Article
Cardiac & Cardiovascular Systems
Guenther Silbernagel, Yan Q. Chen, Martin Rief, Marcus E. Kleber, Michael M. Hoffmann, Tatjana Stojakovic, Andreas Stang, Mark A. Sarzynski, Claude Bouchard, Winfried Maerz, Yue-Wei Qian, Hubert Scharnagl, Robert J. Konrad
Summary: Apolipoprotein C-II (ApoC-II) has an inverse J-shaped relationship with cardiovascular mortality, with the lowest risk observed in the middle quintile. Increasing low circulating ApoC-II levels may reduce cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Review
Immunology
Yusha Tao, Weiming Tang, Emmanuel Fajardo, Mengyuan Cheng, Shiyi He, Jennifer S. Bissram, Lindsey Hiebert, John W. Ward, Roger Chou, Francisco Rodriguez-Frias, Philippa Easterbrook, Joseph D. Tucker
Summary: This study evaluated the effectiveness of reflex VL testing compared with standard nonreflex approaches on outcomes across the HCV care cascade. The results showed that both laboratory-based and clinic-based reflex VL testing increased the uptake of HCV VL testing, reduced testing time, and may improve linkage to care among people with HCV.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Neel Mehta, Renald Gilbert, Parminder S. Chahal, Maria J. Moreno, Nasha Nassoury, Nathalie Coulombe, Viktoria Lytvyn, Mario Mercier, Dorothy Fatehi, Wendy Lin, Emily M. Harvey, Lin-Hua Zhang, Nazila Nazemi-Moghaddam, Seyyed Mehdy Elahi, Colin J. D. Ross, Danica B. Stanimirovic, Michael R. Hayden
Summary: This study aimed to develop a more efficacious AAV gene therapy vector for the treatment of LPLD. The researchers identified AAV8 pVR59 as a superior vector compared to AAV1 (Glybera), with significantly better therapeutic effects at lower doses. AAV8 pVR59 treatment led to long-term correction of LPLD and improvement in pathology.
HUMAN GENE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: The study focused on evaluating the impact of HDL-2 and HDL-3 on VLDL degradation related to hypertriglyceridemia. The findings showed that HDL-3 had a significant effect on the composition and electrophoretic mobility of VLDL, compared to HDL-2.
Article
Immunology
Juan Carlos Quevedo-Abeledo, Candelaria Martin-Gonzalez, Carmen Ferrer-Moure, Laura de Armas-Rillo, Maria Vanesa Hernandez-Hernandez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: The ApoC3, ANGPLT4, and LPL axis is disrupted in patients with SLE, and disease damage is associated with elevated serum levels of LPL.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Margaret E. Hellard, Alisa Pedrana
Summary: Collaborating with local community organizations and using a pay-it-forward approach, Zhang et al. successfully increased hepatitis B and hepatitis C testing among men who have sex with men in China.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Fisheries
Yeyu Chen, Xiaoyun Wu, Jiansheng Lai, Ya Liu, Mingjiang Song, Feiyang Li, Quan Gong
Summary: In this study, two lipid metabolism-associated genes, LPL and apoE, were identified in Acipenser dabryanus, showing different expression patterns in fasting and refeeding experiments and being influenced by feeding frequency. These findings provide valuable insights into the regulation of nutrition in fish.
AQUACULTURE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Marissa Lightbourne, Megan Startzell, Kimberley D. Bruce, Brianna Brite, Ranganath Muniyappa, Monica Skarulis, Robert Shamburek, Ahmed M. Gharib, Ronald Ouwerkerk, Mary Walter, Robert H. Eckel, Rebecca J. Brown
Summary: This study found that volanesorsen can decrease apoC-III and triglycerides in patients with partial lipodystrophy, improve insulin resistance and hepatic steatosis through an LPL-dependent mechanism.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Iva Klobucar, Lucija Klobucar, Margarete Lechleitner, Matias Trbusic, Gudrun Pregartner, Andrea Berghold, Hansjoerg Habisch, Tobias Madl, Sasa Frank, Vesna Degoricija
Summary: This study found that the serum levels of endothelial lipase (EL) were associated with the serum levels and composition of apolipoprotein B (apoB)-containing lipoproteins, and these associations were different between metabolic syndrome (MS) patients and healthy volunteers (HVs). In MS patients, EL levels were negatively correlated with cholesterol levels in large very low-density lipoprotein (VLDL) particles, as well as with total-cholesterol, free-cholesterol, triglyceride, and phospholipid contents of VLDL and intermediate-density lipoprotein particles. In HVs, EL levels were positively correlated with the serum levels of apoB, triglycerides, and phospholipids in large low-density lipoprotein particles. These findings suggest that EL levels are influenced by MS and may play a role in lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Songqing Deng, Wenfang Zhong, Wen Chen, Zilian Wang
Summary: This study found that pregnant women with detectable hepatitis C virus (HCV) viral load are at increased risk of mother-to-child transmission (MTCT) of HCV, and the risk is even higher in those with a viral load >= 6 log(10) copies/mL. Coinfection with human immunodeficiency virus (HIV) further increases the risk of HCV MTCT.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Waqas A. Malick, Ron Do, Robert S. Rosenson
Summary: Severe hypertriglyceridemia (sHTG) is an important risk factor for acute pancreatitis and is caused by genetic defects. Novel pathway-specific therapeutics targeting LPL modulating proteins offer better efficacy in treating sHTG and reducing the risk of acute pancreatitis and atherosclerotic cardiovascular disease events.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Norah A. Terrault, Miriam T. Levy, Ka Wang Cheung, Gonzague Jourdain
Summary: The management of viral hepatitis in pregnancy requires special consideration due to the unique characteristics of each hepatitis virus and their impact on maternal and infant outcomes. Preventing mother-to-child transmission is crucial in reducing the global burden of chronic viral hepatitis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Virology
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
Summary: The life cycle of the hepatitis C virus can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. The replication of HCV genomic RNA is regulated by various factors and has led to the development of direct-acting antivirals targeting the replication complex.
Review
Virology
Ana Carolina Cardoso, Claudio Figueiredo-Mendes, Cristiane A. Villela-Nogueira, Patrick Marcellin
Summary: Staging liver fibrosis has always been a challenge in viral hepatitis and other liver diseases. Non-invasive tests have been developed to overcome the limitations of liver biopsy. This review discusses the use of serological and physical markers for liver fibrosis staging in chronic hepatitis B and C. Furthermore, it addresses the issue of evaluating liver fibrosis after HCV cure.
Review
Hematology
Cas J. Isfordink, Karel J. van Erpecum, Marc van Der Valk, Evelien P. Mauser-Bunschoten, Michael Makris
Summary: The introduction of clotting factor concentrates has greatly improved the lives of people with clotting factor deficiencies, but it also led to a significant epidemic of blood-borne viral infections. Fortunately, advancements in the safety of blood products and antiviral treatments have improved the prospects of patients with hemophilia.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Immunology
Peiju Tsai, Tze-Yu Lin, Shiang-Lin Cheng, Hung-Yu Sun, Sung-Fang Chen, Kung-Chia Young
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Chemistry, Medicinal
Antonio Coluccia, Michela Puxeddu, Marianna Nalli, Chih-Ku Wei, Yu-Hsuan Wu, Eloise Mastrangelo, Tasneem Elamin, Delia Tarantino, Joachim Jakob Bugert, Benno Schreiner, Juliane Nolte, Frank Schwarze, Giuseppe La Regina, Jin-Ching Lee, Romano Silvestri
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Yu-Chieh Su, Yi-Fang Huang, Yu-Wen Wu, Hui-Feng Chen, Yu-Hsuan Wu, Chia-Chun Hsu, Yao-Chin Hsu, Jin-Ching Lee
Article
Biochemistry & Molecular Biology
Yu-Tse Kao, Yi-Siao Chen, Kai-Wei Tang, Jin-Ching Lee, Chih-Hua Tseng, Cherng-Chyi Tzeng, Chia-Hung Yen, Yeh-Long Chen
Review
Engineering, Biomedical
Ya Li, Xiaonan Wang, Yuanyuan Han, Hung-Yu Sun, Jons Hilborn, Liyang Shi
Summary: Click chemistry is a versatile method for generating products that mimic natural examples, occurring in one pot with minimal byproducts and high thermodynamic driving force. It has become a useful tool for the bio-orthogonal preparation of chemical cross-linked biopolymer-based hydrogels, offering a variety of potential backbone toolboxes for hydrogel design in regenerative medicine.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Rebecca L. Pinals, Francis Ledesma, Darwin Yang, Nicole Navarro, Sanghwa Jeong, John E. Pak, Lili Kuo, Yung-Chun Chuang, Yu-Wei Cheng, Hung-Yu Sun, Markita P. Landry
Summary: Developing tools for rapid and accessible diagnosis of actively infected individuals, a SWCNT-based sensor functionalized with ACE2 was introduced for rapid SARS-CoV-2 detection. The sensor exhibited a robust 2-fold fluorescence increase within 90 minutes of exposure to the virus spike protein, showing potential for practical application in diagnostic settings. The study demonstrated the stability and sensing capacity of the ACE2-SWCNT nanosensors in various mediums, highlighting their potential as a rapid optical tool for COVID-19 detection.
Article
Virology
Wei-Chun Chen, Chih-Ku Wei, Monir Hossen, Yao-Chin Hsu, Jin-Ching Lee
Summary: This study demonstrated the potential of (E)-guggulsterone against DENV infection by stimulating Nrf2-mediated HO-1 expression, increasing antiviral interferon responses, and blocking DENV NS2B/3B protease activity. In vivo experiments showed that (E)-guggulsterone protected ICR suckling mice from life-threatening DENV infection with dose-dependent inhibitory effects on DENV protein synthesis and RNA replication without cytotoxicity. These findings suggest that (E)-guggulsterone may be a promising supplement for controlling DENV replication.
Article
Biology
Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young
Summary: In non-alcoholic fatty liver disease (NAFLD), hepatic ApoJ may activate sterol O-acyltransferase 2 to supply cholesteryl-ester for lipid loads, presenting a promising target for treating stress-induced steatosis. This study indicates an interplay between hepatic ApoJ, cholesterol esterification, and lipid deposition in response to NAFLD inducers. Serum ApoJ levels correlate positively with cholesterol and low-density lipoprotein levels in normal glycaemic HCV patients, NAFLD patients, and mice with steatosis.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Pin-Nan Cheng, Hung-Yu Sun, I-Che Feng, Yen-Cheng Chiu, Sin-Tian Wang, Dyoness Charmaine Tan, Hung-Chih Chiu, Shih-Chih Chien, Kung-Chia Young
Summary: This study evaluated the posttherapeutic benefits of lipid and glycemic homeostasis after direct-acting antiviral treatment for chronic hepatitis C. It was found that there was mutual modulation of blood lipids and glucose after treatment, and the changes in blood lipids and glucose were correlated with high-density lipoprotein cholesterol and insulin.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
Wei -Chun Chen, Chung-Hao Huang, Wangta Liu, Jin-Ching Lee
Summary: Dengue virus (DENV) infection is a life-threatening disease with no effective treatment options. However, a study found that sulforaphane (SFN) has significant antiviral activity against DENV by inducing heme oxygenase-1 (HO-1) expression and inhibiting viral protease activity. This suggests that SFN could be a promising candidate for treating DENV.
ANTIVIRAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shih-Han Wang, Yi-Siao Chen, Kuei-Hung Lai, Chung-Kuang Lu, Hsun-Shuo Chang, Ho-Cheng Wu, Feng-Lin Yen, Lo-Yun Chen, Jin-Ching Lee, Chia-Hung Yen
Summary: The extract of Prinsepiae Nux was identified as a potent NRF2 activator and showed potential in preventing UVB-induced skin damage.
Article
Chemistry, Medicinal
I-Wen Lo, Geng-You Liao, Jin-Ching Lee, Chi- Chang, Yang-Chang Wu, Yen-Yu Chen, Shang-Pin Liu, Huey-Jen Su, Chih- Liu, Chia-Yi Kuo, Zheng-Yu Lin, Tsung-Lin Li, Yun-Sheng Lin, Chia-Ching Liaw
Summary: Hybrid natural products produced through mixed biosynthetic pathways have complex structures and diverse medicinal properties. This study reports the discovery of four structurally attractive diterpene-alkaloid conjugates from the barks of Taiwanese Polyalthia longifolia, which exhibit promising anti-DENV2 activity. In vitro experiments and molecular docking analysis suggest that these compounds are novel and effective DENV NS2B-NS3 protease inhibitors.
Article
Multidisciplinary Sciences
Cong Wang, Xue Li, Binbin Xue, Changping Yu, Luoling Wang, Rilin Deng, Hui Liu, Zihao Chen, Yingdan Zhang, Suping Fan, Chaohui Zuo, Hungyu Sun, Haizhen Zhu, Jianli Wang, Songqing Tang
Summary: The study finds that RasGRP1 is a bifunctional regulator, promoting acute inflammation and inhibiting inflammation-associated cancer. At the mRNA level, Rasgrp1 activates the inflammatory response by functioning as a competing endogenous RNA to specifically promote IL-6 expression by sponging let-7a. At the protein level, RasGRP1 overexpression inhibits the tumor-promoting effect of IL-6 in hepatocellular carcinoma progenitor cell-like spheroids.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Shuangdi Duan, Jiayi Pi, Chun-Hsiang Wang, Yi-Chou Hou, Chung-Ying Andy Lee, Cheng-Jui Lin, Liyang Shi, Kung-Chia Young, Hung-Yu Sun
Summary: This study validated the comparable efficacy of the Leadgene ELISA kit to UPLC-MS/MS in quantifying serum IS levels, showing a perfect correlation between the IS levels determined by the two methods in CKD patients.
Article
Virology
Wei-Chun Chen, Monir Hossen, Wangta Liu, Chia-Hung Yen, Chung-Hao Huang, Yao-Chin Hsu, Jin-Ching Lee
Summary: Grape seed proanthocyanidins extract (GSPE) suppresses the replication of DENV and reduces the inflammatory response caused by DENV infection, indicating its potential as a dietary supplement to alleviate DENV infection and severe dengue.