期刊
GREEN CHEMISTRY
卷 20, 期 21, 页码 -出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8gc01180j
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资金
- Ministry of Science and Technology, Taiwan
Visible light mediated copper catalysed denitrogenative oxidative coupling of 2-hydrazinopyridines with terminal alkynes to form 2-(alkyl/arylethynyl) pyridines in the presence of O-2 at room temperature is reported with 42 examples. This is the first report on visible light stimulated N-2 elimination by an in situ generated copper(ii) superoxo/peroxo complex. N-2 and water are the only by-products. The green chemistry metrics evaluation signifies that the current method is ecofriendly and economically feasible. This method allows the green synthesis of mGluR5 receptor antagonists, 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 2-((3-methoxyphenyl)ethynyl)-6-methylpyridine (M-MPEP).
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