期刊
GUT
卷 58, 期 12, 页码 1583-1589出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/gut.2008.171553
关键词
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资金
- Damon Runyon Cancer Research Foundation [CI-36-07]
- JYK
- Foundation of Digestive Health and Nutrition
- NJS
- Chemistry Core of the Michigan Diabetes Research and Training Center
- National Institute of Diabetes and Digestive and Kidney Diseases [K23 DK079291, K08 DK0669907, K23 DK59311, R03 DK075842, NIH5P60, DK020572]
Objective: Barrett's oesophagus is associated with abdominal obesity. Adiponectin is a peptide that is secreted from adipocytes and circulates in three multimeric forms: low molecular weight (LMW), middle molecular weight (MMW), and high molecular weight (HMW). The anti-inflammatory effects of adiponectin are specific to individual multimers, with LMW being most anti-inflammatory. We postulated that circulating levels of adiponectin and its multimers would be associated with the risk of Barrett's oesophagus. Design: Cross-sectional study. Setting: Outpatient clinic in North Carolina, USA. Patients: Cases of Barrett's oesophagus and controls undergoing upper endoscopy for gastro-oesophageal reflux disease (GORD). Main outcome measures: Adjusted odds ratios of plasma adiponectin levels and its multimers for Barrett's oesophagus. Results: There were 112 cases of Barrett's oesophagus and 199 GORD controls. Total adiponectin was not associated with Barrett's oesophagus (3(rd) tertile vs 1(st) tertile adjusted odds ratio (aOR) = 0.88; 95% confidence interval (CI) = 0.44 to 1.78). High levels of LMW adiponectin were associated with a decreased risk of Barrett's oesophagus (3(rd) tertile vs 1(st) tertile aOR= 0.33; 95% CI, 0.16 to 0.69), and a high LMW/total ratio appeared particularly inversely associated with Barrett's oesophagus (3(rd) tertile vs 1(st) tertile aOR= 0.27; 95% CI, 0.13 to 0.58). Conclusions: High levels of LMW adiponectin are associated with a decreased risk of Barrett's oesophagus among patients with GORD. Further human studies are required to confirm these findings, and in vitro studies are needed to understand if there is a mechanism whereby adiponectin may affect Barrett's metaplasia.
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