期刊
GYNECOLOGIC ONCOLOGY
卷 112, 期 1, 页码 210-214出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2008.09.012
关键词
Breast cancer; Association study; Case-control; Candidate genes; SNPs; Gene-gene interaction
资金
- Xunta de Galicia [PGIDIT06PXIB208079PR, PGIDIT06BTF910101PR]
- Spanish Ministerio de Sanidad y Consinno [P1052275, P1061712]
Objectives. A polygenic model has been proposed in order to explain the genetic susceptibility to sporadic breast cancer. According to this model, common population variants Would be responsible for low to modest effects on the risk of developing the disease. We have carried out a high-throughput SNP genotyping project in order to shed some light on the complex genetic aetiology of non-familial breast cancer. Methods. Ninety-one genes have been selected because of their implications in several candidate cell pathways for breast cancer. A total of 640 SNPs in these genes were genotyped in a series of 450 consecutive cases and 448 controls from mainland Spain. Promising SNPs were then studied in an independent series of 294 cases and 299 controls from the Canary Islands. Results. In the first case-control series we identified 25 SNPs with P-values below 0.05 (under a 1 df Chi-square test), five of them with P-values below 0.01 (best=0.0008). In the stage 2 Canary Islands series, odd ratios (OR) for two SNPs in HUSI were in a consistent direction. Conclusions. SNPs located at the gene HUS1 are good candidates for further investigation in independent association Studies and functional assays. (c) 2008 Elsevier Inc. All rights reserved.
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