Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men

Background/Aims: We have a limited understanding of the effect of nonalcoholic fatty liver disease (NAFLD) on the development of type 2 diabetes. Methods: The study subjects included male who had received biennial medical checkups between 2005 and 2009 and who had been diagnosed with fatty liver disease. The subjects with sustained NAFLD (FL, n=107) and sustained non-NAFLD (NFL, n=1,054) were followed to determine the development of type 2 diabetes. Results: In the FL group, there were more subjects with impaired fasting glucose (IFG), type 2 diabetes and high HOMA-IR than there were in the NFL group during the 5-year follow-up period (32.7 vs. 17.6%, 1.9 vs. 0.3%, 17.9 vs. 5.2% respectively, p<0.05). The FL group showed a higher risk than NFL group for abnormal glucose metabolism as determined using IFG (odds ratio [OR], 2.13; confidence interval [Cl], 1.36 to 3.35), type 2 diabetes (OR, 7.63; 95% Cl, 1.03 to 56.79) and high HOMA-IR (OR, 3.25; 95% Cl, 1.79 to 5.91) and metabolic parameters such as body mass index (OR, 3.35; 95% Cl, 1.87 to 6.02), triglyceride (OR, 3.05; 95% Cl, 1.92 to 4.86) and fasting blood sugar (OR, 2.18; 95% Cl, 1.39 to 3.41). Conclusions: Sustained NAFLD appears to be associated with an increased risk for the development of type 2 diabetes and deterioration of metabolic parameters in nonobese, non-diabetic Korean men. (Gut Liver 2012;6:368-373)