Article
Gastroenterology & Hepatology
Soichiro Matsuda, Mototsugu Kato, Yuko Sakakibara, Hiroshige Hamada, Yoshihiro Sasaki, Hideki Mori, Yuichiro Hirai, Shuji Inoue, Tatsuya Toyokawa, Takashi Kagaya, Toshio Kuwai, Naoki Esaka, Haruhiro Yamashita, Noriko Watanabe, Mio Matsumoto, Hiroyuki Fujii, Mamiko Demura, Kimitoshi Kubo, Katsuhiro Mabe, Naohiko Harada
Summary: This study demonstrates that administering vonoprazan once every second day is an effective alternative to proton pump inhibitors in the maintenance treatment of erosive GERD.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
C. Prakash Gyawali, Rena Yadlapati, Ronnie Fass, David Katzka, John Pandolfino, Edoardo Savarino, Daniel Sifrim, Stuart Spechler, Frank Zerbib, Mark R. Fox, Shobna Bhatia, Nicola de Bortoli, Yu Kyung Cho, Daniel Cisternas, Chien-Lin Chen, Charles Cock, Albis Hani, Jose Maria Remes Troche, Yinglian Xiao, Michael F. Vaezi, Sabine Roman
Summary: The Lyon Consensus 2.0 provides conclusive criteria for diagnosing gastro-oesophageal reflux disease (GERD) and offers additional metrics to support or refute the diagnosis when primary criteria are inconclusive. A global team evaluated research since the original Lyon Consensus and collaborated on developing statements to update criteria. The updated consensus includes a modern definition of actionable GERD, describes the likelihood of symptoms being related to reflux episodes, and provides diagnostic strategies and testing options based on proven or unproven GERD.
Article
Gastroenterology & Hepatology
Manar Yanes, Giola Santoni, John Maret-Ouda, Sheraz Markar, Eivind Ness-Jensen, Joonas Kauppila, Martti Farkkila, Elsebeth Lynge, Eero Pukkala, Laufey Tryggvadottir, My Von Euler-Chelpin, Jesper Lagergren
Summary: The study reveals that laparoscopic antireflux surgery has a favorable safety profile in the treatment of gastro-esophageal reflux disease, especially in younger patients without severe comorbidity who undergo surgery at high-volume centers.
Article
Biochemistry & Molecular Biology
Xu Han, Yawen Zhang, Allen Lee, Zhaoshen Li, Jun Gao, Xiaoyin Wu, Jiulong Zhao, Hui Wang, Di Chen, Duowu Zou, Chung Owyang
Summary: This study found that the expression of ASIC1 and 3 is increased in GERD patients and rodent models of reflux esophagitis and non-erosive reflux disease. In addition, it was observed that DRG neurons from RE animals showed hyperexcitability. However, the injection of ASIC specific inhibitors and silencing of ASIC1 and 3 genes prevented visceral hypersensitivity. These results suggest that upregulation of ASIC1 and 3 may contribute to visceral hypersensitivity in GERD.
Article
Gastroenterology & Hepatology
Elisa Blasi, Ettore Stefanelli, Renato Tambucci, Silvia Salvatore, Paola De Angelis, Paolo Quitadamo, Claudia Pacchiarotti, Giovanni Di Nardo, Fanj Crocco, Enrico Felici, Valentina Giorgio, Nicoletta Staropoli, Simona Sestito, Efstratios Saliakellis, Osvaldo Borrelli, Licia Pensabene
Summary: This study investigated the prevalence of pediatric non-erosive esophageal phenotypes (NEEPs) and their treatment response. The results showed that functional heartburn may be the most common pediatric NEEP. Long-term follow-up revealed a higher rate of symptom resolution with proton pump inhibitor (PPI) therapy in non-erosive reflux disease (NERD) patients, while other groups did not benefit from extended acid-suppressive treatment.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Nutrition & Dietetics
Yang Chen, Xiaohong Sun, Wenjuan Fan, Jiao Yu, Peng Wang, Dong Liu, Mingwei Song, Shi Liu, Xiuli Zuo, Rong Zhang, Yuantao Hou, Shaomei Han, Yanqing Li, Jun Zhang, Xiaoqing Li, Meiyun Ke, Xiucai Fang
Summary: This study compared dietary and lifestyle triggers between non-erosive reflux disease (NERD) and reflux esophagitis (RE) in Chinese patients and provided evidence for practical dietary modifications for GERD.
Review
Gastroenterology & Hepatology
Rena Yadlapati, C. Prakash Gyawali, John E. Pandolfino
Summary: This review outlines a personalized diagnostic and therapeutic approach to GERD symptoms and provides detailed recommendations for clinical practice.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Physiology
Jiankang Wu, Yiming Ma, Yan Chen
Summary: GERD is a prevalent medical condition that can cause chronic cough. The underlying molecular mechanism behind GER-related chronic cough (GERC) is still unclear. Different theories, such as reflux theory, reflex theory, airway allergies, and esophageal motility disorders, are linked to GERC. Multichannel intraluminal impedance combined with pH monitoring is the gold standard for diagnosing GERC, but it is invasive and not well tolerated by patients. Recent discoveries in impedance markers and techniques show promise for the diagnosis of GERD, but further investigation is needed for GERC. Advances in pharmacological and non-pharmacological treatments provide more options for managing GERC.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Francesco Saverio Ludovichetti, Giulia Zambon, Matteo Cimolai, Matteo Gallo, Anna Giulia Signoriello, Luca Pezzato, Rachele Bertolini, Sergio Mazzoleni
Summary: This study compared the effectiveness of two different toothpastes in preventing enamel erosion caused by gastroesophageal reflux disease. It found that fluoride toothpaste offered greater remineralization after the first acid attack, but there was no difference in long-term prevention.
APPLIED SCIENCES-BASEL
(2022)
Review
Allergy
Meghan D. Althoff, Alexander Ghincea, Lisa G. Wood, Fernando Holguin, Sunita Sharma
Summary: Asthma is a complex disease with heterogeneous phenotypes and endotypes. Common comorbidities such as obesity, obstructive sleep apnea, and gastroesophageal reflux disease may share inflammatory pathways and worsen asthma control.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Gastroenterology & Hepatology
Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler
Summary: This study found that vonoprazan, a potassium-competitive acid blocker, was noninferior and superior to the PPI lansoprazole in healing and maintenance of erosive esophagitis, particularly in patients with more severe cases.
Article
Surgery
Zia Kanani, Jon C. Gould
Summary: Laparoscopic fundoplication is the standard treatment for medically refractory gastroesophageal reflux disease. While both primary and reoperative fundoplication patients experience improvement in GERD-related symptoms, the degree of improvement is greater in primary patients. Perioperative morbidity rates following reoperative and primary procedures can be similar when performed by an experienced surgeon.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Anna N. Ibele, Peter Nau, Carlos Galvani, J. Scott F. Roth, Ross S. Goldberg, Marina Kurian, Leena Khaitan, Jon K. Gould, Yagnik Pandya, SAGES Foregut Taskforce
Summary: In this study, it was found that many surgeons choose RYGB surgery to treat refractory GERD. However, insurance coverage for RYGB surgery is often restricted due to policy limitations, making it difficult for patients to access the procedure. Therefore, advocacy is necessary to improve the accessibility of surgical treatment for GERD in obese patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Vivian L. Wang, Anahita D. Jalilvand, Anand Gupta, Jennwood Chen, Chaitanya Vadlamudi, Kyle A. Perry
Summary: In this retrospective study, it was found that smokers and non-smokers who underwent LARS surgery had similar outcomes in terms of symptom resolution, PPI cessation rates, and satisfaction with the surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Mohamad Rassoul Abu-Nuwar, Sven E. Eriksson, Inanc S. Sarici, Ping Zheng, Toshitaka Hoppo, Blair A. Jobe, Shahin Ayazi
Summary: Peroral endoscopic myotomy (POEM) is effective for achalasia, but postoperative gastroesophageal reflux disease (GERD) is a major concern. This study aimed to characterize post-POEM GERD and identify factors influencing its development and severity. Results showed that 38.8% of patients had subjective GERD symptoms, 50.5% had objective GERD, and 19.2% had severe objective GERD.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
