☆ 4.6 Article

XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine polymorphisms are associated with response to platinum-based neoadjuvant chemotherapy in cervical cancer

GYNECOLOGIC ONCOLOGY (2008)

期刊

GYNECOLOGIC ONCOLOGY

卷 111, 期 3, 页码 509-515

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE

DOI: 10.1016/j.ygyno.2008.08.034

关键词

Polymorphism; Single nucleotide; Uterine cervical neoplasms; Neoadjuvant therapy; Drug therapy; Dose-response relationships; Drug

类别

Oncology Obstetrics & Gynecology

资金

Seoul National University Hospital Research [04-2006-040]

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

摘要

Objective. The objective of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) of genes which are involved in DNA synthesis and repair with the response to platinum-based neoadjuvant chemotherapy (NAC) and disease-free survival (DFS) in patients with cervical cancer who were treated with NAC followed by radical hysterectomy. Methods. A retrospective review was performed on 66 patients with cervical cancer who were treated with NAC followed by radical hysterectomy in our institute between January 1999 and February 2007. DNA was extracted from the paraffin-embedded, formalin-fixed tissue blocks of hysterectomy specimens. The genotypes of SNPs (MTHFR 677Cytosine/Thymine, XRCC1 Arginine194Tryptophan, GGH-401Cytosine/Thymine, and GSTP1 Isoleucine105Valine) were determined using a single base primer extension assay. The association of SNP genotypes with the response to NAC, which was measured by physical and colposcopic examinations, was evaluated. In addition, DFS based on SNP genotypes was examined. Results. The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were significantly associated with the response to NAC (P=0.023 for XRCC1 Arginine194Tryptophan; P=0.046 for GGH-401Cytosine/Thymine). However, the genotypes of MTHFR 677Cytosine/Thymine and GSTP1 Isoleucine105Valine were not associated with the response to NAC. In subgroup analysis with 39 patients who were treated with regimens containing 5-fluorouracil (5-FU), the genotypes of GGH-401Cytosine/Thymine were significantly associated with the response to NAC (P=0.039). In multifactor dimensionality reduction (MDR) analysis, the combination of XRCC1 Arginine 194Tryptophan and GGH-401Cytosine/Thymine genotypes was associated with the response to NAC (P<0.001). However, no SNP genotypes were associated with DFS, but the cisplatin dose intensity of NAC was associated with DFS. Conclusions. The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were associated with the response to NAC in patients with cervical cancer. However, no SNP genotypes were associated with DFS. (C) 2008 Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

主要评分

4.6

评分不足

次要评分

新颖性

重要性

科学严谨性

评价这篇论文

Pathological Downstaging and Survival Outcomes Associated with Neoadjuvant Chemotherapy for Variant Histology Muscle Invasive Bladder Cancer

Nicholas H. Chakiryan, Da David Jiang, Kyle A. Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit Jain, Jad Chahoud, Michael Poch, Brandon J. Manley, Roger Li, Wade Sexton, Scott M. Gilbert

Summary: The study found that neoadjuvant chemotherapy was associated with pathological downstaging for all histological variants of muscle invasive bladder cancer, and led to improved overall survival for patients with urothelial carcinoma, sarcomatoid variant UC and neuroendocrine carcinoma.

JOURNAL OF UROLOGY (2021)