Article
Immunology
Maura H. Parker, Diane Stone, Kraig Abrams, Melissa Johnson, Noa Granot, Rainer Storb
Summary: Chronic graft-versus-host disease (GVHD) is a significant issue in transplant patients, and targeting specific T-cell populations like CD4(+) and CD8(+) T cells may be crucial in developing effective treatments for the disease. Treatment with anti-inducible costimulator (ICOS) monoclonal antibodies showed promising results in transiently relieving symptoms and prolonging survival in dogs with chronic GVHD, particularly targeting IL-17A(+) cells, but further research is needed to control both CD4(+) and CD8(+) T cells for better outcomes.
Review
Neurosciences
Jingjing Wang, Yuxiao Gao, Yujia Yuan, Huan Wang, Zhao Wang, Xiangjian Zhang
Summary: This paper reviews the mechanism of action of Th17 cells and IL-17A in ischemic stroke and the progress of research on targeted therapy.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Immunology
Jiajia Fu, Yan Huang, Ting Bao, Chengcheng Liu, Xi Liu, Xueping Chen
Summary: Neurodegenerative diseases are characterized by progressive loss of neurons, and immune pathway dysregulation is a common feature. Th 17 cells and IL-17A play important roles in the pathogenesis of these diseases. Targeting IL-17A may represent a potential therapeutic approach for neurodegenerative diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Cinthia M. F. Pacheco, Katia L. M. Maltos, Mostafa S. Shehabeldin, Laura L. Thomas, Zhe Zhuang, Sayuri Yoshizawa, Konstantinos Verdelis, Sarah L. Gaffen, Gustavo P. Garlet, Steven R. Little, Charles Sfeir
Summary: This study developed a local sustained delivery system to inhibit IL-17A hyperactivity in periodontal tissues, demonstrating promising results in inhibiting alveolar bone loss and osteoclastic activity in mice with ligature-induced PD. The formulation also decreased expression of IL-6, known to induce bone resorption in periodontal tissues. This suggests that local and sustained release of IL-17A Abs could be a potential therapeutic strategy for PD and other osteolytic bone diseases mediated by IL-17A-driven inflammation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Manupati Srikanth, Mahaboobkhan Rasool
Summary: Research shows that 3, 3'-diindolylmethane (DIM) can be used to treat psoriasis by blocking the action of interleukin (IL) 17A, reducing symptoms and inhibiting the expression of pathogenic mediators in psoriatic keratinocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Surgery
Ravi Dhital, Shashi Anand, Brianna Graber, Qiang Zeng, Victoria M. Velazquez, Srinivasa R. Boddeda, James R. Fitch, Ranjana W. Minz, Mukut Minz, Ashish Sharma, Rachel Cianciolo, Masako Shimamura
Summary: Human cytomegalovirus (HCMV) infection is associated with renal allograft failure. CMV promotes allograft damage via cytokine-mediated Th1/17 cell recruitment. Pharmacologic inhibition of the Th17 cell signature cytokine, IL-17A, ameliorates CMV-associated allograft damage.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Dermatology
Zhenrui Shi, Xuesong Wu, Chun-Yi Wu, Satya P. Singh, Timothy Law, Daisuke Yamada, Mindy Huynh, William Liakos, Guiyan Yang, Joshua M. Farber, Yu-Jui Yvonne Wan, Samuel T. Hwang
Summary: Bile acids can improve psoriasiform dermatitis through multiple mechanisms, including direct inhibition of IL-17A production and blockade of CCL20-mediated trafficking. These findings support the potential use of bile acids in the treatment of psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Kostareva, Arina Svoeglazova, Ilya Kolyadenko, Alexey Nikulin, Stanislav Evdokimov, Uliana Dzhus, Azat Gabdulkhakov, Svetlana Tishchenko
Summary: Interleukin-17 (IL-17) is a cytokine involved in chronic inflammation in autoimmune diseases. Antibodies targeting IL-17 are used as therapy tools. The crystal structure of an IL-17A-specific antibody in complex with IL-17A has been determined, revealing the interaction between the antibody and specific regions of IL-17A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Hongzhi Liu, Liang Li, Yanyun Hao, Jialu Li, Zhaoyuan Liu, Jingjing Qi, Jingjing Zhang, Ningbo Wu, Dandan Wu, Caixia Gao, Lei Chen, Lei Shen, Jinke Cheng, Bing Su
Summary: This study identifies two major colon ILC2 populations that have the potential to migrate to the lung in response to IL-25 stimulation. One population expresses IL-17A and resembles inflammatory ILC2s, while the other population expresses CD27 but not IL-17A. These two populations have unique surface markers and cytokine profiles and play critical roles in regulating lung and colon immunity and homeostasis.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Dermatology
Yanyun Jiang, Siyao Lu, Yuhsien Lai, Liangchun Wang
Summary: This study investigated the role of topical Entinostat in psoriasis therapy. The results showed that this medication significantly improved psoriatic inflammation and inhibited the expression of inflammatory genes.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Hsuan Lin, Chia-Ling Li, Ling-Jung Yen, Ling-Ying Lu, Hung-Sen Huang, En-Chih Liao, Sheng-Jie Yu
Summary: This study aimed to explore the therapeutic effects and immune regulation of forsythoside A on psoriasis. The results showed that forsythoside A relieved psoriatic skin symptoms, downregulated IL-6, IL-17, and Ki-67 expression, and suppressed Th17 cell development and IL-17A secretion. These findings demonstrate the feasibility of forsythoside A in treating human psoriasis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Chun-Wen Chan, Hung-Wen Chen, Yu-Wen Wang, Chia- Lin, Ya-Hui Chuang
Summary: This study found that the Th17 cell-derived cytokine IL-21 plays a role in the pathogenesis of PBC, exacerbating liver inflammation and fibrosis and increasing the numbers and effector activities of CD8+ T cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Respiratory System
Sara Gerday, Sophie Graff, Catherine Moermans, Francoise Guissard, Virginie Paulus, Monique Henket, Renaud Louis, Florence Schleich
Summary: Several clinical trials have shown that anti-IL-5(R) biologics can improve lung function, asthma control, and reduce exacerbations in eosinophilic asthmatic patients. However, there is variability in clinical responses to these biologics. Our study aimed to evaluate the role of baseline sputum eosinophils in identifying super-responders to mepolizumab and benralizumab. Our findings emphasize the importance of examining sputum eosinophils in severe asthma patients before starting biologic treatment as it is associated with the intensity of response to mepolizumab and benralizumab.
Article
Immunology
Xiaokun Shen, Huiyun Zhang, Hua Xie, Liping Chen, Shinan Li, Junjuan Zheng, Ruonan Chai, Zhao Wang, Yanyan Zang, Shaoheng He
Summary: Human regulatory T (Treg) cells play a central role in controlling allergic inflammation in the airways. Different subsets of Treg cells were investigated in healthy individuals and allergic asthma patients, revealing lower levels of certain Treg cell subsets in the latter group. Studies using mouse models suggested that CCR6(+) Treg cells may play a crucial role in the pathology of allergic asthma by promoting Th17 responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nira de la Vega Gallardo, Marie Dittmer, Yvonne Dombrowski, Denise C. Fitzgerald
NEUROCHEMISTRY INTERNATIONAL
(2019)
Article
Gastroenterology & Hepatology
Henrika Jodeleit, Janina Caesar, Christina Villarroel Aguilera, Sebastian Sterz, Lesca Holdt, Florian Beigel, Johannes Stallhofer, Simone Breiteneicher, Eckart Bartnik, Matthias Siebeck, Roswitha Gropp
INFLAMMATORY BOWEL DISEASES
(2020)
Article
Multidisciplinary Sciences
Christopher E. McMurran, Alerie Guzman de la Fuente, Rosana Penalva, Ofra Ben Menachem-Zidon, Yvonne Dombrowski, John Falconer, Ginez A. Gonzalez, Chao Zhao, Fynn N. Krause, Adam M. H. Young, Julian L. Griffin, Clare A. Jones, Claire Hollins, Markus M. Heimesaat, Denise C. Fitzgerald, Robin J. M. Franklin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Cell Biology
Sarah Kuhn, Laura Gritti, Daniel Crooks, Yvonne Dombrowski
Article
Gastroenterology & Hepatology
P. C. Grunert, P. A. Reuken, J. Stallhofer, N. Teich, A. Stallmach
JOURNAL OF CROHNS & COLITIS
(2020)
Article
Multidisciplinary Sciences
Fabian Schnitzler, Matthias Friedrich, Marianne Angelberger, Julia Diegelmann, Johannes Stallhofer, Christiane Wolf, Joel Duetschler, Samuel Truniger, Torsten Olszak, Florian Beigel, Cornelia Tillack, Peter Lohse, Stephan Brand
Article
Cell Biology
Henrika Jodeleit, Paula Winkelmann, Janina Caesar, Sebastian Sterz, Lesca M. Holdt, Florian Beigel, Johannes Stallhofer, Simone Breiteneicher, Eckart Bartnik, Thomas Leeuw, Matthias Siebeck, Roswitha Gropp
Summary: This study aimed to demonstrate patient stratification for oxelumab treatment using immune profiling and a humanized mouse model of UC. Results showed significant differences in OX40L expression levels between UC and non-UC donors. The efficacy of oxelumab in reducing clinical scores and inflammation was slightly better than adalimumab, suggesting a potential benefit for patients with elevated OX40L levels.
DISEASE MODELS & MECHANISMS
(2021)
Article
Dentistry, Oral Surgery & Medicine
B. Al Natour, F. T. Lundy, P. N. Moynah, I. About, C. Jeanneau, C. R. Irwin, Y. Domberoski, I. A. El Karim
Summary: The study demonstrates that dead odontoblasts can activate NLRP3 inflammasome-dependent sterile inflammation, leading to increased migration, proliferation, and differentiation of dental pulp cells.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Johannes Stallhofer, Lisa Veith, Julia Diegelmann, Philipp Probst, Stephan Brand, Fabian Schnitzler, Torsten Olszak, Helga Toeroek, Julia Mayerle, Andreas Stallmach, Florian Beigel
Summary: In patients with IBD, low levels of vitamin D are associated with iron deficiency, while sufficient vitamin D levels are linked to increased ferritin and transferrin saturation. The higher the 1,25(OH)D:25(OH)D ratio, the lower the hepcidin levels are.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Article
Chemistry, Medicinal
Xenia Kodji, Zizheng Kee, Robyn McKenna, Joao de Sousa Valente, Harriet Ravenscroft, Hayley McMillan, John Gamble, Yvonne Dombrowski, Paul Moynagh, David Brough, Fionnuala T. Lundy, Susan D. Brain, Ikhlas A. El Karim
Summary: Stimulation of TRPA1 plays a key role in TMJ pain, while inhibition of the inflammasome also attenuates pain-like behaviors and inflammatory markers. This suggests that NLRP3 inhibition may offer a new therapeutic strategy for TMJ inflammation and pain, in addition to targeting TRPA1.
Article
Pharmacology & Pharmacy
Richard Creswell, Yvonne Dombrowski
Summary: Neuroinflammation is a characteristic of many neurodegenerative diseases and plays a crucial role in the regeneration of myelin after damage. Both innate and adaptive immune mechanisms are important for successful remyelination, but the specific role of the adaptive immune system is still unclear. Harnessing the beneficial aspects of neuroinflammation could lead to future therapies for regenerating the central nervous system.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Banan Al Natour, Fionnuala T. Lundy, Imad About, Charlotte Jeanneau, Yvonne Dombrowski, Ikhlas A. El Karim
Summary: This study aimed to evaluate the expression and function of NLRP3 inflammasome in caries-induced pulpitis. The results showed differential expression of NLRP3 inflammasome in sound and carious dental pulp. The use of NLRP3 inhibitor reduced the release of inflammatory cytokines, suggesting its potential as a treatment target.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Johannes Stallhofer, Jan Guse, Miriam Kesselmeier, Philip Christian Grunert, Kathleen Lange, Robert Stalmann, Verena Eckardt, Andreas Stallmach
Summary: This study aimed to investigate the effects of immunomodulator comedication on anti-drug antibodies in patients with inflammatory bowel disease. The results of a real-world retrospective cohort study showed that immunomodulator comedication can successfully reverse the loss of therapeutic response to tumor necrosis factor inhibitors.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Meeting Abstract
Neurosciences
D. Crooks, P. Bankhead, D. Fitzgerald, Y. Dombrowski
Meeting Abstract
Neurosciences
L. Gritti, E. Mckay, D. Crooks, A. -L. Boinet, S. Fleville, D. C. Fitzgerald, P. Bankhead, Y. Dombrowski