Article
Gastroenterology & Hepatology
Angela Y. Lam, Jeffrey K. Lee, Sophie Merchant, Christopher D. Jensen, Mai Sedki, Douglas A. Corley
Summary: This retrospective case-control study examined the association between biopsy of non-tumor sites after colorectal cancer (CRC) biopsy and the risk of metachronous CRC. The study found no significant association between biopsy of non-tumor sites after CRC biopsy and the risk of metachronous CRC.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jesper Clausen Nielsen, Magnus Ploug, Gunnar Baatrup, Rasmus Kroijer
Summary: The study found no significant difference in post colonoscopy colorectal cancer occurrence between individuals with either no or low-risk adenomas in the Danish faecal occult blood test screening program. Instead, advancing age and higher faecal test value were associated with an increased risk of post colonoscopy colorectal cancer.
COLORECTAL DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Francesca Privitera, Rossella Gioco, Alba Ilari Civit, Daniela Corona, Simone Cremona, Lidia Puzzo, Salvatore Costa, Giuseppe Trama, Flavia Mauceri, Aurelio Cardella, Giuseppe Sangiorgio, Riccardo Nania, Pierfrancesco Veroux, Massimiliano Veroux
Summary: Kidney transplant recipients do not have an increased risk of developing colorectal cancer compared to the healthy population, but they have a higher risk of developing colorectal adenomas.
Article
Multidisciplinary Sciences
Chien-Hsien Lo, Yu-Hsun Wang, Chin-Feng Tsai, Kuei-Chuan Chan, Li-Ching Li, Tse-Hsien Lo, James Cheng-Chung Wei, Chun-Hung Su
Summary: In patients with systemic lupus erythematosus, hydroxychloroquine treatment did not significantly increase the risk of cardiac arrhythmia or life-threatening ventricular arrhythmia regardless of the different hydroxychloroquine treatment duration, drug adherence rate, or daily dose.
Article
Medicine, General & Internal
Szu-Chia Liao, Hong-Zen Yeh, Chi-Sen Chang, Wei-Chih Chen, Chih-Hsin Muo, Fung-Chang Sung
Summary: Women with gynecologic malignancy, especially endometrial and ovarian cancer, are at a higher risk of developing colorectal cancer. The incidence of CRC increases with age, and early cancer treatments may help reduce the risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Tanimola Martins, Gary Abel, Obioha C. Ukoumunne, Sarah Price, Georgios Lyratzopoulos, Frank Chinegwundoh, William Hamilton
Summary: This study examined the time to diagnosis among different ethnic groups in the UK for seven types of cancer. The results showed that ethnic minority groups experienced a longer time to diagnosis compared to the White group in five out of the seven cancers studied. However, these differences were small and unlikely to be the sole explanation for the disparities in cancer outcomes across ethnic groups.
Article
Cardiac & Cardiovascular Systems
Alejandro Suarez-Pierre, Cecillia Lui, Xun Zhou, Katherine Giuliano, Eric Etchill, Alejandro Almaraz-Espinoza, Todd C. Crawford, Charles D. Fraser III, Glenn J. Whitman, Chun W. Choi, Robert S. Higgins, Ahmet Kilic
Summary: This study compared the survival rates of heart transplant recipients with the general population and found that while heart transplant recipients have considerable long-term survival, their standardized long-term mortality rate is three times higher than that of the general population, with a downward trend over time.
ANNALS OF THORACIC SURGERY
(2021)
Article
Environmental Sciences
Tongchao Zhang, Xiaolin Yin, Xiaorong Yang, Ziyu Yuan, Qiyun Wu, Li Jin, Xingdong Chen, Ming Lu, Weimin Ye
Summary: This study investigated the association between 12 trace elements and gastroesophageal cancers (GOC) using hair and fingernail samples collected from GOC cases and controls in Taixing, China. The results showed that higher levels of Ca, Zn, Fe, Al, Cr, Pb, Se, and V were positively associated with increased GOC, while higher levels of Mg, Mn, Sr, and As were inversely associated with GOC. Interaction effects between hair level of Cr and smoking or alcohol drinking were also observed.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Yoon Suk Jung, Yongho Jee, Eui Im, Min-ho Kim, Chang Mo Moon
Summary: The study showed a significant association between bowel preparation and undergoing colonoscopy with the risk of atrial fibrillation (AF), especially in elderly patients with hypertension.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Surgery
Michael J. Horkoff, Zubir Ahmed, Yuan Xu, Francis R. Sutherland, Elijah Dixon, Chad G. Ball, Oliver F. Bathe
Summary: A retrospective cohort comparison study on incidentally discovered gallbladder cancer cases showed that bile spillage during cholecystectomy has adverse effects on patient outcomes, leading to higher incidence of peritoneal carcinomatosis, lower likelihood of radical re-resection, and shorter disease-free survival.
Article
Gastroenterology & Hepatology
Szu-Min Peng, Wen-Feng Hsu, Ying-Wei Wang, Li-Ju Lin, Amy Ming-Fang Yen, Li-Sheng Chen, Yi-Chia Lee, Ming-Shiang Wu, Tony Hsiu-Hsi Chen, Han-Mo Chiu
Summary: A study in the Taiwanese Colorectal Cancer Screening Program found that subjects with negative colonoscopy after positive FIT who received subsequent FIT screening had a significantly lower risk of incident CRC, suggesting that scheduling subsequent FIT is important in reducing the risk of missed neoplasms and incident CRC in a national FIT screening program.
Article
Hematology
Mark J. R. Smeets, Carolina E. Touw, Frits R. Rosendaal, Banne Nemeth, Suzanne C. Cannegieter
Summary: This study analyzed the influence of different surgical procedures on the risk of VTE. The results showed that although the VTE risk was generally low for most minor surgical procedures, venous stripping, open abdominal/inguinal hernia repair, and laparoscopic cholecystectomy were associated with a significantly increased risk of VTE within 90 postoperative days. These findings suggest the need for enhanced VTE prevention when performing these surgeries.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Oncology
Lennard Y. W. Lee, Thomas Starkey, Maria C. Ionescu, Martin Little, Michael Tilby, Arvind R. Tripathy, Hayley S. Mckenzie, Youssra Al-Hajji, Matthew Barnard, Liza Benny, Alexander Burnett, Emma L. Cattell, Jackie Charman, James J. Clark, Sam Khan, Qamar Ghafoor, George Illsley, Catherine Harper-Wynne, Rosie J. Hattersley, Alvin J. X. Lee, Pauline C. Leonard, Justin K. H. Liu, N. C. R. I. Consumer Forum, Matthew Pang, Jennifer S. Pascoe, James R. Platt, Vanessa A. Potter, Amelia Randle, Anne S. Rigg, Tim M. Robinson, Tom W. Roques, Rene L. Roux, Stefan Rozmanowski, Mark H. Tuthill, Isabella Watts, Sarah Williams, Tim Iveson, Siow Ming Lee, Gary Middleton, Mark Middleton, Andrew Protheroe, Matthew W. Fittall, Tom Fowler, Peter Johnson
Summary: This study evaluated the effectiveness of vaccines against breakthrough SARS-CoV-2 infections in patients with cancer. The results showed that the effectiveness of vaccines in cancer patients is lower compared to the general population.
Article
Gastroenterology & Hepatology
Yanis Dahel, Vanessa Cottet, Cyril Boisson, Sylvain Manfredi, Thibault Degand
Summary: This study aimed to evaluate compliance with French follow-up recommendations after high-risk colorectal adenoma removal and assess the impact of how information was given and if patients actually underwent their control colonoscopy according to the instructions. The results showed poor compliance with follow-up guidelines, with inappropriate intervals often being longer than recommended.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Fahima Dossa, Rinku Sutradhar, Refik Saskin, Eugene Hsieh, Pauline Henry, Devon P. Richardson, Pierre-Anthony Leake, Shawn S. Forbes, Lawrence F. Paszat, Linda Rabeneck, Nancy N. Baxter
Summary: Patient age and tumor location were associated with post-colonoscopy colorectal cancers (PCCRC), while endoscopist quality measures showed no significant association. There were no significant differences in overall survival between PCCRC and detected cancers. This study emphasizes the need for further research into tumor biology in PCCRC development.
COLORECTAL DISEASE
(2021)
Review
Public, Environmental & Occupational Health
Marko Mandic, Hengjing Li, Fatemeh Safizadeh, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to assess if and to what extent potential bias from prediagnostic weight loss has been considered in available epidemiological evidence on the BMI-CRC association. After searching for systematic reviews and meta-analyses, it was found that none of them thoroughly considered or discussed prediagnostic weight loss as a potential source of bias. Results from individual cohort studies included in the latest review were reported heterogeneously, but effect estimates mostly increased with increasing length of exclusion of initial years of follow-up. The impact of overweight and obesity on CRC risk may be larger than suggested by the existing epidemiological evidence.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Xuechen Chen, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister, Hermann Brenner
Summary: Colorectal cancer (CRC) has higher incidence and mortality rates in men compared to women. A study estimated the risk advancement periods (RAPs) for men compared to women to determine at what age men reach comparable levels of risk. The results showed that men had significantly higher CRC risk in the age groups 50-59 and 60-69, with RAPs as high as 8.7 and 6.2 years earlier, respectively. This suggests the need for gender-specific screening starting ages in countries where screening starts above age 50.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Genetics & Heredity
Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y. Brucker, Saundra S. Buys, Jose E. Castelao, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Wendy K. Chung, Sarah Colonna, Sten Cornelissen, Fergus J. Couch, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Laure Dossus, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guenel, Melanie Gundert, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Elaine F. Harkness, Patricia A. Harrington, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Dezheng Huo, Abctb Investigators, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K. Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka-Sabit, Allison W. Kurian, Ava Kwong, James Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A. Murphy, Heli Nevanlinna, William G. Newman, Dieter Niederacher, Katie M. O'Brien, Nadia Obi, Kenneth Offit, Olufunmilayo Olopade, Andrew F. Olshan, Hakan Olsson, Sue K. Park, Alpa Patel, Achal Patel, Charles M. Perou, Julian Peto, Paul D. P. Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U. Rashid, Gad Rennert, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Soo Hwang Teo, Lauren R. Teras, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejia, Melissa A. Troester, Therese Truong, Celine M. Vachon, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H. Wu, Taiki Yamaji, Xiaohong R. Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Douglas F. Easton, Harry Hemingway, Ute Hamann, Karoline B. Kuchenbaecker
Summary: This study identified 14 genes associated with breast cancer using gene-based aggregation analysis, including two newly discovered genes FMNL3 and AC058822.1. Furthermore, associations with established candidate genes like ESR1 were found through the collaboration of multi-ancestral cohorts, highlighting the importance of diversifying study cohorts. These findings provide new insights into the development of breast cancer.
Review
Oncology
Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nobrega Aoki, Martin Oliverius, Ludmila Vodickova, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamas Hussein, Beatrice Mohelnikova-Duchonova, Casper H. J. van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Perez, Martin Lovecek, Markus W. Buechler, Viktor Hlavac, Jakob R. Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Goetz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P. Neoptolemos, Lumir Kunovsky, Stig E. Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F. Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schoettker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Peter Hegyi, Luca Morelli, Niccolo Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C. Lindgaard, Frederik Dijk, Anna Caterina Milanettoj, Francesca Tavano, Klara Cervena, Balint Eross, Sabrina G. Testoni, Judith H. E. Verhagen-Oldenampsen, E. Malecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian
Summary: Pancreatic cancer is a deadly disease with few known risk factors and susceptibility loci. The rarity of the disease and lack of adequate research power have hindered progress in understanding its genetic mechanisms. However, the PANDoRA consortium, the largest in Europe, has made significant contributions in discovering susceptibility loci, which will be crucial in developing preventive strategies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lisa Pennells, Stephen Kaptoge, Helena Bleken Ostergaard, Stephanie H. Read, Fabrizio Carinci, Josep Franch-Nadal, Carmen Petitjean, Owen Taylor, Steven H. J. Hageman, Zhe Xu, Fanchao Shi, Sarah Spackman, Stefano Gualdi, Naomi Holman, Rui Bebiano Da Providencia E Costa, Fabrice Bonnet, Hermann Brenner, Richard F. Gillum, Stefan Kiechl, Deborah A. Lawlor, Louis Potier, Ben Schoettker, Reecha Sofat, Henry Voelzke, Johann Willeit, Zane Baltane, Stephen Fava, Sandor Janos, Astrid Lavens, Santa Pildava, Tamara Poljicanin, Ivan Pristas, Peter Rossing, Reiff Sascha, Christa Scheidt-Nave, Iztok Stotl, Gail Tibor, Vilma Urbancic-Rovan, An-Sofie Vanherwegen, Dorte Vistisen, Yong Du, Matthew R. Walker, Peter Willeit, Brian Ference, Dirk De Bacquer, Martin Halle, Radu Huculeci, John William McEvoy, Adam Timmis, Panagiotis Vardas, Jannick A. N. Dorresteijn, Ian Graham, Angela Wood, Bjorn Eliasson, William Herrington, John Danesh, Didac Mauricio, Massimo Massi Benedetti, Naveed Sattar, Frank L. J. Visseren, Sarah Wild, Emanuele Di Angelantonio, Beverley Balkau, Frederic Fumeron, Hannah Stocker, Bernd Holleczek, Sabine Schipf, Carsten Oliver Schmidt, Marcus Doerr, Herbert Tilg, Christoph Leitner, Marlene Notdurfter, Julie Taylor, Caroline Dale, David Prieto-Merino, Richard F. Gillum, Tamara Buble, Pero Ivanko, Bendix Carstensen, Christin Heidemann, Tibor Gall, Janos Sandor, Jana Lepiksone, Caroline J. Magri, Joseph Azzopardi, Jordi Real, Bogdan Vlacho, Manel Mata-Cases
Summary: The study aimed to develop and validate a recalibrated prediction model (SCORE2-Diabetes) for estimating the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. The model showed good discrimination and improvement over previous models, with risk predictions varying based on individuals' diabetes-related factors. SCORE2-Diabetes enhances the identification of individuals at higher risk of CVD in Europe.
EUROPEAN HEART JOURNAL
(2023)
Letter
Gastroenterology & Hepatology
Thomas Heisser, Michael Hoffmeister, Hermann Brenner
Article
Oncology
Rafael Cardoso, Michael Hoffmeister, Hermann Brenner
Summary: This study analyzed the key characteristics of breast cancer screening programs and mammography use in European countries. The findings showed significant variations in screening programs and mammography use across different countries, calling for improved utilization of mammography screening across Europe, especially in countries with lower development levels.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Michela C. Massi, Nicola R. Franco, Andrea Manzoni, Anna Maria Paganoni, Hanla A. Park, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Francesca Ieva, Paolo Zunino
Summary: Within the precision medicine framework, the stratification of individual genetic susceptibility based on inherited DNA variation is crucial. Traditional Polygenic Risk Scores (PRS) approaches face challenges in modeling complex high-order non-linear SNP-SNP interactions and their effect on the phenotype. In this study, we propose a novel approach called High-order Interactions-aware Polygenic Risk Score (hiPRS), which incorporates high-order interactions and provides a simple and interpretable model. Through comprehensive simulations and real data analysis, hiPRS demonstrates superior performance in scoring and interpretability compared to state of the art methods.
Letter
Oncology
Tobias Niedermaier, Elizabeth Alwers, Xuechen Chen, Thomas Heisser, Michael Hoffmeister, Hermann Brenner
CANCER COMMUNICATIONS
(2023)
Letter
Oncology
Megha Bhardwaj, Ben Schoettker, Bernd Holleczek, Hermann Brenner
CANCER COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Marko Mandic, Fatemeh Safizadeh, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner
Summary: In this population-based case-control study conducted in Germany, overweight and obesity were found to be associated with an increased risk of colorectal cancer (CRC), taking into account substantial prediagnostic weight loss. The study also revealed a positive association between BMI, overweight, obesity, and a 5-unit increase in BMI measured 8 to 10 years before diagnosis, and a negative association between weight loss and CRC risk.
Article
Cell Biology
Jan Moritz Niehues, Philip Quirke, Nicholas P. West, Heike I. Grabsch, Marko van Treeck, Yoni Schirris, Gregory P. Veldhuizen, Gordon G. A. Hutchins, Susan D. Richman, Sebastian Foersch, Titus J. Brinker, Junya Fukuoka, Andrey Bychkov, Wataru Uegami, Daniel Truhn, Hermann Brenner, Alexander Brobeil, Michael Hoffmeister, Jakob Nikolas Kather
Summary: Deep learning can predict microsatellite instability (MSI) from routine histopathology slides of colorectal cancer (CRC). It is unclear whether DL can also predict other biomarkers with high performance and whether DL predictions generalize to external patient populations.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Zhunzhun Liu, Melissa S. Y. Thong, Daniela Doege, Lena Koch-Gallenkamp, Linda Weisser, Heike Bertram, Andrea Eberle, Bernd Holleczek, Alice Nennecke, Annika Waldmann, Sylke Ruth Zeissig, Ron Pritzkuleit, Hermann Brenner, Volker Arndt
Summary: This study explores the relationship between benefit finding/posttraumatic growth and health-related quality of life in long-term cancer survivors. The results show that lower levels of benefit finding are associated with better quality of life, while posttraumatic growth is associated with role functioning and global health status/quality of life. These findings provide further evidence that benefit finding and posttraumatic growth are two distinct positive psychological concepts.
Article
Public, Environmental & Occupational Health
Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister
Summary: Randomized trials on screening endoscopy for colorectal cancer have shown modest reduction in risk, but these estimates include prevalent cases that cannot be prevented by screening. This violates the principle of only including at-risk individuals in preventive measures. Using the NordICC trial as an example, accounting for prevalence bias increases the effect estimates to be more in line with observational studies, highlighting the need for methodological work in future screening studies.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)