期刊
GROWTH FACTORS
卷 30, 期 1, 页码 22-28出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08977194.2011.637034
关键词
Erythropoietin; osteopoiesis; osteogenesis; bone microenvironment
资金
- Department of Defense [PC073952]
- National Institutes of Health [DK082481, DE020721, 1RC1DE020721, CA141426, CA093900]
It has been well established that blood and bone share a unique, regulatory relationship with one another, though the specifics of this relationship still remain unanswered. Erythropoietin (Epo) is known primarily for its role as a hematopoietic hormone. However, after the discovery of Epo receptor outside the hematopoietic tissues, Epo has been avidly studied for its possible nonhematopoietic effects. It has been proposed that Epo interacts with bone both directly, by activating bone marrow stromal cells, and indirectly, through signaling pathways on hematopoietic stem cells. Yet, the role of Epo in regulating skeletal maintenance and regeneration remains controversial. Here, we review the current state of knowledge pertaining to the effects of Epo on the skeleton.
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