Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, Rocco M. Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-oesophageal reflux is the main risk factor for Barrett's oesophagus, with alcohol consumption and hiatal hernia showing the strongest association with its development. Other potential risk factors such as smoking and obesity did not show significant correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pathology
Kevan J. Salimian, Jacqueline Birkness-Gartman, Kevin M. Waters
Summary: This review summarizes the important steps and features in the progression from reflux esophagitis to Barrett esophagus to esophageal adenocarcinoma. The histological features of these entities are discussed, highlighting the challenges in diagnosis and management. The definition of Barrett esophagus is a contentious topic, and the assessment of dysplasia in esophageal adenocarcinoma remains challenging. Emerging targeted therapies and ancillary tests are also discussed.
Review
Oncology
Sarah Killcoyne, Rebecca C. Fitzgerald
Summary: Cancer cells evolve through DNA mutation, cell selection, and population expansion, driven by mutated driver genes and structural alterations to the genome. Early genomic instability in Barrett's esophagus (BE) may lead to esophageal adenocarcinoma (EAC). Understanding these patterns and genomic changes can improve early detection of EAC and provide insights into cancer evolution.
NATURE REVIEWS CANCER
(2021)
Review
Gastroenterology & Hepatology
Leonardo Henry Eusebi, Giovanna Grazia Cirota, Rocco Maurizio Zagari, Alexander Charles Ford
Summary: Chronic gastro-oesophageal reflux can lead to the development of Barrett's oesophagus or oesophageal adenocarcinoma. Global prevalence of Barrett's oesophagus varies geographically and is significantly higher in men. Low-grade dysplasia is common in histologically confirmed cases of Barrett's oesophagus.
Review
Surgery
L. Tullie, A. Kelay, G. S. Bethell, C. Major, N. J. Hall
Summary: Patients born with oesophageal atresia have a relatively high prevalence of Barrett's oesophagus, especially in those who undergo endoscopic screening or surveillance. Despite a limited number of cancers, there is a need to consider the necessity of screening and surveillance.
Article
Medicine, General & Internal
Anna Plocek, Beata Gebora-Kowalska, Wojciech Fendler, Ewa Toporowska-Kowalska
Summary: Diagnosis of gastro-oesophageal reflux disease in children with chronic neurological impairment remains a clinical challenge. This study validated reference values for assessing GOR in these children and determined the optimal cut-off level of the pH-impedance parameter for predicting endoscopic outcomes. Endoscopic findings showed that even with a low number of GOR episodes recorded by pH-impedance, children with chronic NI may still have endoscopic lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
M. Yanes, G. Santoni, J. Maret-Ouda, E. Ness-Jensen, M. Farkkila, E. Lynge, E. Pukkala, P. Romundstad, L. Tryggvadottir, M. Von Euler Chelpin, J. Lagergren
Summary: The study showed that antireflux surgery with fundoplication is associated with lower mortality rates from all causes, cardiovascular disease, respiratory disease, laryngeal or pharyngeal cancer, and lung cancer in patients with reflux oesophagitis or Barrett's oesophagus, compared with antireflux medication. However, there was no difference in mortality rates from oesophageal cancer between the two treatment methods.
BRITISH JOURNAL OF SURGERY
(2021)
Review
Gastroenterology & Hepatology
Yonne Peters, Evi van Grinsven, Peter D. Siersema
Summary: A positive family history of Barrett's oesophagus or oesophageal adenocarcinoma is a strong risk factor for both conditions, and can be a useful indicator for identifying high-risk individuals who may benefit from early detection strategies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Oncology
Leonardo Henry Eusebi, Andrea Telese, Chiara Castellana, Rengin Melis Engin, Benjamin Norton, Apostolis Papaefthymiou, Rocco Maurizio Zagari, Rehan Haidry
Summary: Barrett's oesophagus is a pathological condition characterized by the replacement of normal oesophageal squamous mucosa with specialised, intestinal-type metaplasia, which is strongly associated with chronic gastro-oesophageal reflux. Accurate diagnosis is crucial for managing Barrett's oesophagus to identify patients at high risk of developing neoplasia and guide appropriate endoscopic therapy.
Review
Agriculture, Dairy & Animal Science
Ioannis Savvas, Kiriaki Pavlidou, Tilemachos Anagnostou, Eugenia Flouraki, George Kazakos, Dimitrios Raptopoulos
Summary: This systematic review investigates the effect of preoperative fasting duration and drugs on gastro-oesophageal reflux (GOR) in dogs and cats during anaesthesia. The study found that many factors seem to affect the development of GOR, but due to the limited number of studies and low level of evidence, no reliable conclusions can be drawn.
Article
Gastroenterology & Hepatology
Kit Curtius, Joel H. Rubenstein, Amitabh Chak, John M. Inadomi
Summary: The study aimed to determine whether Barrett's esophagus is the origin of all incident esophageal adenocarcinomas, and found that almost all cases of OAC could be attributed to Barrett's esophagus based on a computational model and population data.
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, R. Maurizio Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-esophageal reflux (GER) symptoms are associated with an increased odds of Barrett's esophagus (BE), especially when the symptoms occur weekly. However, GER symptoms have low sensitivity and specificity for predicting BE, except for a strong association with long segment BE. Screening individuals with weekly GER symptoms may be beneficial to rule out long segment BE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ans Pauwels, Karlien Raymenants, Annelies Geeraerts, Veerle Boecxstaens, Imke Masuy, Charlotte Broers, Tim Vanuytsel, Jan Tack
Summary: Baclofen has shown efficacy in reducing reflux parameters in patients with PPI refractory GERD symptoms, but only SAP+ patients experience clinical benefit after 4 weeks of treatment. pH-impedance monitoring is necessary before treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Surgery
Alfredo Genco, Lidia Castagneto-Gissey, Loredana Gualtieri, Marcello Lucchese, Luca Leuratti, Emanuele Soricelli, Giovanni Casella
Summary: This study investigated the prevalence of GORD and associated oesophageal complications following different bariatric procedures. The findings showed that SG had the highest prevalence of erosive oesophagitis and Barrett's oesophagus, as well as a higher rate of biliary-like gastric stagnation and biliary-type reflux into the oesophagus compared to other procedures.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Jue-Sheng Ong, Jiyuan An, Xikun Han, Matthew H. Law, Priyanka Nandakumar, Johannes Schumacher, Ines Gockel, Anne Bohmer, Janusz Jankowski, Claire Palles, Catherine M. Olsen, Rachel E. Neale, Rebecca Fitzgerald, Aaron P. Thrift, Thomas L. Vaughan, Matthew F. Buas, David A. Hinds, Puya Gharahkhani, Bradley J. Kendall, Stuart MacGregor
Summary: Researchers identified numerous novel risk loci for GERD and BE using a multitrait GWAS model, providing strong evidence for a genetic basis of disease heterogeneity in GERD. They showed that GERD loci associated with obesity are better predictors of BE/EA compared to those associated with depressive symptoms.
Article
Gastroenterology & Hepatology
Lorenzo Fuccio, Leonardo Frazzoni, Cristiano Spada, Alessandro Mussetto, Carlo Fabbri, Mauro Manno, Giovanni Aragona, Rocco Maurizio Zagari, Emanuele Rondonotti, Gianpiero Manes, Pietro Occhipinti, Sergio Cadoni, Franco Bazzoli, Cesare Hassan, Franco Radaelli
Summary: In a prospective observational study among inpatients, factors affecting inadequate colon cleansing were identified. A model to identify patients with inadequate preparation was derived and validated, and an app for clinicians was developed.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Alessandro Vanoli, Federica Grillo, Camilla Guerini, Giuseppe Neri, Giovanni Arpa, Catherine Klersy, Gabriella Nesi, Paolo Giuffrida, Gianluca Sampietro, Sandro Ardizzone, Paolo Fociani, Roberto Fiocca, Giovanni Latella, Fausto Sessa, Antonietta D'Errico, Deborah Malvi, Claudia Mescoli, Massimo Rugge, Stefano Ferrero, Gilberto Poggioli, Fernando Rizzello, Maria C. Macciomei, Donatella Santini, Umberto Volta, Roberto De Giorgio, Giacomo Caio, Antonio Calabro, Carolina Ciacci, Maria D'Armiento, Aroldo Rizzo, Gaspare Solina, Michele Martino, Francesco Tonelli, Vincenzo Villanacci, Renato Cannizzaro, Vincenzo Canzonieri, Ada Maria Florena, Livia Biancone, Giovanni Monteleone, Roberto Caronna, Antonio Ciardi, Luca Elli, Flavio Caprioli, Maurizio Vecchi, Renata D'Inca, Fabiana Zingone, Anna D'Odorico, Marco Vincenzo Lenti, Barbara Oreggia, Luca Reggiani Bonetti, Antonino Giulio Giannone, Augusto Orlandi, Valeria Barresi, Rachele Ciccocioppo, Giuseppe Amodeo, Elena Biletta, Ombretta Luinetti, Paolo Pedrazzoli, Andrea Pietrabissa, Gino Roberto Corazza, Enrico Solcia, Marco Paulli, Antonio Di Sabatino
Summary: The study aimed to investigate the impact of mismatch repair deficiency phenotype, high-risk pathologic features, and tumor histologic subtype on cancer-specific survival in patients with small bowel adenocarcinoma. The results indicated that mismatch repair deficiency, glandular/medullary histologic subtype, and association with celiac disease were significant predictors of favorable cancer-specific survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Leonardo Frazzoni, Marzio Frazzoni, Nicola De Bortoli, Mentore Ribolsi, Salvatore Tolone, Salvatore Russo, Rita Luisa Conigliaro, Roberto Penagini, Lorenzo Fuccio, Rocco Maurizio Zagari, Edoardo Savarino
Summary: The study validated the Lyon Consensus criteria for diagnosing GORD through reflux monitoring. Adding evaluation of impedance parameters, including TRs, PSPW index, and MNBI, improved the diagnostic yield of reflux monitoring.
Review
Gastroenterology & Hepatology
Raquel Ortigao, Goncalo Figueiroa, Leonardo Frazzoni, Pedro Pimentel-Nunes, Cesare Hassan, Mario Dinis-Ribeiro, Lorenzo Fuccio, Diogo Libanio
Summary: This study conducted a systematic review of 52 studies to identify risk factors for metachronous gastric lesions (MGL) and compare the incidence after endoscopic resection (ER) and subtotal gastrectomy. The results showed that the incidence of MGL after ER was significantly higher than after subtotal gastrectomy. Factors such as age, sex, family history, synchronous lesions, gastric mucosal atrophy, intestinal metaplasia, H. pylori infection, and pepsinogen I/II ratio were significantly associated with MGL after ER. The study highlights the importance of individualized follow-up schedules based on different surgical procedures and risk factors.
Article
Gastroenterology & Hepatology
Marzio Frazzoni, Leonardo Frazzoni, Mentore Ribolsi, Nicola De Bortoli, Salvatore Tolone, Salvatore Russo, Rita Conigliaro, Roberto Penagini, Lorenzo Fuccio, Rocco Maurizio Zagari, Edoardo Savarino
Summary: Impedance-pH monitoring is highly clinically valuable in the diagnosis of patients with PPI-refractory heartburn, providing evidence of GERD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Editorial Material
Medicine, General & Internal
Adeline Rosenberg, Slavka Baronikova, Linda Feighery, William Gattrell, Rikke Egelund Olsen, Adam Watson, Tim Koder, Christopher Winchester
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Article
Pathology
Katia Cortese, Gudrun Holland, Lars Moeller, Maria Cristina Gagliani, Emanuela Barisione, Lorenzo Ball, Paolo Pelosi, Federica Grillo, Luca Mastracci, Roberto Fiocca, Michael Laue
Summary: Ultrastructural analysis of autopsy samples from COVID-19 patients reveals that the observed alveolar damage is not associated with virus presence or structural impairment. The lung damage in these patients is likely caused by alternative mechanisms, such as an inappropriate immune or stress response.
Article
Gastroenterology & Hepatology
Giulia Collatuzzo, Lorenzo Fuccio, Leonardo Frazzoni, Franco Radaelli, Cesare Hassan, Carlo Fabbri, Sergio Cadoni, Liboria Laterza, Andrea Anderloni, Cecilia Binda, Marina La Marca, Amedeo Montale, Paola Soriani, Marco Sacco, Paolo Gallittu, Donatella Mura, Mauro Manno, Alessandro Mussetto, Francesca Rogai, Cristina Trovato, Giovanna Vitale, Alessandro Musso, Clara Benedetta Conti, Alessandro Repici, Andrea Farioli, Rocco Maurizio Zagari, Paolo Boffetta
Summary: This study aimed to investigate the determinants of symptoms occurring during preparation for colonoscopy among patients. The results showed that severe symptoms were associated with female sex, longer working hours, previous gastrointestinal symptoms, multiple somatic symptoms, and the day-before regimen. On the other hand, age ≥ 60 years and good mood were protective factors. A high-risk profile was identified, including women with low mood and somatic symptoms.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Cell Biology
Alessandro Gambella, Stefano Scabini, Gabriele Zoppoli, Annalisa De Silvestri, Simona Pigozzi, Michele Paudice, Michela Campora, Roberto Fiocca, Federica Grillo, Luca Mastracci
Summary: This study aims to evaluate the expression and prognostic potential of HLA-G in stage II/III CRCs. The results show heterogeneous expression of HLA-G and a significant association with poor tumor differentiation in the right-sided CRC subgroup. Survival analysis reveals a reduced disease-free survival rate in CRC-related death cases.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ian M. Gralnek, Marine Camus Duboc, Juan Carlos Garcia-Pagan, Lorenzo Fuccio, John Gasdal Karstensen, Tomas Hucl, Ivan Jovanovic, Halim Awadie, Virginia Hernandez-Gea, Marcel Tantau, Alanna Ebigbo, Mostafa Ibrahim, Jiannis Vlachogiannakos, Marc C. Burgmans, Robyn Rosasco, Konstantinos Triantafyllou
Summary: This article summarizes ESGE recommendations for the treatment of patients with chronic liver disease, including the prevention of variceal bleeding, management of acute upper gastrointestinal hemorrhage, and endoscopic therapy.
Article
Gastroenterology & Hepatology
Lorenzo Fuccio
Article
Genetics & Heredity
Anna Ferrari, Roberto Fiocca, Elena Bonora, Chiara Domizio, Eugenio Fonzi, Davide Angeli, Gian Domenico Raulli, Sandro Mattioli, Giovanni Martinelli, Chiara Molinari
Summary: This study conducted genomic analysis on a neoadjuvant chemotherapy-resistant gastroesophageal tumor and identified a novel gene fusion, MSI2-C17orf64, that has never been reported before. This finding highlights the potential of MSI2 as a therapeutic target.
Article
Oncology
Arianna Orsini, Luca Mastracci, Isotta Bozzarelli, Anna Ferrari, Federica Isidori, Roberto Fiocca, Marialuisa Lugaresi, Antonietta D'Errico, Deborah Malvi, Erica Cataldi-Stagetti, Paola Spaggiari, Anna Tomezzoli, Luca Albarello, Ari Ristimaki, Luca Bottiglieri, Kausilia K. Krishnadath, Riccardo Rosati, Uberto Fumagalli Romario, Giovanni De Manzoni, Jari Rasanen, Giovanni Martinelli, Sandro Mattioli, Elena Bonora
Summary: Esophageal adenocarcinoma (EAC) is a severe malignancy with increasing incidence, poorly understood pathogenesis, and low survival rates. TP53 gene alterations, especially missense mutations, negatively affect cancer-specific survival in EAC. HNF1alpha gene disruption is associated with other gene alterations and is identified as a new EAC-mutated gene.
Article
Ethics
William T. Gattrell, Amrit Pali Hungin, Amy Price, Christopher C. Winchester, David Tovey, Ellen L. Hughes, Esther J. van Zuuren, Keith Goldman, Patricia Logullo, Robert Matheis, Niall Harrison
Summary: This study aims to develop a reporting guideline to assist the biomedical research and clinical practice community in describing the methods used to reach consensus in a complete, transparent, and consistent manner.
RESEARCH INTEGRITY AND PEER REVIEW
(2022)
Article
Gastroenterology & Hepatology
Julia Arribas, Giulio Antonelli, Leonardo Frazzoni, Lorenzo Fuccio, Alanna Ebigbo, Fons van der Sommen, Noha Ghatwary, Christoph Palm, Miguel Coimbra, Francesco Renna, J. J. G. H. M. Bergman, Prateek Sharma, Helmut Messmann, Cesare Hassan, Mario J. Dinis-Ribeiro
Summary: Studies have evaluated the diagnostic performance of artificial intelligence in detecting and characterizing upper gastrointestinal lesions, showing a high overall accuracy for diagnosing any neoplastic lesion of the upper GI tract independently of the underlying condition.