Article
Biochemistry & Molecular Biology
Yu-Cheng Lee, Cheng-Han Lin, Wei-Lun Chang, Wen-Der Lin, Jhih-Kai Pan, Wei-Jan Wang, Bor-Chyuan Su, Hsien-Hui Chung, Chen-Hsun Tsai, Forn-Chia Lin, Wen-Ching Wang, Pei-Jung Lu
Summary: This study found that miR-200b and miR-200c can regulate the epithelial-mesenchymal transition in esophageal squamous cell carcinoma, thereby affecting the response of cells to concurrent chemoradiotherapy. These findings contribute to the development of new treatment strategies to improve the therapeutic efficacy for esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hyein Jo, Kyeonghee Shim, Dooil Jeoung
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that play significant roles in cell processes and cancer development. The miR-200 family acts as tumor suppressors and can be used as diagnostic and prognostic markers. Additionally, the miR-200 family is involved in regulating anti-cancer drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Zhenghua Fei, Yanfen Wang, Yuyang Gu, Rongrong Xie, Qiongyu Hao, Yiyan Jiang
Summary: This study identified an upregulated circular RNA, circKIF5B, in liver cancer cells and demonstrated its role in regulating the proliferation, invasion, and metastasis of liver cancer cells through modulation of the miR-192 family. These findings provide mechanistic evidence and suggest circKIF5B as a potential therapeutic target for liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiejie Cui, Mengjia Gong, Shuyu Fang, Chaoqun Hu, Yi Wang, Jingfang Zhang, Ni Tang, Yun He
Summary: All-trans retinoic acid (ATRA) can impact the proliferation, apoptosis, migration, and invasion abilities of hepal-6 hepatocarcinoma cell line by up-regulating specific miRNAs in the miR-200 family, as well as influencing the expression of related transcription factors, suggesting a potential role in suppressing epithelial-mesenchymal transition (EMT).
Review
Biochemistry & Molecular Biology
Vignesh Sundararajan, Ulrike C. Burk, Karolina Bajdak-Rusinek
Summary: The miR-200 family plays a significant role in cellular functions and pathological processes, impacting epithelial homeostasis, tumor suppression, neurodegenerative diseases, and tissue fibrosis. Moreover, miR-200 family members have potential as biomarkers for cancers, aiding in early cancer detection and intervention.
Article
Biochemistry & Molecular Biology
Chiara Fischer, Andrey Turchinovich, Manuel Feisst, Fabian Riedel, Kathrin Hassdenteufel, Philipp Scharli, Andreas D. Hartkopf, Sara Y. Brucker, Laura Michel, Barbara Burwinkel, Andreas Schneeweiss, Markus Wallwiener, Thomas M. Deutsch
Summary: The miR-200 family has shown promising prognostic and predictive potential as a biomarker in metastatic breast cancer (MBC). The expression levels of miR-200s were found to be associated with systemic treatment, circulating tumor cells (CTC) count, and survival outcomes. Higher miR-200 expression and positive CTC status were correlated with poorer overall survival (OS) and progression-free survival (PFS) in MBC patients, indicating their potential as biomarkers for optimizing clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Mason Sweat, Yan Sweat, Wenjie Yu, Dan Su, Riley J. Leonard, Steven L. Eliason, Brad A. Amendt
Summary: The miR-200 family plays a crucial role in regulating the fate and differentiation of epithelial stem cells in the murine lower incisor ectodermal organ. Inhibition of miR-200 family results in an expanded stem cell niche and lack of cell differentiation, highlighting the importance of miR-200 in controlling progenitor cell proliferation and differentiation in vivo.
Review
Biochemistry & Molecular Biology
Masoumeh Amirian, Amir Masoud Jafari-Nozad, Majid Darroudi, Tahereh Farkhondeh, Saeed Samarghandian
Summary: Accumulating evidence has shown the significant role of miR-29 in human malignancies, particularly breast cancer (BC). MiR-29 acts as a tumor suppressor by targeting multiple signaling pathways and transcripts, but it can also promote BC progression through gene and transcription factor targeting. The conflicting roles of miR-29 in BC may be attributed to its regulatory roles dependent on the environment and signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Genetics & Heredity
Shuying Chen, Zile Fu, Shuzhan Wen, Xiaoyi Yang, Chengxuan Yu, Wenhan Zhou, Yong Lin, Yuan Lv
Summary: miR-497 and miR-1246 may serve as biomarkers in HCC by regulating target genes involved in the progression of the disease. Their expression levels are significantly associated with prognosis and diagnosis of HCC.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Qianqian Chen, Yang Miao, Zhipeng Xu, Ruirui Zhang, Sheng Yi
Summary: Schwann cells play a crucial role in nerve regeneration and are commonly used in tissue engineering. Identifying Schwann cells with enhanced migration ability is important for improving recovery effects. This study compared Schwann cells from different anatomical locations and found that dorsal root ganglia (DRG) Schwann cells have faster migration speed than sciatic nerve (SN) Schwann cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Oncology
Jiancheng Lv, Zijian Zhou, Jingzi Wang, Xiao Yang, Hao Yu, Jie Han, Dexiang Feng, Baorui Yuan, Qikai Wu, Pengchao Li, Qiang Lu, Haiwei Yang
Summary: The study found that circFAM114A2 is downregulated in urothelial carcinoma, with higher expression associated with better survival in patients and histological grade. This circRNA inhibits cell proliferation and enhances cisplatin sensitivity by sponging miR-222-3p/miR-146a-5p to regulate P27/P21 expression. CircFAM114A2 shows potential as a prognostic biomarker and therapeutic target for urothelial carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medical Laboratory Technology
Yujia Fang, Dong Yan, Lixin Wang, Jie Zhang, Qingfang He
Summary: This study analyzed the differential expression of miRNAs between HCC patients and controls and found that miR-16 and miR-122 were significantly upregulated in early-stage HCC patients. Combining these miRNAs with AFP improved the diagnostic efficacy for HCC. Furthermore, miR-16 and miR-122 were found to regulate a number of potential target genes involved in cancer pathways.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Andrea Fontana, Raffaela Barbano, Elisa Dama, Barbara Pasculli, Michelina Rendina, Maria Grazia Morritti, Valentina Melocchi, Marina Castelvetere, Vanna Maria Valori, Sara Ravaioli, Sara Bravaccini, Luigi Ciuffreda, Paolo Graziano, Evaristo Maiello, Massimiliano Copetti, Vito Michele Fazio, Manel Esteller, Fabrizio Bianchi, Paola Parrella
Summary: The miR-200 family members show differential expression in breast cancer molecular subtypes, indicating their potential as biomarkers for breast cancer.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Liang Yu, Can Cao, Xu Li, Mili Zhang, Qisheng Gu, Hugh Gao, Jesse J. Balic, Duogang Xu, Lei Zhang, Le Ying, Dakang Xu, Yuqin Yang, Di Wu, Baokun He, Brendan J. Jenkins, Youdong Liu, Jikun Li
Summary: The miR-200 family plays a crucial role in maintaining the epithelial phenotype in gastric cancer, but its suppression in late-stage gastric tumors leads to EMT and affects prognosis.
Review
Pharmacology & Pharmacy
Meng-Nan Liu, Gang Luo, Wan-Jiao Gao, Si-Jin Yang, Hua Zhou
Summary: miR-29 plays a crucial role in cardiovascular disease (CVD), particularly in maintaining arterial integrity and regulating atherosclerosis. Studies have shown the potential of miR-29 as a potential marker for prevention, treatment, and prognostic observation in CVD.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)