and inhibits tumor growth.
Review
Oncology
Philipp Wolf
Summary: Evasion from cell death is a characteristic of cancer, which is promoted by IAPs through suppressing the induction of cell death. Overexpression of IAPs in cancerous tissues contributes to therapeutic resistance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pathology
Xu Wang, Xiaolin Wei, Yu Cao, Peng Xing
Summary: Overexpression of ZNF33A in triple-negative breast cancer is associated with worse prognosis, promoting cell growth and resistance to BET inhibitors. ZNF33A also induces c-Myc, a key player in BET inhibitor resistance. Thus, inhibition of ZNF33A may enhance sensitivity of TNBC cells to BET inhibitors.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Hui Miao, Chang Liu, Hao Ouyang, Peiwen Zhang, Yuping Liu, Chen Zhang, Changping Deng, Yunhui Fu, Jinping Niu, Wenyun Zheng, Fang You, Yi Yang, Xingyuan Ma
Summary: In this study, a novel nanoantibody-based molecular toolkit, called the ubiquitin-proteasome system (Nb4A-Fc-T2A-TRIM21), was created to selectively degrade cytoplasmic and nuclear survivin protein and investigate its subcellular functions. The results revealed that cytoplasmic survivin primarily acts as an anti-apoptotic factor by inhibiting caspase pathway, while nuclear survivin promotes cell proliferation and participates in cell cycle regulation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weizhen Liu, Dongfang Li, Ting Lu, Haosheng Zhang, Zhengxin Chen, Qinli Ruan, Zihui Zheng, Linlin Chen, Jun Guo
Summary: Aberrant expression of SRSF2 is associated with tumorigenesis in colorectal cancer, but its molecular mechanism is unclear. In this study, we found that SRSF2 is highly expressed in colorectal cancer samples and promotes cancer cell proliferation. RNA-seq analysis identified 33 alternative splicing events regulated by SRSF2, and knockdown of SLMAP-L or CETN3-S splice isoform inhibited colon cancer cell growth.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Valeria Lodde, Matteo Floris, Rachel Munk, Jennifer L. Martindale, Davide Piredda, Catello Mario Panu Napodano, Francesco Cucca, Sergio Uzzau, Kotb Abdelmohsen, Myriam Gorospe, Ji Heon Noh, M. Laura Idda
Summary: NF90, an RNA-binding protein, plays a critical role in RNA metabolism, particularly in viral infection and immune response. Studies have shown that NF90 can influence the expression of key genes such as IRF3 and IRF9, thereby modulating the interferon response to SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Etsuko Yamamoto Hattori, Tatsuya Masuda, Yohei Mineharu, Masamitsu Mikami, Yukinori Terada, Yasuzumi Matsui, Hirohito Kubota, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Tatsutoshi Nakahata, Shuji Ikeda, Susumu Miyamoto, Hiroshi Sugiyama, Yoshiki Arakawa, Yasuhiko Kamikubo
Summary: Interfering with RUNX family proteins can reduce the growth of glioblastoma in mice and identify pathways involved in tumor growth maintenance. Specifically, the study reveals that RUNX1, a transcription factor, downregulates p21 by enhancing the expressions of BIRC5 and PIF1, thus conferring anti-apoptotic properties on glioblastoma. Gene switch-off therapy targeting RUNX1 shows promising results by decreasing the expression levels of BIRC5 and PIF1, inducing apoptosis and cell cycle arrest. This pathway may serve as a therapeutic target for glioblastoma.
COMMUNICATIONS BIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Ge Wang, Xiu-Qi Fan, Lu Li, Yan Li, Bian Shi, Ke-Xin Xing, Qi-Long Gao
Summary: Toosendanin (TSN) extracted from Melia toosendan Sieb et Zucc has been demonstrated to possess antitumor activities on ovarian cancer cells, inhibiting cell proliferation, inducing apoptosis, reducing mitochondrial membrane potential, and suppressing invasion and migration. TSN's effects are associated with modulation of expression levels of key proteins related to the caspase-dependent mitochondrial apoptotic pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shijie Wei, Yubao Zhang, Xiaoran Ma, Yan Yao, Qinqin Zhou, Wenfeng Zhang, Chao Zhou, Jing Zhuang
Summary: This study reveals that matrine, an alkaloid from the medicinal plant Sophora flavescens, has strong anticancer effects and can be explored as a new therapeutic agent for triple-negative breast cancer (TNBC). Through bioinformatics analysis and network pharmacology, researchers found that matrine inhibits the PI3K/AKT pathway, suppresses cell proliferation and invasion, induces apoptosis and autophagy, effectively inhibiting the growth and spread of TNBC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Tyler K. Fenstermaker, Svetlana Petruk, Sina K. Kovermann, Hugh W. Brock, Alexander Mazo
Summary: During DNA replication, the transcriptional machinery is believed to dissociate from DNA. However, our study shows that immediately after replication, Pol II, together with other general transcription proteins and immature RNA, re-associates with active genes on both leading and lagging strands of nascent DNA, and rapidly resumes transcription. This suggests that epigenetic marks may not be required for the recruitment of Pol II to newly synthesized DNA during the transition from replication to transcription.
Article
Anatomy & Morphology
Shan Gong, Bo Bai, Guangyu Sun, Haihong Jin, Zhengmao Zhang
Summary: This study found that CDCA3 was up-regulated in ovarian cancer and knockdown of CDCA3 could inhibit proliferation and migration, enhance sensitivity to cisplatin, and induce apoptosis in ovarian cancer cells. In vivo experiments further confirmed the inhibitory effect of CDCA3 knockdown on tumor growth.
Article
Oncology
Sagar Shelake, Umesh T. Sankpal, W. Paul Bowman, Matthew Wise, Anish Ray, Riyaz Basha
INVESTIGATIONAL NEW DRUGS
(2017)
Review
Oncology
Myrna Hurtado, Umesh T. Sankpal, Amalendu Ranjan, Rajasekhar Maram, Jamboor K. Vishwanatha, Ganji Purnachandra Nagaraju, Bassel F. El-Rayes, Riyaz Basha
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2018)
Article
Oncology
Myrna Hurtado, Umesh T. Sankpal, Jaya Chhabra, Deondra T. Brown, Rajasekhar Maram, Rafid Patel, Raj K. Gurung, Jerry Simecka, Alvin A. Holder, Riyaz Basha
INVESTIGATIONAL NEW DRUGS
(2019)
Article
Biochemistry & Molecular Biology
Sagar Shelake, Umesh T. Sankpal, Don Eslin, W. Paul Bowman, Jerry W. Simecka, Sangram Raut, Anish Ray, Riyaz Basha
Article
Oncology
Kunal R. Elete, Karen H. Albritton, Lauren J. Akers, Riyaz Basha, Anish Ray
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Jamboor K. Vishwanatha, Riyaz Basha, Maya Nair, Harlan P. Jones
ETHNICITY & DISEASE
(2019)
Article
Public, Environmental & Occupational Health
Abdullah Mamun, Nana Y. Nsiah, Meenakshi Srinivasan, Ayyappa Chaturvedula, Riyaz Basha, Deanna Cross, Harlan P. Jones, Karabi Nandy, Jamboor K. Vishwanatha
ETHNICITY & DISEASE
(2019)
Article
Genetics & Heredity
Shruti Patil, Umesh T. Sankpal, Myrna Hurtado, W. Paul Bowman, Jeffrey Murray, Kathleen Borgmann, Anuja Ghorpade, Robert Sutphin, Don Eslin, Riyaz Basha
Review
Oncology
Ashwin Chandra, Cima Pius, Madiha Nabeel, Maya Nair, Tambour K. Vishwanatha, Sarfraz Ahmad, Riyaz Basha
Article
Biochemistry & Molecular Biology
Myrna Hurtado, Laszlo Prokai, Umesh T. Sankpal, Blair Levesque, Rajasekhar Maram, Jaya Chhabra, Deondra T. Brown, Raj K. Gurung, Alvin A. Holder, Jamboor K. Vishwanatha, Riyaz Basha
PROCESS BIOCHEMISTRY
(2020)
Article
Genetics & Heredity
Waqas Ahmad, Sarfraz Ahmad, Riyaz Basha
Summary: This study analyzed genome sequences in the Georgia State of the U.S., identifying common variants originating mainly from Southeast England, other parts of the U.S., and Western Europe.
Article
Cell Biology
Myrna Hurtado, Umesh T. Sankpal, Aboubacar Kaba, Shahela Mahammad, Jaya Chhabra, Deondra T. Brown, Raj K. Gurung, Alvin A. Holder, Jamboor K. Vishwanatha, Riyaz Basha
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Meeting Abstract
Oncology
Sagar Shelake, Umesh T. Sankpal, W. Paul Bowman, Matthew Wise, Anish Ray, Riyaz Basha
Meeting Abstract
Oncology
Umesh T. Sankpal, W. Paul Bowman, Jeffrey C. Murray, Riyaz Basha
Meeting Abstract
Oncology
Anish Ray, Bhavani Nagarajan, Umesh T. Sankpal, Sagar Shelake, W. Paul Bowman, Andras Lacko, Riyaz M. Basha
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)