4.8 Article

A convenient guide to help select replacement solvents for dichloromethane in chromatography

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GREEN CHEMISTRY
卷 14, 期 11, 页码 3020-3025

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c2gc36064k

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One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of drug-like compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experimentally-derived solvent selection guide to aid chemists in choosing greener solvents for chromatographic purification, with a particular focus on reducing dichloromethane usage.

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