期刊
GROWTH HORMONE & IGF RESEARCH
卷 18, 期 5, 页码 379-388出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2008.01.007
关键词
growth hormone; growth hormone-releasing hormone receptor; fetus; glucocorticoids; pituitary gland
资金
- Twenty-First Century COE Program
Recent studies have disclosed the molecular mechanisms responsible for the phenotype; determination of the anterior pituitary cell types. However, as far as growth hormone (GH) cells are concerned, particular extra-cellular cues are required for the initiation of GH and GH-releasing hormone (GHRH)-receptor gene production in addition to the expression of the cell type specific transcription factor, pit-1. The glucocorticoids play a principal role in the functional maturation of nascent GH cells in the fetal pituitary glands in rodents, inducing GH and GHRH-receptor gene expression, and establish the GH secretory system regulated by the brain in late gestation. Research supporting this role for glucocorticoid in the development of GH cells is discussed. (C) 2008 Elsevier Ltd. All rights reserved.
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