期刊
GYNECOLOGIC ONCOLOGY
卷 113, 期 3, 页码 391-396出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2009.01.013
关键词
Serous carcinoma; Ovarian carcinoma; Intraepithelial neoplasia; p53
资金
- NCI [P50 CA105009, 1R21CA124688-01A1]
- Charlotte Geyer Foundation
- Columbia Hospital For Women Research Foundation
- Division of Women's and Perinatal Pathology
- Brigham and Women's Hospital
Pelvic serous carcinoma has traditionally been viewed as a rapidly evolving malignancy, due principally to its late stage at diagnosis and tendency for poor outcome, both in the endometrium and the upper genital tract. Recently, studies of women with BRCA1 or BRCA2 mutations (BRCA+) undergoing risk reducing salpingo-oophorectomy have highlighted the distal fallopian tube as a common (80%) site of tumor origin and additional studies of unselected women with pelvic serous carcinoma have demonstrated that serous tubal intraepithelial carcinoma may precede a significant percentage of these tumors. This review examines the serous carcinogenic spectrum in the fallopian tube, highlighting recent evidence that these tumors may follow a defined precursor that has been present for a prolonged interval. The data supporting a candidate precursor, the implications of these findings for early detection and prevention of pelvic serous carcinoma and the caveats, are discussed. (C)2009 Elsevier Inc. All rights reserved.
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