Review
Biochemistry & Molecular Biology
Shuangyu Liu, Lingyu Li, Dongmei Ren
Summary: Epithelial-mesenchymal transition (EMT) is a biological process that allows epithelial cells to transform into mesenchymal cells and acquire some cancer stem cell properties, contributing significantly to metastasis, invasion, and treatment resistance in cancer cells. Research has shown that phytochemicals, as potential sources of safe and effective anti-cancer medications, can disrupt signaling pathways related to malignant cell metastasis and drug resistance by suppressing or reversing the EMT process. This review briefly describes the pathophysiological properties and molecular mechanisms of EMT in cancer progression, and summarizes phytochemicals with diverse structures that can block the EMT process in different types of cancer, providing guidance for future research on phytochemicals targeting EMT.
Article
Biochemistry & Molecular Biology
Hsin-Ying Clair Chiou, Chih-Wen Wang, Szu-Chia Chen, Mei-Lan Tsai, Ming-Hong Lin, Chih-Hsing Hung, Chao-Hung Kuo
Summary: Copper is an essential trace element in the human body, but excessive exposure to it can harm human health. This study evaluated the effect of copper on lung fibrosis using in vitro cell culture models and epidemiologic studies. It was found that copper treatment decreased cell viability and promoted epithelial-mesenchymal transition (EMT) and autophagy in lung cells. Flavonoids were shown to inhibit the effects of copper-induced EMT. In humans, increased urinary copper was associated with an increased risk of lung fibrotic changes. These findings highlight the risk of copper in lung fibrosis and suggest potential remedies.
Article
Biochemical Research Methods
Huai-Song Wang, Xingya Xia, Yingming Wang, Weiping Lyu, Mangmang Sang, Congcong Gu, Wenyuan Liu, Feng Zheng
Summary: This study developed an aptamer probe based on aggregation-induced emission (AIE) to monitor EMT biomarkers on cell membrane and evaluate the efficacy of anti-EMT drugs.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Xiaoxiao Xu, Chuang Ma, Hang Wu, Yuanqiao Ma, Zejin Liu, Peijie Zhong, Chaolei Jin, Wenjuan Ning, Xiao Wu, Yijie Zhang, Jichang Han, Junpeng Wang
Summary: This study explored the impact of fructose on pulmonary fibrosis and the underlying mechanisms. The results showed that high fructose promoted the fibrotic phenotype and epithelial-mesenchymal transition of lung epithelial cells, which was associated with oxidative stress and the activation of TGF-beta 1.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Eirini Filidou, Leonidas Kandilogiannakis, Gesthimani Tarapatzi, Michail Spathakis, Paschalis Steiropoulos, Dimitrios Mikroulis, Konstantinos Arvanitidis, Vasilis Paspaliaris, George Kolios
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with no known effective treatment. Researchers have found that conditioned media (CM) from an immortalized human adipose mesenchymal stem cell line can have anti-inflammatory and anti-fibrotic effects on pulmonary cells. CM reduces the production of chemokines and collagen Type III, and inhibits the migration of myofibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Merve Yildirim, Fusun Oztay, Ozgecan Kayalar, Ahmet Erdal Tasci
Summary: This study revealed the roles of three LncRNAs in regulating myofibroblast differentiation through EMT, showing they interact with proteins and miRNAs associated with EMT and PF. These LncRNAs could be potential targets for treating PF by reducing EMT.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Respiratory System
Simone Periera-Simon, Xiaomei Xia, Paola Catanuto, Ramon Coronado, Joanne Kurtzberg, Michael Bellio, Yee-Shuan Lee, Aisha Khan, Robin Smith, Sharon J. Elliot, Marilyn K. Glassberg
Summary: This study investigates the effectiveness of MSC derived from different sources in treating lung fibrosis, finding that different sources may have varying effects on repair pathways in the body.
Article
Cell Biology
Min Hou, Furong Luo, Yujie Ding, Xuan Bao, Xiaoyun Chen, Liangping Liu, Mingxing Wu
Summary: This study found that hsa-let-7c-3p is downregulated in fibrotic cataract, and overexpression of hsa-let-7c-3p can suppress LEC proliferation and migration, attenuate EMT, and inhibit ASC development. Hsa-let-7c-3p achieves these effects by directly targeting the CDH11 gene.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yiran Lu, Yu Ding, Jiahui Wei, Song He, Xinmiao Liu, Huihao Pan, Bao Yuan, Qing Liu, Jiabao Zhang
Summary: Breast cancer is a common malignant tumor with EMT being a crucial process that allows tumor cells to acquire invasive and metastatic properties. Therapies targeting EMT have become increasingly important in cancer treatment, and studies have shown that Traditional Chinese Medicine compounds can inhibit breast cancer cell growth and development by inhibiting EMT.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Ian T. Stancil, Jacob E. Michalski, Corinne E. Hennessy, Kristina L. Hatakka, Ivana Yang, Jonathan S. Kurche, Mercedes Rincon, David A. Schwartz
Summary: This study demonstrates that in lung injury and fibrotic lung disease, airway epithelial cells undergo aberrant fluidization, a process that is associated with activation of the IL-6 signaling pathway and dependence on the SFK-YAP axis. The fibrotic mesenchyme acts as a source of IL-6 family cytokines, driving airway fluidization. Inhibition of the IL-6-SFK-YAP cascade prevents fluidization from occurring.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Gunsmaa Nyamsuren, Gregor Rapp, Hassan Dihazi, Elisabeth M. Zeisberg, Desiree Tampe, Bjoern Tampe, Michael Zeisberg
Summary: Phosphorylation of the Ser77 residue is critical for ARNT-ARNT homodimer formation and stabilization, and inhibition of PP2A phosphatase activity can enhance the formation of ARNT-ARNT homodimers. Combinations of FK506 or GPI1046 with LB100 elicit additive anti-fibrotic activities in murine models of kidney and liver fibrosis.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Lili Liang, Andreas M. Kaufmann
Summary: Cancer stem cells (CSCs) have been identified and characterized in both hematopoietic and solid tumors. They possess unique properties, including slow proliferation, self-renewal, differentiation, and the ability to undergo epithelial-mesenchymal transition (EMT) and its reverse process. CSCs play a crucial role in tumor growth, therapy resistance, and cancer metastasis. Strategies targeting CSCs are being developed for novel anti-metastasis treatments, aiming to improve therapeutic efficiency and prognosis with fewer side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Fanyun Kong, Lihong Ma, Xing Wang, Hongjuan You, Kuiyang Zheng, Renxian Tang
Summary: Research has found that lysine acetylation plays a role in modulating molecules involved in EMT, including marker proteins, transcription factors, and signal transduction molecules. Histone acetylation functions through epigenetic regulation, while non-histone acetylation is a post-translational modification, both contributing to the control of EMT. Inhibitors targeting KATs and KDACs have potential therapeutic value in cancer treatment by suppressing EMT and tumor development.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fei Bi, Huilin Tang, Zhijun Zhang, Yun Lyu, Fangjun Huo, Guoqing Chen, Weihua Guo
Summary: Research has shown that using HERS cells for periodontal tissue regeneration has potential and can be used to repair severely damaged periodontal tissue.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Domonkos Pap, Csenge Pajtok, Apor Veres-Szekely, Beata Szebeni, Csenge Szasz, Peter Bokrossy, Reka Zrufko, Adam Vannay, Tivadar Tulassay, Attila J. Szabo
Summary: Recent studies have shown that excessive salt intake can induce fibrotic changes in the peritoneum. This study aimed to better understand the underlying mechanisms. The results demonstrated that high-salt environments and increased osmolarity can lead to the production of inflammatory cytokines, profibrotic growth factors, and components of the renin-angiotensin-aldosterone system. Additionally, high salt was found to induce mesenchymal transition and increase extracellular matrix production. These findings contribute to our understanding of peritoneal fibrosis development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)