Review
Chemistry, Applied
Yanan Wang, Zhegao Ye, Han Zhang, Zheliang Yuan
Summary: The introduction of trifluoromethylselenolation has attracted attention for its attractive lipophilicity and strong electron-withdrawing effect, with direct formation of C-SeCF3 being more efficient compared to indirect methods.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Chemistry, Organic
Komal Jakhar
Summary: Recent innovations in fluorination techniques highlight the significant role of ionic liquids in fluorotransformations, such as the use of tagged ionic liquids in nucleophilic fluorinations, ionic liquid assisted biological fluorination, enantioselective fluorinations using chiral electrophilic reagents in ionic liquid media, task-specific ionic liquids in electrochemical fluorinations with mediators, and ionic liquid promoted synthesis of medicinally important fluorinated heteroaromatics and radiopharmaceuticals.
CURRENT ORGANIC SYNTHESIS
(2022)
Review
Biochemistry & Molecular Biology
Young-Ho Oh, Dong Wook Kim, Sungyul Lee
Summary: Ionic liquids (ILs) have great potential as organocatalysts/promoters in chemical reactions, using their ionic nature and interactions with functional groups in substrates to enhance reaction rates. However, the full application of ILs as organocatalysts/promoters has not been achieved yet.
Article
Chemistry, Multidisciplinary
Gustavo B. Blodorn, Manoela Sacramento, Eduardo M. A. Sandagorda, Ariana S. Lima, Joel S. Reis, Marcio S. Silva, Diego Alves
Summary: In this study, symmetrical tellurides were synthesized by reacting different arylboronic acids with elemental tellurium using a simple methodology with a silver catalyst. Unlike other reported methods, this protocol skips the preparation steps of organotellurium compounds as intermediates and utilizes Te-0 for the synthesis of tellurides. The developed method showed tolerance towards various arylboronic acids, allowing the synthesis of tellurides with different electron withdrawing and donating groups attached to the aryl group at different positions, providing insight into the influence of these groups on the reaction.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Organic
Pran Gopal Karmaker, Feng Huo
Summary: The incorporation of the cyanato-chalcogen group has attracted the interest of researchers in modern organic synthetic chemistry. However, the development of methodologies for selenocyanation is lagging behind compared to OCN and SCN chemistry due to the scarcity of SeCN transfer reagents and synthetic approaches. In recent years, new reagents and techniques have been introduced that allow the uncomplicated creation of the selenocyanato group under gentle reaction conditions, which was seemingly unimaginable.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sourav Kar, Debipada Chatterjee, Jean-Francois Halet, Sundargopal Ghosh
Summary: Through thermolysis reactions, boron-containing tri-niobium polychalcogenide species were successfully isolated and characterized using various methods. The study revealed the significant role of the tri-niobium framework in stabilizing borate, borane, and chalcogen units.
Review
Chemistry, Physical
Zhenyu Zhang, Zirui Zhao, Binshen Wang, Jiaheng Zhang
Summary: Boron-based HILs with low viscosity have emerged as new potential fuels for bipropellant systems, and their derivatives can enhance hypergolicity as additives in HILs.
GREEN ENERGY & ENVIRONMENT
(2021)
Article
Engineering, Environmental
Muhammad Ishaq Khan, Muhammad Mubashir, Dzulkarnain Zaini, Mater H. Mahnashi, Bandar A. Alyami, Ali O. Alqarni, Pau Loke Show
Summary: This research work developed a comprehensive tool for assessing the cumulative ecotoxicological impact of ionic liquids (ILs) on aquatic life. The study evaluated the impact of different ILs on various aquatic species and determined the acceptable concentrations and risk values. Results indicated that certain imidazolium ILs had lower risk values and were more suitable for selected aquatic species.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Chemical
Lianwen He, Jing He, Peng Cui, Yuting Feng, Mingqing Hua, Jinrui Zhang, Peiwen Wu, Wenshuai Zhu, Huaming Li, Zhichang Liu, Chunming Xu
Summary: By introducing porous boron nitride into ionic liquids, the efficiency of sulfur extraction from fuel oil can be improved. Using m-BN-PIL as an extractant under optimized conditions achieves desulfurization performances of 59.2% and 61.8% for dibenzothiophene and 4-methyldibenzothiophene, respectively. After four stepwise extractions, the extraction efficiency over dibenzothiophene reaches 98.2%, achieving deep desulfurization of fuel oil.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Wen-Qiang Gong, Xian-Lu Wu, Zhang-Min Li, Yan Zhou, Wenshuai Zhu, Duan-Jian Tao
Summary: The study prepared a kind of sulfate functionalized ILs impregnated hexagonal boron nitride nanosheets for capture of low-concentration SO2, showing high uptake, selectivity, and fast adsorption rate. The material demonstrated excellent separation performance and reversibility in dynamic column breakthrough tests for removing 2000 ppm SO2 in a mixture of SO2/CO2/N-2.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Materials Science, Ceramics
Guoxun Sun, Jianqiang Bi
Summary: This study reports a scalable method to exfoliate boron nitride nanosheets in ionic liquids via shear-assisted thermal treatment, successfully preparing few-layer BNNSs with well-preserved structural integrity. The synergistic effects of physical adsorption, intercalation of IL molecules, chemical interactions between HF and h-BN, activation energy from heat treatment, and shear forces from stirring contribute to the exfoliation of BNNSs.
CERAMICS INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
Khursand E. Yorov, Andrey P. Zhdanov, Rustam Kh Kamilov, Alexander E. Baranchikov, Gennady P. Kopitsa, Oleg Pokrovskiy, Anton L. Popov, Olga S. Ivanova, Laszlo Almasy, Yury G. Kolyagin, Konstantin Yu Zhizhin, Vladimir K. Ivanov
Summary: A SiO2 aerogel material with high specific surface and open porosity, containing a closo-decaborate moiety, was successfully synthesized and showed excellent neutron capture properties. The borylated aerogel demonstrated pronounced dose-dependent toxicity towards malignant cells and low toxicity towards normal cells, making it a potential candidate for shielding in boron neutron capture therapy procedures.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Physical
Damiano Tanini, Tommaso Pecchi, Nikolai Ignat'ev, Antonella Capperucci
Summary: The ring opening reactions of strained heterocycles can be efficiently carried out in ionic liquids using silyl chalcogenides, resulting in the synthesis of beta-functionalized sulfides and selenides under mild conditions.
Article
Chemistry, Multidisciplinary
Gen Li, Marissa N. Lavagnino, Siraj Z. Ali, Shicheng Hu, Alexander T. Radosevich
Summary: A synthetic method for the reductive transformation of nitroarenes into ortho-aminated and-annulated products is reported, which involves deoxygenation and ring expansion reactions to generate functionalized products.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Arnaud De-Zordo Banliat, Kevin Grollier, Aurelie Damond, Thierry Billard, Guillaume Dagousset, Emmanuel Magnier, Bruce Pegot
Summary: The online-available [bmim][SeCN] has shown high efficiency in the selenocyanation of alkyl halides, with no organic solvents used in the process and reduced reaction times by utilizing microwave heating. The ionic liquid was carefully recycled and selenocyanate compounds were successfully transformed into trifluoromethylselenides in a one-pot two-step procedure.
Article
Biochemistry & Molecular Biology
Joelma M. M. Sarturi, Luciano Dornelles, Natalia V. V. Segatto, Tiago Collares, Fabiana K. K. Seixas, Bruna Candia Piccoli, Fernanda D'Avila da Silva, Folorunsho Bright Omage, Joao Batista Teixeira da Rocha, Renata A. A. Balaguez, Diego Alves, Eder J. J. Lenardao, Eric F. F. Lopes, Anna Kula-Pacurar, Krzysztof Pyrc, Luca Sancineto, Oscar E. D. Rodrigues
Summary: This study synthesized and evaluated the multi-target behavior of new 5'-hydroxy-3-(chalcogenyl-triazoyl)-thymidine derivatives as antioxidant and anti-HIV agents. The compounds showed good activity and no apparent toxicity in mice. The design strategy of modifying the AZT nucleus via the 1,3-dipolar Huisgen cycloaddition reaction proved effective in achieving the desired biological activities.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Mariana G. Fronza, Manoela Sacramento, Diego Alves, Domenico Pratico, Lucielli Savegnago
Summary: This study demonstrates that QTC-4-MeOBnE has a moderate effect in a transgenic model of AD, preventing memory impairment and depressive-like behavior, and modulating multiple pathways involved in the onset and progression of AD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marcelo Heinemann Presa, Marcia Juciele da Rocha, Camila Simoes Pires, Kauane Nayara Bahr Ledebuhr, Gabriel Pereira da Costa, Diego Alves, Cristiani Folharini Bortolatto, Ceisar Augusto Bruning
Summary: This study evaluated the antidepressant-like effect of a hybrid compound containing triazole and acetophenone, demonstrating that it modulates the serotonergic system through 5-HT2A/2C and 5-HT4 receptors and inhibits monoamine oxidase A activity in the hippocampus. The compound showed penetration into the central nervous system and low toxicity at a high dose, making it an interesting candidate for the development of a new therapeutic strategy for major depressive disorder (MDD).
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Organic
Gabriel P. P. Da Costa, Gustavo B. B. Blodorn, Thiago Barcellos, Marcio S. Silva, Rafael Luque, Diego Alves
Summary: We described a simple and metal-free protocol for the synthesis of [1,2,3]triazolo[1,5-a]quinoline 3-carboxamides. The synthesis involves two steps, with the first step utilizing organocatalysis and the second step involving the use of an inorganic base. The reactions were performed in dimethylsulfoxide as solvent at 70°C for 2 hours. The synthetic protocol yielded a variety of [1,2,3]triazolo[1,5-a]quinoline 3-carboxamides in good to excellent yields (63-96%) for secondary compounds and moderate to good yields (48-76%) for tertiary compounds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Helen A. A. Goulart, Daniela R. R. Araujo, Lucas E. B. Iarocz, Bruna R. R. Pizzi, Thiago Barcellos, Marcio S. Silva, Gelson Perin
Summary: We developed a new synthetic method for the production of dialkyl(1-(organolthio)naphthalen-2-yl)phosphates and derivatives. This method involves a dehydrogenative phosphorylation reaction between functionalized naphthols and H-phosphonates, using diphenyl ditelluride as an organocatalyst and sonochemistry as an alternative energy source. The reaction conditions were optimized using factorial design approach, and under ultrasound irradiation, the desired products were obtained in yields ranging from 51-98% after 2 hours of sonication. The protocol also worked well with phenol and thiophenol starting materials.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Physical
Ricardo H. Bartz, Luiz H. Dapper, Jean C. Kazmierczak, Ricardo F. Schumacher, Gelson Perin, Samuel Thurow, Filipe Penteado, Eder J. Lenardao
Summary: This review provides an overview of recent advances in photocatalyzed reactions for the formation of carbon-sulfur and carbon-selenium bonds. The authors present a comprehensive update on the state of the art in the light-induced synthesis of organochalcogen compounds from 2019 to present, with a total of 136 references and 81 cited articles. The discussion covers topics such as direct sulfenylation of C-C p-bonds to synthesize sulfides, sulfone synthesis, activation of C-sp2-N bond for C-sp2-S bond formation, thiol ester/thioether/thioacetal synthesis, and organoselenium compound synthesis, with detailed reaction conditions and selected examples for each protocol.
Article
Chemistry, Multidisciplinary
Joao M. Anghinoni, Sabrina S. Ferreira, Paulo C. Piquini, Bernardo A. Iglesias, Gelson Perin, Filipe Penteado, Eder J. Lenardao
Summary: This paper describes a new method for synthesizing α-carbonyl selenocyanates by reacting triselenium dicyanide and styrenes under blue light irradiation and O2 atmosphere. The method provides a useful tool for synthesizing α-carbonyl selenocyanates and demonstrates their potential in the synthesis of other compounds. α-Carbonyl selenocyanates were also explored as a synthetic platform for preparing 2-phenylimidazo[1,2-a]pyridine derivatives, which were evaluated for their photophysical properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Emilay B. T. Diogo, Fabio G. Delolo, Gabriela A. P. Graca, Esther R. S. Paz, icaro A. O. Bozzi, Renata Diniz, Juliano P. Passos, Tulio Matencio, Liane K. Soares, Diego Alves, Pedro M. S. Costa, Claudia Pessoa, Cynthia L. M. Pereira, Lutz Ackermann, Eufranio N. da Silva Junior
Summary: Undivided electrochemical cells are used to economically prepare sulphur-containing naphthoquinones through electrochemical sulphenylation of quinoidal compounds. This environmentally friendly and efficient protocol eliminates the need for chemical oxidants and enables the synthesis of desired molecules. It offers an efficient and versatile method for synthesizing cytotoxic quinones against cancer cell lines.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Loana I. Monzon, Nicole C. M. Rocha, Gabriela T. Quadros, Pamela P. P. Nunes, Roberta Cargnelutti, Raquel G. Jacob, Eder J. Lenardao, Gelson Perin, Daniela Hartwig
Summary: A general methodology for synthesizing valuable 4-(phenylchalcogenyl)tetrazolo[1,5-a]quinolines was developed by reacting 2-azidobenzaldehyde with phenylchalcogenylacetonitriles using potassium carbonate as a catalyst. The method tolerated a variety of functional groups and yielded twelve different 4-(phenylchalcogenyl)tetrazolo[1,5-a]quinolines selectively. The structure of the synthesized 4-(phenylselenyl)tetrazolo[1,5-a]quinoline was confirmed by X-ray analysis.
Review
Biochemistry & Molecular Biology
Gabriel Pereira da Costa, Gustavo Bierhals Blodorn, Angelita Manke Barcellos, Diego Alves
Summary: The importance of organoselenium compounds has been increasing in synthetic chemistry. They can serve as electrophiles, nucleophiles, and catalysts for organic transformations. The combination of inorganic and organic oxidants with organoselenium catalysts enables efficient, mild, and selective reactions.
Review
Biochemistry & Molecular Biology
Joao M. Anghinoni, Paloma T. Birmann, Marcia J. da Rocha, Caroline S. Gomes, Michael J. Davies, Cesar A. Bruening, Lucielli Savegnago, Eder J. Lenardao
Summary: In this review, the synthesis and bioassays of organic selenium compounds with antioxidant activity in the past five years are discussed, presenting the most active compounds in each series.
Article
Neurosciences
Ana Claudia Funguetto-Ribeiro, Kelly Ayumi Nakama, Mikaela Peglow Pinz, Renata Leivas de Oliveira, Manoela do Sacramento, Flavia S. Oliveira Pereira, Simone Pinton, Ethel Antunes Wilhelm, Cristiane Luchese, Diego Alves, Daiana Silva avila, Sandra Elisa Haas
Summary: This study developed and investigated the effects of TQ-loaded polymeric nanocapsules (NCTQ) in an AD model, showing low toxicity and the potential to improve memory impairment.
Article
Chemistry, Multidisciplinary
Joao M. Anghinoni, Sabrina S. S. Ferreira, Ricardo F. F. Schumacher, Bernardo A. A. Iglesias, Gelson Perin, Filipe Penteado, Eder J. J. Lenardao
Summary: Benzeneseleninic acid (BSA) derivatives were used as a convenient source of Se(ii)-based electrophiles for the formation of C-Se bonds via thermal decomposition. The reaction with 2-substituted imidazopyridines resulted in the synthesis of 3-selanylimidazopyridines. A total of thirty-four derivatives were prepared, with seventeen of them being previously unreported. The reaction protocol is simple and efficient, yielding only H2O and diaryl diselenide as by-products, which can be easily recovered and reused.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.
