Article
Gastroenterology & Hepatology
Ayaka Tajiri, Ryu Ishihara, Hirohisa Sakurai, Takahiko Nakamura, Yasuhiro Tani, Takahiro Inoue, Katsunori Matsueda, Muneaki Miyake, Kotaro Waki, Hiromu Fukuda, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Tomoki Michida, Takashi Matsunaga
Summary: The activation patterns of alcohol-metabolizing enzymes are associated with the age at onset of esophageal squamous cell carcinoma, lesion location, and metachronous esophageal squamous cell carcinoma and head and neck squamous cell carcinoma. Different approaches to the prophylaxis and treatment of esophageal cancer should be considered based on the enzyme activity pattern.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ju Eun Seol, Jeongseon Kim, Bong-Hwa Lee, Dae-Yong Hwang, Jinyoung Jeong, Hun-Jae Lee, Yoon-Ok Ahn, Jung Eun Lee, Dong-Hyun Kim
Summary: This study found that alcohol intake increased the risk of colorectal cancer in East Asian populations, and there may be an interaction between ALDH2 gene and methyl diets, where a low methyl diet increased the risk of CRC among individuals with the ALDH2 A allele.
PUBLIC HEALTH NUTRITION
(2021)
Article
Oncology
Chang Kyun Choi, Min-Ho Shin, Sang-Hee Cho, Hye-Yeon Kim, Wei Zheng, Jirong Long, Sun-Seog Kweon
Summary: This study found that the ALDH2 rs671 genotype related to alcohol consumption was associated with a reduced risk of colorectal cancer in men, especially among regular drinkers. However, the ADH1B rs1229984 genotype showed no significant association with colorectal cancer risk. The combined genotype with the highest genetically predicted alcohol consumption was associated with a higher risk for colorectal cancer.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Ting-Gang Chang, Ting-Ting Yen, Chia-Yi Wei, Tzu-Hung Hsiao, I-Chieh Chen
Summary: This study aimed to evaluate the associations of ADH1B rs1229984 and ALDH2 rs671 with the risks of alcohol-related disorder and cancer. The results showed significant additive and synergic risks of these genetic variants for alcohol-related disorders and cancer. It is recommended to advise high-risk individuals carrying these variants to reduce alcohol consumption as a preventive measure.
Article
Medicine, General & Internal
Kelly C. Young-Wolff, Tara R. Foti, Andrea Green, Andrea Altschuler, Monique B. Does, Melanie Jackson-Morris, Sara R. Adams, Deborah Ansley, Amy Conway, Nancy Goler, Maha N. Mian, Esti Iturralde
Summary: As rates of prenatal cannabis use increase and cannabis legalization spreads across the US, this qualitative study aimed to understand pregnant individuals' perspectives on the legalization of cannabis for adult use in California. The findings suggest that legalization has made it easier for pregnant individuals to access cannabis, reduced stigma, and encouraged discussions about prenatal cannabis use with healthcare practitioners. However, opinions regarding the impact of retailer marketing, advertising, and concerns about Child Protective Services involvement varied.
Article
Cell Biology
Bolun Cheng, Jian Yang, Shiqiang Cheng, Chuyu Pan, Li Liu, Peilin Meng, Xuena Yang, Wenming Wei, Huan Liu, Yumeng Jia, Yan Wen, Feng Zhang
Summary: This study examines the association between HLA alleles and depression and anxiety and identifies significant HLA alleles associated with self-reported depression and anxiety scores. It also reveals the interaction effects of HLA alleles with environmental factors on the risk of depression and anxiety.
Article
Microbiology
Wenqing Rao, Zheng Lin, Shuang Liu, Zhihui Zhang, Qianwen Xie, Huilin Chen, Xi Lin, Yuanmei Chen, Huimin Yang, Kaili Yu, Zhijian Hu
Summary: Alcohol consumption is associated with alterations in both the diversity and composition of the oesophageal microbiota in ESCC patients. Specific bacteria related to alcohol consumption in ESCC patients were identified, with differences observed in the diversity and abundance of microbiota. The relative abundance of certain bacterial genera was found to be affected by the frequency and years of alcohol consumption in ESCC patients.
Article
Multidisciplinary Sciences
Supa Pengpid, Karl Peltzer
Summary: This study aimed to evaluate the prevalence and correlates of current tobacco use, heavy drinking, and both behaviors in Mongolia from 2009 to 2019. The results showed an increase in tobacco use prevalence and a decrease in heavy drinking and combined tobacco use and heavy drinking. Factors such as gender, age, physical activity, urban residence, obesity, and hypertension were associated with these behaviors.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Liza D. Morales, Douglas T. Cromack, Devjit Tripathy, Marcel Fourcaudot, Satish Kumar, Joanne E. Curran, Melanie Carless, Harald H. H. Goring, Shirley L. Hu, Juan Carlos Lopez-Alvarenga, Kristina M. Garske, Paeivi Pajukanta, Kerrin S. Small, Craig A. Glastonbury, Swapan K. Das, Carl Langefeld, Robert L. Hanson, Wen-Chi Hsueh, Luke Norton, Rector Arya, Srinivas Mummidi, John Blangero, Ralph A. DeFronzo, Ravindranath Duggirala, Christopher P. Jenkinson
Summary: The expression of ADH1B is inversely correlated with BMI in Mexican Americans, African Americans, Europeans, and Pima Indians, with BMI increasing as ADH1B expression decreases. ADH1B plays a crucial role in the development and metabolic activity of adipose tissues, which is suppressed by obesity.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yukihiro Sugimoto, Yuriko N. Koyanagi, Yukino Kawakatsu, Isao Oze, Yukari Taniyama, Yumiko Kasugai, Tsutomu Tanaka, Tetsuya Abe, Masahiro Tajika, Yasuhiro Shimizu, Hidemi Ito, Kenji Wakai, Keitaro Matsuo
Summary: Alcohol is metabolized to acetaldehyde and acetate through the actions of alcohol dehydrogenase and aldehyde dehydrogenase. The ADH1B rs1229984 polymorphism is associated with drinking habits and the risk of esophageal cancer. Mediation analysis showed that this genetic variant increases the risk of esophageal cancer by affecting alcohol metabolism and drinking intensity.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ngoc Minh Luu, Thi Tra Bui, Thi Phuong Thao Tran, Thi Huyen Trang Nguyen, Jin-Kyoung Oh
Summary: The study aimed to identify latent classes based on lifestyle behavior trajectories and investigate their association with cancer risk. The research found that only a small percentage of participants maintained a long-term healthy lifestyle, highlighting the importance of linking behavior combinations to cancer prevention.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Biao Zhang, Yu-Hui Peng, Yun Luo, Chao-Qun Hong, Yi-Wei Lin, Yu-Ling Zhang, Yi-Wei Xu, Xue-Fen Su, Fang-Cai Wu
Summary: This meta-analysis study found that ADH1B rs1229984 is significantly associated with an increased risk of ESCC.
Article
Public, Environmental & Occupational Health
Alexander B. Barker, John Britton, Emily Thomson, Rachael L. Murray
Summary: The research found that tobacco was rare in soap operas, but alcohol content was common, potentially influencing the consumption behavior of young people.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Seo Yeon Yoon, You Hyun Park, Hyo Jeong Lee, Dae Ryong Kang, Yong Wook Kim
Summary: This study found associations between lifestyle factors and the development of Parkinson's disease (PD) in a Korean population. Smoking had an inverse association with PD in men, while alcohol consumption and physical activity were related to reduced PD development in both sexes. Regular health screening showed a consistent relationship between lifestyle factors and PD development, while lifestyle factors in those without regular health screening had a decreased relationship with PD.
Article
Psychology, Developmental
Gretchen R. B. Saunders, Matt McGue, William G. Iacono, Scott Vrieze
Summary: Variation in ALDH2 and ADH1B genes strongly affect alcohol use and dependence. This study used an adoption design to examine the causal role of alcohol use on other drug use, as well as the moderating role of adoptive parent, sibling, and peer alcohol use. The findings suggest that ALDH2 has protective effects on alcohol use, with the magnitude of the effect increasing with age. Peer alcohol use was a significant predictor of adopted individuals' alcohol use, while parent and sibling use did not have a significant impact. There was no strong evidence of associations between ALDH2 status and tobacco, marijuana, or illegal drug use.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Oncology
Shinya Kidogami, Tomohiro Iguchi, Kuniaki Sato, Yukihiro Yoshikawa, Quingjang Hu, Sho Nambara, Hisateru Komatsu, Masami Ueda, Yosuke Kuroda, Takaaki Masuda, Masaki Mori, Yuichiro Doki, Koshi Mimori
ANTICANCER RESEARCH
(2020)
Article
Oncology
Shuhei Ito, Takaaki Masuda, Miwa Noda, Qingjiang Hu, Dai Shimizu, Yosuke Kuroda, Hidetoshi Eguchi, Taro Tobo, Tohru Utsunomiya, Koshi Mimori
Article
Multidisciplinary Sciences
Atsushi Niida, Takanori Hasegawa, Hideki Innan, Tatsuhiro Shibata, Koshi Mimori, Satoru Miyano
Article
Multidisciplinary Sciences
Hirofumi Omori, Miki Nishio, Muneyuki Masuda, Yosuke Miyachi, Fumihito Ueda, Takafumi Nakano, Kuniaki Sato, Koshi Mimori, Kenichi Taguchi, Hiroki Hikasa, Hiroshi Nishina, Hironori Tashiro, Tohru Kiyono, Tak Wah Mak, Kazuwa Nakao, Takashi Nakagawa, Tomohiko Maehama, Akira Suzuki
Article
Genetics & Heredity
Shotaro Sakimura, Satoshi Nagayama, Mitsuko Fukunaga, Qingjiang Hu, Akihiro Kitagawa, Yuta Kobayashi, Takanori Hasegawa, Miwa Noda, Yuta Kouyama, Dai Shimizu, Tomoko Saito, Atsushi Niida, Yusuke Tsuruda, Hajime Otsu, Yoshihiro Matsumoto, Hiroki Uchida, Takaaki Masuda, Keishi Sugimachi, Shin Sasaki, Kazutaka Yamada, Kazuki Takahashi, Hideki Innan, Yutaka Suzuki, Hiromi Nakamura, Yasushi Totoki, Shinichi Mizuno, Masanobu Ohshima, Tatsuhiro Shibata, Koshi Mimori
Summary: This study revealed the significant role of copy number aberrations in cancer evolution, as well as the importance of neoantigens and diverse T cell receptor repertoire in postoperative recurrence. The comparison of driver mutations and immune response-related molecules between early and metastatic sites showed differences, and the postoperative recurrence was associated with neoantigen levels and TCR diversity in the metastatic sites.
Article
Oncology
Atsushi Fujii, Takaaki Masuda, Michio Iwata, Taro Tobo, Hiroaki Wakiyama, Kensuke Koike, Keisuke Kosai, Takafumi Nakano, Shotaro Kuramitsu, Akihiro Kitagawa, Kuniaki Sato, Yuta Kouyama, Dai Shimizu, Yoshihiro Matsumoto, Tohru Utsunomiya, Takao Ohtsuka, Yoshihiro Yamanishi, Masafumi Nakamura, Koshi Mimori
Summary: The study identified ASAP2 as a novel driver gene in PDAC, with high expression contributing to a poor prognosis and promoting tumor growth by facilitating cell cycle progression. Niclosamide, repositioned as a drug targeting the ASAP2 pathway, suppresses PDAC growth by inhibiting ASAP2 expression.
Article
Oncology
Hidenari Hirata, Atsushi Niida, Nobuyuki Kakiuchi, Ryutaro Uchi, Keishi Sugimachi, Takaaki Masuda, Tomoko Saito, Shun-Ichiro Kageyama, Yushi Motomura, Shuhei Ito, Tadamasa Yoshitake, Daisuke Tsurumaru, Yusuke Nishimuta, Akira Yokoyama, Takanori Hasegawa, Kenichi Chiba, Yuichi Shiraishi, Junyan Du, Fumihito Miura, Masaru Morita, Yasushi Toh, Masakazu Hirakawa, Yoshiyuki Shioyama, Takashi Ito, Tetsuo Akimoto, Satoru Miyano, Tatsuhiro Shibata, Masaki Mori, Yutaka Suzuki, Seishi Ogawa, Kousei Ishigami, Koshi Mimori
Summary: A study sequencing 52 tumor samples from 33 ESCC patients who received radiotherapy combined with 5-fluorouracil/platinum revealed the impact of chemoradiotherapy on clonal evolution, with MYC gain potentially serving as a marker for therapy resistance. The findings enhance understanding of therapeutic resistance and support the rationale for precision chemoradiotherapy.
Article
Oncology
Kuniko Sunami, Hideaki Bando, Yasushi Yatabe, Yoichi Naito, Hideaki Takahashi, Katsuya Tsuchihara, Shinichi Toyooka, Koshi Mimori, Shinji Kohsaka, Hiroyuki Uetake, Ichiro Kinoshita, Keigo Komine, Masayuki Takeda, Tetsu Hayashida, Kenji Tamura, Kazuto Nishio, Noboru Yamamoto
Summary: Comprehensive genomic profiling (CGP) is increasingly used in Japan for the clinical management of solid cancers, with some restrictions such as patient eligibility and opportunities for testing. The implementation of CGP based on plasma circulating tumor DNA (ctDNA) may raise issues regarding the selection and use of tissue DNA and ctDNA CGP.
Article
Oncology
Takaaki Masuda, Osamu Niizeki, Takashi Niizeki, Kenji Fujiyoshi, Yuki Ando, Hiroshi Niizeki, Koshi Mimori
Summary: This case describes a MBC patient with predominant liver metastases who declined systemic therapy and opted for hepatic arterial infusion chemotherapy (HAIC), showing partial response or stable disease in the liver and slow progression in other sites, surviving for 1 year and 3 months. The study suggests that HAIC may be a therapeutic option for advanced breast cancer patients with liver metastases who cannot tolerate systemic therapy.
CASE REPORTS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hajime Otsu, Sho Nambara, Qingjiang Hu, Yuichi Hisamatsu, Takeo Toshima, Kazuki Takeishi, Yusuke Yonemura, Takaaki Masuda, Eiji Oki, Koshi Mimori
Summary: The study aimed to identify individuals at high risk of gastric cancer by detecting microRNAs (miRNA) in the blood as biomarkers. Specific miRNA combinations may serve as promising biomarkers for precancerous lesions in gastric cancer.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Satoshi Nagayama, Yuta Kobayashi, Mitsuko Fukunaga, Shotaro Sakimura, Keishi Sugimachi, Shin Sasaki, Takaaki Masuda, Ken-ichi Mafune, Masanobu Oshima, Tatsuhiro Shibata, Yutaka Suzuki, Koshi Mimori
Summary: The detection and sequencing of mutated ctDNA is essential in postoperative management of colorectal cancer (CRC). This study conducted target resequencing of ctDNA and found that mutated genes in ctDNA indicated immune-resistance traits due to the loss of neoantigen presentation in primary CRC tumors. Therefore, ctDNA mutations can be frequently detected postoperatively to identify recurrence, but they come from immune-tolerated clones.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori
Summary: The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) remain poorly understood. This study investigates the importance of events occurring at the invasion front for CRC treatment strategies. The findings highlight the signaling between CRC cell populations and stromal cell populations, specifically at the invasion front.
Review
Gastroenterology & Hepatology
Masaaki Iwatsuki, Chihiro Matsumoto, Koshi Mimori, Hideo Baba
Summary: Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare familial gastric cancer syndrome caused by a mutation in the APC gene. Treatment involves standard methods for gastric cancer, with prognosis depending on the presence of distant metastasis and the use of total gastrectomy. Prophylactic total gastrectomy is recommended in cases of dysplasia, but careful consideration of the patient's background is necessary. Currently, there are no guidelines for screening, timing of prophylactic total gastrectomy, or endoscopic surveillance for GAPPS.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Editorial Material
Gastroenterology & Hepatology
Koshi Mimori
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Oncology
Hirofumi Ohmura, Taro Tobo, Koshi Mimori, Eishi Baba, Takahiko Horiuchi
Summary: We report a case of colon neuroendocrine carcinoma (NEC) that developed Trousseau's syndrome. The patient experienced disease progression after multiple lines of therapy and ultimately died due to worsening condition.
CASE REPORTS IN ONCOLOGY
(2023)
