Article
Cell Biology
Jun Muratsu, Fumihiro Sanada, Nobutaka Koibuchi, Kana Shibata, Naruto Katsuragi, Shoji Ikebe, Yasuo Tsunetoshi, Hiromi Rakugi, Ryuichi Morishita, Yoshiaki Taniyama
Summary: This study aimed to investigate the role of periostin (POSTN) in a rhabdomyolysis mice model of acute kidney injury (AKI). The study found that POSTN was highly expressed in the kidney after rhabdomyolysis and acted as a positive regulator of AKI. POSTN-null mice exhibited lower expression of inflammation-associated mRNAs and reduced tubular injury compared to wildtype mice. Targeting POSTN may provide a new therapeutic strategy against the development of AKI.
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Tao Huang, Yang Gao, Yanwei Cao, Qinghai Wang, Zhen Dong
Summary: This study revealed the significant role of mmu_circ_0000943 in renal transplant by regulating miR-377-3p and Egr2, offering a novel insight into the treatment of AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Wenjun Lin, Xianfeng Wu, Jiejun Wen, Yang Fei, Junnan Wu, Xiaomei Li, Qunzi Zhang, Yang Dong, Tao Xu, Ying Fan, Niansong Wang
Summary: This study demonstrated the renal protective effect of nicotinamide on rhabdomyolysis-induced AKI, with Klotho preservation being essential for this effect. The study provided insight into the interaction between nicotinamide and Klotho, and proposed a new preventive strategy for rhabdomyolysis-induced AKI.
Article
Medicine, Research & Experimental
Elshymaa A. Abdel-Hakeem, Sara Mohamed Naguib Abdel Hafez, Bothina A. Kamel, Heba A. Abdel-Hamid
Summary: The study demonstrated the potential protective effect of Angiotensin 1-7 in rhabdomyolysis-induced kidney injury in rats, possibly through modulation of multiple pathways.
Article
Biochemistry & Molecular Biology
Keyvan Amirshahrokhi
Summary: The study demonstrated that thalidomide significantly alleviated the inflammatory responses in rhabdomyolysis-induced AKI, leading to reductions in blood creatinine, blood urea nitrogen, renal tissue damage, and other inflammatory markers.
Article
Biochemistry & Molecular Biology
Sukkum Ngullie Chang, Muhammad Haroon, Debasish Kumar Dey, Sun Chul Kang
Summary: This study demonstrates the protective effects of epigallocatechin gallate (EGCG) in rhabdomyolysis-induced acute kidney injury (RIAKI). EGCG treatment reduced serum creatinine, blood urea nitrogen, and lactate dehydrogenase levels, as well as the formation of damaged tubules. It also suppressed inflammation, endoplasmic reticulum stress, and oxidative stress. Furthermore, EGCG inhibited apoptosis in kidney tubules and HEK-293 cells and downregulated markers of the intrinsic mitochondrial apoptotic pathway. These findings suggest that EGCG has therapeutic potential for AKI.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chung-Kuan Wu, Chia-Lin Wu, Tzong-Shyuan Lee, Yu Ru Kou, Der-Cherng Tarng
Summary: The study found that TRPA1 plays a role in AKI by sensing oxidative stress and regulating inflammation in renal tubular cells. TRPA1 expression increased in patients with AKI and in a mouse model of IR-induced injury, highlighting its importance in kidney injury. In vitro experiments showed that TRPA1 activation by ROS under hypoxia-reoxygenation injury conditions led to increased intracellular Ca2+ level and activation of inflammatory signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Xi Xiong, Likun Gao, Chen Chen, Kai Zhu, Pengcheng Luo, Lili Li
Summary: This study investigates the harmful effects of microplastics on mouse kidneys. The results show that exposure to microplastics can induce inflammation, oxidative stress, and cell apoptosis in the kidneys, leading to kidney injury and fibrosis. Additionally, different sizes of microplastics cause varying degrees of damage to the kidneys.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Medicine, General & Internal
Lakshmi Kannan
Summary: Drug abuse is a major problem in the modern world, with both prescribed drugs and illegal drugs causing kidney injury. This review examines the renal effects of recreational drugs, highlighting the importance of understanding their adverse effects. The study conducted a thorough search of published case reports and case series to provide comprehensive information on renal complications associated with drug abuse.
Article
Nanoscience & Nanotechnology
Ashraf Al-Brakati, Khalaf F. Alsharif, Khalid J. Alzahrani, Saeed Kabrah, Osama Al-Amer, Atif Abdulwahab Oyouni, Ola A. Habotta, Maha S. Lokman, Amira A. Bauomy, Rami B. Kassab, Ahmed E. Abdel Moneim
Summary: The study demonstrated that LYC-SeNPs exhibited strong renoprotective activity in an acute kidney injury model, suggesting its potential therapeutic value.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Environmental Sciences
Rami B. Kassab, Ahmed A. Elhenawy, Abdulrahman Theyab, Yousef M. Hawsawi, Osama M. Al-Amer, Atif Abdulwahab A. Oyouni, Ola A. Habotta, Hussam A. Althagafi, Fahad Alharthi, Maha S. Lokman, Khalaf F. Alsharif, Ashraf Albrakati, Ali O. Al-Ghamdy, Ehab Kotb Elmahallawy, Mohamed A. Elhefny, Kalid E. Hassan, Alaa Jameel A. Albarakati, Ahmed E. Abdel Moneim, Ahmed A. Moustafa
Summary: This study investigated the therapeutic potential and underlying mechanisms of daidzein, a dietary isoflavone, against glycerol-induced acute kidney injury (AKI) in male rats. The results demonstrated that daidzein pre-administration effectively improved kidney function, reduced kidney injury markers, enhanced antioxidant capacity, suppressed inflammation, and attenuated apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Radhia Hamdi, Amana Saadallah-Kallel, Slima Ferchichi-Trimeche, Raja Mokdad-Gargouri, Abdelhedi Miled, Bachir Benarba
Summary: The study found that DNA hypomethylation of the p66shc promoter in chronic renal failure patients is correlated with oxidative and inflammatory stress as well as disease stages.
Article
Acoustics
Ping Zhao, Qiuyang LI, Shuo Wang, Yiru Wang, Jianing Zhu, Lianhua Zhu, Jie Tang, Yukun Luo
Summary: The aim of this study was to evaluate renal perfusion changes in rats with acute kidney injury induced by rhabdomyolysis using contrast-enhanced ultrasound (CEUS) and quantitative parameters. The results showed significant differences in CEUS quantitative parameters between the experimental and control groups, indicating that CEUS has diagnostic value for rhabdomyolysis-induced acute kidney injury.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Urology & Nephrology
Chen Yuqiang, Zhang Lisha, Wen Jiejun, Xue Qin, Wang Niansong
Summary: This study suggests that p53 may be a therapeutic target for AKI caused by glycerol. Pretreatment of pifithrin-alpha or using it as a rescue therapy can effectively protect against severe injury.
Article
Multidisciplinary Sciences
Raul Lombardi, Alejandro Ferreiro, Daniela Ponce, Rolando Claure-Del Granado, Gustavo Aroca, Yanissa Venegas, Mariana Pereira, Jonathan Chavez-Iniguez, Nelson Rojas, Ana Villa, Marcos Colombo, Cristina Carlino, Caio Guimaraes, Mauricio Younes-Ibrahim, Lilia Maria Rizo, Gisselle Guzman, Carlos Varela, Guillermo Rosa-Diez, Diego Janiques, Roger Ayala, Galo Coronel, Eric Roessler, Serena Amor, Washington Osorio, Natalia Rivas, Benedito Pereira, Caroline de Azevedo, Adriana Flores, Jose Ubillo, Julieta Rano, Luis Yu, Emmanuel A. Burdmann, Luis Rodriguez, Gianny Galagarza-Gutierrez, Jesus Curitomay-Cruz
Summary: This study describes the characteristics of acute kidney disease associated with COVID-19 infection. The study found that kidney injury was mainly caused by COVID-19 MODS and volume depletion, and some patients exhibited proteinuria. The study also highlighted the importance of proteinuria detection in monitoring disease progression.
Article
Multidisciplinary Sciences
Farid Samaan, Elisa Carneiro de Paula, Fabrizzio Batista Guimaraes de Lima Souza, Luiz Fernando Cardoso Mendes, Paula Regina Gan Rossi, Rafaela Andrade Penalva Freitas, Fernando Takahashi Nakagawa, Alexandre Toledo Maciel, Sylvia Aranha, Eduardo Osawa, Henrique Pinheiro Konigsfeld, Riberto Garcia da Silva, Ricardo Barbosa Cintra de Souza, Saurus Mayer Coutinho, Tales Dantas Vieira, Karina De Bonis Thomaz, Elias Marcos Silva Flato, Renata Cristina da Silva, Lucas Vicente Andrade, Muna Badaoui, Eduardo Pogetti Badaoui, Miguel Angelo Goes, Sergio Henrique do Amaral, Karlla Cunha, Ines Marin Muniz, Jacqueline Siqueira Sampaio, Marcelino de Souza Durao Junior, Dirce M. Trevisan Zanetta, Emmanuel A. Burdmann
Summary: AKI-RRT associated with COVID-19 occurred in patients with a heavy burden of comorbidities and had a high mortality rate. The number of organ dysfunctions at admission and RRT efficiency were independent factors associated with mortality. A significant proportion of survivors were discharged while still dependent on RRT.
Article
Public, Environmental & Occupational Health
Gustavo C. de Almeida, Ubiratan de P. Santos, Yuri de D. M. Parente, Philippe de F. B. Colares, Rafael F. Mizutani, Fabiola del C. Bernardi, Ricardo M. Terra, Mario Terra-Filho
Summary: Malignant pleural mesothelioma is an aggressive tumor typically associated with asbestos exposure. Mesothelioma in situ has been proposed as an early stage of the disease, but its diagnostic criteria have only recently been defined. We present a case that provides insight into the unusual behavior of this disease, which is important for guiding follow-up and treatment strategies.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2022)
Letter
Urology & Nephrology
Veronica T. Costa e Silva, Lesley A. Inker, Emmanuel A. Burdmann, Andrew S. Levey
KIDNEY INTERNATIONAL
(2022)
Letter
Urology & Nephrology
Precil D. Neves, Renato A. Caires, Manoel P. Guimaraes, Elerson C. Costalonga, Livia B. Cavalcante, Veronica T. Costa e Silva, Francisco Z. Mattedi, Leonardo F. Santana, Antonio A. Teixeira-Junior, Orlando V. Gomes, Gyl E. Silva, Emmanuel A. Burdmann, Luiz F. Onuchic
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Veronica T. Costa e Silva, Luiz A. Gil Jr, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro Jr, Maria Dp Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonangelo, Lia Marcal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann
Summary: This study compares the performance of different equations for glomerular filtration rate (GFR) evaluation in cancer patients. The results show that the Cockcroft-Gault equation is the least accurate, while the CKD-EPI equation and eGFRcr-cys equation perform better. Therefore, it is recommended to adopt guideline-recommended methods for GFR evaluation in oncology practice and clinical trials.
KIDNEY INTERNATIONAL
(2022)
Article
Psychology, Clinical
Geraldo F. Busatto, Adriana Ladeira de Araujo, Joao Mauricio Castaldelli-Maia, Rodolfo Furlan Damiano, Marta Imamura, Bruno F. Guedes, Fabio de Rezende Pinna, Marcio Valente Yamada Sawamura, Marcio C. Mancini, Katia R. da Silva, Michelle L. Garcia, Nairo Sumita, Andre Russowsky Brunoni, Alberto J. da Silva Duarte, Emmanuel A. Burdmann, Esper G. Kallas, Giovanni G. Cerri, Ricardo Nitrini, Ricardo F. Bento, Vanderson Geraldo Rocha, Heraldo Possolo de Souza, Euripedes C. Miguel, Carlos R. R. de Carvalho, Orestes Forlenza, Linamara Rizzo Batistella
Summary: A study was conducted to investigate the patterns of symptom co-occurrence and their biological correlates in individuals with post-acute sequelae of SARS-CoV-2 infection. The results showed that fatigue, psychiatric, and cognitive symptoms were highly discriminative and associated with physical disability and persistent systemic inflammation.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Urology & Nephrology
Heitor S. Ribeiro, Emmanuel A. Burdmann, Edilene A. Vieira, Mateus L. Ferreira, Aparecido P. Ferreira, Antonio J. Inda-Filho
Summary: This study found that hypomagnesemia at ICU admission was associated with the development of acute kidney injury (AKI), while hypermagnesemia was not significantly associated with AKI. Both hypomagnesemia and hypermagnesemia were associated with higher mortality risks.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Letter
Urology & Nephrology
Veronica T. Costa e Silva, Luiz A. Gil Jr, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro Jr, Maria D. P. Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonangelo, Lia Marcal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Multidisciplinary Sciences
Farid Samaan, Rafaela Andrade Penalva Freitas, Renata Viana, Livia Gambaro, Karlla Cunha, Tales Dantas Vieira, Valkercyo Feitosa, Eric Aragao Correa, Alexandre Toledo Maciel, Sylvia Aranha, Eduardo Atsushi Osawa, Roberta Pillar, Elias Marcos da Silva Flato, Renata Cristina da Silva, Elisa Carneiro, Fabrizzio Batista Guimaraes de Lima Souza, Paula Regina Gan Rossi, Munira Bittencourt Abud, Henrique Pinheiro Konigsfeld, Riberto Garcia da Silva, Ricardo Barbosa Cintra de Souza, Saurus Mayer Coutinho, Miguel angelo Goes, Barbara Antunes Bruno da Silva, Dirce Maria Trevisan Zanetta, Emmanuel Almeida Burdmann
Summary: In the megalopolis of Sao Paulo, Brazil, the lethality of critically ill patients with COVID-19-associated AKI treated with KRT was higher in the second wave of the pandemic, despite these patients being younger and having fewer comorbidities. Potential factors related to this poor outcome were difficulties in health care access, lack of intra-hospital resources, delay vaccination and virus variants.
Letter
Respiratory System
Gustavo Correa de Almeida, Rafael Futoshi Mizutani, Mario Terra-Filho, Ubiratan de Paula Santos
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2023)
Article
Respiratory System
Stella Regina Martins, Alberto Jose de Araujo, Fernando C. Wehrmeister, Beatriz Martins Freitas, Rafaela Giunti Basso, Alfredo Nicodemos Cruz Santana, Ubiratan de Paula Santos
Summary: This study aimed to evaluate the prevalence of experimentation with and current use of water pipes and e-cigarettes among medical students. The study collected information through an online questionnaire on experimentation with and current use of conventional cigarettes, water pipes, and e-cigarettes, as well as beliefs and attitudes toward tobacco products, religiosity, and demographics. The results showed a high prevalence of experimentation with tobacco products among medical students, especially among those with siblings or friends who smoke.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2023)
Meeting Abstract
Oncology
Veronica Torres Costa E Silva, Luiz A. Gil-, Lesley Inker, Renato Caires, Elerson Costalonga, George Coura-Filho, Maria Del Pilar Estevez-Diz, Gilberto Castro, Paul Mathew, Andrew Levey, Emmanuel de Almeida Burdmann
JOURNAL OF CLINICAL ONCOLOGY
(2022)