Article
Public, Environmental & Occupational Health
James S. Floyd, Maralyssa A. Bann, Andrew H. Felcher, Daniel Sapp, Michael D. Nguyen, Adebola Ajao, Robert Ball, David S. Carrell, Jennifer C. Nelson, Brian Hazlehurst
Summary: This study assessed the accuracy of ICD-10 diagnosis codes for acute pancreatitis in inpatient, emergency department (ED), and outpatient settings. The results showed that the codes accurately identified acute pancreatitis in the inpatient setting, but not in the ED and outpatient settings. Laboratory data significantly improved the algorithm performance.
Article
Pharmacology & Pharmacy
Shengyu Zhang, Ziying Han, Yuelun Zhang, Xiaomao Gao, Shicheng Zheng, Ruifeng Wang, Dong Wu
Summary: The study indicated that PPIs therapy was not associated with reduced mortality or total hospital stay in patients with acute pancreatitis, but it was related to a reduction in the occurrence of pancreatic pseudocysts.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Pediatrics
Racha Khalaf, Michael Narkewicz, Maisam Abu El-Haija
Summary: Two adolescent girls with catamenial acute pancreatitis were diagnosed with hereditary pancreatitis, a potential cause of chronic pancreatitis. It is important to consider hereditary pancreatitis in teenage girls with menstrual cycle-associated acute pancreatitis and a family history of pancreatic disease.
JOURNAL OF PEDIATRICS
(2021)
Review
Medicine, General & Internal
Frank U. Weiss, Felix Laemmerhirt, Markus M. Lerch
Summary: Acute pancreatitis, caused by various factors such as gallstones and alcohol consumption, poses challenges in early identification of patients at risk for systemic complications and organ failure. The presence of complex gene-environment interactions plays a role in the pathogenesis of pancreatitis, but predictive genetic biomarkers are not yet implemented into routine clinical care for AP patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Li Chen, Xiangxian Zhang, Yu Liu, Li Liu, Xiao Liang, Shengqun Yang, Qing Xia, Tao Jin, Yun Ma, Yonghua Chen, Xia Yuan, Yan Tie, Yangzhuo Gu, Chunju Fang, Siyuan Chen, Fei Mo, Ting Yu, Yuzhu Hu, Zhiyong Qian, Yong Peng, Jia Geng, Zongguang Zhou, Min Wu, Jiansheng Ding, Daoke Yang, Xiawei Wei
Summary: Acute pancreatitis (AP) can lead to lung injury due to the upregulation of Jumonji domain-containing protein 3 (JMJD3), which is activated by mitochondrial DNA (mtDNA) or oxidized-mtDNA released from tissue injury caused by AP. Inflammatory monocytes are infiltrated in the lung through the STING/TLR9-NF-kB-JMJD3-TNF-a pathway. Inhibition of JMJD3 or blocking the STING/TLR9 pathway could be potential therapeutic strategies for treating AP and its associated lung injury.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Parasitology
Annabell Coors, Max J. Hassenstein, Gerard Krause, Tobias Kerrinnes, Manuela Harries, Monique M. B. Breteler, Stefanie Castell
Summary: This study aimed to investigate the seropositivity for Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) and its risk factors in the Rhineland Study population in Bonn, North Rhine-Westphalia, Germany, and to compare it with previous surveys to evaluate potential effects of climate change. The findings showed that increasing age and male sex were associated with increased odds for IgG seropositivity, and there was evidence of increased seropositivity in the highly educated group. Furthermore, the seroprevalence of B. burgdorferi s.l. remained constant over the past decade in this regional German population.
PARASITES & VECTORS
(2022)
Article
Medicine, General & Internal
Longxiang Cao, Yingjie Chen, Siyao Liu, Wei Huang, Dong Wu, Donghuang Hong, Zuozheng Wang, Yi Sun, Kaixiu Qin, Feng Guo, Cuizhu Luo, Qinghai Jiao, Xiang Luo, Jing Zhou, Gang Li, Bo Ye, Tao Chen, Man Liu, Wenjian Mao, Lanting Wang, Shuai Li, John A. Windsor, Yuxiu Liu, Lu Ke, Zhihui Tong, Weiqin Li
Summary: This study evaluated the association between plasmapheresis and the incidence and duration of organ failure in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP). The results showed that although plasmapheresis can lower plasma triglyceride levels, it was not associated with the incidence and duration of organ failure after adjusting for confounders, but was associated with increased ICU requirements.
Review
Medicine, General & Internal
Monica C. M. Bischof, Mariana I. E. Stadelmann, Simone Janett, Mario G. Bianchetti, Pietro Camozzi, Barbara Goeggel Simonetti, Sebastiano A. G. Lava, Gregorio P. Milani
Summary: Long-term medication with valproic acid is associated with acute pancreatitis. This study investigated the features of this pancreatitis and found that approximately 84% of patients recovered and 16% died within 11 months of starting valproic acid. Among patients rechallenged with valproic acid, about 84% developed a further episode of pancreatitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Ahmet Tarik Eminler, Aydin Seref Koksal, Bilal Toka, Cengiz Karacaer, Mustafa Ihsan Uslan, Erkan Parlak
Summary: This study retrospectively investigated the occurrence of benign biliary strictures (BBS) in patients with acute biliary pancreatitis (ABP). The results showed that the majority of patients showed improvement in the stricture within 3 months after endoscopic management, and temporary stenting prevented complications during this period.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Immunology
Zhengjian Wang, Fan Li, Jin Liu, Yalan Luo, Haoya Guo, Qi Yang, Caiming Xu, Shurong Ma, Hailong Chen
Summary: This study reviews the mechanisms of the microbiota-gut-lung axis in pancreatic-associated lung injury (PALI) and discusses potential therapeutic strategies for PALI by regulating the intestinal microbiota.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Satish Munigala, Sami Almaskeen, Divya S. Subramaniam, Sriya Bandi, Benjamin Bowe, Hong Xian, Sunil G. Sheth, Thomas E. Burroughs, Banke Agarwal
Summary: In this study, the researchers investigated the long-term risk of pancreatic ductal adenocarcinoma (PDAC) after acute pancreatitis (AP) and its association with the etiology of AP, recurrence frequency, and progression to chronic pancreatitis (CP). Their findings indicate a higher PDAC risk 3-10 years after AP, independent of the etiology, and this risk increases with the number of AP episodes and is additive to the risk associated with CP.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pediatrics
Andrew T. Trout, Rupesh Patel, Jaimie D. Nathan, Tom K. Lin, David S. Vitale, Alexander Nasr, Bin Zhang, Maisam Abu-El-Haija
Summary: This study systematically documented ultrasound findings in children with acute pancreatitis and found that peripancreatic edema was the most frequently identified finding, with almost perfect interobserver agreement. Duct dilation, considered a reliable finding in acute pancreatitis, was rare in the sample studied.
PEDIATRIC RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Mariachiara Carestia, Massimo Andreoni, Ersilia Buonomo, Fausto Ciccacci, Luigi De Angelis, Gerardo De Carolis, Patrizia De Filippis, Daniele Di Giovanni, Leonardo Emberti Gialloreti, Carla Fontana, Luca Guarente, Andrea Magrini, Marco Mattei, Stefania Moramarco, Laura Morciano, Claudia Mosconi, Stefano Orlando, Giuseppe Quintavalle, Fabio Riccardi, Viviana Santoro, Leonardo Palombi
Summary: In Italy, the integration of microbiology laboratory data with electronic health records (EHRs) has provided a valuable tool for evaluating healthcare-associated infections (HAIs) and antimicrobial resistance (AMR). This study successfully established a management system that accurately assessed the burden of HAIs and the impact of AMR. Despite a low percentage of HAIs caused by antimicrobial resistant bacteria, the contribution of AMR to increased mortality risk was significant.
Article
Neurosciences
Woo Hyun Paik, Dong Kee Jang, Soyoung Cho, Jin Ho Choi, Min Kyu Kim, In Rae Cho, Ji Kon Ryu, Yong-Tae Kim, Kyung-Do Han, Sang Hyub Lee
Summary: This study investigated the effect of acute pancreatitis on dementia in patients with type 2 diabetes. It found that a history of acute pancreatitis was a significant risk factor for dementia in these patients, particularly in individuals under the age of 65, males, and those who smoke or consume alcohol.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Xiaomin Hu, Liang Gong, Ruilin Zhou, Ziying Han, Li Ji, Yan Zhang, Shuyang Zhang, Dong Wu
Summary: HTGAP patients have higher rates of severe AP, organ failure, and longer hospital stays compared to non-HTGAP patients. Changes in gut microbiota are associated with disease severity and poor prognosis in HTGAP patients, suggesting a potential link between gut microbiota and hypertriglyceridemia-related acute pancreatitis.