Article
Virology
Paula Fernandez-Alvarez, Maria Fernanda Guerra-Veloz, Angel Vilches-Arenas, Patricia Cordero-Ruiz, Francisco Bellido-Munoz, Angel Caunedo-Alvarez, Isabel Carmona-Soria
Summary: This study aimed to determine risk factors associated with the development of liver-related events (LREs) after achieving sustained virological response (SVR) with direct-acting antivirals (DAAs), focusing on the utility of non-invasive markers. The study found that HCV patients with SVR remain at risk of developing liver complications, and FIB-4 evaluation may help predict this risk and select patients for surveillance.
Review
Biochemistry & Molecular Biology
Wenqi Liu, Daokuan Zhai, Tingjing Zhang, Nyasha Grace Mudoti, Qing Chang, Yashu Liu, Yuhong Zhao, Yang Ding, Yang Xia
Summary: Based on a meta-analysis of multiple studies, this research found a positive correlation between the intake of major foods with added fructose and the prevalence of non-alcoholic fatty liver disease (NAFLD). Reducing added fructose consumption may serve as an early strategy to mitigate or prevent NAFLD.
Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Danbee Kang, Mira Kang, Eliseo Guallar, Yun Soo Hong, Kyung Hyun Lee, Jiyeon Park, Juhee Cho, Geum-Youn Gwak
Summary: This cohort study found that patients with NAFLD are at increased risk of sarcopenia, as indicated by a faster loss of skeletal muscle mass. Patients with NAFLD, especially those with intermediate to high NFS, may require screening and early intervention to mitigate the loss of skeletal muscle mass.
Review
Gastroenterology & Hepatology
Hyun Young Kim, Sadatsugu Sakane, Alvaro Eguileor, Raquel Carvalho Gontijo Weber, Wonseok Lee, Xiao Liu, Kevin Lam, Kei Ishizuka, Sara Brin Rosenthal, Karin Diggle, David A. Brenner, Tatiana Kisseleva
Summary: Liver fibrosis is a serious global health problem with no effective therapy currently available. Studies have shown that liver fibrosis is reversible and regression can occur when the underlying cause is removed. This review discusses the research progress in understanding the molecular mechanisms underlying the development and reversibility of liver fibrosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)
Article
Gastroenterology & Hepatology
Noha Anwar Hassuna, Aya Nabil Gamil, Mahmoud Shokry Mahmoud, Wafaa Khairy Mohamed, Rasha Khairy
Summary: This study found that miR-122 and miR-155 were upregulated in HCV-4 patients, while miR-196 and miR-29 were downregulated. These four miRNAs could be valuable biomarkers for predicting response to DAAs, with miR-196 being the most significant predictor of treatment response.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Changle Ke, Changchen Xiao, Jiamin Li, Xianpeng Wu, Yu Zhang, Yongjian Chen, Shuyuan Sheng, Zaiyang Fu, Lingjun Wang, Cheng Ni, Jing Zhao, Yanna Shi, Yan Wu, Zhiwei Zhong, Jinliang Nan, Wei Zhu, Jinghai Chen, Rongrong Wu, Xinyang Hu
Summary: FMO2 deficiency is associated with increased lipogenesis and worsened hepatic steatosis, inflammation, and fibrosis in NAFL/NASH, whereas FMO2 overexpression improves these conditions. Mechanistically, FMO2 interacts with SREBP1 competitively with SCAP to inhibit lipogenesis, making it a promising target for NAFL/NASH treatment.
Article
Medicine, Research & Experimental
Akif Altinbas, Jacinta A. Holmes, Shadi Salloum, Anna Lidofsky, Nadia Alatrakchi, Ma Somsouk, Peter Hunt, Steven Deeks, Kara W. Chew, Georg Lauer, Annie Kruger, Wenyu Lin, Raymond T. Chung
Summary: This study assessed the relationship between LOXL-2 and TNC-C levels and fibrosis severity in HIV and/or HCV-infected individuals. The study found that LOXL-2 and TNC-C levels were significantly higher in individuals with intermediate fibrosis in HCV and HCV/HIV co-infected individuals.
BIOMARKERS IN MEDICINE
(2022)
Article
Immunology
Lindsay T. Fourman, Takara L. Stanley, Isabel Zheng, Chelsea S. Pan, Meghan N. Feldpausch, Julia Purdy, Julia Aepfelbacher, Colleen Buckless, Andrew Tsao, Kathleen E. Corey, Raymond T. Chung, Martin Torriani, David E. Kleiner, Colleen M. Hadigan, Steven K. Grinspoon
Summary: This study observed high rates of hepatic fibrosis and progression in patients with HIV-associated NAFLD. Visceral adiposity was identified as a novel predictor of worsening fibrosis. Baseline histologic characteristics did not relate to fibrosis progression.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Akito Nozaki, Makoto Chuma, Koji Hara, Satoshi Moriya, Hiroyuki Fukuda, Kazushi Numata, Katsuaki Tanaka, Manabu Morimoto, Kentaro Sakamaki, Takeharu Yamanaka, Masaaki Kondo, Shin Maeda
Summary: Oral direct-acting antiviral (DAA) treatment for HCV infection can lead to regression of fibrosis in patients who achieved sustained virological response (SVR). M2BPGi showed good correlation with other fibrosis markers and had diagnostic value at week 48 after treatment initiation.
Article
Multidisciplinary Sciences
Liyu Chen, Lingyao Du, Shuang Kang, Fanghua Ma, Changmin Li, Min He, Lang Bai, Hong Tang
Summary: In Liangshan, China, people living with HIV have a high prevalence of HCV coinfection. A 24-week regimen of SOF+RBV can achieve good efficacy and is well-tolerated in this population. This treatment has the potential to be generalized in regions with limited resources.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Freya Wellhoener, Nico Doescher, Franziska Woelfl, Marius Vital, Iris Plumeier, Silke Kahl, Andrej Potthoff, Michael Peter Manns, Dietmar Helmut Pieper, Markus Cornberg, Heiner Wedemeyer, Benjamin Heidrich
Summary: The study aimed to analyze changes in the gut microbiome of patients with chronic HCV who received DAA treatment and achieved SVR. The results showed that SVR had an impact on the patients' intestinal microbiota, but significant changes were only observed in patients without liver cirrhosis.
Article
Biochemistry & Molecular Biology
Ottavia Giampaoli, Fabio Sciubba, Elisa Biliotti, Mariangela Spagnoli, Riccardo Calvani, Alberta Tomassini, Giorgio Capuani, Alfredo Miccheli, Gloria Taliani
Summary: This study measured the urinary concentration of ribavirin (RBV) and its metabolites in hepatitis C virus (HCV) patients in order to evaluate their drug metabolism ability and assess the adverse effects. The results showed that tailoring drug dose based on individual metabolic ability may be an effective approach in precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Andreas Geier, Dina Tiniakos, Helmut Denk, Michael Trauner
Summary: Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Understanding its pathological and molecular hallmarks is crucial for appropriate clinical management and research. This disease has evolved from a nebulous entity in the 19th century to a vigorously investigated liver disease today.
Article
Cardiac & Cardiovascular Systems
Yu Rim Shin, Seung Up Kim, Sak Lee, Jae Young Choi, Han Ki Park, Jeong Eun Yoo, Young Nyun Park
Summary: Patients with Fontan circulation have a high incidence of liver fibrosis and cirrhosis. This study found that transient elastography (TE) and the enhanced liver fibrosis (ELF) test were unable to predict the degree of liver fibrosis in Fontan patients. Elevated N-terminal pro-brain natriuretic peptide levels and ventricular end-diastolic pressure may be associated with advanced liver fibrosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Gastroenterology & Hepatology
Tracey G. Simon, Bjorn Roelstraete, Hannes Hagstrom, Johan Sundstroem, Jonas F. Ludvigsson
Summary: This study demonstrated that patients with biopsy-proven NAFLD have a significantly higher risk of major adverse cardiovascular events, including ischemic heart disease, stroke, congestive heart failure, and cardiovascular mortality, compared to matched population controls. The risk of such events increases progressively with worsening NAFLD severity.
Article
Gastroenterology & Hepatology
Arthur Berger, Federico Ravaioli, Oana Farcau, Davide Festi, Horia Stefanescu, Francois Buisson, Pierre Nahon, Christophe Bureau, Nathalie Ganne-Carrie, Annalisa Berzigotti, Victor de Ledinghen, Salvatore Petta, Paul Cales
Summary: The study aimed to improve strategies to rule out varices needing treatment in patients with chronic liver disease by including data on the ratio of platelets to liver stiffness. VariScreen algorithm was found to be safe and effective in ruling out varices in patients with chronic liver disease of any etiology or severity, making it a valuable tool for clinical practice.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
E. Nguyen-Khac, R. Sarba, L. Spahr, W. Staszewicz, A. DeGottardi, F. Storni, L. Elkrief, S. Dokmak, D. Valla, D. Pricope, C. Sabbagh, J. M. Regimbeau
Summary: Based on the comparison of patients with cirrhosis undergoing implantation of alfapump(R) combined with concomitant hernia repair versus those receiving standard treatment, it was found that the former group had reduced need for peritoneal drainage, lower rate of infectious complications, shorter hospital stay, and improved paracentesis-free survival.
JOURNAL OF VISCERAL SURGERY
(2021)
Letter
Gastroenterology & Hepatology
Jean-Jacques Kiladjian, Pierre-Edouard Debureaux, Aurelie Plessier, Juliette Soret-Dulphy, Dominique Valla, Bruno Cassinat, Pierre-Emmanuel Rautou
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Chloe De Broucker, Aurelie Plessier, Isabelle Ollivier-Hourmand, Sebastien Dharancy, Christophe Bureau, Jean-Paul Cervoni, Philippe Sogni, Odile Goria, Olivier Corcos, Riccardo Sartoris, Maxime Ronot, Valerie Vilgrain, Emmanuelle de Raucourt, Kamal Zekrini, Hortense Davy, Francois Durand, Audrey Payance, Nadira Fidouh-Houhou, Yazdan Yazdanpanah, Dominique Valla, Pierre-Emmanuel Rautou
Summary: Recent PVT patients with features of mononucleosis syndrome may have CMV disease. CMV disease does not affect the extension or recanalization of thrombosis, but CMV positive patients are more likely to carry the prothrombin G20210A gene variant.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Valerie Duvivier, Stepanie Creusot, Olivier Broux, Aurelie Helbert, Ludovic Lessage, Kevin Moreau, Nicolas Lesueur, Lindsay Gerard, Karine Lemaitre, Nicolas Provost, Edwige-Ludiwyne Hubert, Tania Baltauss, Angelique Brzustowski, Nathalie De Preville, Julia Geronimi, Lucie Adoux, Franck Letourneur, Adel Hammoutene, Dominique Valla, Valerie Paradis, Philippe Delerive
Summary: This study reports the development of a dietary model of NASH in the Gottingen minipig, which recapitulates most features of human NASH and may have improved translational value. The model was characterized using biochemical, histological, and transcriptional analyses, and the pharmacological response to treatment with Obeticholic acid was evaluated.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Article
Hematology
Aurelie Plessier, Marina Esposito-Farese, Anna Baiges, Akash Shukla, Juan Carlos Garcia Pagan, Emmanuelle De Raucourt, Isabelle Ollivier-Hourmand, Jean-Paul Cervoni, Victor De Ledinghen, Zoubida Tazi, Jean-Baptiste Nousbaum, Rene Bun, Christophe Bureau, Christine Silvain, Olivier Tournilhac, Mathieu Gerfaud-Valentin, Francois Durand, Odile Goria, Luis Tellez, Agustin Albillos, Stefania Gioia, Oliviero Riggio, Andrea De Gottardi, Audrey Payance, Pierre-Emmanuel Rautou, Louis Terriou, Aude Charbonnier, Laure Elkrief, Regis Peffault de la Tour, Dominique-Charles Valla, Nathalie Gault, Flore Sicre de Fontbrune
Summary: The study aimed to assess the impact of eculizumab on the outcome of patients with paroxysmal nocturnal hemoglobinuria (PNH) and vascular liver disease (VLD). The results showed that eculizumab was significantly associated with lower mortality and less thrombotic recurrence in these patients, while other secondary outcomes did not reach statistical significance.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shantha Ram Valainathan, Riccardo Sartoris, Laure Elkrief, Marta Magaz, Fabian Betancourt, Silvia Pellegrino, Arianna Nivolli, Marco Dioguardi Burgio, Yves Flattet, Sylvain Terraz, Nicolas Drilhon, Marie Lazareth, Julia Herrou, Onorina Bruno, Audrey Payance, Aurelie Plessier, Francois Durand, Maxime Ronot, Dominique-Charles Valla, Valerie Paradis, Juan Carlos Garcia-Pagan, Valerie Vilgrain, Pierre-Emmanuel Rautou
Summary: This study demonstrates that liver surface nodularity (LSN) and CT features are highly correlated with the diagnosis of Porto-sinusoidal vascular disorder (PSVD). A combination of LSN < 2.5 and normal-sized or enlarged segment IV strongly suggests PSVD in patients with signs of portal hypertension.
Article
Gastroenterology & Hepatology
Roberto de Franchis, Jaime Bosch, Guadalupe Garcia-Tsao, Thomas Reiberger, Cristina Ripoll
Summary: The Baveno VII workshop focused on personalized care for portal hypertension in patients with compensated cirrhosis or cACLD, discussing various aspects including diagnosis, treatment, and prevention measures in 9 main topics, resulting in a series of consensus recommendations.
JOURNAL OF HEPATOLOGY
(2022)
Correction
Gastroenterology & Hepatology
Roberto de Franchis, Jaime Bosch, Guadalupe Garcia-Tsao, Thomas Reiberger, Cristina Ripoll
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olivier Deckmyn, Thierry Poynard, Pierre Bedossa, Valerie Paradis, Valentina Peta, Raluca Pais, Vlad Ratziu, Dominique Thabut, Angelique Brzustowski, Jean-Francois Gautier, Patrice Cacoub, Dominique Valla
Summary: In patients with non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM) may exacerbate the associations between alpha-2 macroglobulin (A2M), apolipoprotein Al (ApoA1), haptoglobin, liver fibrosis, inflammation, and COVID-19.
Article
Medical Laboratory Technology
Alexandre Raynor, Anna Soavelomandroso, Tiphaine Robert-Mercier, Dominique Valla, Katell Peoc'h, Celia Raulet-Bussian
Summary: The reference values for ALT and AST vary depending on the analytical method and individual characteristics, and it is important for clinical laboratories to update their reference values according to factors such as sex, body mass index, and age.
ANNALES DE BIOLOGIE CLINIQUE
(2022)
Article
Hematology
Julien Bissonnette, Alix Riescher-Tuczkiewicz, Elia Gigante, Carole Bourdin, Larbi Boudaoud, Heithem Soliman, Francois Durand, Maxime Ronot, Dominique Valla, Valerie Vilgrain, Emmanuelle de Raucourt, Pierre-Emmanuel Rautou
Summary: Global hemostasis tests and clinical questionnaires do not improve prediction of liver biopsy-related bleeding, but pain 2 hours after liver biopsy may indicate potential bleeding complications.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gwenael Page, Felicia Julea, Valerie Paradis, Valerie Vilgrain, Dominique Valla, Bernard E. Van Beers, Philippe Garteiser
Summary: This study describes an MRE reconstruction algorithm that adjusts the ratio between shear wavelength and pixel size and evaluates its performance in different use cases. The results show that MARS has the best diagnostic performance in detecting advanced fibrosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Gastroenterology & Hepatology
Adel Hammoutene, Samira Laouirem, Miguel Albuquerque, Nathalie Colnot, Angelique Brzustowski, Dominique Valla, Nicolas Provost, Philippe Delerive, Valerie Paradis
Summary: This study investigates the therapeutic potential of a new NRF2 activator, S217879, in treating human MAFLD and its underlying mechanisms. The results demonstrate that S217879 can improve lipid metabolism, activate antioxidant response, enhance autophagy, and reduce DNA damage, apoptosis, inflammation, and fibrogenesis.
Article
Gastroenterology & Hepatology
Simon B. Gressens, Dominique Cazals-Hatem, Virginie Lloyd, Aurelie Plessier, Audrey Payance, Didier Lebrec, Francois Durand, Gerard Socie, Dominique Valla, Valerie Paradis, David Michonneau, Pierre -Emmanuel Rautou
Summary: Liver sinusoidal obstruction syndrome (SOS) can be diagnosed using hepatic venous pressure gradient (HVPG) measurement, but low HVPG values do not rule out the presence of SOS, so HVPG should be combined with transjugular liver biopsy for the diagnosis of SOS.