Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo

The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon

(2013) J. B. J. Ward et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Translational Approaches for Pharmacotherapy Development for Acute Diarrhea

(2012) Mark Donowitz et al.   GASTROENTEROLOGY

Epidermal growth factor chronically upregulates Ca2+-dependent Cl−conductance and TMEM16A expression in intestinal epithelial cells

(2012) Magdalena S. Mroz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Farnesoid X receptor represses hepatic human APOA gene expression

(2011) Indumathi Chennamsetty et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles of microRNA-29a in the Antifibrotic Effect of Farnesoid X Receptor in Hepatic Stellate Cells

(2011) J. Li et al.   MOLECULAR PHARMACOLOGY

Tissue-specific function of farnesoid X receptor in liver and intestine

(2011) Yan Zhu et al.   PHARMACOLOGICAL RESEARCH

D-Glucose Acts via Sodium/Glucose Cotransporter 1 to Increase NHE3 in Mouse Jejunal Brush Border by a Na+/H+ Exchange Regulatory Factor 2–Dependent Process

(2010) Rong Lin et al.   GASTROENTEROLOGY

Managing bile acid diarrhoea

(2010) Julian R. F. Walters et al.   Therapeutic Advances in Gastroenterology

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

(2009) Julian R.F. Walters et al.   Clinical Gastroenterology and Hepatology

Oral Cholic Acid for Hereditary Defects of Primary Bile Acid Synthesis: A Safe and Effective Long-term Therapy

(2009) Emmanuel Gonzales et al.   GASTROENTEROLOGY

Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells

(2009) Niamh Keating et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Focus on acute diarrhoeal disease

(2009) Fabio Baldi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation

(2008) Francesco Raimondi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development

(2008) R. R.M. Maran et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY