Review
Immunology
Shiyu Liu, Peter Szatmary, Jing-wen Lin, Qiqi Wang, Robert Sutton, Lu Chen, Tingting Liu, Wei Huang, Qing Xia
Summary: Acute pancreatitis is a common gastrointestinal disease characterized by acute onset of abdominal pain, often leading to organ failure and death. Monocytes, a type of cells in the innate immune system, are highlighted as key contributors and regulators of the inflammatory response and organ failure in acute pancreatitis, with a special focus on lipid modulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jamie van Son, Sabrina M. Oussaada, Aydin Sekercan, Martijn Beudel, Dave A. Dongelmans, Sander van Assen, Ingo A. Eland, Hazra S. Moeniralam, Tom P. J. Dormans, Colin A. J. van Kalkeren, Renee A. Douma, Daisy Rusch, Suat Simsek, Limmie Liu, Ruud S. Kootte, Caroline E. Wyers, Richard G. IJzerman, Joop P. van den Bergh, Coen D. A. Stehouwer, Max Nieuwdorp, Kasper W. ter Horst, Mireille J. Serlie
Summary: Overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury in hospitalized COVID-19 patients, but not with in-hospital mortality or length of hospital stay.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Aljawhara R. AlSaadoun, Tariq R. AlSaadoun, Abdullah K. Al Ghumlas
Summary: Liraglutide, a long-acting GLP-1 analog, is effective for weight loss and glycemic control in type 2 diabetes. However, overdose can lead to acute pancreatitis. The association between Liraglutide use and acute pancreatitis remains inconclusive, and further research is recommended.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Lone B. Enebo, Kasper K. Berthelsen, Martin Kankam, Michael T. Lund, Domenica M. Rubino, Altynai Satylganova, David C. W. Lau
Summary: The study aimed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the combination of Cagrilintide and Semaglutide for weight management. Results showed that concomitant treatment with Cagrilintide and Semaglutide was well tolerated with an acceptable safety profile. Larger and longer trials are needed to fully assess the efficacy and safety of this treatment combination.
Article
Multidisciplinary Sciences
Adeel Ahmad Khan, Fateen Ata, Zohaib Yousaf, Mohamad Safwan Aljafar, Mohammed Najdat Seijari, Ahmad Matarneh, Bassel Dakkak, Malik Halabiya, Bassam Muthanna, Abdul Majeed Maliyakkal, Anand Kartha
Summary: This retrospective study aimed to compare the clinical characteristics and outcomes of patients with diabetic ketoacidosis (DKA) with or without acute pancreatitis (AP). The results showed that patients with concomitant DKA and AP had more severe clinical outcomes and greater healthcare utilization than those with only DKA.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Thomas Chaigneau, Remy Morello, Elise Vannier, Marietta Musikas, Marie -Astrid Piquet, Benoit Dupont
Summary: This study evaluated the impact of sarcopenia and sarcopenic obesity on the occurrence of severe pancreatitis and studied the performance of anthropometric indices to predict severe forms. The results showed that sarcopenic obesity was associated with severe acute pancreatitis.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Pedro Cortes, Vivek Kumbhari, Samuel O. Antwi, Michael B. Wallace, Massimo Raimondo, Baoan Ji, Yan Bi
Summary: The study aimed to establish a risk score, DORM65, based on known variables to predict the likelihood of a positive endoscopic ultrasound (EUS) result in patients with idiopathic acute pancreatitis. The DORM65 score includes five predictors: delayed EUS, obesity, no repeated transabdominal ultrasound, male sex, and age >= 65 years. The score system accurately predicts the positive EUS result in patients with idiopathic acute pancreatitis.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Multidisciplinary Sciences
Carrie T. Chan
Summary: This study aims to investigate the association between BMI and the incidence of PSF among pediatric patients with AIS. The results show that there is no significant association between underweight, overweight, or obese BMI categories and incident PSF.
Article
Multidisciplinary Sciences
Megan A. Lewis, Laura K. Wagner, Lisa G. Rosas, Nan Lv, Elizabeth M. Venditti, Lesley E. Steinman, Bryan J. Weiner, Jeremy D. Goldhaber-Fiebert, Mark B. Snowden, Jun Ma
Summary: Through semi-structured interviews with 54 randomly selected trial participants and 37 other stakeholders, skepticism towards the collaborative care approach was reported initially, but participants and stakeholders gradually gained confidence in the potential public health impact over time, providing actionable information to enhance program impact.
Article
Multidisciplinary Sciences
Jennifer L. Kuk, Simone B. Daniels, Chris I. Ardern, Rubin Pooni
Summary: There were differences in the types of weight loss strategies used by individuals over time, with variations in their popularity of use by sex and obesity status. Women and those with obesity were more likely to engage in weight loss practices, with diet-related weight loss being the most common and the use of weight loss drugs and products being the least common. The prevalence of exercise weight loss practices increased significantly among women with obesity.
Article
Multidisciplinary Sciences
Mercedes Mora-Plazas, Isabella Carolyn Aida Higgins, Luis Fernando Gomez, Marissa Hall, Maria Fernanda Parra, Maxime Bercholz, Nandita Murukutla, Lindsey Smith Taillie
Summary: The study found that nutrient warnings performed better in many aspects, helping people to choose healthier foods and correctly identify products high in nutrients of concern more effectively. Compared to other labels, nutrient warnings were more effective in reminding consumers to avoid high-content products.
Article
Multidisciplinary Sciences
Juan Carlos Caro
Summary: Parental behavior plays a crucial role in child health and skill formation. This study examines the distributional effects of parental time allocation on children's outcomes, specifically socioemotional development and body mass index. The findings show significant heterogeneity in the returns to parental time investments, with a substantial improvement in socioemotional development for children at the bottom of the distribution. However, children with high developmental scores are unlikely to benefit from additional parenting time.
Article
Gastroenterology & Hepatology
Frank Anderson, Thandinkosi E. Madiba, Sandie R. Thomson
Summary: This study compared different scoring systems in predicting adverse outcomes in HIV-associated acute pancreatitis. The APACHE II score was found to be the best predictor of severe disease in both HIV+ve and HIV-ve patients.
Review
Medicine, General & Internal
Michael A. Mederos, Howard A. Reber, Mark D. Girgis
Summary: Acute pancreatitis is a significant cause of hospital admissions from gastrointestinal diseases in the United States, with proper management involving risk stratification, fluid and nutritional management. Early aggressive fluid resuscitation and enteral nutrition are associated with better outcomes, but the optimal fluid type and rate are still uncertain.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Natalya Usheva, Mina Lateva, Sonya Galcheva, Berthold V. Koletzko, Greet Cardon, Marieke De Craemer, Odysseas Androutsos, Aneta Kotowska, Piotr Socha, Luis A. Moreno, Yannis Manios, Violeta Iotova
Summary: The study found no significant association between breastfeeding practices and childhood obesity, but factors such as educational level, smoking habits, pre-pregnancy weight, and age may impact the duration of breastfeeding practices.
Article
Medicine, General & Internal
Min-Kyu Kang, Jung-Hun Baek, Young-Oh Kweon, Won-Young Tak, Se-Young Jang, Yu-Rim Lee, Keun Hur, Gyeonghwa Kim, Hye-Won Lee, Man-Hoon Han, Joon-Hyuk Choi, Soo-Young Park, Jung-Gil Park
Summary: Visceral adiposity is correlated with the histologic severity of NAFLD and independently associated with advanced fibrosis.
Article
Gastroenterology & Hepatology
Sun Young Moon, Jun Heo, Min Kyu Jung, Chang Min Cho
Summary: This study compared the efficacy of temporary self-expanding metallic stent (SEMS) and angioembolization for refractory immediate ERCP-related bleeding. The results showed that temporary SEMS and angioembolization had similar success rates in hemostasis, but the angioembolization group required more blood transfusions.
CLINICAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Sun Young Moon, Min Kyu Jung, Jun Heo
Summary: Percutaneous endoscopic gastrostomy (PEG) is a common method for long-term enteral nutrition. The over-the-scope clip system is a new device used for hemostasis and fistula closure. In this case, the over-the-scope clip device was used to achieve hemostasis and fistula closure for persistent bleeding around the PEG tube.
CLINICAL ENDOSCOPY
(2022)
Article
Medicine, General & Internal
Young-Gon Kim, Kyungsang Kim, Dufan Wu, Hui Ren, Won Young Tak, Soo Young Park, Yu Rim Lee, Min Kyu Kang, Jung Gil Park, Byung Seok Kim, Woo Jin Chung, Mannudeep K. Kalra, Quanzheng Li
Summary: Imaging plays an important role in assessing the severity of COVID-19 pneumonia. This paper proposes a fully automated framework that utilizes deep learning models to assist in quantifying the regional pulmonary opacities of COVID-19 pneumonia. The results show a correlation between the proposed method and the radiographic assessment conducted by physicians.
Article
Gastroenterology & Hepatology
Jong Yop Pae, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Jun Heo, Jang Hoon Lee, Min Ae Park
Summary: This study compared the risk of gastrointestinal bleeding (GIB) for non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin. The results showed that NOACs patients had a lower risk of overall GIB than warfarin patients, but a higher risk of post-polypectomy GIB. Among NOACs, apixaban had the lowest risk of GIB.
INTESTINAL RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Sang Hyub Lee, Jung Wan Choe, Young Koog Cheon, Miyoung Choi, Min Kyu Jung, Dong Kee Jang, Jung Hyun Jo, Jae Min Lee, Eui Joo Kim, Sung Yong Han, Young Hoon Choi, Hyung-Il Seo, Dong Ho Lee, Hong Sik Lee
Summary: Acute pancreatitis can vary in severity and have life-threatening complications. In order to improve the management of acute pancreatitis and contribute to healthcare improvements, the Korean Pancreatobiliary Association developed guidelines in 2013. However, challenging issues and new evidence have led to an extensive revision of the guidelines.
Editorial Material
Medicine, General & Internal
Se Young Jang, Young Seok Han, Sang Yub Lee, Ja Ryung Han, Young Oh Kweon, Won Young Tak, Soo Young Park, Yu Rim Lee, Hun Kyu Ryeom, Jung Guen Cha, Jihoon Hong, Yoo Na Kang
Summary: An inflammatory pseudotumor is a benign disease characterized by tumor-like lesions consisting of inflammatory cells including plasma cells and fibrous tissue. Some cases of inflammatory pseudotumor have been identified as Immunoglobulin G4-related disease (IgG4-RD), which is a fibroinflammatory condition characterized by lymphoplasmacytic infiltration, predominance of IgG4-positive plasma cells, storiform fibrosis, and elevated serum IgG4 concentrations. We report a case of IgG4-RD in the form of an inflammatory pseudotumor in the liver with combined sclerosing cholangitis. Adequate tissue samples and clinical follow-up are recommended for accurate diagnosis of IgG4-RD.
Article
Genetics & Heredity
Se Young Jang, Gyeonghwa Kim, Won Young Tak, Young Oh Kweon, Yu Rim Lee, Young Seok Han, Ja Ryung Han, Jung Gil Park, Min Kyu Kang, Hye Won Lee, Won Kee Lee, Soo Young Park, Keun Hur
Summary: This study evaluated the clinical significance of hsa_circ_0003570 expression in hepatocellular carcinoma (HCC) and found that its expression was associated with tumor size, vessel invasion, tumor-node metastasis stage, Barcelona Clinic Liver Cancer stage, and AFP level. In addition, high hsa_circ_0003570 expression was correlated with better overall survival and progression-free survival in patients with HCC.
Article
Medicine, General & Internal
Min-Kyu Kang, Yu-Rim Lee, Jeung-Eun Song, Young-Oh Kweon, Won-Young Tak, Se-Young Jang, Jung-Gil Park, Soo-Young Park
Summary: This study aimed to evaluate the impact of body composition and pre-existing risk factors on mortality in hospitalized patients with COVID-19. The findings showed that low muscle density and high proportion of myosteatosis were associated with mortality, while diabetes and a high fibrosis-4 index were also significant risk factors.
Article
Multidisciplinary Sciences
Hyungjun Kwon, Min Kyu Jung, Sung Jin Park, Jun Heo, Dong Wook Lee, Yoo Na Kang, Jaryung Han, Young Seok Han, Won Kee Lee
Summary: A study showed that combining endobiliary biopsy and/or SEMS cytology could provide higher sensitivity and specificity for diagnosing suspected malignant biliary obstruction.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Eunae Cho, Seong-Hun Kim, Seong Ji Choi, Min Kyu Jung, Byeong Jun Song, Jin Myung Park, Jingu Kang, Won Suk Park, Joo Kyung Park, Sang Myung Woo, Hyo Jung Kim
Summary: This study investigates the current practice of diagnosing and treating perihilar cholangiocarcinoma (CCA) in Korea. It suggests the need for a new coding system for classifying CCAs and the development of guidelines based on the clinical situation in Korea.
Article
Oncology
Thanaporn Viriyasaranon, Jung Won Chun, Young Hwan Koh, Jae Hee Cho, Min Kyu Jung, Seong-Hun Kim, Hyo Jung Kim, Woo Jin Lee, Jang-Hwan Choi, Sang Myung Woo
Summary: Researchers have developed an innovative self-supervised learning algorithm that improves the differentiation of malignant and benign lesions, leading to increased accuracy in computer-assisted pancreatic cancer diagnosis. By utilizing a pseudo-lesion segmentation self-supervised learning model, the performance of convolutional neural network-based and transformer-based deep learning models was significantly enhanced. The study also found that self-supervised learning can improve the performance and robustness of the model on unseen and small datasets.
Article
Medicine, General & Internal
O. Seong Kweon, Jun Heo, Min Kyu Jung
Summary: This study aimed to evaluate the recurrence rate of choledocholithiasis and identify risk factors for recurrent choledocholithiasis in patients following gastrectomy. The study found that the recurrence rate of choledocholithiasis was 14.5%, and the stone removal modality, no use of balloon sphincteroplasty, and the presence of periampullary diverticulum were significant risk factors for recurrent choledocholithiasis. Therefore, the study recommends using ERCP with active use of balloon sphincteroplasty to decrease recurrent CBD stones following gastrectomy.
Article
Medicine, General & Internal
Min Kyu Jung, Sanghee Yeo, Won Kee Lee
Summary: Empathy is crucial for healthcare professionals, as it can improve patient adherence, satisfaction, and treatment outcomes. Female students scored higher in empathy compared to male students, and students aspiring to be attending faculty showed better empathy scores. Additionally, students with empathy towards patients performed better in clinical comprehensive assessments.
Article
Medicine, General & Internal
Min Su Jung, Man-Hoon Han, Tae In Park, Min Kyu Jung
Summary: This study investigated the relationship among ICC number, gallbladder contractibility, and gallstones in patients undergoing cholecystectomy. Results showed that male participants had a higher number of ICC in the mucosal layer compared to females, and larger gallbladder size was associated with decreased ICC in the muscular layer. The number of ICC in the muscular layer decreased with an increase in gallbladder stone number, but there was no significant correlation with other factors.
