Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice

End-stage liver disease complications

(2013) Robert S. Rahimi et al.   CURRENT OPINION IN GASTROENTEROLOGY

Molecular basis of organ fibrosis: Potential therapeutic approaches

(2013) Asish K Ghosh et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Ductular reaction in hereditary hemochromatosis: The link between hepatocyte senescence and fibrosis progression

(2013) Marnie J. Wood et al.   HEPATOLOGY

Role of Hepatic Progenitor Cells in Nonalcoholic Fatty Liver Disease Development: Cellular Cross-Talks and Molecular Networks

(2013) Guido Carpino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Underlying potential: cellular and molecular determinants of adult liver repair

(2013) Anna Mae Diehl et al.   JOURNAL OF CLINICAL INVESTIGATION

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Therapy for Fibrotic Diseases: Nearing the Starting Line

(2013) S. L. Friedman et al.   Science Translational Medicine

Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver

(2013) Giovanni Musso et al.   TRENDS IN MOLECULAR MEDICINE

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

(2012) Regina Español–Suñer et al.   GASTROENTEROLOGY

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans

(2012) James Pritchett et al.   HEPATOLOGY

Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ASK8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study

(2011) M J H Boumans et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases

(2011) Toshimitsu Uede   PATHOLOGY INTERNATIONAL

Pharmacokinetic characterization of an RNA aptamer against osteopontin and demonstration of in vivo efficacy in reversing growth of human breast cancer cells

(2011) Lindsay Jones Talbot et al.   SURGERY

Hepatic Progenitor Cells: An Update

(2010) Tania Roskams et al.   Clinics in Liver Disease

Neutralization of Osteopontin Inhibits Obesity-Induced Inflammation and Insulin Resistance

(2010) F. W. Kiefer et al.   DIABETES

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

(2009) Steve S. Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

(2009) Wing–Kin Syn et al.   GASTROENTEROLOGY

Role of transforming growth factor β signaling and expansion of progenitor cells in regenerating liver

(2009) Arun Thenappan et al.   HEPATOLOGY

Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production

(2009) Alessia Omenetti et al.   HEPATOLOGY

Global gene expression profiling reveals a key role of CD44 in hepatic oval-cell reaction after 2-AAF/CCl4 injury in rodents

(2009) Chien-Chang Chiu et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The quest for liver progenitor cells: A practical point of view

(2009) Laurent Dollé et al.   JOURNAL OF HEPATOLOGY

Ski and SnoN, potent negative regulators of TGF-β signaling

(2008) Julien Deheuninck et al.   CELL RESEARCH

Immune Interactions in Hepatic Fibrosis

(2008) Andrew P. Holt et al.   Clinics in Liver Disease

Osteopontin: Role in immune regulation and stress responses

(2008) Kathryn X. Wang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

RNA Aptamer Blockade of Osteopontin Inhibits Growth and Metastasis of MDA-MB231 Breast Cancer Cells

(2008) Zhiyong Mi et al.   MOLECULAR THERAPY

Fate-Mapping Evidence That Hepatic Stellate Cells Are Epithelial Progenitors in Adult Mouse Livers

(2008) Liu Yang et al.   STEM CELLS