Article
Nutrition & Dietetics
Hugo A. Penny, Anupam Rej, Elisabeth M. R. Baggus, Sarah. H. Coleman, Rosalie Ward, Graeme Wild, Gerd Bouma, Nick Trott, John A. Snowden, Josh Wright, Simon S. Cross, Marios Hadjivassiliou, David S. Sanders
Summary: This study characterized the causes of non-responsive coeliac disease (NRCD) and provided contemporary mortality data in refractory coeliac disease (RCD). The study also found a high frequency of positive urine gluten immunogenic peptides (GIPs) in patients with RCD1, suggesting common gluten exposure in this group.
Article
Medicine, General & Internal
Anupam Rej, David S. Sanders
Summary: Coeliac disease is a common autoimmune-mediated gastrointestinal disorder with a prevalence of around 1%, but many cases remain undiagnosed. The cornerstone of management is strict adherence to a gluten-free diet with support and education from a gastrointestinal dietitian, sometimes requiring re-evaluation of symptoms and repeat biopsies. Refractory CD affects a small subset of individuals and requires specialist intervention.
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, David S. Sanders, Paola Baiardi, Giacomo Caio, Carolina Ciacci, Katri Kaukinen, Benjamin Lebwohl, Daniel Leffler, Georgia Malamut, Joseph A. Murray, Kamran Rostami, Alberto Rubio-Tapia, Umberto Volta, Federico Biagi
Summary: This study achieved a consensus on the definitions and diagnostic criteria for seronegative coeliac disease and chronic non-coeliac enteropathies in adults through the Delphi process.
Review
Nutrition & Dietetics
Anna Szaflarska-Poplawska
Summary: Potential celiac disease (PCD) is a heterogeneous disease with few accurate prognostic factors for progression. Therapeutic decisions should be individualized, and patients with clinical gastroenterological symptoms may benefit from a gluten-free diet.
Article
Surgery
Marine Bordet, Philippe Tresson, Ugo Huvelle, Anne Long, Guillaume Passot, Charlotte Bergoin, Patrick Lermusiaux, Antoine Millon, Nellie Della Schiava
Summary: This study aimed to evaluate the prognosis of asymptomatic superior mesenteric artery (SMA) stenosis according to the presence of associated coeliac artery (CA) and/or inferior mesenteric artery (IMA) stenosis. The results suggest that patients with SMA stenosis associated with other arterial stenosis have a higher risk of developing mesenteric ischaemia, emphasizing the importance of cardiovascular risk factor assessment and optimization of medical treatment for these patients.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Gastroenterology & Hepatology
Fabiana Zingone, Stiliano Maimaris, Renata Auricchio, Giacomo Pietro Ismaele Caio, Antonio Carroccio, Luca Elli, Ermenegildo Galliani, Marco Montagnani, Flavio Valiante, Federico Biagi
Summary: These guidelines provide practical guidance for the diagnosis, management, and follow-up of coeliac patients and dermatitis herpetiformis in children and adults, aiming to improve clinicians' ability to diagnose and manage patients with coeliac disease.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Multidisciplinary Sciences
Lorenzo Falsetti, Matteo Rucco, Marco Proietti, Giovanna Viticchi, Vincenzo Zaccone, Mattia Scarponi, Laura Giovenali, Gianluca Moroncini, Cinzia Nitti, Aldo Salvi
Summary: The study utilized topological data analysis and machine learning techniques to identify risk factors for therapeutic failure, stroke/TIA, and major bleeding in critically ill patients with pre-existing atrial fibrillation. Specific risk factors were identified and dedicated clinical prediction models were successfully engineered, accurately predicting clinical outcomes for these patients.
SCIENTIFIC REPORTS
(2021)
Review
Health Care Sciences & Services
Annie Massart, Daniel P. Hunt
Summary: Internists often face the challenge of managing patients with chronic breathlessness, which can significantly impact patients' quality of life and mental health. Recent research covers a variety of interventions for managing breathlessness, including non-pharmacologic and pharmacologic options that should be considered holistically.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Flavia Persechino, Gloria Galli, Severino Persechino, Francesco Valitutti, Letizia Zenzeri, Angela Mauro, Vito Domenico Corleto, Pasquale Parisi, Chiara Ziparo, Melania Evangelisti, Giovanna Quatrale, Giovanni Di Nardo
Summary: Celiac disease is an immune-mediated enteropathy caused by gluten ingestion, affecting approximately 1% of the worldwide population. Extraintestinal symptoms, such as dermatitis herpetiformis, may be the first signs of CD. The role of a gluten-free diet is crucial for improving symptoms associated with CD, including skin manifestations.
Article
Gastroenterology & Hepatology
Anais Levescot, Georgia Malamut, Nadine Cerf-Bensussan
Summary: Coeliac disease is an immune enteropathy induced by genetic and environmental factors. The antigluten immune response and epithelial damage are key events in its pathogenesis, with the JAK/STAT pathway playing a crucial role. However, there are still many unanswered questions and challenges, such as the variability of the disease and improving the patients' quality of life.
Article
Gastroenterology & Hepatology
Michal Kori, Yonatan Zamir, Sami Or Yermiyahu, Inessa Ainbinder, Svetlana Daichman, Gavriel David Pinto, Yiska Loewenberg Weisband, Shira Greenfeld, Revital Kariv, Natan Lederman, Eran Matz, Raanan Shamir, Iris Dotan, Dan Turner
Summary: This study found that the prevalence of coeliac disease (CeD) and coeliac autoimmunity (CeA) is higher in patients with inflammatory bowel diseases (IBD), especially in paediatric-onset IBD and Crohn's disease (CD). The diagnosis of CeD usually precedes the diagnosis of IBD, and patients with both IBD and CeD receive more intensified treatment for IBD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Multidisciplinary Sciences
Moritz Kleinjans, Carolin Schneider, Tony Bruns, Pavel Strnad
Summary: Coeliac disease (CeD) shares similarities in morbidity and mortality with Crohn's disease (CD) and ulcerative colitis (UC), while the specific conditions of CeD may be driven by both inherited and acquired factors.
SCIENTIFIC REPORTS
(2022)
Review
Gastroenterology & Hepatology
Pilvi Laurikka, Laura Kivela, Kalle Kurppa, Katri Kaukinen
Summary: The systemic consequences of coeliac disease have a significant impact on the overall health of patients, affecting multiple organ systems including skeletal, reproductive, cardiovascular, and neurological systems. Early diagnosis and treatment with a gluten-free diet are beneficial for most conditions, but potential negative metabolic and psychosocial effects should be considered.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Denis Chang, Delia O'Shea, Amelie Therrien, Jocelyn A. Silvester
Summary: Coeliac disease, previously considered a childhood disease, can now occur in genetically susceptible individuals of any age. While HLA genotypes play a strong predictive role, other triggers of coeliac disease autoimmunity and their effects in adulthood are still not well-known. Understanding the factors leading to coeliac disease can aid in the management of potential coeliac disease patients and improve diagnostic and management approaches at different developmental stages.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Rheumatology
David R. Jayne, Juergen Steffgen, Juanita Romero-Diaz, Ingeborg Bajema, Dimitrios T. Boumpas, Kajohnsak Noppakun, Hirofumi Amano, Harold Michael Gomez, Bancha Satirapoj, Yingyos Avihingsanon, Ratana Chawanasuntorapoj, Magdalena Madero, Beata Naumnik, Rhona Recto, Nora Fagan, Ivette Revollo, Jing Wu, Sudha Visvanathan, Richard Furie
Summary: This study aimed to investigate the dose-response relationship of the anti-CD40 monoclonal antibody BI 655064 in patients with active lupus nephritis (LN). The results showed no dose-response relationship for the primary endpoint of complete renal response (CRR) at week 52; however, post hoc analyses suggested a potential benefit of BI 655064 180 mg in patients with active LN.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
I. A. Hujoel, C. T. Van Dyke, T. Brantner, J. Larson, K. S. King, A. Sharma, J. A. Murray, A. Rubio-Tapia
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Medicine, General & Internal
Adam C. Bledsoe, Katherine S. King, Joseph J. Larson, Melissa Snyder, Imad Absah, Rok Seon Choung, Joseph A. Murray
MAYO CLINIC PROCEEDINGS
(2019)
Article
Medicine, General & Internal
Shilpa S. Nellikkal, Yamen Hafed, Joseph J. Larson, Joseph A. Murray, Imad Absah
MAYO CLINIC PROCEEDINGS
(2019)
Editorial Material
Medicine, General & Internal
Amrit K. Kamboj, Rondell P. Graham, Joseph A. Murray
MAYO CLINIC PROCEEDINGS
(2020)
Article
Medicine, General & Internal
Rok Seon Choung, Yuri A. Saito, Cathy D. Schleck, William S. Harmsen, Alan R. Zinsmeister, Joseph A. Murray, Nicholas J. Talley
Summary: The study found that the overall population prevalence of chronic unexplained GI symptoms is stable over a 20-year period in a single US community, but transitions of symptoms are common in individuals, with only 29% having the same symptom category in different surveys. Higher non-GI somatic symptom scores were significantly associated with both symptom transitions and sustained symptoms.
MAYO CLINIC PROCEEDINGS
(2021)
Editorial Material
Gastroenterology & Hepatology
Joseph A. Murray
Article
Gastroenterology & Hepatology
David Bergman, James King, Benjamin Lebwohl, Mark S. Clements, Bjorn Roelstraete, Gilaad G. Kaplan, Peter H. R. Green, Joseph A. Murray, Jonas F. Ludvigsson
Summary: The incidence of CD in Sweden peaked in 2002-2003 for females and in 2006 for males. Despite increasing duodenal/jejunal biopsies, the incidence of CD has declined, indicating that increased awareness and investigation are unlikely to elevate the disease incidence in Sweden. The lifetime risk of developing CD is relatively high in Sweden, with 1 in 44 females and 1 in 72 males expected to be diagnosed.
Article
Gastroenterology & Hepatology
Mudar Zand Irani, Michael P. Jones, Magnus Halland, Linda Herrick, Rok Seon Choung, Yuri A. Saito Loftus, Marjorie M. Walker, Joseph A. Murray, Nicholas J. Talley
Summary: Rumination syndrome and functional dyspepsia (FD) overlap in clinical features with shared risk factors, suggesting a common pathophysiological basis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Rok Seon Choung, Ayush Sharma, Victor G. Chedid, Imad Absah, Zongming Eric Chen, Joseph A. Murray
Summary: This study reports the use of topical budesonide as an alternative therapy for collagenous gastritis (CG). The results show that most patients with CG had a clinical and histologic response to topical budesonide treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Caecilie Crawley, Nadia Savino, Cecilie Halby, Stine Dydensborg Sander, Anne-Marie Nybo Andersen, Manimozhiyan Arumugam, Joseph Murray, Robin Christensen, Steffen Husby
Summary: This study investigated whether gluten induces gastrointestinal symptoms and mental health symptoms in adolescents. The results showed that compared with placebo, adding gluten to the diet did not induce gastrointestinal symptoms or worsened mental health.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Joseph A. Murray, Jack A. Syage, Tsung-Teh Wu, Matthew A. Dickason, Ana G. Ramos, Carol Van Dyke, Irina Horwath, Philip T. Lavin, Markku Maki, Isabel Hujoel, Konstantinos A. Papadakis, Adam C. Bledsoe, Chaitan Khosla, Jennifer A. Sealey-Voyksner
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, David S. Sanders, Paola Baiardi, Giacomo Caio, Carolina Ciacci, Katri Kaukinen, Benjamin Lebwohl, Daniel Leffler, Georgia Malamut, Joseph A. Murray, Kamran Rostami, Alberto Rubio-Tapia, Umberto Volta, Federico Biagi
Summary: This study achieved a consensus on the definitions and diagnostic criteria for seronegative coeliac disease and chronic non-coeliac enteropathies in adults through the Delphi process.
Article
Engineering, Industrial
Alexander T. Miller, Michelle B. Herberts, Stephanie L. Hansel, Jean C. Fox, M. Susan Hallbeck, John League, Chadrick Hinson, Carol Van Dyke, Joseph A. Murray
Summary: This study describes the risk factors and consequences of musculoskeletal injuries among gastroenterologists. It found that activity-limiting injuries have a negative impact on procedural volume and efficiency.
APPLIED ERGONOMICS
(2022)
Editorial Material
Gastroenterology & Hepatology
Joseph A. Murray
Article
Gastroenterology & Hepatology
Anupama Ravi, Eric Marietta, Jeffrey A. Alexander, Kathryn Peterson, Crystal Lavey, Debra M. Geno, Joseph A. Murray, David A. Katzka
Summary: The study found that food antigens show prolonged presence in the esophageal epithelium of EoE patients, potentially triggering the Th2 allergic pathway. Active EoE patients had higher antigen staining density compared to inactive patients, especially for whey.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)