Review
Biochemistry & Molecular Biology
Fengyuan Xu, Ialu Shi, Xueyun Qin, Zimeng Zheng, Min Chen, Zhi Lin, Jiangfeng Ye, Mingqing Li
Summary: Endocrine-related cancers and hormones are closely linked, with hormones playing a crucial role in tumor induction and progression. The role of glutamine metabolism in mediating tumorigenesis and development, as well as the regulation of glutamine metabolism by hormones such as estrogen, progesterone, androgen, prostaglandin, thyroid hormone, and insulin, have been extensively studied. However, the relationship between these three factors still needs to be further elucidated. This review provides an updated overview of glutamine metabolism traits and its influence on endocrine oncology, as well as its upstream hormonal regulation. The hormone/glutamine metabolism axis may serve as a potential target for novel therapeutic strategies in endocrine-related cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Marie Smedberg, Johan Helleberg, Ake Norberg, Inga Tjader, Olav Rooyackers, Jan Wernerman
Summary: A study on 269 patients found that hyperglutaminemia was associated with increased six-month mortality, indicating it is an independent mortality predictor. The study suggests further investigation into the mechanism of hyperglutaminemia and the prognostic value of repeated measurements for ICU patients.
Article
Endocrinology & Metabolism
Rasmus Juul Kildemoes, Michael Hojby Rasmussen, Henrik Agerso, Rune Viig Overgaard
Summary: Linear models were developed to predict mean and peak IGF-I levels based on samples taken on different days after somapacitan administration, showing strong linear relationships between IGF-I sampled on any day and the weekly mean and peak levels. Monitoring IGF-I levels on day 4 and day 2 after dosing provided the most accurate estimates of mean and peak levels, respectively, offering a simple and reliable tool for optimal monitoring of IGF-I.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Keisuke Nonaka, Kaiyo Takubo, Junko Aida, Yoriko Watai, Akiko Komatsu, Fujiya Gomi, Yuuki Shichi, Yuto Yamazaki, Toshiyuki Ishiwata, Hironobu Sasano, Tomio Arai
Summary: This study demonstrated telomere shortening in ZR cells of adrenal glands in patients who died after PCI, suggesting that the abnormal proliferation of ZR cells accelerates the aging process in these patients' cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Sebastian Mathes, Alexandra Fahrner, Edlira Luca, Jan Kruetzfeldt
Summary: The study found that IGF-I can directly regulate SPARC expression in muscle cells at the promoter level; GH/IGF-I can restore the decreased levels of SPARC in aged skeletal muscle; the glycerol model induces higher levels of adipocyte markers in aged skeletal muscle; GH treatment does not prevent IMAT formation in the glycerol model.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Endocrinology & Metabolism
David R. Clemmons, Martin Bidlingmaier
Summary: Standard treatment for acromegaly focuses on achieving specific levels of growth hormone (GH) and insulin-like growth factor (IGF-I). However, the appropriateness of these targets is not well-defined. GH measurements indicate tumor size changes, while failure in GH suppression after glucose stimulation is associated with tumor recurrence. IGF-I levels are closely associated with symptom and sign changes. Lowering GH and IGF-I concentrations is linked to increased longevity, although only GH increase has been analyzed in detail. Lowering GH and IGF-I consistently leads to improved outcomes, but previous studies' reported absolute levels are now out-of-date.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Yaojun Peng, Qiyan Wu, Qing Zhou, Zhanglin Yang, Fan Yin, Lingxiong Wang, Qi Chen, Cong Feng, Xuewen Ren, Tianyi Liu
Summary: Severe trauma and sepsis can lead to multiple organ dysfunction syndrome, which has a high mortality rate. Genomic changes similar to trauma and sepsis were observed, which involve innate immune activation and adaptive immunity suppression. Dysregulation of immune-related genes and immune cell subsets were found in trauma and sepsis, and their diagnostic and prognostic values were evaluated.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Paul Fellinger, Hannes Beiglboeck, Georg Semmler, Lorenz Pfleger, Sabina Smajis, Clemens Baumgartner, Martin Gajdosik, Rodrig Marculescu, Greisa Vila, Yvonne Winhofer, Thomas Scherer, Michael Trauner, Alexandra Kautzky-Willer, Martin Krssak, Michael Krebs, Peter Wolf
Summary: This study investigated the relationship between growth hormone/insulin-like growth factor-I (GH/IGF-I) axis activity and non-alcoholic fatty liver disease (NAFLD). The results showed that GH/IGF-I axis activity is correlated with intrahepatic lipid content, lipid composition, and phosphor metabolism. GH/IGF-I axis activity is a predictor for NAFLD and has an impact on hepatic lipid and phosphate metabolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Immunology
Sharmely Sharon Ballon Romero, Lih-Jyh Fuh, Shih-Ya Hung, Yu-Chen Lee, Yu-Chuen Huang, Szu-Yu Chien, Yi-Hung Chen
Summary: This study aimed to investigate whether single or multiple dental pulp injuries induce persistent dental pain and their association with trigeminal central nociceptive pathways. The results showed that multiple dental pulp injuries resulted in persistent dental pain, while single dental pulp injury did not. Electroacupuncture treatment provided prolonged analgesic and neuroprotective effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Haremaru Kubo, Shojiro Sawada, Michihiro Satoh, Yoichiro Asai, Shinjiro Kodama, Toshihiro Sato, Seitaro Tomiyama, Junro Seike, Kei Takahashi, Keizo Kaneko, Junta Imai, Hideki Katagiri
Summary: Low IGF-1 levels may serve as an important marker of adiposity-associated metabolic disorders in obese patients, associated with higher body fat mass, chronic inflammation, and other factors.
SCIENTIFIC REPORTS
(2022)
Review
Andrology
Marta Tenuta, Francesco Carlomagno, Biagio Cangiano, George Kanakis, Carlotta Pozza, Emilia Sbardella, Andrea M. Isidori, Csilla Krausz, Daniele Gianfrilli
Summary: The crosstalk between the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-somatotropic (HPS) axes plays a crucial role in male subjects at different stages of life, particularly in the development of reproductive organs and gonads.
Article
Gastroenterology & Hepatology
Suehelay Acevedo-Acevedo, Megan L. Stefkovich, Sun Woo Sophie Kang, Rory P. Cunningham, Constance M. Cultraro, Natalie Porat-Shliom
Summary: This study reveals the important role of liver kinase B1 (LKB1) in the transition from feeding to fasting states in the liver. Knocking out LKB1 leads to significant changes in the hepatic lobule and metabolic inefficiency in the whole body.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Kevin B. Laupland, Mahesh Ramanan, Kiran Shekar, Felicity Edwards, Pierre Clement, Alexis Tabah
Summary: The study found that most patients with prolonged stays in the ICU are alive one year post-admission. Older age and previous comorbidities are associated with adverse long-term mortality outcome, while severity of illness or duration of ICU stay are not correlated with long-term survival.
Article
Nursing
Claire Minton, Lesley Batten
Summary: Nurses caring for chronically critically ill patients in the ICU face challenges such as an unpredictable trajectory of prolonged critical illness, uncertainty, and witnessing suffering, as well as the pressure of completing multiple tasks within a short period. Understanding these challenges is crucial in improving nurses' practice and enhancing the quality of care provided.
NURSING IN CRITICAL CARE
(2021)
Article
Psychiatry
Weili Lu, Philip T. Yanos, William R. Waynor, Carol E. Gao, Carolyn Bazan, Giovanna Giacobbe, Kenneth Gill, Deanna Bullock, Holly G. Prigerson
Summary: This study investigated the rates of posttraumatic stress disorder (PTSD) and prolonged grief disorder (PGD) among individuals receiving community mental health services, as well as the clinical correlates of co-occurring PTSD/PGD. The findings highlight the prevalence of traumatic experiences and possible PTSD/PGD among individuals with serious mental illnesses, emphasizing the need for trauma informed services and grief counseling for this population.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Peripheral Vascular Disease
Lawrie Katerina, O'Neill Stephen, Waldauf Petr, Balaz Peter
Summary: The VAVASC study is an international research project aiming to validate the AVAS classification system for arteriovenous access on the upper limb. The study is currently recruiting participants and collecting data on vascular status and functionality of the created arteriovenous access. Statistical analysis will be conducted using predictive models.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Engineering, Biomedical
Pavel Jansky, Zuzana Motovska, Josef Kroupa, Petr Waldauf, Petr Kafka, Jiri Knot, Jiri Jarkovsky
Summary: This study analyzed the influence of the hospital admitting department on adherence to the European Society of Cardiology guidelines for management of acute coronary syndromes (ACS) in patients after out-of-hospital cardiac arrest (OHCA) of coronary etiology. The results showed that the choice of admission department significantly affected the extent to which recommended treatments were used, and examination by a cardiologist upon admission increased the likelihood of early diagnosis of ACS as the cause of OHCA.
BIOMEDICAL PAPERS-OLOMOUC
(2023)
Review
Chemistry, Analytical
Petr Tuma
Summary: This review evaluates the progress made in the past decade in on-line, at-line, and in-line sample treatment coupled with capillary and microchip electrophoresis. The first part discusses various types of flow-gating interfaces (FGI) and their fabrication using materials like polydimethylsiloxane and commercially available fittings. The second part focuses on the coupling of electrophoresis with different extraction techniques, highlighting modern approaches such as supported liquid membrane extraction and microdialysis with high spatial and temporal resolution. The final section explores the design of sequential electrophoretic analyzers and the fabrication of SPE microcartridges with specialized sorbents. Applications of these techniques range from monitoring metabolites and proteins in living organisms to analyzing nutrients and waste compounds in food and wastewater.
ANALYTICA CHIMICA ACTA
(2023)
Letter
Anesthesiology
Metodej Renza, David Peran, Roman Sykora, Michael Stern, Vaclav Zvonicek, Petr Waldauf, Frantisek Duska
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Cardiac & Cardiovascular Systems
Ondrej Sussenbek, Leonard Rademakers, Petr Waldauf, Pavel Jurak, Radovan Smisek, Petr Stros, Lukas Poviser, Jana Vesela, Filip Plesinger, Josef Halamek, Pavel Leinveber, Dalibor Herman, Pavel Osmancik, Karol Curila
Summary: Biventricular pacing and left bundle branch area pacing are two methods of cardiac resynchronization therapy, and this study compared their differences in ventricular activation using ultra-high frequency electrocardiography. Left bundle branch area pacing led to shorter e-DYS and Vdmean.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Marek Hozman, Sabri Hassouna, Lukas Grochol, Petr Waldauf, Tomas Hracek, Blanka Zborilova Pazdiorova, Stanislav Adamec, Pavel Osmancik
Summary: This study aimed to assess the impact of antithrombotic therapy on in-hospital and 6-month outcomes and determine the re-initiation rate of antithrombotics after a bleeding event. The results showed no association between antithrombotic treatment and in-hospital outcomes, but the development of hemorrhagic shock predicted poor prognosis. Furthermore, higher 6-month mortality was observed in older patients, patients with more comorbidities, with liver cirrhosis and cancer.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Mizner, Petr Waldauf, Domenico Grieco, Hana Linkova, Oana Ionita, Pugazhendhi Vijayaraman, Robert Petr, Radka Rakova, Jana Vesela, Petr Stros, Dalibor Herman, Pavel Osmancik, Karol Curila
Summary: This study compared the effects of His bundle pacing (HBP) and right ventricular pacing (RVP) on left ventricular ejection fraction (LVEF) and studied their impact on serum markers of collagen metabolism. The results showed that in high-risk pacing-induced cardiomyopathy (PICM) patients, HBP was superior to RVP in providing better ventricular function. In RVP patients, those with higher baseline levels of Gal-3 and ST2-IL experienced a greater decline in LVEF.
KARDIOLOGIA POLSKA
(2023)
Article
Chemistry, Analytical
Petr Tuma, Blanka Sommerova, Dusan Koval, Michaela Siklova, Michal Koc
Summary: In this study, capillary electrophoresis was used to determine minor nitrogen metabolites, including creatine, 2-aminobutyric acid (2-AB), and acetyl-carnitine (Ac-carn), in human plasma. Baseline separation of these metabolites was achieved using a 6% PAMAPTAC coated fused silica capillary and a counter-current mode. Plasma levels of these metabolites were monitored during a 60-hour fasting period, and significant differences were observed compared to baseline levels.
MICROCHEMICAL JOURNAL
(2023)
Article
Pathology
Jan Hrudka, Zuzana Prouzova, Michaela Kendall Bartu, Jan Hojny, David Capka, Nicolette Zavillova, Radoslav Matej, Petr Waldauf
Summary: Penile squamous cell carcinoma (pSCC) is a rare malignancy with a slowly increasing incidence and variable prognosis. Regional lymph node involvement signifies poor prognosis but represents a late sign, and more prognostic markers for effective patient risk stratification are urgently needed. In this study, traditional pathological variables, tumour budding, p53, p16, and mismatch repair proteins (MMR) immunohistochemistry were analyzed in 152 tumor samples. The results showed that the density of tumour lymphocytic infiltrate and the presence of tumor budding were significant predictors of overall survival and cancer-specific survival.
Article
Chemistry, Analytical
Frantisek Opekar, Petr Tuma
Summary: A miniature probe for electromembrane extraction was developed. It was made of polypropylene hollow fiber with a supported liquid membrane. The probe parameters were tested for extraction of creatinine and basic amino acids with promising results in increased sensitivity. The probe is simple to prepare and can be used for all-day measurements.
Article
Pharmacology & Pharmacy
David Peran, Michael Stern, Petr Cernohorsky, Roman Sykora, Stanislav Popela, Frantisek Duska
Summary: This case series discusses the signs, symptoms, and management of kratom overdose in the prehospital setting and intensive care. A retrospective analysis of 10 cases in the Czech Republic revealed neurological symptoms and vegetative instability. Naloxone was effective in preventing intubation in some cases. All patients survived and recovered within two days.
Review
Endocrinology & Metabolism
Vladimira Fejfarova, Radka Jarosikova, Jan Polak, Blanka Sommerova, Jitka Husakova, Veronika Woskova, Michal Dubsky, Petr Tuma
Summary: Diabetic foot is a serious complication caused by infection and ischaemia, requiring prompt and aggressive treatment to avoid amputation. Peripheral arterial disease therapy can be easily verified using ultrasound or other examinations, but infection treatment success is difficult to establish. Intravenous antibiotics are recommended for moderate or serious infections, and microdialysis techniques show promise in determining antibiotic levels in diabetic foot lesions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Analytical
Frantisek Opekar, Petr Tuma
Summary: This article introduces a method for extracting the anesthetic ketamine using electromembrane extraction coupled with capillary electrophoresis. The extraction occurs in a flow-through extraction mini probe, consisting of a porous hollow fiber filled with nitrophenyloctyl ether as extraction liquid. The pH of the sample solution does not affect the extraction efficiency, and the calibration dependence is linear in both model samples and urine. The LOD values are around 1 µM.
MICROCHEMICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Adela Krajcova, Vlasta Nemcova, Milada Halacova, Petr Waldauf, Martin Balik, Frantisek Duska
Summary: Amiodarone, but not propafenone, can cause mitochondrial dysfunction in human cardiomyocytes, leading to a switch from oxidative metabolism to anaerobic glycolysis and affecting autophagy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Clinical Neurology
Radek Kaiser, Michal Varga, Otto Lang, Petr Waldauf, Petr Vanek, Karel Saur, Vladimir Benes, David Netuka
Summary: The study investigated the effectiveness of posterior interbody fusion on patients with SPECT/CT positive lumbar degenerative disc disease. The results showed that fusion surgery led to significant clinical improvement and high satisfaction with the treatment. SPECT/CT imaging could be a useful tool for assessing patients with chronic low back pain, especially when MRI findings are inconclusive.
ACTA NEUROCHIRURGICA
(2023)