Synthesis of C6-azolyl purine nucleosides via C-N coupling reaction of unprotected 6-chloropurine nucleosides and N-heterocycles under catalyst- and solvent-free conditions

C6-azolyl purine nucleoside products are prepared in high yields under solvent-and catalyst-free conditions via C-N coupling reaction of unprotected 6-chloropurine nucleosides and N-heterocycles, providing a unifying, simple and environmentally friendly complement to the available methods.