Article
Chemistry, Organic
Jun-An Xiao, Xiu-Liang Cheng, Ru-Fang Meng, Xiao-Shi Qin, Hai Peng, Ji-Wei Ren, Zhen-Zhen Xie, Jian-Guo Cui, Yan-Min Huang
Summary: A metal- and oxidant-free method using a newly developed electrophilic selenocyanating reagent was reported for the preparation of 3-selenocyanato-substituted chromones from 2-hydroxyphenyl enaminones. A series of 3-selenocyanato- or 3-thiocyanato-substituted chromones and quinolinones were obtained in good to excellent yields under grinding reaction conditions, demonstrating the generality and utility of this approach through a scale-up reaction and transformations of one of the products.
SYNTHESIS-STUTTGART
(2021)
Article
Chemistry, Multidisciplinary
Yanyan Kong, Jung Keun Kim, Yabo Li, Jianye Zhang, Mengmeng Huang, Yangjie Wu
Summary: A direct electrooxidative cross-dehydrogenative-coupling (CDC) reaction has been developed for the construction of 3-tetrahydroisoquinoline substituted coumarins without the need for catalysts. Various N-aryl-tetrahydroisoquinolines and 4-hydroxycoumarins were found to be compatible with this transformation to give the corresponding products in moderate to excellent yields. Control experiments, cyclic voltammetry experiments, and density functional theory (DFT) calculations suggest that the electrooxidative CDC reaction may involve both radical addition and nucleophilic addition processes.
Article
Chemistry, Physical
Serena Traboni, Emiliano Bedini, Alfredo Landolfi, Giulia Vessella, Alfonso Iadonisi
Summary: A solvent-free method has been developed for regioselective functionalization of carbohydrate polyols with tosyl group, using cheap reagents and simple experimental procedures, resulting in selective functionalization of a specific saccharide site in a short period of time.
Review
Chemistry, Organic
Saima Malik, Aditya G. Lavekar, Bimal Krishna Banik
Summary: Radical chemistry, which has a history of two centuries, focuses on radical-mediated reactions that attract organic chemists to prepare new compounds with diverse stereochemistry. The tin-based radical annulation method is commonly used for synthesizing a wide range of organic compounds with medicinal significance, following atom economical principles. Recent stereoselective tin-mediated radical cyclization reactions demonstrate the versatility of tin-based reagents in encouraging chemists to construct many other molecules of interest.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Bing Yi, Qiang Wang, Jian-Ping Tan, Ziqi Yi, Daiguang Li, Shiyuan Kang, Wenhui Zhang, Huan Tang, Yanjun Xie
Summary: This study presents a visible-light mediated, iodine catalyzed radical cascade sulfonylation/cyclization reaction, which can efficiently synthesize a variety of sulfone-containing coumarin derivatives without the need for photocatalysts and oxidants. The method is green, cost-effective, and demonstrates a new opportunity for accessing diverse sulfone-containing coumarin derivatives.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Takayuki Ota, Valentina Montagna, Yuji Higuchi, Takashi Kato, Masaru Tanaka, Haritz Sardon, Kazuki Fukushima
Summary: This study investigates the ring-opening reactions of γ-carbonyl-substituted ε-caprolactones and finds that chain propagation hardly occurs, as the propagating species preferentially transform to α-substituted five-membered lactones. This study contributes to understanding the chemistry of ring-opening reactions of substituted lactones for designing functional degradable polymers.
Article
Chemistry, Physical
Yu-Chen Wei, Liang-Yan Hsu
Summary: This article demonstrates that quantum electrodynamic (QED) effects can significantly enhance the rate of electron transfer (ET) without the use of cavities. By incorporating the effect of infinite one-photon states into Marcus theory and introducing the concept of electron transfer overlap, the study provides new insights into the involvement of cavity-free QED effects in ET reactions.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Review
Chemistry, Organic
Zhi-Hao Shang, Jun Pan, Zeyu Wang, Ze-Xin Zhang, Jingjing Wu
Summary: Organoboron compounds are versatile in various fields and their preparation usually requires reactive organometallic reagents or transition metals. However, recent developments in transition-metal-free borylation methodologies using radical chemistry have attracted much attention. Through thermochemical, photochemical, or electrochemical pathways, successful approaches from different radical precursors have been developed. This review provides an overview of recent advances in transition-metal-free radical borylation processes.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Shiyin Li, Xinru Lin, Xiling Gao, Wangyu Zeng, Xiaoyi Wu, Xuan Shi, Shengjie Chen, Yan Zhang
Summary: This study achieved, for the first time, one-pot multicomponent reactions involving indole, aromatic aldehydes, and dimedone under solvent-free conditions. A class of unsymmetrical indole-substituted methane derivatives were synthesized through this green organic synthetic method. Based on experimental results, the reasonable mechanism for this condensation was emphasized.
LETTERS IN ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Zhipeng Huang, Yang Yang, Junju Mu, Genheng Li, Jianyu Han, Puning Ren, Jian Zhang, Nengchao Luo, Ke-Li Han, Feng Wang
Summary: Radicals are key intermediates in reactions and their reactivity poses challenges to controlling reactions over heterogeneous catalysts. Metal nanoparticles can stabilize and manipulate free radical species generated from photo-excited TiO2, facilitating controlled radical reactions on catalyst surfaces. These insights are crucial for designing advanced heterogeneous catalytic systems.
CHINESE JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Faranak Manteghi, Fatemeh Zakeri, Owen James Guy, Zari Tehrani
Summary: A chromium-containing metal-organic framework MIL-101 was effectively used as a heterogeneous catalyst for the solvent-free synthesis of 2,4,5-trisubstituted imidazoles, showing advantages such as high efficiency, reusability, and ease of isolation. The catalytic reaction achieved a high yield in a short time, making it a promising alternative to other catalysts.
Article
Polymer Science
Ahmad Arar, Assi Al Mousawi, Fabrice Morlet-Savary, Jacques Lalevee
Summary: Redox free radical polymerization (RFRP) is a cost-effective technique for producing polymers quickly and without energy consumption. By blending metal salts as oxidizing agents and reducing agents, a process with economic, low toxicity, and high stability is achieved under mild conditions. This method also allows for good control of gel time and an original chemical mechanism for the redox initiators is provided based on electron spin resonance experiments.
Article
Chemistry, Multidisciplinary
Filip Sebest, Lalita Radtanajiravong, Siim Kaukver, Andrew J. P. White, Silvia Diez-Gonzalez
Summary: A straightforward method for the synthesis of aryl aziridines from readily available azides and alkenes in the presence of technical solvents and air is reported. This methodology does not require any additives and the obtained compounds can be used in ring-opening and ring-expansion reactions.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Swadhapriya Bhukta, Rana Chatterjee, Rambabu Dandela
Summary: A novel and efficient method for the synthesis of substituted imidazoles has been developed using the I-2-DMSO concerted system. The reactions proceed efficiently in solvent-free conditions, resulting in good yields of various substituted imidazoles. This method offers advantages such as metal- and solvent-free process, mild conditions, and easily accessible reactants.
SYNTHESIS-STUTTGART
(2023)
Review
Environmental Sciences
Chuqi Guo, Jennifer Richmond-Bryant
Summary: Long-lived EPFR exposures can lead to respiratory and cardiovascular effects, attributed to their ability to produce reactive oxygen species. Characterizing EPFR exposure and health impacts requires systematic analysis protocols. Solvent extraction methods for EPFR analysis show varying recovery results based on radical species and solvent structure.
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.
