Review
Biochemistry & Molecular Biology
Yi Ting Lee, Mohd Heikal Mohd Yunus, Azizah Ugusman, Muhammad Dain Yazid
Summary: This review examines the role of natural compounds in the treatment of osteoarthritis and their impact on the oxidative stress signaling pathway. Through comprehensive analysis of relevant articles, it is found that natural compounds have potential clinical applications in the treatment of osteoarthritis.
Article
Biochemistry & Molecular Biology
Patricia D. O. de Almeida, Gleyce dos Santos Barbosa Jobim, Caio Cesar dos Santos Ferreira, Lucas Rocha Bernardes, Rosane B. Dias, Caroline B. Schlaepfer Sales, Ludmila de F. Valverde, Clarissa A. G. Rocha, Milena B. P. Soares, Daniel P. Bezerra, Fernando de Carvalho da Silva, Mariana Filomena do Carmo Cardoso, Vitor Francisco Ferreira, Larissa F. Brito, Lirlandia Pires de Sousa, Marne C. de Vasconcellos, Emerson S. Lima
Summary: Quinones are plant-derived secondary metabolites with diverse pharmacological properties, including anti-tumor activity. A new naphthoquinone compound, CNFD, demonstrated cytotoxic effects on different tumor cell lines, particularly in MCF-7 breast adenocarcinoma cells. CNFD induced apoptosis through various mechanisms, such as gene expression modulation, activation of JNK and p38, and inhibition of ERK1/2 pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Isidoro Cobo, Anyan Cheng, Jessica Murillo-Saich, Roxana Coras, Alyssa Torres, Yohei Abe, Addison J. Lana, Johannes Schlachetzki, Ru Liu-Bryan, Robert Terkeltaub, Elsa Sanchez-Lopez, Christopher K. Glass, Monica Guma
Summary: MSUc induces a metabolic-inflammatory response in non-primed macrophages, leading to metabolic rewiring in gouty arthritis patients and mice. This response is regulated by JUN and JNK signaling and is independent of LPS stimulation and inflammasome activation.
Review
Endocrinology & Metabolism
Ruben Nogueiras, Guadalupe Sabio
Summary: The article highlights the role of hypothalamic stress induced by nutrient overload as a major contributor to obesity and related diseases, with a particular focus on the importance of the JNK kinases in the brain. Recent research suggests opposing roles for JNK1 and JNK3 in AgRP neurons of the hypothalamus, demonstrating the complexity of JNK biology.
Article
Integrative & Complementary Medicine
Hong Zong-Chao, Cai Quan, Wu He-Zhen, Yang Yan-Fang, Fan Heng, Duan Xue-Yun
Summary: Ulcerative colitis is a chronic disease that is difficult to cure, new biomarkers can aid in understanding and early diagnosis. Compound Sophorae Decoction is effective in treating UC by regulating multiple metabolic pathways.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Clinical Neurology
Emrin Horgusluoglu, Ryan Neff, Won-Min Song, Minghui Wang, Qian Wang, Matthias Arnold, Jan Krumsiek, Beatriz Galindo-Prieto, Chen Ming, Kwangsik Nho, Gabi Kastenmueller, Xianlin Han, Rebecca Baillie, Qi Zeng, Shea Andrews, Haoxiang Cheng, Ke Hao, Alison Goate, David A. Bennett, Andrew J. Saykin, Rima Kaddurah-Daouk, Bin Zhang
Summary: This study aims to identify AD-specific metabolomic changes and their potential upstream genetic and transcriptional regulators through an integrative systems biology framework. The findings suggest that short-chain acylcarnitines/amino acids and medium/long-chain acylcarnitines are most associated with AD clinical outcomes. Integration of gene expression data reveals ABCA1 and CPT1A are involved in regulating acylcarnitines and amino acids in AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Multidisciplinary Sciences
Idalia Cura-Esquivel, Marlene Marisol Perales-Quintana, Liliana Torres-Gonzalez, Katia Guzman-Avilan, Linda Munoz-Espinosa, Paula Cordero-Perez
Summary: This study describes the metabolic, inflammatory and adipokine differences in overweight/obese children with and without metabolic syndrome (MetS). Results showed that children with MetS had higher levels of C-reactive protein, while children with normal body weight had lower levels of PAI-1 and leptin. The findings suggest that the triglyceride/high-density lipoprotein cholesterol ratio, obtainable from routine lab tests, can help identify MetS.
Article
Multidisciplinary Sciences
Valentina Vacca, Claudia Rossi, Luisa Pieroni, Federica De Angelis, Giacomo Giacovazzo, Ilaria Cicalini, Domenico Ciavardelli, Flaminia Pavone, Roberto Coccurello, Sara Marinelli
Summary: This study uncovers the role of adipose tissue in sex-specific neuropathic pain responses and reveals differences between females and males in their neuropathic pain reactions. Females show higher energy expenditure and fatty acid oxidation, while males exhibit lower energy expenditure and decreased levels of unsaturated fatty acids.
Article
Ecology
Naoki Tsukuda, Kana Yahagi, Taeko Hara, Yohei Watanabe, Hoshitaka Matsumoto, Hiroshi Mori, Koichi Higashi, Hirokazu Tsuji, Satoshi Matsumoto, Ken Kurokawa, Takahiro Matsuki
Summary: This study explored the early life relationships between SCFA and gut microbiota by analyzing faecal samples collected from 12 subjects over the first two years of life. The research identified three distinct phases of SCFA profiles and their associations with specific gut microbiota. The results showed that butyrate production was linked to Clostridiales species and breastfeeding cessation, while formate production was associated with infant-type bifidobacterial species and HMO-derived fucose.
Review
Biochemistry & Molecular Biology
Rong Jin, Jiaqing Hao, Yanmei Yi, Edward Sauter, Bing Li
Summary: Macrophages play crucial roles in maintaining tissue homeostasis and can exhibit heterogeneous phenotypes and functions depending on their activation states, influenced by various environmental stimuli. Fatty acid binding proteins, particularly A-FABP and E-FABP, are key players in integrating metabolic and inflammatory pathways in different subsets of activated macrophages, contributing to their functional diversity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Pharmacology & Pharmacy
Jinghui Zhang, Jiajun Fan, Xian Zeng, Mingming Nie, Jingyun Luan, Yichen Wang, Dianwen Ju, Kai Yin
Summary: The Hedgehog (HH) signaling pathway is crucial in gastrointestinal carcinogenesis and the tumor microenvironment (TME), affecting tumor growth, immune tolerance, inflammation, and drug resistance. Inflammatory factors and cancer-associated fibroblasts play vital roles in these processes, and inhibiting HH signaling can normalize the TME. Aberrant HH signaling activation promotes cancer stem cell proliferation and gastrointestinal tumor drug resistance.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell Biology
Kelsey N. S. Thompson, Kevin S. E. Bonham, Nicholas E. J. Ilott, Graham J. Britton, Paula J. Colmenero, Samuel J. J. Bullers, Lauren J. McIver, Siyuan H. Ma, Long H. Nguyen, Andrew Filer, India Brough, Claire Pearson, Caroline Moussa, Vinod H. Kumar, Lilian H. A. Lam, Matthew A. Jackson, April Pawluk, Serafim R. Kiriakidis, Peter C. Taylor, Lucy R. P. Wedderburn, Brian R. Marsden, Stephen P. J. Young, Dan R. G. Littman, Jeremiah J. Faith, Arthur G. Pratt, Paul Bowness, Karim Raza, Fiona Powrie, Curtis Huttenhower
Summary: Musculoskeletal diseases impact 20% of adults globally. The connection between gut microbiome and inflammatory conditions, like arthritis, has not been fully understood. The Inflammatory Arthritis Microbiome Consortium analyzed 440 stool samples and found differential microbiome composition and functional processes in patients with inflammatory arthritis compared to healthy individuals. This research enhances our understanding of how systemic inflammation during arthritis affects the gut ecosystem.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maite Garcia-Guasch, Lourdes Navarro, Vanessa Rivero, Irmgard Costa, Eduard Escrich, Raquel Moral
Summary: Breast cancer is the most common malignancy in women worldwide, with dietary and environmental factors playing a role in its etiology. The study found that high fat diets have different effects on tumor progression, and metabolic changes play a role in the molecular modulation of different signaling pathways in the context of tumor malignancy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Huijun Zhang, Xiang Gao, Kelei Li, Yandi Liu, Dhanushka S. Hettiarachichi, Bruce Sunderland, Duo Li
Summary: Our study found that sandalwood seed oil has an ameliorative effect on insulin resistance induced by a high-fat/high-sucrose diet in rats by regulating hepatic inflammation related blockage of the insulin signaling pathway.
Article
Cell Biology
Jan Frohlich, Kristina Kovacovicova, Marco Raffaele, Tereza Virglova, Eliska Cizkova, Jan Kucera, Julie Bienertova-Vasku, Martin Wabitsch, Marion Peyrou, Francesca Bonomini, Rita Rezzani, George N. Chaldakov, Anton B. Tonchev, Michelino Di Rosa, Nicolas Blavet, Vaclav Hejret, Manlio Vinciguerra
Summary: This study demonstrates that GDF11 treatment in ob/ob mice can improve glucose/insulin homeostasis, reduce weight gain, and decrease white adipocyte size. Additionally, GDF11 treatment inhibits adipogenesis in pre-adipocytes and increases glucose uptake by mature adipocytes.
CELL PROLIFERATION
(2022)