Article
Chemistry, Multidisciplinary
Fazlulhaq Fazl, Morteza Torabi, Meysam Yarie, Mohammad Ali Zolfigol
Summary: In this study, a new urea-benzoic acid containing ligand was synthesized and used for the functionalization of silica coated magnetic nanoparticles. The resulting catalyst showed excellent activity and selectivity in the synthesis of 2,3-disubstituted thiazolidin-4-ones and hexahydroquinolines under mild and green reaction conditions. The catalyst also exhibited good recyclability.
Article
Chemistry, Organic
Sensheng Liu, Yangbin Liu, Arthur Flaget, Cheng Zhang, Clement Mazet
Summary: This study describes a Cu-catalyzed regio- and enantioselective protoboration of 2,3-disubstituted 1,3-dienes. The protocol operates under mild conditions and is applicable to symmetrically and unsymmetrically substituted dienes, providing access to homoallylic boronates with consistently high yield, regioselectivity, and enantiomeric ratio. Preliminary investigations suggest a complex mechanism.
Article
Chemistry, Organic
Wei-Yang Ma, Coralie Gelis, Damien Bouchet, Pascal Retailleau, Xavier Moreau, Luc Neuville, Geraldine Masson
Summary: A highly enantio- and regioselective (3 + 2) formal cycloaddition catalyzed by a BINOL- and SPINOL-derived phosphoric acid is reported, leading to the synthesis of a wide variety of 2,3-disubstituted 2-aminoindolines with generally high yields and excellent enantioselectivities. The reaction showed moderate to complete diastereoselectivities in most cases, producing products with up to 98% yield and up to 99% ee.
Article
Chemistry, Organic
Qifa Chen, Yue Teng, Fan Xu
Summary: In this study, a lanthanide silylamide-catalyzed tandem reaction was developed for the synthesis of pyrano[2,3-b]indol-2-ones in high yields. The catalytic activity of lanthanide amides may be influenced by the cooperation of the Lewis acidity of the lanthanide center and the Bronsted basicity of the N(SiMe3)(2) anion.
Article
Chemistry, Multidisciplinary
Jianguo Sun, Taimin Wang, Xuecheng Zhu, Wei Xu, Bin Cheng, Hongbin Zhai
Summary: Thiazolidin-4-ones were successfully synthesized from alpha-enolic dithioesters and alpha-halohydroxamates via active 1,3-dipolar aza-oxyallyl cations, resulting in five-membered heterocycles with Z-exocyclic double bonds and diverse substituents. This synthetic pathway demonstrates regio- and stereoselectivity in achieving the desired products through a formal [3+2] cycloaddition approach.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
You-Ya Zhang, Lin Li, Xiang-Zhi Zhang, Jin-Bao Peng
Summary: A metal-free catalytic approach has been developed for the remote C6-functionalization of 2,3-disubstituted indoles. By using catalytic amounts of Bronsted acid, the beta,gamma-unsaturated alpha-ketoesters can selectively react with 2,3-disubstituted indoles at the C6 position. This methodology offers a concise and efficient route for the synthesis of C6-functionalized indole derivatives.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Organic
Wen-Jun Huang, Ya-Ya Ma, Li-Xia Liu, Bo Wu, Guo-Fang Jiang, Yong-Gui Zhou
Summary: The study presents a method for direct regio- and enantioselective C6 functionalization of 2,3-disubstituted indoles with azadienes using chiral phosphoric acid as catalyst. Mechanistic studies show that N-alkylation of 2,3-disubstituted indoles with azadienes is reversible, enabling enantioselective C6 functionalization.
Article
Chemistry, Applied
Yu-Feng Liu, Gang-Ming Cao, Lei Chen, Ke Li, Xiao-Ling Lin, Xin-Xin Xu, Zhang-Gao Le, Guo-Ping Yang
Summary: We reported a method for the synthesis of 3,3'-disubstituted isobenzofuran-1(3H)-ones via the carbonyl difunctionalization of 2-acylbenzoic acids. The reaction yielded functionalized isobenzofuran-1(3H)-ones with a range of nucleophiles, achieving factual yield of 61-96%. The reaction was catalyzed by Cs0.5H2.5PW12O40 and water was the only by-product. The method enables the introduction of various functional groups to the isobenzofuran-1(3H)-one skeletons, offering opportunities for the synthesis of potential biologically active molecules.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
C. B. Pradeep Kumar, M. S. Raghu, K. N. N. Prasad, S. Chandrasekhar, B. K. Jayanna, Fahad A. Alharthi, M. K. Prashanth, K. Yogesh Kumar
Summary: Compounds 3g and 3h exhibited strong anti-tuberculosis activity with good affinity towards the target protein, making them potential lead compounds for the treatment of multi-drug resistant tuberculosis. Studies also indicated enhanced DNA binding properties of compound 3g compared to 3h, with promising K-b values. Density functional theory was utilized to obtain ground state geometries and energy calculations for further insight into the compounds' mechanism of action.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhenli Luo, Zhewei Li, Haoqiang Zhao, Ji Yang, Lijin Xu, Ming Lei, Qinghua Fan, Patrick J. Walsh
Summary: Significant progress has been made in the efficient synthesis of enantioenriched 1,2,3,4-tetrahydroquinoxalines in recent years. However, the access to trans-2,3-disubstituted 1,2,3,4-tetrahydroquinoxalines with enantio- and diastereoselectivity remains largely unexplored. In this study, a frustrated Lewis pair-based catalyst was used to achieve the one-pot tandem cyclization/hydrosilylation of 1,2-diaminobenzenes and 1,2-diketones, resulting in high yields of trans-2,3-disubstituted 1,2,3,4-tetrahydroquinoxalines with excellent diastereoselectivities. The reaction can be rendered asymmetric by using an enantioenriched borane-based catalyst, leading to enantioenriched products with high yields and complete diastereo- and enantiocontrol. The mechanistic pathway and the origin of the excellent stereoselectivity were elucidated through experiments and calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Julien Annibaletto, Thomas Martzel, Vincent Levacher, Sylvain Oudeyer, Jean-Francois Briere
Summary: The strategy reported involves a multicomponent catalytic enantioselective synthesis of beta-substituted isoxazolidin-5-ones via a KMC process promoted by a suitable bifunctional organocatalyst. The hydroxamic acid component with sterically hindered amide moiety is crucial for the successful formation and transformation of the N-amide isoxazolidin-5-ones obtained.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Dongping Cheng, Xianhang Yan, Yueqi Pu, Jing Shen, Xiaoliang Xu, Jizhong Yan
Summary: An efficient tandem oxidative annulation for the synthesis of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via DDQ-mediated dual cross-dehydrogenative-coupling (CDC) reactions is described, resulting in moderate to excellent yields of the corresponding products.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Yang-Ting Hsia, Yu-Lin Lu, Rekha Bai, Satpal Singh Badsara, Chin-Fa Lee
Summary: In this study, we report the efficient synthesis of indoles through the electrophilic cyclization of N, N-dimethylo-alkynylanilines with arylsiloxanes using [Pd(OAc)(2)] and Ag2O as catalysts. The reaction successfully cleaves the C-Si bond in a range of aryl(trimethoxy)silanes with different electron-donating and electron-withdrawing groups, providing a diverse variety of substituted indoles. With good functional group tolerance and wide substrate scope, this protocol yields 2,3-diaryl-N-methylindoles in 26-88% yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Zhou-Hao Zhu, Yi-Xuan Ding, Bo Wu, Yong-Gui Zhou
Summary: The asymmetric reduction of tetrasubstituted olefins has seen significant development, leading to an urgent demand for an effective method. By mimicking the coenzyme NAD(P)H, researchers have successfully reduced 2,3-substituted 1H-inden-1-ones using the catalytic chiral NAD(P)H model CYNAM, achieving high yields (up to 98%) and good enantioselectivity (up to 99% ee). The reduced product can also be efficiently used for the concise synthesis of chiral bioactive molecules.
Article
Environmental Sciences
Sultana Shaik, Rama Mohana Reddy Sirigireddy, Kumar Godugu, Venkatramu Vemula, Raghava Reddy Kakarla, Ekambaram Balaraman, Chinna Gangi Reddy Nallagondu, Tejraj M. Aminabhavi
Summary: An environmentally friendly FCDR strategy has been developed for the synthesis of (Z)-THIs using silica-supported perchloric acid as catalyst, with high stereospecificity. The method offers a wide substrate scope, high product yields, short reaction times, and reusable catalyst.
Article
Dermatology
Rajna Ogrin, Mohammod A. Motin, Behzad Aliahmad, Kylie Elder, Jacinta Anderson, Dinesh Kumar
Summary: This study investigated the effectiveness of using thermal imaging to predict venous leg ulcer healing in the homes of participants. The results showed that thermal imaging could not predict the healing progression of ulcers when taken in home settings.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Umer, Manish Motwani, John L. Jefferies, Sherif F. Nagueh, Dinesh K. Kalra
Summary: Fabry disease is a rare X-linked disorder that affects glycosphingolipid metabolism. It is caused by alpha-galactosidase A enzyme deficiency, leading to the accumulation of GL3 in lysosomes. Multiple systems are affected, with cardiac involvement being a significant manifestation. Early symptoms include neuropathic pain, skin lesions, anhidrosis, corneal changes, and gastrointestinal symptoms. Later stages may involve strokes, hearing loss, and life-threatening complications. This review focuses on the cardiac manifestations of Fabry disease and the role of multimodality imaging in diagnosis and monitoring.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sangita Dattatray Shinde, Dinesh Parshuram Satpute, Santosh Kumar Behera, Dinesh Kumar
Summary: Male breast cancer is a rare disease with poorer prognosis compared to female breast cancer. In this study, deleterious variations in the BRCA2 gene were analyzed to identify potential biomarkers for diagnosing, predicting prognosis, and developing therapeutic targets for male breast cancer.
Review
Biochemistry & Molecular Biology
Suresh C. C. Tyagi, Sathnur Pushpakumar, Utpal Sen, Sri Prakash L. Mokshagundam, Dinesh K. K. Kalra, Mohamed A. A. Saad, Mahavir Singh
Summary: Although the mechanisms underlying respiratory failure in Duchenne muscular dystrophy (DMD) and long-COVID are unclear, there is evidence of neopterin (NPT) involvement in both conditions. Studies have shown increased levels of NPT and other inflammatory markers in lung tissue, leading to fibrosis of the diaphragm. Understanding the epigenetic regulation and generation of NPT in long-COVID patients is of interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Umer, Dinesh K. Kalra
Summary: Fabry disease is a rare genetic disorder caused by a deficiency in the alpha-galactosidase A enzyme, leading to the accumulation of globotriaosylceramide in various organs. Fabry cardiomyopathy is characterized by abnormalities in the heart, including increased ventricular wall thickness, valvular disease, arrhythmias, and heart failure. Early diagnosis and treatment are crucial to prevent complications and improve patient outcomes. This review focuses on the role of cardiovascular magnetic resonance imaging in the diagnosis, decision-making, and monitoring of treatment efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Aangi J. Shah, Taylor Beckmann, Mounica Vorla, Dinesh K. Kalra
Summary: Pulmonary arterial hypertension (PAH) is a chronic and progressive disorder that affects the pulmonary vasculature and leads to pulmonary and cardiac remodeling. Despite improved life expectancy through targeted therapies, PAH still remains a progressive disease with significant morbidity and mortality. Current vasodilator therapies do not target the underlying pathogenesis of the disease, highlighting the need for the development of new drugs and interventional therapies. This review focuses on newer targets, drugs, and interventional therapies that modify various pathways involved in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sathnur Pushpakumar, Mahavir Singh, Yuting Zheng, Oluwaseun E. Akinterinwa, Sri Prakash L. Mokshagundam, Utpal Sen, Dinesh K. Kalra, Suresh C. Tyagi
Summary: Renal denervation (RDN) protects against hypertension, hypertrophy, and heart failure (HF) but it is unclear whether RDN preserves ejection fraction (EF) during HFpEF. By creating an aorta-vena cava fistula (AVF) in mice, this study demonstrated that RDN is cardioprotective during HFpEF via preservation of eNOS and endocardial-endothelial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Muhammad Umer, Dinesh K. K. Kalra
Summary: Fabry disease is a rare genetic disorder that affects the metabolism of glycosphingolipids. It results in the accumulation of globotriaosylceramide in lysosomes due to a deficiency of the alpha-galactosidase A enzyme. This disease affects multiple organs, mainly the kidneys, heart, and cerebrovascular system. Early diagnosis and treatment are crucial in preventing irreversible tissue damage, organ failure, and life-threatening complications that can significantly impact life expectancy. This review focuses on the current and emerging treatment options for Fabry disease.
Article
Cardiac & Cardiovascular Systems
Amit Rout, Sanchit Duhan, Muhammad Umer, Miranda Li, Dinesh Kalra
Review
Cardiac & Cardiovascular Systems
Dinesh K. Kalra, Mounica Vorla, Erin D. Michos, Anandita Agarwala, Salim Virani, Bart Duell, Frederick J. Raal
Summary: With the improvement of antiretroviral therapy, the life expectancy of people living with HIV has increased, but cardiovascular disease has become a major cause of morbidity and mortality in this aging population. Therefore, it is crucial to assess and treat cardiovascular disease risk factors, including dyslipidemia, in this population. However, there is limited evidence regarding the pathogenesis and management of dyslipidemia in people living with HIV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
U. Sagheer, M. K. Shotwell, M. Umer, W. Furtado, J. Joshi, D. K. Kalra
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
S. Hammad Jafri, Maya Guglin, Roopa Rao, Onyedika Ilonze, Kareem Ballut, Zulfiqar Qutrio Baloch, Mohammed Qintar, Joel Cohn, Matthew Wilcox, Andrew M. Freeman, Dinesh K. Kalra, Wen-Chih Wu
Summary: This study found that patients with heart failure (HF) were able to achieve similar or even better functional and psychosocial outcomes after intensive cardiac rehabilitation (ICR), despite their lower baseline functional status and psychosocial scores compared to non-HF patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Nachiket Apte, Dinesh K. Kalra
Summary: Ventricular ectopy is a common cardiac arrhythmia that can be managed with antiarrhythmic drugs. However, the use of these drugs should be done cautiously due to potential side effects.
Article
Mechanics
Tejaswini Kumari, Dinesh Kumar, K. N. Rai, S. K. Singh
Summary: This paper presents a mathematical heat transfer model for predicting the temperature profile at the tumor position during hyperthermia treatment in multi-layer skin tissue. It combines the dual-phase-lag model with a Gaussian heat source term and discusses the effects of various parameters and boundary conditions. The study concludes with a discussion on a better approach to treat tumor cells during hyperthermia treatment without harming neighboring healthy tissues.
MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES
(2023)
Article
Mathematics, Applied
D. L. Suthar, Dinesh Kumar, Haile Habenom
Summary: This article discusses the possible solutions of the fractional kinetic equation associated with the generalized multiindex Bessel function using the Laplace transform method. Numerical results and graphical solutions of the main theorems are also provided.
DIFFERENTIAL EQUATIONS AND DYNAMICAL SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.
